#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P85970 uniprotkb:Q9EP80 intact:EBI-1223150 intact:EBI-77728|uniprotkb:Q546X4|uniprotkb:Q925D1 psi-mi:arpc2_rat(display_long)|uniprotkb:Arpc2(gene name)|psi-mi:Arpc2(display_short)|uniprotkb:Arp2/3 complex 34 kDa subunit(gene name synonym) psi-mi:pick1_rat(display_long)|uniprotkb:Pick1(gene name)|psi-mi:Pick1(display_short)|uniprotkb:Prkcabp(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Nakamura et al. (2011) mint:MINT-8118932|pubmed:21252856|imex:IM-15357|doi:10.1038/emboj.2010.357 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8567525|mint:MINT-8119054|imex:IM-15357-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-RNO-5663213|interpro:IPR007188(Arp2/3 complex, 34kDa subunit p34-Arc)|rgd:1305848|interpro:IPR034666|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0019894"(kinesin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030141"(secretory granule)|go:"GO:0030426"(growth cone)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031941"(filamentous actin)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034021"(response to silicon dioxide)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036195"(muscle cell projection membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061825"(podosome core)|go:"GO:0061826"(podosome ring)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0061834"(actin filament branch point)|go:"GO:0061835"(ventral surface of cell)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097440"(apical dendrite)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000814"(positive regulation of barbed-end actin filament capping)|reactome:R-RNO-2029482|reactome:R-RNO-3928662|reactome:R-RNO-8856828|mint:MINT-8119056(identity) rgd:69437|refseq:NP_445912.1|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|rcsb pdb:2LUI|rcsb pdb:2PKU|rcsb pdb:3HPK|rcsb pdb:3HPM|reactome:R-RNO-416993|mint:Q9EP80|dip:DIP-30941N|mint:MINT-8119057(identity) - - - comment:homomint|comment:mint|figure legend:f8a f8b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-hippocampus_neuron)|taxid:10116(Rattus norvegicus) - 2011/02/23 2014/10/16 rogid:btMZRS12WGW/Bm3iHleBFvmF+i010116 rogid:py6ehB6OMAq34c71Oad5GTeNfHg10116 intact-crc:D10D2C366D37464E|rigid:60mFGDCxwOtoo8U+hjmrWupVRww false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)