#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75460	uniprotkb:O75460	intact:EBI-371750|uniprotkb:A1L457|uniprotkb:A8K8N8|uniprotkb:A8MXS7|uniprotkb:Q59EE2|ensembl:ENSP00000401445	intact:EBI-371750|uniprotkb:A1L457|uniprotkb:A8K8N8|uniprotkb:A8MXS7|uniprotkb:Q59EE2|ensembl:ENSP00000401445	psi-mi:ern1_human(display_long)|uniprotkb:ERN1(gene name)|psi-mi:ERN1(display_short)|uniprotkb:Inositol-requiring protein 1(gene name synonym)|uniprotkb:Ire1-alpha(gene name synonym)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)|uniprotkb:IRE1(gene name synonym)	psi-mi:ern1_human(display_long)|uniprotkb:ERN1(gene name)|psi-mi:ERN1(display_short)|uniprotkb:Inositol-requiring protein 1(gene name synonym)|uniprotkb:Ire1-alpha(gene name synonym)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)|uniprotkb:IRE1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Ali et al. (2011)	mint:MINT-8143953|pubmed:21317875|imex:IM-15386|doi:10.1038/emboj.2011.18	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8592001|mint:MINT-8143959|imex:IM-15386-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001424.3|go:"GO:0070054"(mRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0098787"(mRNA cleavage involved in mRNA processing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990332"(Ire1 complex)|go:"GO:1990579"(peptidyl-serine trans-autophosphorylation)|go:"GO:1990597"(AIP1-IRE1 complex)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|ensembl:ENSG00000178607(gene)|ensembl:ENST00000433197(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006379"(mRNA cleavage)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019899"(enzyme binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|mint:O75460|rcsb pdb:2HZ6|rcsb pdb:3P23|rcsb pdb:4U6R|rcsb pdb:4YZ9|rcsb pdb:4YZC|rcsb pdb:4YZD|rcsb pdb:4Z7G|rcsb pdb:4Z7H|rcsb pdb:5HGI|rcsb pdb:6HV0|rcsb pdb:6HX1|rcsb pdb:6SHC|rcsb pdb:6URC|rcsb pdb:6W39|rcsb pdb:6W3A|rcsb pdb:6W3B|rcsb pdb:6W3C|rcsb pdb:6W3E|rcsb pdb:6W3K|rcsb pdb:6XDB|rcsb pdb:6XDD|rcsb pdb:6XDF|reactome:R-HSA-381070|dip:DIP-31711N|mint:MINT-8143961(identity)	refseq:NP_001424.3|go:"GO:0070054"(mRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0098787"(mRNA cleavage involved in mRNA processing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990332"(Ire1 complex)|go:"GO:1990579"(peptidyl-serine trans-autophosphorylation)|go:"GO:1990597"(AIP1-IRE1 complex)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|ensembl:ENSG00000178607(gene)|ensembl:ENST00000433197(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006379"(mRNA cleavage)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019899"(enzyme binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|mint:O75460|rcsb pdb:2HZ6|rcsb pdb:3P23|rcsb pdb:4U6R|rcsb pdb:4YZ9|rcsb pdb:4YZC|rcsb pdb:4YZD|rcsb pdb:4Z7G|rcsb pdb:4Z7H|rcsb pdb:5HGI|rcsb pdb:6HV0|rcsb pdb:6HX1|rcsb pdb:6SHC|rcsb pdb:6URC|rcsb pdb:6W39|rcsb pdb:6W3A|rcsb pdb:6W3B|rcsb pdb:6W3C|rcsb pdb:6W3E|rcsb pdb:6W3K|rcsb pdb:6XDB|rcsb pdb:6XDD|rcsb pdb:6XDF|reactome:R-HSA-381070|dip:DIP-31711N|mint:MINT-8143961(identity)	-	comment:"Stoichiometry: 2.0"	comment:"Stoichiometry: 2.0"	comment:mint|figure legend:f1 f2a t1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/07	2014/10/16	rogid:rJWQK9ZK0YCvATvj1lDrh9n7FHQ9606	rogid:rJWQK9ZK0YCvATvj1lDrh9n7FHQ9606	intact-crc:FBEA00653989BDB5|rigid:tFi40iqbcu/ZbSykXLrb3yeVjXI	false	binding-associated region:547-977(MINT-8143963)	binding-associated region:547-977(MINT-8143963)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75460	-	intact:EBI-371750|uniprotkb:A1L457|uniprotkb:A8K8N8|uniprotkb:A8MXS7|uniprotkb:Q59EE2|ensembl:ENSP00000401445	-	psi-mi:ern1_human(display_long)|uniprotkb:ERN1(gene name)|psi-mi:ERN1(display_short)|uniprotkb:Inositol-requiring protein 1(gene name synonym)|uniprotkb:Ire1-alpha(gene name synonym)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)|uniprotkb:IRE1(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Ali et al. (2011)	mint:MINT-8143953|pubmed:21317875|imex:IM-15386|doi:10.1038/emboj.2011.18	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8592025|mint:MINT-8143973|imex:IM-15386-1	-	-	psi-mi:"MI:0503"(self)	-	psi-mi:"MI:0503"(self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_001424.3|go:"GO:0070054"(mRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0098787"(mRNA cleavage involved in mRNA processing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990332"(Ire1 complex)|go:"GO:1990579"(peptidyl-serine trans-autophosphorylation)|go:"GO:1990597"(AIP1-IRE1 complex)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|ensembl:ENSG00000178607(gene)|ensembl:ENST00000433197(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006379"(mRNA cleavage)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019899"(enzyme binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|mint:O75460|rcsb pdb:2HZ6|rcsb pdb:3P23|rcsb pdb:4U6R|rcsb pdb:4YZ9|rcsb pdb:4YZC|rcsb pdb:4YZD|rcsb pdb:4Z7G|rcsb pdb:4Z7H|rcsb pdb:5HGI|rcsb pdb:6HV0|rcsb pdb:6HX1|rcsb pdb:6SHC|rcsb pdb:6URC|rcsb pdb:6W39|rcsb pdb:6W3A|rcsb pdb:6W3B|rcsb pdb:6W3C|rcsb pdb:6W3E|rcsb pdb:6W3K|rcsb pdb:6XDB|rcsb pdb:6XDD|rcsb pdb:6XDF|reactome:R-HSA-381070|dip:DIP-31711N|mint:MINT-8143975(identity)	-	-	-	-	comment:mint|figure legend:f2b f4a f4b|intra-molecular:true|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/07	2014/10/16	rogid:rJWQK9ZK0YCvATvj1lDrh9n7FHQ9606	-	intact-crc:75676D48EFB5F108	false	phosphorylated residue:724-724(MINT-8143980)	-	-	-	psi-mi:"MI:0113"(western blot)	-
intact:EBI-8592038	uniprotkb:O75460	intact:MINT-8143995	intact:EBI-371750|uniprotkb:A1L457|uniprotkb:A8K8N8|uniprotkb:A8MXS7|uniprotkb:Q59EE2|ensembl:ENSP00000401445	psi-mi:s2(display_short)|psi-mi:EBI-8592038(display_long)	psi-mi:ern1_human(display_long)|uniprotkb:ERN1(gene name)|psi-mi:ERN1(display_short)|uniprotkb:Inositol-requiring protein 1(gene name synonym)|uniprotkb:Ire1-alpha(gene name synonym)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)|uniprotkb:IRE1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Ali et al. (2011)	mint:MINT-8143953|pubmed:21317875|imex:IM-15386|doi:10.1038/emboj.2011.18	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8592043|mint:MINT-8143986|imex:IM-15386-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	mint:MINT-8143997(identity)	refseq:NP_001424.3|go:"GO:0070054"(mRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0098787"(mRNA cleavage involved in mRNA processing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990332"(Ire1 complex)|go:"GO:1990579"(peptidyl-serine trans-autophosphorylation)|go:"GO:1990597"(AIP1-IRE1 complex)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|ensembl:ENSG00000178607(gene)|ensembl:ENST00000433197(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006379"(mRNA cleavage)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019899"(enzyme binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|mint:O75460|rcsb pdb:2HZ6|rcsb pdb:3P23|rcsb pdb:4U6R|rcsb pdb:4YZ9|rcsb pdb:4YZC|rcsb pdb:4YZD|rcsb pdb:4Z7G|rcsb pdb:4Z7H|rcsb pdb:5HGI|rcsb pdb:6HV0|rcsb pdb:6HX1|rcsb pdb:6SHC|rcsb pdb:6URC|rcsb pdb:6W39|rcsb pdb:6W3A|rcsb pdb:6W3B|rcsb pdb:6W3C|rcsb pdb:6W3E|rcsb pdb:6W3K|rcsb pdb:6XDB|rcsb pdb:6XDD|rcsb pdb:6XDF|reactome:R-HSA-381070|dip:DIP-31711N|mint:MINT-8143988(identity)	-	comment:mint|no-uniprot-update:	-	figure legend:f4e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/07	2014/10/16	rogid:DgsLWh4pyBAIFNqne/vlX05GHYQ-2	rogid:rJWQK9ZK0YCvATvj1lDrh9n7FHQ9606	intact-crc:0A98633C76571197|rigid:eFT2ElIeeZH70FPYlw3Kg8OIFY4	false	biotin tag:?-?(MINT-8151293)	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0396"(predetermined participant)