#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96Q42	uniprotkb:P20339	intact:EBI-1044902|uniprotkb:Q8N1E0|uniprotkb:Q96PC4|uniprotkb:Q96Q41|uniprotkb:Q9H973|uniprotkb:Q9HCK9|uniprotkb:Q53TT1|uniprotkb:Q53TV2|ensembl:ENSP00000264276|ensembl:ENSP00000505043|ensembl:ENSP00000505092|ensembl:ENSP00000505187|ensembl:ENSP00000505218	intact:EBI-399437|uniprotkb:B4DJA5|intact:EBI-1048179|uniprotkb:Q6FI44|ensembl:ENSP00000273047	psi-mi:als2_human(display_long)|uniprotkb:Amyotrophic lateral sclerosis 2 protein(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein(gene name synonym)|uniprotkb:ALS2(gene name)|psi-mi:ALS2(display_short)|uniprotkb:KIAA1563(gene name synonym)|uniprotkb:ALS2CR6(gene name synonym)	psi-mi:rab5a_human(display_long)|uniprotkb:RAB5A(gene name)|psi-mi:RAB5A(display_short)|uniprotkb:RAB5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Otomo et al. (2011)	pubmed:21300063|mint:MINT-8088034|mint:d-10-02068|doi:10.1016/j.febslet.2011.01.045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8582725|mint:MINT-8088056	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129217.1|refseq:NP_065970.2|interpro:IPR037191|reactome:R-HSA-8876198|reactome:R-HSA-9013149|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR003409(MORN motif)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|ensembl:ENSG00000003393(gene)|ensembl:ENST00000264276(transcript)|ensembl:ENST00000679435(transcript)|ensembl:ENST00000679516(transcript)|ensembl:ENST00000680163(transcript)|ensembl:ENST00000680861(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001881"(receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007032"(endosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008219"(cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042802"(identical protein binding)|ensembl:ENSP00000264276|ensembl:ENST00000409632|ensembl:ENSP00000386384|ensembl:ENST00000467448|ensembl:ENSP00000429223|ensembl:ENSP00000505218|ensembl:ENST00000679503|ensembl:ENSP00000505968|ensembl:ENSP00000505187|ensembl:ENSP00000505092|ensembl:ENST00000680188|ensembl:ENSP00000505665|ensembl:ENSP00000505043|refseq:XP_006712717.1|mint:MINT-8088058(identity)	refseq:NP_004153.2|refseq:NP_001278977.1|dip:DIP-380N|ensembl:ENSG00000144566(gene)|ensembl:ENST00000273047(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20339|rcsb pdb:1N6H|rcsb pdb:1N6I|rcsb pdb:1N6K|rcsb pdb:1N6L|rcsb pdb:1N6N|rcsb pdb:1N6O|rcsb pdb:1N6P|rcsb pdb:1N6R|rcsb pdb:1R2Q|rcsb pdb:1TU3|rcsb pdb:1TU4|rcsb pdb:3MJH|rcsb pdb:4Q9U|rcsb pdb:7BL1|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9636383|reactome:R-HSA-983231|mint:MINT-8088062(identity)	-	-	-	figure legend:f1b|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/31	2014/10/16	rogid:/CbIkwBlU9LPad9mVvtQAgsHwmk9606	rogid:SgowwV7QSVCvfsqSDE+6CHmPmKA9606	intact-crc:8EA82BD0B4427D44|rigid:9/UwhIPbA3hOik/qmApbYbcNt5Y	false	mutation increasing interaction:157-157(MINT-8088067)|flag tag:?-?(MINT-8088059)	glutathione s tranferase tag:?-?(MINT-8088063)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P63000	uniprotkb:Q96Q42	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	intact:EBI-1044902|uniprotkb:Q8N1E0|uniprotkb:Q96PC4|uniprotkb:Q96Q41|uniprotkb:Q9H973|uniprotkb:Q9HCK9|uniprotkb:Q53TT1|uniprotkb:Q53TV2|ensembl:ENSP00000264276|ensembl:ENSP00000505043|ensembl:ENSP00000505092|ensembl:ENSP00000505187|ensembl:ENSP00000505218	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:als2_human(display_long)|uniprotkb:Amyotrophic lateral sclerosis 2 protein(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein(gene name synonym)|uniprotkb:ALS2(gene name)|psi-mi:ALS2(display_short)|uniprotkb:KIAA1563(gene name synonym)|uniprotkb:ALS2CR6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Otomo et al. (2011)	pubmed:21300063|mint:MINT-8088034|mint:d-10-02068|doi:10.1016/j.febslet.2011.01.045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8582708|mint:MINT-8088042	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N|mint:MINT-8088045(identity)	refseq:NP_001129217.1|refseq:NP_065970.2|interpro:IPR037191|reactome:R-HSA-8876198|reactome:R-HSA-9013149|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR003409(MORN motif)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|ensembl:ENSG00000003393(gene)|ensembl:ENST00000264276(transcript)|ensembl:ENST00000679435(transcript)|ensembl:ENST00000679516(transcript)|ensembl:ENST00000680163(transcript)|ensembl:ENST00000680861(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001881"(receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007032"(endosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008219"(cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042802"(identical protein binding)|ensembl:ENSP00000264276|ensembl:ENST00000409632|ensembl:ENSP00000386384|ensembl:ENST00000467448|ensembl:ENSP00000429223|ensembl:ENSP00000505218|ensembl:ENST00000679503|ensembl:ENSP00000505968|ensembl:ENSP00000505187|ensembl:ENSP00000505092|ensembl:ENST00000680188|ensembl:ENSP00000505665|ensembl:ENSP00000505043|refseq:XP_006712717.1|mint:MINT-8088044(identity)	-	-	-	figure legend:f1b|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/31	2014/10/16	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	rogid:/CbIkwBlU9LPad9mVvtQAgsHwmk9606	intact-crc:45B1D79A63956661|rigid:KXx/NCGopeXZIHyFJmxNhmFRIWw	false	glutathione s tranferase tag:?-?(MINT-8088047)	flag tag:?-?(MINT-8088051)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96Q42	uniprotkb:P20339	intact:EBI-1044902|uniprotkb:Q8N1E0|uniprotkb:Q96PC4|uniprotkb:Q96Q41|uniprotkb:Q9H973|uniprotkb:Q9HCK9|uniprotkb:Q53TT1|uniprotkb:Q53TV2|ensembl:ENSP00000264276|ensembl:ENSP00000505043|ensembl:ENSP00000505092|ensembl:ENSP00000505187|ensembl:ENSP00000505218	intact:EBI-399437|uniprotkb:B4DJA5|intact:EBI-1048179|uniprotkb:Q6FI44|ensembl:ENSP00000273047	psi-mi:als2_human(display_long)|uniprotkb:Amyotrophic lateral sclerosis 2 protein(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein(gene name synonym)|uniprotkb:ALS2(gene name)|psi-mi:ALS2(display_short)|uniprotkb:KIAA1563(gene name synonym)|uniprotkb:ALS2CR6(gene name synonym)	psi-mi:rab5a_human(display_long)|uniprotkb:RAB5A(gene name)|psi-mi:RAB5A(display_short)|uniprotkb:RAB5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Otomo et al. (2011)	pubmed:21300063|mint:MINT-8088034|mint:d-10-02068|doi:10.1016/j.febslet.2011.01.045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8582746|mint:MINT-8088071	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129217.1|refseq:NP_065970.2|interpro:IPR037191|reactome:R-HSA-8876198|reactome:R-HSA-9013149|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR003409(MORN motif)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|ensembl:ENSG00000003393(gene)|ensembl:ENST00000264276(transcript)|ensembl:ENST00000679435(transcript)|ensembl:ENST00000679516(transcript)|ensembl:ENST00000680163(transcript)|ensembl:ENST00000680861(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001881"(receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007032"(endosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008219"(cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042802"(identical protein binding)|ensembl:ENSP00000264276|ensembl:ENST00000409632|ensembl:ENSP00000386384|ensembl:ENST00000467448|ensembl:ENSP00000429223|ensembl:ENSP00000505218|ensembl:ENST00000679503|ensembl:ENSP00000505968|ensembl:ENSP00000505187|ensembl:ENSP00000505092|ensembl:ENST00000680188|ensembl:ENSP00000505665|ensembl:ENSP00000505043|refseq:XP_006712717.1|mint:MINT-8088073(identity)	refseq:NP_004153.2|refseq:NP_001278977.1|dip:DIP-380N|ensembl:ENSG00000144566(gene)|ensembl:ENST00000273047(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20339|rcsb pdb:1N6H|rcsb pdb:1N6I|rcsb pdb:1N6K|rcsb pdb:1N6L|rcsb pdb:1N6N|rcsb pdb:1N6O|rcsb pdb:1N6P|rcsb pdb:1N6R|rcsb pdb:1R2Q|rcsb pdb:1TU3|rcsb pdb:1TU4|rcsb pdb:3MJH|rcsb pdb:4Q9U|rcsb pdb:7BL1|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9636383|reactome:R-HSA-983231|mint:MINT-8088079(identity)	-	-	-	figure legend:f1b|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/31	2014/10/16	rogid:/CbIkwBlU9LPad9mVvtQAgsHwmk9606	rogid:SgowwV7QSVCvfsqSDE+6CHmPmKA9606	intact-crc:86948E0E5C8E6A18|rigid:9/UwhIPbA3hOik/qmApbYbcNt5Y	false	flag tag:?-?(MINT-8088076)|mutation increasing interaction:540-540(MINT-8088074)	glutathione s tranferase tag:?-?(MINT-8088080)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q15075	uniprotkb:Q96Q42	intact:EBI-298113|uniprotkb:Q14221|ensembl:ENSP00000317955	intact:EBI-1044902|uniprotkb:Q8N1E0|uniprotkb:Q96PC4|uniprotkb:Q96Q41|uniprotkb:Q9H973|uniprotkb:Q9HCK9|uniprotkb:Q53TT1|uniprotkb:Q53TV2|ensembl:ENSP00000264276|ensembl:ENSP00000505043|ensembl:ENSP00000505092|ensembl:ENSP00000505187|ensembl:ENSP00000505218	psi-mi:eea1_human(display_long)|uniprotkb:EEA1(gene name)|psi-mi:EEA1(display_short)|uniprotkb:ZFYVE2(gene name synonym)|uniprotkb:Endosome-associated protein p162(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 2(gene name synonym)	psi-mi:als2_human(display_long)|uniprotkb:Amyotrophic lateral sclerosis 2 protein(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein(gene name synonym)|uniprotkb:ALS2(gene name)|psi-mi:ALS2(display_short)|uniprotkb:KIAA1563(gene name synonym)|uniprotkb:ALS2CR6(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Otomo et al. (2011)	pubmed:21300063|mint:MINT-8088034|mint:d-10-02068|doi:10.1016/j.febslet.2011.01.045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8582794|mint:MINT-8088105	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102189(gene)|ensembl:ENST00000322349(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005969"(serine-pyruvate aminotransferase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044308"(axonal spine)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|mint:Q15075|rcsb pdb:1HYI|rcsb pdb:1HYJ|rcsb pdb:1JOC|rcsb pdb:3MJH|reactome:R-HSA-168138|refseq:NP_003557.2|mint:MINT-8088114(identity)	refseq:NP_001129217.1|refseq:NP_065970.2|interpro:IPR037191|reactome:R-HSA-8876198|reactome:R-HSA-9013149|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR003409(MORN motif)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|ensembl:ENSG00000003393(gene)|ensembl:ENST00000264276(transcript)|ensembl:ENST00000679435(transcript)|ensembl:ENST00000679516(transcript)|ensembl:ENST00000680163(transcript)|ensembl:ENST00000680861(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001881"(receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007032"(endosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008219"(cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042802"(identical protein binding)|ensembl:ENSP00000264276|ensembl:ENST00000409632|ensembl:ENSP00000386384|ensembl:ENST00000467448|ensembl:ENSP00000429223|ensembl:ENSP00000505218|ensembl:ENST00000679503|ensembl:ENSP00000505968|ensembl:ENSP00000505187|ensembl:ENSP00000505092|ensembl:ENST00000680188|ensembl:ENSP00000505665|ensembl:ENSP00000505043|refseq:XP_006712717.1|mint:MINT-8088108(identity)	go:"GO:0005769"(early endosome)	-	-	comment:homomint|comment:mint|figure legend:f3c f5a	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2011/01/31	2014/10/16	rogid:aKGquyBsTFm+hhbJiIbz1Lv88Hw9606	rogid:/CbIkwBlU9LPad9mVvtQAgsHwmk9606	intact-crc:B7F7A0F556AE81E6|rigid:0ZOtQXVGpyuNOkmOxnNwiDtZPqw	false	-	flag tag:?-?(MINT-8088111)|mutation disrupting interaction:540-540(MINT-8088109)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q96Q42	uniprotkb:Q15075	intact:EBI-1044902|uniprotkb:Q8N1E0|uniprotkb:Q96PC4|uniprotkb:Q96Q41|uniprotkb:Q9H973|uniprotkb:Q9HCK9|uniprotkb:Q53TT1|uniprotkb:Q53TV2|ensembl:ENSP00000264276|ensembl:ENSP00000505043|ensembl:ENSP00000505092|ensembl:ENSP00000505187|ensembl:ENSP00000505218	intact:EBI-298113|uniprotkb:Q14221|ensembl:ENSP00000317955	psi-mi:als2_human(display_long)|uniprotkb:Amyotrophic lateral sclerosis 2 protein(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein(gene name synonym)|uniprotkb:ALS2(gene name)|psi-mi:ALS2(display_short)|uniprotkb:KIAA1563(gene name synonym)|uniprotkb:ALS2CR6(gene name synonym)	psi-mi:eea1_human(display_long)|uniprotkb:EEA1(gene name)|psi-mi:EEA1(display_short)|uniprotkb:ZFYVE2(gene name synonym)|uniprotkb:Endosome-associated protein p162(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 2(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Otomo et al. (2011)	pubmed:21300063|mint:MINT-8088034|mint:d-10-02068|doi:10.1016/j.febslet.2011.01.045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8582775|mint:MINT-8088090	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129217.1|refseq:NP_065970.2|interpro:IPR037191|reactome:R-HSA-8876198|reactome:R-HSA-9013149|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR003409(MORN motif)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|ensembl:ENSG00000003393(gene)|ensembl:ENST00000264276(transcript)|ensembl:ENST00000679435(transcript)|ensembl:ENST00000679516(transcript)|ensembl:ENST00000680163(transcript)|ensembl:ENST00000680861(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001881"(receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007032"(endosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008219"(cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042802"(identical protein binding)|ensembl:ENSP00000264276|ensembl:ENST00000409632|ensembl:ENSP00000386384|ensembl:ENST00000467448|ensembl:ENSP00000429223|ensembl:ENSP00000505218|ensembl:ENST00000679503|ensembl:ENSP00000505968|ensembl:ENSP00000505187|ensembl:ENSP00000505092|ensembl:ENST00000680188|ensembl:ENSP00000505665|ensembl:ENSP00000505043|refseq:XP_006712717.1|mint:MINT-8088092(identity)	ensembl:ENSG00000102189(gene)|ensembl:ENST00000322349(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005969"(serine-pyruvate aminotransferase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044308"(axonal spine)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|mint:Q15075|rcsb pdb:1HYI|rcsb pdb:1HYJ|rcsb pdb:1JOC|rcsb pdb:3MJH|reactome:R-HSA-168138|refseq:NP_003557.2|mint:MINT-8088093(identity)	go:"GO:0005769"(early endosome)	-	-	comment:homomint|comment:mint|figure legend:f3c f5a	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2011/01/31	2014/10/16	rogid:/CbIkwBlU9LPad9mVvtQAgsHwmk9606	rogid:aKGquyBsTFm+hhbJiIbz1Lv88Hw9606	intact-crc:AA703DCA5862569F|rigid:0ZOtQXVGpyuNOkmOxnNwiDtZPqw	false	flag tag:?-?(MINT-8088096)|mutation disrupting interaction:157-157(MINT-8088102)	-	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q96Q42	uniprotkb:Q15075	intact:EBI-1044902|uniprotkb:Q8N1E0|uniprotkb:Q96PC4|uniprotkb:Q96Q41|uniprotkb:Q9H973|uniprotkb:Q9HCK9|uniprotkb:Q53TT1|uniprotkb:Q53TV2|ensembl:ENSP00000264276|ensembl:ENSP00000505043|ensembl:ENSP00000505092|ensembl:ENSP00000505187|ensembl:ENSP00000505218	intact:EBI-298113|uniprotkb:Q14221|ensembl:ENSP00000317955	psi-mi:als2_human(display_long)|uniprotkb:Amyotrophic lateral sclerosis 2 protein(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein(gene name synonym)|uniprotkb:ALS2(gene name)|psi-mi:ALS2(display_short)|uniprotkb:KIAA1563(gene name synonym)|uniprotkb:ALS2CR6(gene name synonym)	psi-mi:eea1_human(display_long)|uniprotkb:EEA1(gene name)|psi-mi:EEA1(display_short)|uniprotkb:ZFYVE2(gene name synonym)|uniprotkb:Endosome-associated protein p162(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 2(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Otomo et al. (2011)	pubmed:21300063|mint:MINT-8088034|mint:d-10-02068|doi:10.1016/j.febslet.2011.01.045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8582813|mint:MINT-8088118	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129217.1|refseq:NP_065970.2|interpro:IPR037191|reactome:R-HSA-8876198|reactome:R-HSA-9013149|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR003409(MORN motif)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|ensembl:ENSG00000003393(gene)|ensembl:ENST00000264276(transcript)|ensembl:ENST00000679435(transcript)|ensembl:ENST00000679516(transcript)|ensembl:ENST00000680163(transcript)|ensembl:ENST00000680861(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001881"(receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007032"(endosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008219"(cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042802"(identical protein binding)|ensembl:ENSP00000264276|ensembl:ENST00000409632|ensembl:ENSP00000386384|ensembl:ENST00000467448|ensembl:ENSP00000429223|ensembl:ENSP00000505218|ensembl:ENST00000679503|ensembl:ENSP00000505968|ensembl:ENSP00000505187|ensembl:ENSP00000505092|ensembl:ENST00000680188|ensembl:ENSP00000505665|ensembl:ENSP00000505043|refseq:XP_006712717.1|mint:MINT-8088121(identity)	ensembl:ENSG00000102189(gene)|ensembl:ENST00000322349(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005969"(serine-pyruvate aminotransferase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044308"(axonal spine)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|mint:Q15075|rcsb pdb:1HYI|rcsb pdb:1HYJ|rcsb pdb:1JOC|rcsb pdb:3MJH|reactome:R-HSA-168138|refseq:NP_003557.2|mint:MINT-8088127(identity)	go:"GO:0005769"(early endosome)	-	-	figure legend:f5a|comment:homomint|comment:mint	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2011/01/31	2014/10/16	rogid:/CbIkwBlU9LPad9mVvtQAgsHwmk9606	rogid:aKGquyBsTFm+hhbJiIbz1Lv88Hw9606	intact-crc:008276BFF88142CC|rigid:0ZOtQXVGpyuNOkmOxnNwiDtZPqw	false	mutation disrupting interaction:1603-1603(MINT-8088124)|flag tag:?-?(MINT-8088122)	-	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q96Q42	uniprotkb:Q96Q42	intact:EBI-1044902|uniprotkb:Q8N1E0|uniprotkb:Q96PC4|uniprotkb:Q96Q41|uniprotkb:Q9H973|uniprotkb:Q9HCK9|uniprotkb:Q53TT1|uniprotkb:Q53TV2|ensembl:ENSP00000264276|ensembl:ENSP00000505043|ensembl:ENSP00000505092|ensembl:ENSP00000505187|ensembl:ENSP00000505218	intact:EBI-1044902|uniprotkb:Q8N1E0|uniprotkb:Q96PC4|uniprotkb:Q96Q41|uniprotkb:Q9H973|uniprotkb:Q9HCK9|uniprotkb:Q53TT1|uniprotkb:Q53TV2|ensembl:ENSP00000264276|ensembl:ENSP00000505043|ensembl:ENSP00000505092|ensembl:ENSP00000505187|ensembl:ENSP00000505218	psi-mi:als2_human(display_long)|uniprotkb:Amyotrophic lateral sclerosis 2 protein(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein(gene name synonym)|uniprotkb:ALS2(gene name)|psi-mi:ALS2(display_short)|uniprotkb:KIAA1563(gene name synonym)|uniprotkb:ALS2CR6(gene name synonym)	psi-mi:als2_human(display_long)|uniprotkb:Amyotrophic lateral sclerosis 2 protein(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein(gene name synonym)|uniprotkb:ALS2(gene name)|psi-mi:ALS2(display_short)|uniprotkb:KIAA1563(gene name synonym)|uniprotkb:ALS2CR6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Otomo et al. (2011)	pubmed:21300063|mint:MINT-8088034|mint:d-10-02068|doi:10.1016/j.febslet.2011.01.045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8582840|mint:MINT-8088151	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129217.1|refseq:NP_065970.2|interpro:IPR037191|reactome:R-HSA-8876198|reactome:R-HSA-9013149|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR003409(MORN motif)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|ensembl:ENSG00000003393(gene)|ensembl:ENST00000264276(transcript)|ensembl:ENST00000679435(transcript)|ensembl:ENST00000679516(transcript)|ensembl:ENST00000680163(transcript)|ensembl:ENST00000680861(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001881"(receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007032"(endosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008219"(cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042802"(identical protein binding)|ensembl:ENSP00000264276|ensembl:ENST00000409632|ensembl:ENSP00000386384|ensembl:ENST00000467448|ensembl:ENSP00000429223|ensembl:ENSP00000505218|ensembl:ENST00000679503|ensembl:ENSP00000505968|ensembl:ENSP00000505187|ensembl:ENSP00000505092|ensembl:ENST00000680188|ensembl:ENSP00000505665|ensembl:ENSP00000505043|refseq:XP_006712717.1|mint:MINT-8088153(identity)	refseq:NP_001129217.1|refseq:NP_065970.2|interpro:IPR037191|reactome:R-HSA-8876198|reactome:R-HSA-9013149|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR003409(MORN motif)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|ensembl:ENSG00000003393(gene)|ensembl:ENST00000264276(transcript)|ensembl:ENST00000679435(transcript)|ensembl:ENST00000679516(transcript)|ensembl:ENST00000680163(transcript)|ensembl:ENST00000680861(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001881"(receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007032"(endosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008219"(cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042802"(identical protein binding)|ensembl:ENSP00000264276|ensembl:ENST00000409632|ensembl:ENSP00000386384|ensembl:ENST00000467448|ensembl:ENSP00000429223|ensembl:ENSP00000505218|ensembl:ENST00000679503|ensembl:ENSP00000505968|ensembl:ENSP00000505187|ensembl:ENSP00000505092|ensembl:ENST00000680188|ensembl:ENSP00000505665|ensembl:ENSP00000505043|refseq:XP_006712717.1|mint:MINT-8088154(identity)	-	-	-	comment:homomint|figure legend:sf1|comment:mint	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2011/01/31	2014/10/16	rogid:/CbIkwBlU9LPad9mVvtQAgsHwmk9606	rogid:/CbIkwBlU9LPad9mVvtQAgsHwmk9606	intact-crc:25EF7D0FA7672A45|rigid:Nx7RGAUf+zP+3ox62EurZKQ1x9M	false	flag tag:?-?(MINT-8088156)	ha tag:?-?(MINT-8088160)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)