#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O97758 uniprotkb:Q9CQX5 intact:EBI-6988333|intact:MINT-1778189 intact:EBI-8575597|ensembl:ENSMUSP00000023426|ensembl:ENSMUSP00000125497|intact:MINT-8085662|uniprotkb:Q3U7C4 psi-mi:zo1_canlf(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym) psi-mi:cldn1_mouse(display_long)|uniprotkb:Claudin-25(gene name synonym)|uniprotkb:Cldn25(gene name synonym)|uniprotkb:Cldnd1(gene name)|psi-mi:Cldnd1(display_short)|uniprotkb:D11Moh34(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Mineta et al. (2011) mint:MINT-8085654|pubmed:21276448|mint:d-10-02112|doi:10.1016/j.febslet.2011.01.028 taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8575592|mint:MINT-8085659 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR035597|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0009986"(cell surface)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|refseq:NP_001003140.1|mint:O97758|interpro:IPR036028|interpro:IPR036034|mint:MINT-8085661(identity) refseq:XP_006522157.1|ensembl:ENSMUSG00000022744(gene)|ensembl:ENSMUST00000023426(transcript)|ensembl:ENSMUST00000162057(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR042356|refseq:NP_741968.1|mint:MINT-8085674(identity) go:"GO:0005923"(bicellular tight junction) comment:mint|function:The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions comment:mint figure legend:f4|comment:mint taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells") - 2011/01/17 2014/10/16 rogid:ahJn9QpY395wArDFwZ2FwDxf6s89615 rogid:pr5rOOMVLyzG3T1AsufRjuzESZQ10090 intact-crc:16AC9242F0F60EF7|rigid:zfqGpPARrY4rL8mkXGJsHw0IfZw false - fusion protein:?-?(MINT-8085677) - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:Q9D563 uniprotkb:O97758 intact:EBI-6988402|ensembl:ENSMUSP00000023400|intact:MINT-8085693 intact:EBI-6988333|intact:MINT-1778189 psi-mi:tm114_mouse(display_long)|uniprotkb:Claudin-26(gene name synonym)|uniprotkb:Cldn26(gene name synonym)|uniprotkb:Tmem114(gene name)|psi-mi:Tmem114(display_short) psi-mi:zo1_canlf(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Mineta et al. (2011) mint:MINT-8085654|pubmed:21276448|mint:d-10-02112|doi:10.1016/j.febslet.2011.01.028 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8575621|mint:MINT-8085683 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000022715(gene)|ensembl:ENSMUST00000023400(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR039951|refseq:NP_083346.1|mint:MINT-8085688(identity) interpro:IPR035597|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0009986"(cell surface)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|refseq:NP_001003140.1|mint:O97758|interpro:IPR036028|interpro:IPR036034|mint:MINT-8085686(identity) go:"GO:0005923"(bicellular tight junction) comment:mint comment:mint|function:The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions figure legend:f4|comment:mint taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells") - 2011/01/17 2014/10/16 rogid:zL1ABdiTZ1B4gbofVUFVnKPcapE10090 rogid:ahJn9QpY395wArDFwZ2FwDxf6s89615 intact-crc:9FA9C2BCA7280003|rigid:QUz/BAEhN+UXTZ+Vaq20FCAvZEM false fusion protein:?-?(MINT-8085689) - - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0422"(immunostaining)