#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P01275 uniprotkb:Q12884 intact:EBI-7629173|ensembl:ENSP00000364647|ensembl:ENSP00000387662|uniprotkb:A6NN65|intact:MINT-8090511|uniprotkb:Q53TP6 intact:EBI-4319803|uniprotkb:O00199|uniprotkb:Q53TP5|uniprotkb:Q86Z29|uniprotkb:Q99998|uniprotkb:Q9UID4|ensembl:ENSP00000188790 psi-mi:gluc_human(display_long)|uniprotkb:GCG(gene name)|psi-mi:GCG(display_short) psi-mi:sepr_human(display_long)|uniprotkb:Integral membrane serine protease(gene name synonym)|uniprotkb:FAP(gene name)|psi-mi:FAP(display_short)|uniprotkb:170 kDa melanoma membrane-bound gelatinase(gene name synonym)|uniprotkb:Fibroblast activation protein alpha(gene name synonym)|uniprotkb:Dipeptidyl peptidase FAP(gene name synonym)|uniprotkb:Gelatine degradation protease FAP(gene name synonym)|uniprotkb:Post-proline cleaving enzyme(gene name synonym)|uniprotkb:Serine integral membrane protease(gene name synonym)|uniprotkb:Surface-expressed protease(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588513|mint:MINT-8090539 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-420092|reactome:R-HSA-422085|reactome:R-HSA-9660821|reactome:R-HSA-418555|ensembl:ENSG00000115263(gene)|ensembl:ENST00000375497(transcript)|ensembl:ENST00000418842(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014823"(response to activity)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR015550(Glucagon-like)|mint:P01275|rcsb pdb:1BH0|rcsb pdb:1D0R|rcsb pdb:1NAU|rcsb pdb:2G49|rcsb pdb:2L63|rcsb pdb:2L64|rcsb pdb:2M5P|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|rcsb pdb:2M5Q|rcsb pdb:3IOL|rcsb pdb:4APD|rcsb pdb:4ZGM|rcsb pdb:5OTU|rcsb pdb:5OTV|rcsb pdb:5OTW|rcsb pdb:5OTX|rcsb pdb:5VAI|rcsb pdb:5YQZ|rcsb pdb:6EDS|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6NZN|rcsb pdb:6PHI|rcsb pdb:6PHJ|rcsb pdb:6PHK|rcsb pdb:6PHL|rcsb pdb:6PHO|rcsb pdb:6PHP|rcsb pdb:6VCB|rcsb pdb:6X18|rcsb pdb:7D68|reactome:R-HSA-163359|reactome:R-HSA-381676|reactome:R-HSA-381771|reactome:R-HSA-416476|refseq:NP_002045.1|dip:DIP-46470N|mint:MINT-8090542(identity) refseq:NP_004451.2|refseq:NP_001278736.1|ensembl:ENSG00000078098(gene)|ensembl:ENST00000188790(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1902362"(melanocyte apoptotic process)|go:"GO:1903054"(negative regulation of extracellular matrix organization)|go:"GO:1905368"(peptidase complex)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|interpro:IPR031245|rcsb pdb:1Z68|rcsb pdb:6Y0F|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|mint:MINT-8090541(identity) - comment:mint|comment:homomint - comment:homomint|comment:mint|figure legend:t1 t2 f5 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:lZLjmf6wPVM15tLWwCJkDwY3CSw9606 rogid:EP0sQlmVlm/H+15legbkc2IvEeg9606 intact-crc:9207D687649734D5|rigid:XIGA1flQ5zpD4CaCT6Dn7Y9RMXg false binding-associated region:92-128(MINT-8090549) binding-associated region:?-?(MINT-8090545) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01275 uniprotkb:Q12884 intact:EBI-7629173|ensembl:ENSP00000364647|ensembl:ENSP00000387662|uniprotkb:A6NN65|intact:MINT-8090511|uniprotkb:Q53TP6 intact:EBI-4319803|uniprotkb:O00199|uniprotkb:Q53TP5|uniprotkb:Q86Z29|uniprotkb:Q99998|uniprotkb:Q9UID4|ensembl:ENSP00000188790 psi-mi:gluc_human(display_long)|uniprotkb:GCG(gene name)|psi-mi:GCG(display_short) psi-mi:sepr_human(display_long)|uniprotkb:Integral membrane serine protease(gene name synonym)|uniprotkb:FAP(gene name)|psi-mi:FAP(display_short)|uniprotkb:170 kDa melanoma membrane-bound gelatinase(gene name synonym)|uniprotkb:Fibroblast activation protein alpha(gene name synonym)|uniprotkb:Dipeptidyl peptidase FAP(gene name synonym)|uniprotkb:Gelatine degradation protease FAP(gene name synonym)|uniprotkb:Post-proline cleaving enzyme(gene name synonym)|uniprotkb:Serine integral membrane protease(gene name synonym)|uniprotkb:Surface-expressed protease(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588533|mint:MINT-8090553 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-420092|reactome:R-HSA-422085|reactome:R-HSA-9660821|reactome:R-HSA-418555|ensembl:ENSG00000115263(gene)|ensembl:ENST00000375497(transcript)|ensembl:ENST00000418842(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014823"(response to activity)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR015550(Glucagon-like)|mint:P01275|rcsb pdb:1BH0|rcsb pdb:1D0R|rcsb pdb:1NAU|rcsb pdb:2G49|rcsb pdb:2L63|rcsb pdb:2L64|rcsb pdb:2M5P|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|rcsb pdb:2M5Q|rcsb pdb:3IOL|rcsb pdb:4APD|rcsb pdb:4ZGM|rcsb pdb:5OTU|rcsb pdb:5OTV|rcsb pdb:5OTW|rcsb pdb:5OTX|rcsb pdb:5VAI|rcsb pdb:5YQZ|rcsb pdb:6EDS|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6NZN|rcsb pdb:6PHI|rcsb pdb:6PHJ|rcsb pdb:6PHK|rcsb pdb:6PHL|rcsb pdb:6PHO|rcsb pdb:6PHP|rcsb pdb:6VCB|rcsb pdb:6X18|rcsb pdb:7D68|reactome:R-HSA-163359|reactome:R-HSA-381676|reactome:R-HSA-381771|reactome:R-HSA-416476|refseq:NP_002045.1|dip:DIP-46470N|mint:MINT-8090559(identity) refseq:NP_004451.2|refseq:NP_001278736.1|ensembl:ENSG00000078098(gene)|ensembl:ENST00000188790(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1902362"(melanocyte apoptotic process)|go:"GO:1903054"(negative regulation of extracellular matrix organization)|go:"GO:1905368"(peptidase complex)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|interpro:IPR031245|rcsb pdb:1Z68|rcsb pdb:6Y0F|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|mint:MINT-8090555(identity) - comment:mint|comment:homomint - comment:homomint|comment:mint|figure legend:t1 t2 f5 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:lZLjmf6wPVM15tLWwCJkDwY3CSw9606 rogid:EP0sQlmVlm/H+15legbkc2IvEeg9606 intact-crc:3C3CCDE9D94C169C|rigid:XIGA1flQ5zpD4CaCT6Dn7Y9RMXg false binding-associated region:146-178(MINT-8090560) binding-associated region:?-?(MINT-8090556) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P09681 uniprotkb:P27487 intact:EBI-8588553|ensembl:ENSP00000350005|uniprotkb:Q6NTD3|uniprotkb:Q4VB42|intact:MINT-8090589 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 psi-mi:gip_human(display_long)|uniprotkb:Incretin hormone(gene name synonym)|uniprotkb:GIP(gene name)|psi-mi:GIP(display_short)|uniprotkb:Glucose-dependent insulinotropic polypeptide(gene name synonym) psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588604|mint:MINT-8090565 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000159224(gene)|ensembl:ENST00000357424(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009749"(response to glucose)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0033993"(response to lipid)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035640"(exploration behavior)|go:"GO:0038192"(gastric inhibitory peptide signaling pathway)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0042594"(response to starvation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043200"(response to amino acid)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0048678"(response to axon injury)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0055123"(digestive system development)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0070328"(triglyceride homeostasis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR039078|rcsb pdb:1T5Q|rcsb pdb:2B4N|rcsb pdb:2L70|go:"GO:0042493"|rcsb pdb:2L71|rcsb pdb:2OBU|reactome:R-HSA-9660821|rcsb pdb:2QKH|reactome:R-HSA-400511|reactome:R-HSA-418555|reactome:R-HSA-420092|dip:DIP-46469N|refseq:NP_004114.1|mint:MINT-8090611(identity) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090567(identity) - comment:mint - comment:homomint|comment:mint|figure legend:t1 t2 f7 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:uDk65FsDVA70YuVfSkYyfbSCFeQ9606 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 intact-crc:1541C8A1BE08F5A6|rigid:U4AYKTO3nmfkn/V7K6jRhQYBDU0 false - binding-associated region:39-766(MINT-8090568) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01282 uniprotkb:Q12884 intact:EBI-751454|uniprotkb:Q5TCY8|uniprotkb:Q5TCY9|uniprotkb:Q96QK3|ensembl:ENSP00000356213 intact:EBI-4319803|uniprotkb:O00199|uniprotkb:Q53TP5|uniprotkb:Q86Z29|uniprotkb:Q99998|uniprotkb:Q9UID4|ensembl:ENSP00000188790 psi-mi:vip_human(display_long)|uniprotkb:VIP(gene name)|psi-mi:VIP(display_short) psi-mi:sepr_human(display_long)|uniprotkb:Integral membrane serine protease(gene name synonym)|uniprotkb:FAP(gene name)|psi-mi:FAP(display_short)|uniprotkb:170 kDa melanoma membrane-bound gelatinase(gene name synonym)|uniprotkb:Fibroblast activation protein alpha(gene name synonym)|uniprotkb:Dipeptidyl peptidase FAP(gene name synonym)|uniprotkb:Gelatine degradation protease FAP(gene name synonym)|uniprotkb:Post-proline cleaving enzyme(gene name synonym)|uniprotkb:Serine integral membrane protease(gene name synonym)|uniprotkb:Surface-expressed protease(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588618|mint:MINT-8090577 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003372.1|refseq:NP_919416.1|ensembl:ENSG00000146469(gene)|ensembl:ENST00000367244(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007589"(body fluid secretion)|go:"GO:0007611"(learning or memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0032812"(positive regulation of epinephrine secretion)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048242"(epinephrine secretion)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070459"(prolactin secretion)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR015523(Vasoactive intestinal peptide)|rcsb pdb:2RRH|rcsb pdb:2RRI|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|mint:MINT-8090615(identity) refseq:NP_004451.2|refseq:NP_001278736.1|ensembl:ENSG00000078098(gene)|ensembl:ENST00000188790(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1902362"(melanocyte apoptotic process)|go:"GO:1903054"(negative regulation of extracellular matrix organization)|go:"GO:1905368"(peptidase complex)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|interpro:IPR031245|rcsb pdb:1Z68|rcsb pdb:6Y0F|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|mint:MINT-8090579(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 f6 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:4wBOw0yxQ/xvUzZPXUCV/qZvh6A9606 rogid:EP0sQlmVlm/H+15legbkc2IvEeg9606 intact-crc:F15E465CAE4C4EB7|rigid:5MPQciyUEx6HfNIHU/fKuUtGv/o false binding-associated region:81-107(MINT-8090617) binding-associated region:?-?(MINT-8090580) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01286 uniprotkb:Q12884 intact:EBI-8588643|ensembl:ENSP00000237527|ensembl:ENSP00000362716|uniprotkb:Q4KN10|intact:MINT-8090632|uniprotkb:Q5JYR1 intact:EBI-4319803|uniprotkb:O00199|uniprotkb:Q53TP5|uniprotkb:Q86Z29|uniprotkb:Q99998|uniprotkb:Q9UID4|ensembl:ENSP00000188790 psi-mi:slib_human(display_long)|uniprotkb:GHRH(gene name)|psi-mi:GHRH(display_short)|uniprotkb:GHRF(gene name synonym)|uniprotkb:Growth hormone-releasing factor(gene name synonym)|uniprotkb:Growth hormone-releasing hormone(gene name synonym)|uniprotkb:Somatocrinin(gene name synonym)|uniprotkb:Somatorelin(gene name synonym) psi-mi:sepr_human(display_long)|uniprotkb:Integral membrane serine protease(gene name synonym)|uniprotkb:FAP(gene name)|psi-mi:FAP(display_short)|uniprotkb:170 kDa melanoma membrane-bound gelatinase(gene name synonym)|uniprotkb:Fibroblast activation protein alpha(gene name synonym)|uniprotkb:Dipeptidyl peptidase FAP(gene name synonym)|uniprotkb:Gelatine degradation protease FAP(gene name synonym)|uniprotkb:Post-proline cleaving enzyme(gene name synonym)|uniprotkb:Serine integral membrane protease(gene name synonym)|uniprotkb:Surface-expressed protease(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588638|mint:MINT-8090620 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000118702(gene)|ensembl:ENST00000237527(transcript)|ensembl:ENST00000373614(transcript)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016608"(growth hormone-releasing hormone activity)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031770"(growth hormone-releasing hormone receptor binding)|go:"GO:0032094"(response to food)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0046005"(positive regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0060124"(positive regulation of growth hormone secretion)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|rcsb pdb:5BQM|rcsb pdb:7CZ5|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|refseq:XP_011527086.1|refseq:XP_011527090.1|refseq:NP_001171660.1|refseq:NP_066567.1|mint:MINT-8090626(identity) refseq:NP_004451.2|refseq:NP_001278736.1|ensembl:ENSG00000078098(gene)|ensembl:ENST00000188790(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1902362"(melanocyte apoptotic process)|go:"GO:1903054"(negative regulation of extracellular matrix organization)|go:"GO:1905368"(peptidase complex)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|interpro:IPR031245|rcsb pdb:1Z68|rcsb pdb:6Y0F|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|mint:MINT-8090622(identity) - comment:mint - comment:homomint|comment:mint|figure legend:t1 t2 f6 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:S0wIMHV/xTCB+GZhmoNi4F/vo8A9606 rogid:EP0sQlmVlm/H+15legbkc2IvEeg9606 intact-crc:5B6B0089151838AA|rigid:0mKhUUAJv3U0M0b4nu0602xTJV4 false - binding-associated region:?-?(MINT-8090623) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q12884 uniprotkb:P10082 intact:EBI-4319803|uniprotkb:O00199|uniprotkb:Q53TP5|uniprotkb:Q86Z29|uniprotkb:Q99998|uniprotkb:Q9UID4|ensembl:ENSP00000188790 intact:EBI-6655667|ensembl:ENSP00000353198|uniprotkb:Q5U5Q6|uniprotkb:Q6FGH8 psi-mi:sepr_human(display_long)|uniprotkb:Integral membrane serine protease(gene name synonym)|uniprotkb:FAP(gene name)|psi-mi:FAP(display_short)|uniprotkb:170 kDa melanoma membrane-bound gelatinase(gene name synonym)|uniprotkb:Fibroblast activation protein alpha(gene name synonym)|uniprotkb:Dipeptidyl peptidase FAP(gene name synonym)|uniprotkb:Gelatine degradation protease FAP(gene name synonym)|uniprotkb:Post-proline cleaving enzyme(gene name synonym)|uniprotkb:Serine integral membrane protease(gene name synonym)|uniprotkb:Surface-expressed protease(gene name synonym) psi-mi:pyy_human(display_long)|uniprotkb:PYY(gene name)|psi-mi:PYY(display_short)|uniprotkb:PYY-I(gene name synonym)|uniprotkb:Peptide tyrosine tyrosine(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588697|mint:MINT-8090673 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004451.2|refseq:NP_001278736.1|ensembl:ENSG00000078098(gene)|ensembl:ENST00000188790(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1902362"(melanocyte apoptotic process)|go:"GO:1903054"(negative regulation of extracellular matrix organization)|go:"GO:1905368"(peptidase complex)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|interpro:IPR031245|rcsb pdb:1Z68|rcsb pdb:6Y0F|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|mint:MINT-8090675(identity) refseq:XP_011523337.1|ensembl:ENST00000360085(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0031841"(neuropeptide Y receptor binding)|go:"GO:0060575"(intestinal epithelial cell differentiation)|interpro:IPR001955(Pancreatic hormone)|interpro:IPR020392|rcsb pdb:2DEZ|rcsb pdb:2DF0|rcsb pdb:2L60|rcsb pdb:2NA5|reactome:R-HSA-375276|reactome:R-HSA-418594|ensembl:ENSG00000131096(gene)|refseq:NP_004151.3|mint:MINT-8090679(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 f3 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:EP0sQlmVlm/H+15legbkc2IvEeg9606 rogid:VKGXqAYXru2Kad45HYBcvqSIEyY9606 intact-crc:5B6A347EDFAF4E5B|rigid:qjeV+5C2QmWOpwubgtnHw+Z9F+I false binding-associated region:?-?(MINT-8090676) binding-associated region:29-64(MINT-8090720) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q12884 uniprotkb:P16860 intact:EBI-4319803|uniprotkb:O00199|uniprotkb:Q53TP5|uniprotkb:Q86Z29|uniprotkb:Q99998|uniprotkb:Q9UID4|ensembl:ENSP00000188790 intact:EBI-747044|uniprotkb:Q6FGY0|uniprotkb:B0ZBE9|uniprotkb:Q9P2Q7|ensembl:ENSP00000365651 psi-mi:sepr_human(display_long)|uniprotkb:Integral membrane serine protease(gene name synonym)|uniprotkb:FAP(gene name)|psi-mi:FAP(display_short)|uniprotkb:170 kDa melanoma membrane-bound gelatinase(gene name synonym)|uniprotkb:Fibroblast activation protein alpha(gene name synonym)|uniprotkb:Dipeptidyl peptidase FAP(gene name synonym)|uniprotkb:Gelatine degradation protease FAP(gene name synonym)|uniprotkb:Post-proline cleaving enzyme(gene name synonym)|uniprotkb:Serine integral membrane protease(gene name synonym)|uniprotkb:Surface-expressed protease(gene name synonym) psi-mi:anfb_human(display_long)|uniprotkb:NPPB(gene name)|psi-mi:NPPB(display_short)|uniprotkb:Gamma-brain natriuretic peptide(gene name synonym)|uniprotkb:Brain natriuretic factor prohormone(gene name synonym)|uniprotkb:Iso-ANP(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588737|mint:MINT-8090723 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004451.2|refseq:NP_001278736.1|ensembl:ENSG00000078098(gene)|ensembl:ENST00000188790(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1902362"(melanocyte apoptotic process)|go:"GO:1903054"(negative regulation of extracellular matrix organization)|go:"GO:1905368"(peptidase complex)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|interpro:IPR031245|rcsb pdb:1Z68|rcsb pdb:6Y0F|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|mint:MINT-8090725(identity) refseq:NP_002512.1|go:"GO:0051427"(hormone receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0097746"(blood vessel diameter maintenance)|interpro:IPR000663(Natriuretic peptide)|interpro:IPR002408(Natriuretic peptide, brain type)|interpro:IPR030480|rcsb pdb:1YK1|rcsb pdb:3N56|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042311"(vasodilation)|go:"GO:0043114"(regulation of vascular permeability)|ensembl:ENSG00000120937(gene)|ensembl:ENST00000376468(transcript)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007168"(receptor guanylyl cyclase signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008613"(diuretic hormone activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030308"(negative regulation of cell growth)|mint:MINT-8090729(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 f4 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:EP0sQlmVlm/H+15legbkc2IvEeg9606 rogid:BWrb9PssxGVBOVPQLcUOTprCtNI9606 intact-crc:811FDE6106624CC9|rigid:clb3jYHPofA5j4R31yRs14ffFP4 false binding-associated region:?-?(MINT-8090726) binding-associated region:103-134(MINT-8090730) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q12884 uniprotkb:P01303 intact:EBI-4319803|uniprotkb:O00199|uniprotkb:Q53TP5|uniprotkb:Q86Z29|uniprotkb:Q99998|uniprotkb:Q9UID4|ensembl:ENSP00000188790 intact:EBI-3905877|ensembl:ENSP00000242152|ensembl:ENSP00000384364|ensembl:ENSP00000385282 psi-mi:sepr_human(display_long)|uniprotkb:Integral membrane serine protease(gene name synonym)|uniprotkb:FAP(gene name)|psi-mi:FAP(display_short)|uniprotkb:170 kDa melanoma membrane-bound gelatinase(gene name synonym)|uniprotkb:Fibroblast activation protein alpha(gene name synonym)|uniprotkb:Dipeptidyl peptidase FAP(gene name synonym)|uniprotkb:Gelatine degradation protease FAP(gene name synonym)|uniprotkb:Post-proline cleaving enzyme(gene name synonym)|uniprotkb:Serine integral membrane protease(gene name synonym)|uniprotkb:Surface-expressed protease(gene name synonym) psi-mi:npy_human(display_long)|uniprotkb:NPY(gene name)|psi-mi:NPY(display_short) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588757|mint:MINT-8090736 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004451.2|refseq:NP_001278736.1|ensembl:ENSG00000078098(gene)|ensembl:ENST00000188790(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1902362"(melanocyte apoptotic process)|go:"GO:1903054"(negative regulation of extracellular matrix organization)|go:"GO:1905368"(peptidase complex)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|interpro:IPR031245|rcsb pdb:1Z68|rcsb pdb:6Y0F|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|mint:MINT-8090738(identity) refseq:NP_000896.1|ensembl:ENSG00000122585(gene)|ensembl:ENST00000242152(transcript)|ensembl:ENST00000405982(transcript)|ensembl:ENST00000407573(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001878"(response to yeast)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031841"(neuropeptide Y receptor binding)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0098992"(neuronal dense core vesicle)|interpro:IPR001955(Pancreatic hormone)|interpro:IPR020392|mint:P01303|rcsb pdb:1QFA|rcsb pdb:1RON|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-9615017|mint:MINT-8090742(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 f3 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:EP0sQlmVlm/H+15legbkc2IvEeg9606 rogid:UTmbtVQkF1DB3LfhgJjN1hEHXrw9606 intact-crc:120E5F9D43BD11CD|rigid:XBL3Yu3hutbud5qOKjgX6INAw7A false binding-associated region:?-?(MINT-8090739) binding-associated region:29-64(MINT-8090743) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P01275 uniprotkb:P27487 intact:EBI-7629173|ensembl:ENSP00000364647|ensembl:ENSP00000387662|uniprotkb:A6NN65|intact:MINT-8090511|uniprotkb:Q53TP6 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 psi-mi:gluc_human(display_long)|uniprotkb:GCG(gene name)|psi-mi:GCG(display_short) psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588814|mint:MINT-8090772 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-420092|reactome:R-HSA-422085|reactome:R-HSA-9660821|reactome:R-HSA-418555|ensembl:ENSG00000115263(gene)|ensembl:ENST00000375497(transcript)|ensembl:ENST00000418842(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014823"(response to activity)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR015550(Glucagon-like)|mint:P01275|rcsb pdb:1BH0|rcsb pdb:1D0R|rcsb pdb:1NAU|rcsb pdb:2G49|rcsb pdb:2L63|rcsb pdb:2L64|rcsb pdb:2M5P|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|rcsb pdb:2M5Q|rcsb pdb:3IOL|rcsb pdb:4APD|rcsb pdb:4ZGM|rcsb pdb:5OTU|rcsb pdb:5OTV|rcsb pdb:5OTW|rcsb pdb:5OTX|rcsb pdb:5VAI|rcsb pdb:5YQZ|rcsb pdb:6EDS|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6NZN|rcsb pdb:6PHI|rcsb pdb:6PHJ|rcsb pdb:6PHK|rcsb pdb:6PHL|rcsb pdb:6PHO|rcsb pdb:6PHP|rcsb pdb:6VCB|rcsb pdb:6X18|rcsb pdb:7D68|reactome:R-HSA-163359|reactome:R-HSA-381676|reactome:R-HSA-381771|reactome:R-HSA-416476|refseq:NP_002045.1|dip:DIP-46470N|mint:MINT-8090778(identity) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090774(identity) - comment:mint|comment:homomint - comment:homomint|comment:mint|figure legend:t1 t2 f5 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:lZLjmf6wPVM15tLWwCJkDwY3CSw9606 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 intact-crc:72408442CA8BB1F7|rigid:SNZK9kpsluEErIRHi4lTmwyCNxY false binding-associated region:146-178(MINT-8090779) binding-associated region:39-766(MINT-8090775) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01275 uniprotkb:P27487 intact:EBI-7629173|ensembl:ENSP00000364647|ensembl:ENSP00000387662|uniprotkb:A6NN65|intact:MINT-8090511|uniprotkb:Q53TP6 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 psi-mi:gluc_human(display_long)|uniprotkb:GCG(gene name)|psi-mi:GCG(display_short) psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588797|mint:MINT-8090760 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-420092|reactome:R-HSA-422085|reactome:R-HSA-9660821|reactome:R-HSA-418555|ensembl:ENSG00000115263(gene)|ensembl:ENST00000375497(transcript)|ensembl:ENST00000418842(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014823"(response to activity)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR015550(Glucagon-like)|mint:P01275|rcsb pdb:1BH0|rcsb pdb:1D0R|rcsb pdb:1NAU|rcsb pdb:2G49|rcsb pdb:2L63|rcsb pdb:2L64|rcsb pdb:2M5P|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|rcsb pdb:2M5Q|rcsb pdb:3IOL|rcsb pdb:4APD|rcsb pdb:4ZGM|rcsb pdb:5OTU|rcsb pdb:5OTV|rcsb pdb:5OTW|rcsb pdb:5OTX|rcsb pdb:5VAI|rcsb pdb:5YQZ|rcsb pdb:6EDS|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6NZN|rcsb pdb:6PHI|rcsb pdb:6PHJ|rcsb pdb:6PHK|rcsb pdb:6PHL|rcsb pdb:6PHO|rcsb pdb:6PHP|rcsb pdb:6VCB|rcsb pdb:6X18|rcsb pdb:7D68|reactome:R-HSA-163359|reactome:R-HSA-381676|reactome:R-HSA-381771|reactome:R-HSA-416476|refseq:NP_002045.1|dip:DIP-46470N|mint:MINT-8090766(identity) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090762(identity) - comment:mint|comment:homomint - comment:homomint|comment:mint|figure legend:t1 t2 f5 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:lZLjmf6wPVM15tLWwCJkDwY3CSw9606 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 intact-crc:CC748B3026B70AC7|rigid:SNZK9kpsluEErIRHi4lTmwyCNxY false binding-associated region:92-128(MINT-8090767) binding-associated region:39-766(MINT-8090763) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P20366 uniprotkb:Q12884 intact:EBI-717291|uniprotkb:O60600|uniprotkb:O60601|uniprotkb:Q00072|uniprotkb:Q549V0|uniprotkb:Q549V1|uniprotkb:Q549V2|uniprotkb:Q6FHM1|uniprotkb:Q53GH4|ensembl:ENSP00000321106 intact:EBI-4319803|uniprotkb:O00199|uniprotkb:Q53TP5|uniprotkb:Q86Z29|uniprotkb:Q99998|uniprotkb:Q9UID4|ensembl:ENSP00000188790 psi-mi:tkn1_human(display_long)|uniprotkb:PPT(gene name synonym)|uniprotkb:TAC1(gene name)|psi-mi:TAC1(display_short)|uniprotkb:NKA(gene name synonym)|uniprotkb:NKNA(gene name synonym)|uniprotkb:TAC2(gene name synonym) psi-mi:sepr_human(display_long)|uniprotkb:Integral membrane serine protease(gene name synonym)|uniprotkb:FAP(gene name)|psi-mi:FAP(display_short)|uniprotkb:170 kDa melanoma membrane-bound gelatinase(gene name synonym)|uniprotkb:Fibroblast activation protein alpha(gene name synonym)|uniprotkb:Dipeptidyl peptidase FAP(gene name synonym)|uniprotkb:Gelatine degradation protease FAP(gene name synonym)|uniprotkb:Post-proline cleaving enzyme(gene name synonym)|uniprotkb:Serine integral membrane protease(gene name synonym)|uniprotkb:Surface-expressed protease(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588777|mint:MINT-8090748 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003173.1|refseq:NP_054702.1|refseq:NP_054703.1|refseq:NP_054704.1|ensembl:ENSG00000006128(gene)|ensembl:ENST00000319273(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007320"(insemination)|go:"GO:0007616"(long-term memory)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008306"(associative learning)|go:"GO:0009582"(detection of abiotic stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0030424"(axon)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031835"(substance P receptor binding)|go:"GO:0031836"(neuromedin K receptor binding)|go:"GO:0031837"(substance K receptor binding)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043278"(response to morphine)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048265"(response to pain)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902093"(positive regulation of flagellated sperm motility)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000854"(positive regulation of corticosterone secretion)|interpro:IPR008215(Tachykinin)|interpro:IPR008216(Protachykinin)|interpro:IPR013055(Tachykinin/Neurokinin like, conserved site)|rcsb pdb:2B19|rcsb pdb:2KS9|rcsb pdb:2KSA|rcsb pdb:2KSB|rcsb pdb:4HOM|reactome:R-HSA-380095|reactome:R-HSA-416476|mint:MINT-8090754(identity) refseq:NP_004451.2|refseq:NP_001278736.1|ensembl:ENSG00000078098(gene)|ensembl:ENST00000188790(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1902362"(melanocyte apoptotic process)|go:"GO:1903054"(negative regulation of extracellular matrix organization)|go:"GO:1905368"(peptidase complex)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|interpro:IPR031245|rcsb pdb:1Z68|rcsb pdb:6Y0F|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|mint:MINT-8090750(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 f4 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:+e/D1Z1bYytcPhDrHuZJlJjg5g49606 rogid:EP0sQlmVlm/H+15legbkc2IvEeg9606 intact-crc:4A60DE62380A2AFF|rigid:HaZxjCJgpkBubRn9QhFpv2Wk4GY false binding-associated region:58-68(MINT-8090755) binding-associated region:?-?(MINT-8090751) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01275 uniprotkb:P27487 intact:EBI-7629173|ensembl:ENSP00000364647|ensembl:ENSP00000387662|uniprotkb:A6NN65|intact:MINT-8090511|uniprotkb:Q53TP6 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 psi-mi:gluc_human(display_long)|uniprotkb:GCG(gene name)|psi-mi:GCG(display_short) psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588848|mint:MINT-8090796 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-420092|reactome:R-HSA-422085|reactome:R-HSA-9660821|reactome:R-HSA-418555|ensembl:ENSG00000115263(gene)|ensembl:ENST00000375497(transcript)|ensembl:ENST00000418842(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014823"(response to activity)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR015550(Glucagon-like)|mint:P01275|rcsb pdb:1BH0|rcsb pdb:1D0R|rcsb pdb:1NAU|rcsb pdb:2G49|rcsb pdb:2L63|rcsb pdb:2L64|rcsb pdb:2M5P|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|rcsb pdb:2M5Q|rcsb pdb:3IOL|rcsb pdb:4APD|rcsb pdb:4ZGM|rcsb pdb:5OTU|rcsb pdb:5OTV|rcsb pdb:5OTW|rcsb pdb:5OTX|rcsb pdb:5VAI|rcsb pdb:5YQZ|rcsb pdb:6EDS|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6NZN|rcsb pdb:6PHI|rcsb pdb:6PHJ|rcsb pdb:6PHK|rcsb pdb:6PHL|rcsb pdb:6PHO|rcsb pdb:6PHP|rcsb pdb:6VCB|rcsb pdb:6X18|rcsb pdb:7D68|reactome:R-HSA-163359|reactome:R-HSA-381676|reactome:R-HSA-381771|reactome:R-HSA-416476|refseq:NP_002045.1|dip:DIP-46470N|mint:MINT-8090806(identity) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090800(identity) - comment:mint|comment:homomint - comment:homomint|comment:mint|figure legend:t1 t2 sf1 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:lZLjmf6wPVM15tLWwCJkDwY3CSw9606 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 intact-crc:31C0F4B4EC4611F2|rigid:SNZK9kpsluEErIRHi4lTmwyCNxY false binding-associated region:53-81(MINT-8090808) binding-associated region:39-766(MINT-8090801) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01282 uniprotkb:P27487 intact:EBI-751454|uniprotkb:Q5TCY8|uniprotkb:Q5TCY9|uniprotkb:Q96QK3|ensembl:ENSP00000356213 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 psi-mi:vip_human(display_long)|uniprotkb:VIP(gene name)|psi-mi:VIP(display_short) psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588865|mint:MINT-8090811 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003372.1|refseq:NP_919416.1|ensembl:ENSG00000146469(gene)|ensembl:ENST00000367244(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007589"(body fluid secretion)|go:"GO:0007611"(learning or memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0032812"(positive regulation of epinephrine secretion)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048242"(epinephrine secretion)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070459"(prolactin secretion)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR015523(Vasoactive intestinal peptide)|rcsb pdb:2RRH|rcsb pdb:2RRI|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|mint:MINT-8090817(identity) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090813(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 f6 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:4wBOw0yxQ/xvUzZPXUCV/qZvh6A9606 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 intact-crc:C69267805924565F|rigid:LGKCzbO1sn1E3TNQIqkaizi6y0w false binding-associated region:81-107(MINT-8090818) binding-associated region:39-766(MINT-8090814) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P09681 uniprotkb:Q12884 intact:EBI-8588553|ensembl:ENSP00000350005|uniprotkb:Q6NTD3|uniprotkb:Q4VB42|intact:MINT-8090589 intact:EBI-4319803|uniprotkb:O00199|uniprotkb:Q53TP5|uniprotkb:Q86Z29|uniprotkb:Q99998|uniprotkb:Q9UID4|ensembl:ENSP00000188790 psi-mi:gip_human(display_long)|uniprotkb:Incretin hormone(gene name synonym)|uniprotkb:GIP(gene name)|psi-mi:GIP(display_short)|uniprotkb:Glucose-dependent insulinotropic polypeptide(gene name synonym) psi-mi:sepr_human(display_long)|uniprotkb:Integral membrane serine protease(gene name synonym)|uniprotkb:FAP(gene name)|psi-mi:FAP(display_short)|uniprotkb:170 kDa melanoma membrane-bound gelatinase(gene name synonym)|uniprotkb:Fibroblast activation protein alpha(gene name synonym)|uniprotkb:Dipeptidyl peptidase FAP(gene name synonym)|uniprotkb:Gelatine degradation protease FAP(gene name synonym)|uniprotkb:Post-proline cleaving enzyme(gene name synonym)|uniprotkb:Serine integral membrane protease(gene name synonym)|uniprotkb:Surface-expressed protease(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588831|mint:MINT-8090786 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000159224(gene)|ensembl:ENST00000357424(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009749"(response to glucose)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0033993"(response to lipid)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035640"(exploration behavior)|go:"GO:0038192"(gastric inhibitory peptide signaling pathway)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0042594"(response to starvation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043200"(response to amino acid)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0048678"(response to axon injury)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0055123"(digestive system development)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0070328"(triglyceride homeostasis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR039078|rcsb pdb:1T5Q|rcsb pdb:2B4N|rcsb pdb:2L70|go:"GO:0042493"|rcsb pdb:2L71|rcsb pdb:2OBU|reactome:R-HSA-9660821|rcsb pdb:2QKH|reactome:R-HSA-400511|reactome:R-HSA-418555|reactome:R-HSA-420092|dip:DIP-46469N|refseq:NP_004114.1|mint:MINT-8090788(identity) refseq:NP_004451.2|refseq:NP_001278736.1|ensembl:ENSG00000078098(gene)|ensembl:ENST00000188790(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1902362"(melanocyte apoptotic process)|go:"GO:1903054"(negative regulation of extracellular matrix organization)|go:"GO:1905368"(peptidase complex)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|interpro:IPR031245|rcsb pdb:1Z68|rcsb pdb:6Y0F|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|mint:MINT-8090790(identity) - comment:mint - comment:homomint|comment:mint|figure legend:t1 t2 f7 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:uDk65FsDVA70YuVfSkYyfbSCFeQ9606 rogid:EP0sQlmVlm/H+15legbkc2IvEeg9606 intact-crc:42B95829F30D39E6|rigid:yBawQeqs18eftznY5NH24iiUck8 false - binding-associated region:?-?(MINT-8090791) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01286 uniprotkb:P27487 intact:EBI-8588643|ensembl:ENSP00000237527|ensembl:ENSP00000362716|uniprotkb:Q4KN10|intact:MINT-8090632|uniprotkb:Q5JYR1 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 psi-mi:slib_human(display_long)|uniprotkb:GHRH(gene name)|psi-mi:GHRH(display_short)|uniprotkb:GHRF(gene name synonym)|uniprotkb:Growth hormone-releasing factor(gene name synonym)|uniprotkb:Growth hormone-releasing hormone(gene name synonym)|uniprotkb:Somatocrinin(gene name synonym)|uniprotkb:Somatorelin(gene name synonym) psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588882|mint:MINT-8090823 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000118702(gene)|ensembl:ENST00000237527(transcript)|ensembl:ENST00000373614(transcript)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016608"(growth hormone-releasing hormone activity)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031770"(growth hormone-releasing hormone receptor binding)|go:"GO:0032094"(response to food)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0046005"(positive regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0060124"(positive regulation of growth hormone secretion)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|rcsb pdb:5BQM|rcsb pdb:7CZ5|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|refseq:XP_011527086.1|refseq:XP_011527090.1|refseq:NP_001171660.1|refseq:NP_066567.1|mint:MINT-8090829(identity) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090825(identity) - comment:mint - comment:homomint|comment:mint|figure legend:t1 t2 f6 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:S0wIMHV/xTCB+GZhmoNi4F/vo8A9606 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 intact-crc:0C939001581DF4EA|rigid://w6tcPRDtp/wsO2FfTyXCoqbzk false - binding-associated region:39-766(MINT-8090826) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01275 uniprotkb:P27487 intact:EBI-7629173|ensembl:ENSP00000364647|ensembl:ENSP00000387662|uniprotkb:A6NN65|intact:MINT-8090511|uniprotkb:Q53TP6 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 psi-mi:gluc_human(display_long)|uniprotkb:GCG(gene name)|psi-mi:GCG(display_short) psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588896|mint:MINT-8090833 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-420092|reactome:R-HSA-422085|reactome:R-HSA-9660821|reactome:R-HSA-418555|ensembl:ENSG00000115263(gene)|ensembl:ENST00000375497(transcript)|ensembl:ENST00000418842(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014823"(response to activity)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR015550(Glucagon-like)|mint:P01275|rcsb pdb:1BH0|rcsb pdb:1D0R|rcsb pdb:1NAU|rcsb pdb:2G49|rcsb pdb:2L63|rcsb pdb:2L64|rcsb pdb:2M5P|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|rcsb pdb:2M5Q|rcsb pdb:3IOL|rcsb pdb:4APD|rcsb pdb:4ZGM|rcsb pdb:5OTU|rcsb pdb:5OTV|rcsb pdb:5OTW|rcsb pdb:5OTX|rcsb pdb:5VAI|rcsb pdb:5YQZ|rcsb pdb:6EDS|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6NZN|rcsb pdb:6PHI|rcsb pdb:6PHJ|rcsb pdb:6PHK|rcsb pdb:6PHL|rcsb pdb:6PHO|rcsb pdb:6PHP|rcsb pdb:6VCB|rcsb pdb:6X18|rcsb pdb:7D68|reactome:R-HSA-163359|reactome:R-HSA-381676|reactome:R-HSA-381771|reactome:R-HSA-416476|refseq:NP_002045.1|dip:DIP-46470N|mint:MINT-8090843(identity) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090837(identity) - comment:mint|comment:homomint - comment:homomint|comment:mint|figure legend:t1 t2 sf2 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:lZLjmf6wPVM15tLWwCJkDwY3CSw9606 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 intact-crc:29BA71E2E1CB9C7B|rigid:SNZK9kpsluEErIRHi4lTmwyCNxY false binding-associated region:53-89(MINT-8090845) binding-associated region:39-766(MINT-8090838) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P27487 uniprotkb:P01282 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 intact:EBI-751454|uniprotkb:Q5TCY8|uniprotkb:Q5TCY9|uniprotkb:Q96QK3|ensembl:ENSP00000356213 psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:vip_human(display_long)|uniprotkb:VIP(gene name)|psi-mi:VIP(display_short) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588913|mint:MINT-8090848 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090854(identity) refseq:NP_003372.1|refseq:NP_919416.1|ensembl:ENSG00000146469(gene)|ensembl:ENST00000367244(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007589"(body fluid secretion)|go:"GO:0007611"(learning or memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0032812"(positive regulation of epinephrine secretion)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048242"(epinephrine secretion)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070459"(prolactin secretion)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR015523(Vasoactive intestinal peptide)|rcsb pdb:2RRH|rcsb pdb:2RRI|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|mint:MINT-8090850(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 sf1 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 rogid:4wBOw0yxQ/xvUzZPXUCV/qZvh6A9606 intact-crc:F27F8260C5E9E80A|rigid:LGKCzbO1sn1E3TNQIqkaizi6y0w false binding-associated region:39-766(MINT-8090855) binding-associated region:125-152(MINT-8090851) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P27487 uniprotkb:P10082 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 intact:EBI-6655667|ensembl:ENSP00000353198|uniprotkb:Q5U5Q6|uniprotkb:Q6FGH8 psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:pyy_human(display_long)|uniprotkb:PYY(gene name)|psi-mi:PYY(display_short)|uniprotkb:PYY-I(gene name synonym)|uniprotkb:Peptide tyrosine tyrosine(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589004|mint:MINT-8090877 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090879(identity) refseq:XP_011523337.1|ensembl:ENST00000360085(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0031841"(neuropeptide Y receptor binding)|go:"GO:0060575"(intestinal epithelial cell differentiation)|interpro:IPR001955(Pancreatic hormone)|interpro:IPR020392|rcsb pdb:2DEZ|rcsb pdb:2DF0|rcsb pdb:2L60|rcsb pdb:2NA5|reactome:R-HSA-375276|reactome:R-HSA-418594|ensembl:ENSG00000131096(gene)|refseq:NP_004151.3|mint:MINT-8090883(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 f3 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 rogid:VKGXqAYXru2Kad45HYBcvqSIEyY9606 intact-crc:98AD9315A49EF7A8|rigid:8RtOsygub2SJOgFG3m/ev7+xD8Y false binding-associated region:39-766(MINT-8090880) binding-associated region:29-64(MINT-8090884) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P18509 uniprotkb:P27487 intact:EBI-8588930|ensembl:ENSP00000411658|ensembl:ENSP00000462647|intact:MINT-2801501|uniprotkb:B2R7N4|uniprotkb:Q52LQ0 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 psi-mi:paca_human(display_long)|uniprotkb:ADCYAP1(gene name)|psi-mi:ADCYAP1(display_short) psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8588987|mint:MINT-8090860 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000141433(gene)|ensembl:ENST00000450565(transcript)|ensembl:ENST00000579794(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001821"(histamine secretion)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002878"(negative regulation of acute inflammatory response to non-antigenic stimulus)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016521"(pituitary adenylate cyclase activating polypeptide activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030073"(insulin secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031858"(pituitary adenylate cyclase-activating polypeptide receptor binding)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042311"(vasodilation)|go:"GO:0042594"(response to starvation)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045471"(response to ethanol)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0090274"(positive regulation of somatostatin secretion)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR039080|rcsb pdb:1GEA|rcsb pdb:2D2P|rcsb pdb:2JOD|rcsb pdb:6LPB|rcsb pdb:6M1I|rcsb pdb:6P9Y|rcsb pdb:6VN7|reactome:R-HSA-187024|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|dip:DIP-60936N|refseq:NP_001093203.1|refseq:NP_001108.2|mint:MINT-8090872(identity) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090866(identity) - comment:mint|function:Stimulates adenylate cyclase in pituitary cells - comment:homomint|comment:mint|figure legend:t1 t2 sf2 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:6aY+rXh6mpnvgTz0F7cAE4Hk3d09606 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 intact-crc:19D70869D45605DB|rigid:jeExyo1EiUtJpWtkfzIldcQGWok false binding-associated region:132-169(MINT-8090874) binding-associated region:39-766(MINT-8090867) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P16860 uniprotkb:P27487 intact:EBI-747044|uniprotkb:Q6FGY0|uniprotkb:B0ZBE9|uniprotkb:Q9P2Q7|ensembl:ENSP00000365651 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 psi-mi:anfb_human(display_long)|uniprotkb:NPPB(gene name)|psi-mi:NPPB(display_short)|uniprotkb:Gamma-brain natriuretic peptide(gene name synonym)|uniprotkb:Brain natriuretic factor prohormone(gene name synonym)|uniprotkb:Iso-ANP(gene name synonym) psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589021|mint:MINT-8090889 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002512.1|go:"GO:0051427"(hormone receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0097746"(blood vessel diameter maintenance)|interpro:IPR000663(Natriuretic peptide)|interpro:IPR002408(Natriuretic peptide, brain type)|interpro:IPR030480|rcsb pdb:1YK1|rcsb pdb:3N56|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042311"(vasodilation)|go:"GO:0043114"(regulation of vascular permeability)|ensembl:ENSG00000120937(gene)|ensembl:ENST00000376468(transcript)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007168"(receptor guanylyl cyclase signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008613"(diuretic hormone activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030308"(negative regulation of cell growth)|mint:MINT-8090895(identity) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090891(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 f4 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:BWrb9PssxGVBOVPQLcUOTprCtNI9606 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 intact-crc:6400143E7A0E5029|rigid:v0DEXgeqqJUk5xiYm2hxKmW+oQ0 false binding-associated region:103-134(MINT-8090896) binding-associated region:39-766(MINT-8090892) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P27487 uniprotkb:P01303 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 intact:EBI-3905877|ensembl:ENSP00000242152|ensembl:ENSP00000384364|ensembl:ENSP00000385282 psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:npy_human(display_long)|uniprotkb:NPY(gene name)|psi-mi:NPY(display_short) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589038|mint:MINT-8090901 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090903(identity) refseq:NP_000896.1|ensembl:ENSG00000122585(gene)|ensembl:ENST00000242152(transcript)|ensembl:ENST00000405982(transcript)|ensembl:ENST00000407573(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001878"(response to yeast)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031841"(neuropeptide Y receptor binding)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0098992"(neuronal dense core vesicle)|interpro:IPR001955(Pancreatic hormone)|interpro:IPR020392|mint:P01303|rcsb pdb:1QFA|rcsb pdb:1RON|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-9615017|mint:MINT-8090907(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 f3 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 rogid:UTmbtVQkF1DB3LfhgJjN1hEHXrw9606 intact-crc:D1C9F8F6388CA83E|rigid:Jyz0pfRopDJqDanwKmethHKueYg false binding-associated region:39-766(MINT-8090904) binding-associated region:29-64(MINT-8090908) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P27487 uniprotkb:P20366 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 intact:EBI-717291|uniprotkb:O60600|uniprotkb:O60601|uniprotkb:Q00072|uniprotkb:Q549V0|uniprotkb:Q549V1|uniprotkb:Q549V2|uniprotkb:Q6FHM1|uniprotkb:Q53GH4|ensembl:ENSP00000321106 psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:tkn1_human(display_long)|uniprotkb:PPT(gene name synonym)|uniprotkb:TAC1(gene name)|psi-mi:TAC1(display_short)|uniprotkb:NKA(gene name synonym)|uniprotkb:NKNA(gene name synonym)|uniprotkb:TAC2(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589055|mint:MINT-8090912 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090914(identity) refseq:NP_003173.1|refseq:NP_054702.1|refseq:NP_054703.1|refseq:NP_054704.1|ensembl:ENSG00000006128(gene)|ensembl:ENST00000319273(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007320"(insemination)|go:"GO:0007616"(long-term memory)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008306"(associative learning)|go:"GO:0009582"(detection of abiotic stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0030424"(axon)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031835"(substance P receptor binding)|go:"GO:0031836"(neuromedin K receptor binding)|go:"GO:0031837"(substance K receptor binding)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043278"(response to morphine)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048265"(response to pain)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902093"(positive regulation of flagellated sperm motility)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000854"(positive regulation of corticosterone secretion)|interpro:IPR008215(Tachykinin)|interpro:IPR008216(Protachykinin)|interpro:IPR013055(Tachykinin/Neurokinin like, conserved site)|rcsb pdb:2B19|rcsb pdb:2KS9|rcsb pdb:2KSA|rcsb pdb:2KSB|rcsb pdb:4HOM|reactome:R-HSA-380095|reactome:R-HSA-416476|mint:MINT-8090918(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 f4 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 rogid:+e/D1Z1bYytcPhDrHuZJlJjg5g49606 intact-crc:6402E149A5863B56|rigid:mASbqRHeHyQ7ryg77M+QpqgWAas false binding-associated region:39-766(MINT-8090915) binding-associated region:58-68(MINT-8090919) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P27487 uniprotkb:P13501 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921 psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589102|mint:MINT-8090927 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090933(identity) refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG|mint:MINT-8090941(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 sf3 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606 intact-crc:FE51ABC50C78330F|rigid:BrfvdbgYLsfbJZg+9R1lzDWGR9Q false binding-associated region:39-766(MINT-8090934) binding-associated region:24-91(MINT-8090950) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P27487 uniprotkb:P51671 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234 psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589119|mint:MINT-8090954 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8090956(identity) refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N|mint:MINT-8090960(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 sf4 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606 intact-crc:DCAD1BFB41512394|rigid:OwXujBT7+H12o6LUdhJyX4VASCE false binding-associated region:39-766(MINT-8090957) binding-associated region:24-97(MINT-8090961) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O00626 uniprotkb:P27487 intact:EBI-3907871|uniprotkb:B2R4W2|uniprotkb:A0N0Q6|ensembl:ENSP00000219235 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 psi-mi:ccl22_human(display_long)|uniprotkb:CCL22(gene name)|psi-mi:CCL22(display_short)|uniprotkb:MDC(gene name synonym)|uniprotkb:SCYA22(gene name synonym)|uniprotkb:CC chemokine STCP-1(gene name synonym)|uniprotkb:"MDC(1-69)"(gene name synonym)|uniprotkb:Macrophage-derived chemokine(gene name synonym)|uniprotkb:Small-inducible cytokine A22(gene name synonym)|uniprotkb:Stimulated T-cell chemotactic protein 1(gene name synonym)|uniprotkb:A-152E5.1(orf name) psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589136|mint:MINT-8091012 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002981.2|ensembl:ENSG00000102962(gene)|ensembl:ENST00000219235(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR030598|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-6783783|reactome:R-HSA-6785807|refseq:XP_016879020.1|dip:DIP-5849N|mint:MINT-8091018(identity) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8091014(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 sf4 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:B3l0KQM+QPLGtb/lCXyYU+rmZgI9606 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 intact-crc:A9551EE6CE2FB37D|rigid:7zneAakkkNQO4JcHkCEsDCVMfjo false binding-associated region:1-69(MINT-8091019) binding-associated region:39-766(MINT-8091015) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19875 uniprotkb:P27487 intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym) psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589153|mint:MINT-8091061 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|mint:MINT-8091067(identity) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8091063(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 sf5 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 intact-crc:5804493620410B6A|rigid:L4KNRiz8dofYtRfZOKWX96ahM4Q false binding-associated region:39-107(MINT-8091068) binding-associated region:39-766(MINT-8091064) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P48061 uniprotkb:P27487 intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym) psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589204|mint:MINT-8091118 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N|mint:MINT-8091124(identity) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8091120(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 sf7 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 intact-crc:61D82AA2553696DB|rigid:BXvKkULViQon7fwWRVKl7Ql8QLI false binding-associated region:21-88(MINT-8091125) binding-associated region:39-766(MINT-8091121) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P27487 uniprotkb:Q07325 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901 psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589170|mint:MINT-8091083 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8091085(identity) refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N|mint:MINT-8091089(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 sf6 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606 intact-crc:9ADFEFC74B599C81|rigid:WFfFcuViIRhVAEVfzCwKHoCpb5E false binding-associated region:39-766(MINT-8091086) binding-associated region:22-125(MINT-8091090) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P02778 uniprotkb:P27487 intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym) psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589187|mint:MINT-8091106 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N|mint:MINT-8091112(identity) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8091108(identity) - comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 - comment:homomint|comment:mint|figure legend:t1 t2 sf6 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 intact-crc:66B1F77076793CBC|rigid:766j6Z6g8Eosm64ecrf0FYOSbug false binding-associated region:22-98(MINT-8091113) binding-associated region:39-766(MINT-8091109) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01282 uniprotkb:Q12884 intact:EBI-751454|uniprotkb:Q5TCY8|uniprotkb:Q5TCY9|uniprotkb:Q96QK3|ensembl:ENSP00000356213 intact:EBI-4319803|uniprotkb:O00199|uniprotkb:Q53TP5|uniprotkb:Q86Z29|uniprotkb:Q99998|uniprotkb:Q9UID4|ensembl:ENSP00000188790 psi-mi:vip_human(display_long)|uniprotkb:VIP(gene name)|psi-mi:VIP(display_short) psi-mi:sepr_human(display_long)|uniprotkb:Integral membrane serine protease(gene name synonym)|uniprotkb:FAP(gene name)|psi-mi:FAP(display_short)|uniprotkb:170 kDa melanoma membrane-bound gelatinase(gene name synonym)|uniprotkb:Fibroblast activation protein alpha(gene name synonym)|uniprotkb:Dipeptidyl peptidase FAP(gene name synonym)|uniprotkb:Gelatine degradation protease FAP(gene name synonym)|uniprotkb:Post-proline cleaving enzyme(gene name synonym)|uniprotkb:Serine integral membrane protease(gene name synonym)|uniprotkb:Surface-expressed protease(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589238|mint:MINT-8094195 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003372.1|refseq:NP_919416.1|ensembl:ENSG00000146469(gene)|ensembl:ENST00000367244(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007589"(body fluid secretion)|go:"GO:0007611"(learning or memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0032812"(positive regulation of epinephrine secretion)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048242"(epinephrine secretion)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070459"(prolactin secretion)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR015523(Vasoactive intestinal peptide)|rcsb pdb:2RRH|rcsb pdb:2RRI|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|mint:MINT-8094197(identity) refseq:NP_004451.2|refseq:NP_001278736.1|ensembl:ENSG00000078098(gene)|ensembl:ENST00000188790(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1902362"(melanocyte apoptotic process)|go:"GO:1903054"(negative regulation of extracellular matrix organization)|go:"GO:1905368"(peptidase complex)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|interpro:IPR031245|rcsb pdb:1Z68|rcsb pdb:6Y0F|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|mint:MINT-8094201(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 sf1 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:4wBOw0yxQ/xvUzZPXUCV/qZvh6A9606 rogid:EP0sQlmVlm/H+15legbkc2IvEeg9606 intact-crc:E8FD4FEFB8CBB8B0|rigid:5MPQciyUEx6HfNIHU/fKuUtGv/o false binding-associated region:125-152(MINT-8094198) binding-associated region:?-?(MINT-8094202) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14625 uniprotkb:P27487 intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym) psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589221|mint:MINT-8091131 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N|mint:MINT-8091137(identity) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ|mint:MINT-8091133(identity) - - - comment:homomint|comment:mint|figure legend:t1 t2 sf7 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 intact-crc:3D4C422950F9C3C1|rigid:FiCmkoChXW6RAsDQ3YsPIUIBGwM false binding-associated region:22-94(MINT-8091138) binding-associated region:39-766(MINT-8091134) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01275 uniprotkb:Q12884 intact:EBI-7629173|ensembl:ENSP00000364647|ensembl:ENSP00000387662|uniprotkb:A6NN65|intact:MINT-8090511|uniprotkb:Q53TP6 intact:EBI-4319803|uniprotkb:O00199|uniprotkb:Q53TP5|uniprotkb:Q86Z29|uniprotkb:Q99998|uniprotkb:Q9UID4|ensembl:ENSP00000188790 psi-mi:gluc_human(display_long)|uniprotkb:GCG(gene name)|psi-mi:GCG(display_short) psi-mi:sepr_human(display_long)|uniprotkb:Integral membrane serine protease(gene name synonym)|uniprotkb:FAP(gene name)|psi-mi:FAP(display_short)|uniprotkb:170 kDa melanoma membrane-bound gelatinase(gene name synonym)|uniprotkb:Fibroblast activation protein alpha(gene name synonym)|uniprotkb:Dipeptidyl peptidase FAP(gene name synonym)|uniprotkb:Gelatine degradation protease FAP(gene name synonym)|uniprotkb:Post-proline cleaving enzyme(gene name synonym)|uniprotkb:Serine integral membrane protease(gene name synonym)|uniprotkb:Surface-expressed protease(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589258|mint:MINT-8094207 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-420092|reactome:R-HSA-422085|reactome:R-HSA-9660821|reactome:R-HSA-418555|ensembl:ENSG00000115263(gene)|ensembl:ENST00000375497(transcript)|ensembl:ENST00000418842(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014823"(response to activity)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR015550(Glucagon-like)|mint:P01275|rcsb pdb:1BH0|rcsb pdb:1D0R|rcsb pdb:1NAU|rcsb pdb:2G49|rcsb pdb:2L63|rcsb pdb:2L64|rcsb pdb:2M5P|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|rcsb pdb:2M5Q|rcsb pdb:3IOL|rcsb pdb:4APD|rcsb pdb:4ZGM|rcsb pdb:5OTU|rcsb pdb:5OTV|rcsb pdb:5OTW|rcsb pdb:5OTX|rcsb pdb:5VAI|rcsb pdb:5YQZ|rcsb pdb:6EDS|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6NZN|rcsb pdb:6PHI|rcsb pdb:6PHJ|rcsb pdb:6PHK|rcsb pdb:6PHL|rcsb pdb:6PHO|rcsb pdb:6PHP|rcsb pdb:6VCB|rcsb pdb:6X18|rcsb pdb:7D68|reactome:R-HSA-163359|reactome:R-HSA-381676|reactome:R-HSA-381771|reactome:R-HSA-416476|refseq:NP_002045.1|dip:DIP-46470N|mint:MINT-8094213(identity) refseq:NP_004451.2|refseq:NP_001278736.1|ensembl:ENSG00000078098(gene)|ensembl:ENST00000188790(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1902362"(melanocyte apoptotic process)|go:"GO:1903054"(negative regulation of extracellular matrix organization)|go:"GO:1905368"(peptidase complex)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|interpro:IPR031245|rcsb pdb:1Z68|rcsb pdb:6Y0F|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|mint:MINT-8094209(identity) - comment:mint|comment:homomint - comment:homomint|comment:mint|figure legend:t1 t2 sf1 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:lZLjmf6wPVM15tLWwCJkDwY3CSw9606 rogid:EP0sQlmVlm/H+15legbkc2IvEeg9606 intact-crc:AAD33313873D204B|rigid:XIGA1flQ5zpD4CaCT6Dn7Y9RMXg false binding-associated region:53-81(MINT-8094214) binding-associated region:?-?(MINT-8094210) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P18509 uniprotkb:Q12884 intact:EBI-8588930|ensembl:ENSP00000411658|ensembl:ENSP00000462647|intact:MINT-2801501|uniprotkb:B2R7N4|uniprotkb:Q52LQ0 intact:EBI-4319803|uniprotkb:O00199|uniprotkb:Q53TP5|uniprotkb:Q86Z29|uniprotkb:Q99998|uniprotkb:Q9UID4|ensembl:ENSP00000188790 psi-mi:paca_human(display_long)|uniprotkb:ADCYAP1(gene name)|psi-mi:ADCYAP1(display_short) psi-mi:sepr_human(display_long)|uniprotkb:Integral membrane serine protease(gene name synonym)|uniprotkb:FAP(gene name)|psi-mi:FAP(display_short)|uniprotkb:170 kDa melanoma membrane-bound gelatinase(gene name synonym)|uniprotkb:Fibroblast activation protein alpha(gene name synonym)|uniprotkb:Dipeptidyl peptidase FAP(gene name synonym)|uniprotkb:Gelatine degradation protease FAP(gene name synonym)|uniprotkb:Post-proline cleaving enzyme(gene name synonym)|uniprotkb:Serine integral membrane protease(gene name synonym)|uniprotkb:Surface-expressed protease(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589278|mint:MINT-8094219 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000141433(gene)|ensembl:ENST00000450565(transcript)|ensembl:ENST00000579794(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001821"(histamine secretion)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002878"(negative regulation of acute inflammatory response to non-antigenic stimulus)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016521"(pituitary adenylate cyclase activating polypeptide activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030073"(insulin secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031858"(pituitary adenylate cyclase-activating polypeptide receptor binding)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042311"(vasodilation)|go:"GO:0042594"(response to starvation)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045471"(response to ethanol)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0090274"(positive regulation of somatostatin secretion)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR039080|rcsb pdb:1GEA|rcsb pdb:2D2P|rcsb pdb:2JOD|rcsb pdb:6LPB|rcsb pdb:6M1I|rcsb pdb:6P9Y|rcsb pdb:6VN7|reactome:R-HSA-187024|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|dip:DIP-60936N|refseq:NP_001093203.1|refseq:NP_001108.2|mint:MINT-8094225(identity) refseq:NP_004451.2|refseq:NP_001278736.1|ensembl:ENSG00000078098(gene)|ensembl:ENST00000188790(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1902362"(melanocyte apoptotic process)|go:"GO:1903054"(negative regulation of extracellular matrix organization)|go:"GO:1905368"(peptidase complex)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|interpro:IPR031245|rcsb pdb:1Z68|rcsb pdb:6Y0F|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|mint:MINT-8094221(identity) - comment:mint|function:Stimulates adenylate cyclase in pituitary cells - comment:homomint|comment:mint|figure legend:t1 t2 sf2 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:6aY+rXh6mpnvgTz0F7cAE4Hk3d09606 rogid:EP0sQlmVlm/H+15legbkc2IvEeg9606 intact-crc:F80009D26E1F3780|rigid:7I9d0W5NNte8BB65Vk5WCK4RPUQ false binding-associated region:132-169(MINT-8094226) binding-associated region:?-?(MINT-8094222) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01275 uniprotkb:Q12884 intact:EBI-7629173|ensembl:ENSP00000364647|ensembl:ENSP00000387662|uniprotkb:A6NN65|intact:MINT-8090511|uniprotkb:Q53TP6 intact:EBI-4319803|uniprotkb:O00199|uniprotkb:Q53TP5|uniprotkb:Q86Z29|uniprotkb:Q99998|uniprotkb:Q9UID4|ensembl:ENSP00000188790 psi-mi:gluc_human(display_long)|uniprotkb:GCG(gene name)|psi-mi:GCG(display_short) psi-mi:sepr_human(display_long)|uniprotkb:Integral membrane serine protease(gene name synonym)|uniprotkb:FAP(gene name)|psi-mi:FAP(display_short)|uniprotkb:170 kDa melanoma membrane-bound gelatinase(gene name synonym)|uniprotkb:Fibroblast activation protein alpha(gene name synonym)|uniprotkb:Dipeptidyl peptidase FAP(gene name synonym)|uniprotkb:Gelatine degradation protease FAP(gene name synonym)|uniprotkb:Post-proline cleaving enzyme(gene name synonym)|uniprotkb:Serine integral membrane protease(gene name synonym)|uniprotkb:Surface-expressed protease(gene name synonym) psi-mi:"MI:0435"(protease assay) Keane et al. (2011) mint:MINT-8090457|pubmed:21314817|doi:10.1111/j.1742-4658.2011.08051|mint:fj-10-1113.r1 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8589329|mint:MINT-8094231 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-420092|reactome:R-HSA-422085|reactome:R-HSA-9660821|reactome:R-HSA-418555|ensembl:ENSG00000115263(gene)|ensembl:ENST00000375497(transcript)|ensembl:ENST00000418842(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014823"(response to activity)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR015550(Glucagon-like)|mint:P01275|rcsb pdb:1BH0|rcsb pdb:1D0R|rcsb pdb:1NAU|rcsb pdb:2G49|rcsb pdb:2L63|rcsb pdb:2L64|rcsb pdb:2M5P|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|rcsb pdb:2M5Q|rcsb pdb:3IOL|rcsb pdb:4APD|rcsb pdb:4ZGM|rcsb pdb:5OTU|rcsb pdb:5OTV|rcsb pdb:5OTW|rcsb pdb:5OTX|rcsb pdb:5VAI|rcsb pdb:5YQZ|rcsb pdb:6EDS|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6NZN|rcsb pdb:6PHI|rcsb pdb:6PHJ|rcsb pdb:6PHK|rcsb pdb:6PHL|rcsb pdb:6PHO|rcsb pdb:6PHP|rcsb pdb:6VCB|rcsb pdb:6X18|rcsb pdb:7D68|reactome:R-HSA-163359|reactome:R-HSA-381676|reactome:R-HSA-381771|reactome:R-HSA-416476|refseq:NP_002045.1|dip:DIP-46470N|mint:MINT-8094237(identity) refseq:NP_004451.2|refseq:NP_001278736.1|ensembl:ENSG00000078098(gene)|ensembl:ENST00000188790(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1902362"(melanocyte apoptotic process)|go:"GO:1903054"(negative regulation of extracellular matrix organization)|go:"GO:1905368"(peptidase complex)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|interpro:IPR031245|rcsb pdb:1Z68|rcsb pdb:6Y0F|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|mint:MINT-8094233(identity) - comment:mint|comment:homomint - comment:homomint|comment:mint|figure legend:t1 t2 sf2 taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:lZLjmf6wPVM15tLWwCJkDwY3CSw9606 rogid:EP0sQlmVlm/H+15legbkc2IvEeg9606 intact-crc:B2A9B6458AB0ADC2|rigid:XIGA1flQ5zpD4CaCT6Dn7Y9RMXg false binding-associated region:53-89(MINT-8094238) binding-associated region:?-?(MINT-8094234) - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0396"(predetermined participant)