#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35710	uniprotkb:O15266	intact:EBI-3505677|uniprotkb:O88184|uniprotkb:O89018	intact:EBI-3505698|uniprotkb:O00412|uniprotkb:O00413|uniprotkb:O15267|ensembl:ENSP00000370990	psi-mi:sox5_mouse(display_long)|uniprotkb:Sox5(gene name)|psi-mi:Sox5(display_short)|uniprotkb:Sox-5(gene name synonym)	psi-mi:shox_human(display_long)|uniprotkb:SHOX(gene name)|psi-mi:SHOX(display_short)|uniprotkb:PHOG(gene name synonym)|uniprotkb:Pseudoautosomal homeobox-containing osteogenic protein(gene name synonym)|uniprotkb:Short stature homeobox-containing protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Aza-Carmona et al. (2011)	pubmed:21262861|imex:IM-16923	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3505676|imex:IM-16923-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230092.1|interpro:IPR009071(High mobility group box, HMG)|rcsb pdb:1I11|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001502"(cartilage condensation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060164"(regulation of timing of neuron differentiation)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|interpro:IPR036910	refseq:NP_000442.1|refseq:NP_006874.1|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|ensembl:ENSG00000185960(gene)|ensembl:ENST00000381578(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/01/27	2014/10/16	rogid:17dZjlhfMpf4+eAZHs3qmNxJcIo10090	rogid:E54IosMZLj9xeXbKw+g+571s2tw9606	intact-crc:EFF1565EBCCAFFB7|rigid:xo1Gw3HxkXhKt+9TgfzGIrGDaes	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15266	uniprotkb:P40645	intact:EBI-3505698|uniprotkb:O00412|uniprotkb:O00413|uniprotkb:O15267|ensembl:ENSP00000370990	intact:EBI-3505685|uniprotkb:Q62250|uniprotkb:Q9QWS5|ensembl:ENSMUSP00000072583|ensembl:ENSMUSP00000129027	psi-mi:shox_human(display_long)|uniprotkb:SHOX(gene name)|psi-mi:SHOX(display_short)|uniprotkb:PHOG(gene name synonym)|uniprotkb:Pseudoautosomal homeobox-containing osteogenic protein(gene name synonym)|uniprotkb:Short stature homeobox-containing protein(gene name synonym)	psi-mi:sox6_mouse(display_long)|uniprotkb:Sox6(gene name)|psi-mi:Sox6(display_short)|uniprotkb:Sox-6(gene name synonym)|uniprotkb:SOX-LZ(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Aza-Carmona et al. (2011)	pubmed:21262861|imex:IM-16923	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3505683|imex:IM-16923-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000442.1|refseq:NP_006874.1|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|ensembl:ENSG00000185960(gene)|ensembl:ENST00000381578(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)	refseq:XP_011240009.1|refseq:XP_011240013.1|refseq:NP_035575.1|ensembl:ENSMUSG00000051910(gene)|ensembl:ENSMUST00000072804(transcript)|ensembl:ENSMUST00000166207(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0021529"(spinal cord oligodendrocyte cell differentiation)|go:"GO:0021778"(oligodendrocyte cell fate specification)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0051216"(cartilage development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR027153|interpro:IPR036910|reactome:R-MMU-3769402|refseq:NP_001264255.1|refseq:NP_001264257.1	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/01/27	2014/10/16	rogid:E54IosMZLj9xeXbKw+g+571s2tw9606	rogid:/75ue2MRV87y9md6501iiDfVHJQ10090	intact-crc:69E8C98C175A7A35|rigid:q47wBSuf8y7tRCyiP1dy3Av7p6o	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15266	uniprotkb:P35711	intact:EBI-3505698|uniprotkb:O00412|uniprotkb:O00413|uniprotkb:O15267|ensembl:ENSP00000370990	intact:EBI-3505701|uniprotkb:Q86UK8|uniprotkb:Q8J017|uniprotkb:Q8J018|uniprotkb:Q8J019|uniprotkb:Q8J020|uniprotkb:Q8N1D9|uniprotkb:Q8N7E0|uniprotkb:Q8TEA4|uniprotkb:B7Z8V0|uniprotkb:F5H5B0|ensembl:ENSP00000398273	psi-mi:shox_human(display_long)|uniprotkb:SHOX(gene name)|psi-mi:SHOX(display_short)|uniprotkb:PHOG(gene name synonym)|uniprotkb:Pseudoautosomal homeobox-containing osteogenic protein(gene name synonym)|uniprotkb:Short stature homeobox-containing protein(gene name synonym)	psi-mi:sox5_human(display_long)|uniprotkb:SOX5(gene name)|psi-mi:SOX5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Aza-Carmona et al. (2011)	pubmed:21262861|imex:IM-16923	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3505759|imex:IM-16923-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000442.1|refseq:NP_006874.1|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|ensembl:ENSG00000185960(gene)|ensembl:ENST00000381578(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)	refseq:NP_008871.3|refseq:NP_694534.1|refseq:NP_821078.1|refseq:NP_001248343.1|refseq:NP_001248344.1|ensembl:ENSG00000134532(gene)|ensembl:ENST00000451604(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001502"(cartilage condensation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0051216"(cartilage development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:P35711|refseq:NP_001317714.1|refseq:XP_016875385.1	omim:127300(see-also)	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/01/27	2014/10/16	rogid:E54IosMZLj9xeXbKw+g+571s2tw9606	rogid:YVl5zcnqafFgRvQt8B79kMtbz+g9606	intact-crc:815984387F726636|rigid:eAdiHcDxFIIUAPocLWX/WfR6HQQ	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35712	uniprotkb:O15266	intact:EBI-3505706|uniprotkb:Q86VX7|uniprotkb:Q9BXQ3|uniprotkb:Q9BXQ4|uniprotkb:Q9BXQ5|uniprotkb:Q9H0I8|ensembl:ENSP00000433233|ensembl:ENSP00000507545	intact:EBI-3505698|uniprotkb:O00412|uniprotkb:O00413|uniprotkb:O15267|ensembl:ENSP00000370990	psi-mi:sox6_human(display_long)|uniprotkb:SOX6(gene name)|psi-mi:SOX6(display_short)	psi-mi:shox_human(display_long)|uniprotkb:SHOX(gene name)|psi-mi:SHOX(display_short)|uniprotkb:PHOG(gene name synonym)|uniprotkb:Pseudoautosomal homeobox-containing osteogenic protein(gene name synonym)|uniprotkb:Short stature homeobox-containing protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Aza-Carmona et al. (2011)	pubmed:21262861|imex:IM-16923	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3505766|imex:IM-16923-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139283.1|refseq:NP_001139291.1|refseq:NP_059978.1|refseq:NP_201583.2|ensembl:ENSG00000110693(gene)|ensembl:ENST00000528429(transcript)|ensembl:ENST00000683767(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001502"(cartilage condensation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007517"(muscle organ development)|go:"GO:0021529"(spinal cord oligodendrocyte cell differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045165"(cell fate commitment)|go:"GO:0051216"(cartilage development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR027153|interpro:IPR036910|mint:P35712|reactome:R-HSA-3769402	refseq:NP_000442.1|refseq:NP_006874.1|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|ensembl:ENSG00000185960(gene)|ensembl:ENST00000381578(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)	omim:127300(see-also)	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/01/27	2014/10/16	rogid:UV6EBIPo7xAUw/24j8y9bwJpOg49606	rogid:E54IosMZLj9xeXbKw+g+571s2tw9606	intact-crc:93C9F6A9AF72A937|rigid:dMZOhLlvDYBnnPVxLC2aHBN5ocQ	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15266	uniprotkb:O15266	intact:EBI-3505698|uniprotkb:O00412|uniprotkb:O00413|uniprotkb:O15267|ensembl:ENSP00000370990	intact:EBI-3505698|uniprotkb:O00412|uniprotkb:O00413|uniprotkb:O15267|ensembl:ENSP00000370990	psi-mi:shox_human(display_long)|uniprotkb:SHOX(gene name)|psi-mi:SHOX(display_short)|uniprotkb:PHOG(gene name synonym)|uniprotkb:Pseudoautosomal homeobox-containing osteogenic protein(gene name synonym)|uniprotkb:Short stature homeobox-containing protein(gene name synonym)	psi-mi:shox_human(display_long)|uniprotkb:SHOX(gene name)|psi-mi:SHOX(display_short)|uniprotkb:PHOG(gene name synonym)|uniprotkb:Pseudoautosomal homeobox-containing osteogenic protein(gene name synonym)|uniprotkb:Short stature homeobox-containing protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Aza-Carmona et al. (2011)	pubmed:21262861|imex:IM-16923	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3505754|imex:IM-16923-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000442.1|refseq:NP_006874.1|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|ensembl:ENSG00000185960(gene)|ensembl:ENST00000381578(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)	refseq:NP_000442.1|refseq:NP_006874.1|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|ensembl:ENSG00000185960(gene)|ensembl:ENST00000381578(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)	omim:127300(see-also)	-	-	figure legend:1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/01/27	2014/10/16	rogid:E54IosMZLj9xeXbKw+g+571s2tw9606	rogid:E54IosMZLj9xeXbKw+g+571s2tw9606	intact-crc:DD1F2152E4EEBE64|rigid:XCWp1TsfDNs0sfLLW1wACl2k93M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35712	uniprotkb:O15266	intact:EBI-3505706|uniprotkb:Q86VX7|uniprotkb:Q9BXQ3|uniprotkb:Q9BXQ4|uniprotkb:Q9BXQ5|uniprotkb:Q9H0I8|ensembl:ENSP00000433233|ensembl:ENSP00000507545	intact:EBI-3505698|uniprotkb:O00412|uniprotkb:O00413|uniprotkb:O15267|ensembl:ENSP00000370990	psi-mi:sox6_human(display_long)|uniprotkb:SOX6(gene name)|psi-mi:SOX6(display_short)	psi-mi:shox_human(display_long)|uniprotkb:SHOX(gene name)|psi-mi:SHOX(display_short)|uniprotkb:PHOG(gene name synonym)|uniprotkb:Pseudoautosomal homeobox-containing osteogenic protein(gene name synonym)|uniprotkb:Short stature homeobox-containing protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Aza-Carmona et al. (2011)	pubmed:21262861|imex:IM-16923	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3509155|imex:IM-16923-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139283.1|refseq:NP_001139291.1|refseq:NP_059978.1|refseq:NP_201583.2|ensembl:ENSG00000110693(gene)|ensembl:ENST00000528429(transcript)|ensembl:ENST00000683767(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001502"(cartilage condensation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007517"(muscle organ development)|go:"GO:0021529"(spinal cord oligodendrocyte cell differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045165"(cell fate commitment)|go:"GO:0051216"(cartilage development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR027153|interpro:IPR036910|mint:P35712|reactome:R-HSA-3769402	refseq:NP_000442.1|refseq:NP_006874.1|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|ensembl:ENSG00000185960(gene)|ensembl:ENST00000381578(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)	omim:127300(see-also)	-	-	figure legend:1, 6|comment:Binding of deletion mutant 263-787 increased binding over full-length protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/01/27	2014/10/16	rogid:UV6EBIPo7xAUw/24j8y9bwJpOg49606	rogid:E54IosMZLj9xeXbKw+g+571s2tw9606	intact-crc:489BA1DF28B747CA|rigid:dMZOhLlvDYBnnPVxLC2aHBN5ocQ	false	necessary binding region:263-444|sufficient binding region:479-787	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15266	uniprotkb:P35711	intact:EBI-3505698|uniprotkb:O00412|uniprotkb:O00413|uniprotkb:O15267|ensembl:ENSP00000370990	intact:EBI-3505701|uniprotkb:Q86UK8|uniprotkb:Q8J017|uniprotkb:Q8J018|uniprotkb:Q8J019|uniprotkb:Q8J020|uniprotkb:Q8N1D9|uniprotkb:Q8N7E0|uniprotkb:Q8TEA4|uniprotkb:B7Z8V0|uniprotkb:F5H5B0|ensembl:ENSP00000398273	psi-mi:shox_human(display_long)|uniprotkb:SHOX(gene name)|psi-mi:SHOX(display_short)|uniprotkb:PHOG(gene name synonym)|uniprotkb:Pseudoautosomal homeobox-containing osteogenic protein(gene name synonym)|uniprotkb:Short stature homeobox-containing protein(gene name synonym)	psi-mi:sox5_human(display_long)|uniprotkb:SOX5(gene name)|psi-mi:SOX5(display_short)	psi-mi:"MI:0018"(two hybrid)	Aza-Carmona et al. (2011)	pubmed:21262861|imex:IM-16923	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3505695|imex:IM-16923-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000442.1|refseq:NP_006874.1|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|ensembl:ENSG00000185960(gene)|ensembl:ENST00000381578(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)	refseq:NP_008871.3|refseq:NP_694534.1|refseq:NP_821078.1|refseq:NP_001248343.1|refseq:NP_001248344.1|ensembl:ENSG00000134532(gene)|ensembl:ENST00000451604(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001502"(cartilage condensation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0051216"(cartilage development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:P35711|refseq:NP_001317714.1|refseq:XP_016875385.1	omim:127300(see-also)	-	-	figure legend:1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/01/27	2014/10/16	rogid:E54IosMZLj9xeXbKw+g+571s2tw9606	rogid:YVl5zcnqafFgRvQt8B79kMtbz+g9606	intact-crc:4A56169398D79EDC|rigid:eAdiHcDxFIIUAPocLWX/WfR6HQQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15266	uniprotkb:P35712	intact:EBI-3505698|uniprotkb:O00412|uniprotkb:O00413|uniprotkb:O15267|ensembl:ENSP00000370990	intact:EBI-3505706|uniprotkb:Q86VX7|uniprotkb:Q9BXQ3|uniprotkb:Q9BXQ4|uniprotkb:Q9BXQ5|uniprotkb:Q9H0I8|ensembl:ENSP00000433233|ensembl:ENSP00000507545	psi-mi:shox_human(display_long)|uniprotkb:SHOX(gene name)|psi-mi:SHOX(display_short)|uniprotkb:PHOG(gene name synonym)|uniprotkb:Pseudoautosomal homeobox-containing osteogenic protein(gene name synonym)|uniprotkb:Short stature homeobox-containing protein(gene name synonym)	psi-mi:sox6_human(display_long)|uniprotkb:SOX6(gene name)|psi-mi:SOX6(display_short)	psi-mi:"MI:0018"(two hybrid)	Aza-Carmona et al. (2011)	pubmed:21262861|imex:IM-16923	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3505704|imex:IM-16923-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000442.1|refseq:NP_006874.1|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|ensembl:ENSG00000185960(gene)|ensembl:ENST00000381578(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)	refseq:NP_001139283.1|refseq:NP_001139291.1|refseq:NP_059978.1|refseq:NP_201583.2|ensembl:ENSG00000110693(gene)|ensembl:ENST00000528429(transcript)|ensembl:ENST00000683767(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001502"(cartilage condensation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007517"(muscle organ development)|go:"GO:0021529"(spinal cord oligodendrocyte cell differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045165"(cell fate commitment)|go:"GO:0051216"(cartilage development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR027153|interpro:IPR036910|mint:P35712|reactome:R-HSA-3769402	omim:127300(see-also)	-	-	figure legend:1, 4, 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/01/27	2014/10/16	rogid:E54IosMZLj9xeXbKw+g+571s2tw9606	rogid:UV6EBIPo7xAUw/24j8y9bwJpOg49606	intact-crc:6FC8449623195586|rigid:dMZOhLlvDYBnnPVxLC2aHBN5ocQ	false	mutation disrupting interaction:132-132|sufficient binding region:178-211|mutation decreasing interaction:116-116|mutation decreasing interaction:168-168|mutation decreasing interaction:173-173|mutation disrupting interaction:170-170|mutation decreasing interaction:195-195|mutation decreasing interaction:233-233|mutation decreasing interaction:278-278	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)