#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-3513896	uniprotkb:P08508	-	intact:EBI-3598524	psi-mi:drozitumab(display_short)|psi-mi:EBI-3513896(display_long)	psi-mi:fcgr3_mouse(display_long)|uniprotkb:Fcgr3(gene name)|psi-mi:Fcgr3(display_short)|uniprotkb:Fc-gamma RIII(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Wilson et al. (2011)	pubmed:21251615|imex:IM-15767	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3598529|imex:IM-15767-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	interpro:IPR036179|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0001788"(antibody-dependent cellular cytotoxicity)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001820"(serotonin secretion)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019770"(IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042590"(antigen processing and presentation of exogenous peptide antigen via MHC class I)|go:"GO:0045576"(mast cell activation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|reactome:R-MMU-198933	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1D.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/15	2014/10/16	-	rogid:EEW7yPAXR+JVaPxFok4wS8bLx4Y10090	intact-crc:861E240617D2CAD2	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-3513896	uniprotkb:P26151	-	intact:EBI-3584363|ensembl:ENSMUSP00000029748	psi-mi:drozitumab(display_short)|psi-mi:EBI-3513896(display_long)	psi-mi:fcgr1_mouse(display_long)|uniprotkb:Fcgr1(gene name)|psi-mi:Fcgr1(display_short)|uniprotkb:Fcg1(gene name synonym)|uniprotkb:Fc-gamma RI(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Wilson et al. (2011)	pubmed:21251615|imex:IM-15767	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3574609|imex:IM-15767-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_034316.1|ensembl:ENSMUSG00000015947(gene)|ensembl:ENSMUST00000029748(transcript)|go:"GO:0001788"(antibody-dependent cellular cytotoxicity)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019770"(IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019884"(antigen processing and presentation of exogenous antigen)|go:"GO:0031774"(leukotriene receptor binding)|go:"GO:0042590"(antigen processing and presentation of exogenous peptide antigen via MHC class I)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-1236978|reactome:R-MMU-2029481|reactome:R-MMU-2029482|reactome:R-MMU-2029485	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1D.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/15	2014/10/16	-	rogid:B3K+QT3lLXemp6nHRtb+rXCI25I10090	intact-crc:611018158E798B71	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A0A0B4J1G0	intact:EBI-3513896	intact:EBI-3574603|uniprotkb:Q3TC44|ensembl:ENSMUSP00000077873|uniprotkb:Q8R2R4|uniprotkb:Q8R477	-	psi-mi:fcgr4_mouse(display_long)|uniprotkb:Fcgr4(gene name)|psi-mi:Fcgr4(display_short)|uniprotkb:CD16-2(gene name synonym)|uniprotkb:FcgammaRIV(gene name synonym)	psi-mi:drozitumab(display_short)|psi-mi:EBI-3513896(display_long)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Wilson et al. (2011)	pubmed:21251615|imex:IM-15767	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3513897|imex:IM-15767-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000059089(gene)|ensembl:ENSMUST00000078825(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019767"(IgE receptor activity)|go:"GO:0019770"(IgG receptor activity)|go:"GO:0019863"(IgE binding)|go:"GO:0019864"(IgG binding)|go:"GO:0042060"(wound healing)|go:"GO:0042119"(neutrophil activation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-2029481|reactome:R-MMU-2029482|reactome:R-MMU-2029485|refseq:NP_653142.2	-	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1D.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/15	2017/01/20	rogid:Y2BN9RHagY8xF/tQpjAybQv+KAg10090	-	intact-crc:506532FC82D0C298	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08101	intact:EBI-3513896	intact:EBI-3592455|uniprotkb:P08102|uniprotkb:P12316|uniprotkb:P97917|uniprotkb:Q60938|uniprotkb:Q60939|uniprotkb:Q60940|uniprotkb:Q61170|uniprotkb:Q61558	-	psi-mi:fcgr2_mouse(display_long)|uniprotkb:Fcgr2(gene name)|psi-mi:Fcgr2(display_short)|uniprotkb:Fcgr2b(gene name synonym)|uniprotkb:Ly-17(gene name synonym)|uniprotkb:Fc gamma receptor IIB(gene name synonym)|uniprotkb:IgG Fc receptor II beta(gene name synonym)|uniprotkb:Lymphocyte antigen 17(gene name synonym)	psi-mi:drozitumab(display_short)|psi-mi:EBI-3513896(display_long)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Wilson et al. (2011)	pubmed:21251615|imex:IM-15767	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3592451|imex:IM-15767-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR036179|refseq:NP_034317.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0002434"(immune complex clearance)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0006952"(defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016358"(dendrite development)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043197"(dendritic spine)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:0002638"(negative regulation of immunoglobulin production)|reactome:R-MMU-198933|reactome:R-MMU-2029481|reactome:R-MMU-2029482|reactome:R-MMU-2029485|reactome:R-MMU-6798695	-	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1D.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/15	2014/10/16	rogid:ffILGupZ54cxJGz7XGD9GNYqtbc10090	-	intact-crc:1469D345340752A1	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12318	intact:EBI-3513896	intact:EBI-1395970|uniprotkb:Q8WUN1|uniprotkb:Q8WW64|ensembl:ENSP00000271450	-	psi-mi:fcg2a_human(display_long)|uniprotkb:FCGR2A(gene name)|psi-mi:FCGR2A(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:FCGR2A1(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-a(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:drozitumab(display_short)|psi-mi:EBI-3513896(display_long)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Wilson et al. (2011)	pubmed:21251615|imex:IM-15767	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3623877|imex:IM-15767-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129691.1|refseq:NP_067674.2|ensembl:ENSG00000143226(gene)|ensembl:ENST00000271450(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0019864"(IgG binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0050776"(regulation of immune response)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1FCG|rcsb pdb:1H9V|rcsb pdb:3D5O|rcsb pdb:3RY4|rcsb pdb:3RY5|rcsb pdb:3RY6|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6798695|reactome:R-HSA-9664323	-	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 6A.|agonist:anti-κ antibody|comment:"drozitumab exhibited approximately 2- to 3-fold higher affinity for recombinant  human FcγRIIA131H versus FcγRIIA131R -(natural variants/polymophisms)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/15	2014/10/16	rogid:nLZVU54CX2WcrlhLnD3LQ8Sabgc9606	-	intact-crc:C786269C6D1CA97E	false	sufficient binding region:34..34-217..217|his tag:c-c|glutathione s tranferase tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08637	intact:EBI-3513896	intact:EBI-2833956|uniprotkb:Q6PIJ0|uniprotkb:Q53FL6|uniprotkb:A2N6W9|uniprotkb:Q5EBR4|uniprotkb:Q65ZM6|uniprotkb:Q53FJ0|ensembl:ENSP00000356944|ensembl:ENSP00000392047|ensembl:ENSP00000416607	-	psi-mi:fcg3a_human(display_long)|uniprotkb:FCGR3A(gene name)|psi-mi:FCGR3A(display_short)|uniprotkb:CD16A(gene name synonym)|uniprotkb:FCG3(gene name synonym)|uniprotkb:FCGR3(gene name synonym)|uniprotkb:IGFR3(gene name synonym)|uniprotkb:CD16a antigen(gene name synonym)|uniprotkb:Fc-gamma RIII-alpha(gene name synonym)|uniprotkb:FcR-10(gene name synonym)|uniprotkb:IgG Fc receptor III-2(gene name synonym)	psi-mi:drozitumab(display_short)|psi-mi:EBI-3513896(display_long)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Wilson et al. (2011)	pubmed:21251615|imex:IM-15767	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3623893|imex:IM-15767-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000560.6|refseq:NP_001121064.2|refseq:NP_001316049.1|ensembl:ENSG00000203747(gene)|ensembl:ENST00000367967(transcript)|ensembl:ENST00000436743(transcript)|ensembl:ENST00000443193(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-2029481|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019864"(IgG binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3AY4|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3WN5|rcsb pdb:5BW7|rcsb pdb:5D6D|rcsb pdb:5ML9|rcsb pdb:5MN2|rcsb pdb:5VU0|rcsb pdb:5XJE|go:"GO:0007166"(cell surface receptor signaling pathway)|rcsb pdb:5XJF|rcsb pdb:5YC5|reactome:R-HSA-198933|refseq:NP_001121065.1|refseq:NP_001121067.1|refseq:NP_001121068.1	-	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 6C.|agonist:anti-κ antibody|comment:"drozitumab exhibited higher affinity for recombinant FcγRIIIA158V versus FcγRIIIA158F- (natural variants/polymorphisms)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/15	2014/10/16	rogid:qnL5hzgVCJeoN2OBxQCpXJxH/tE9606	-	intact-crc:1612E09474B1B47A	false	his tag:c-c|sufficient binding region:17..17-208..208|glutathione s tranferase tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9QZM4	uniprotkb:O89110	intact:EBI-3623837|uniprotkb:Q6GSD9|uniprotkb:Q9JJL5|uniprotkb:Q9JJL6|ensembl:ENSMUSP00000022663	intact:EBI-851690|uniprotkb:O35669|ensembl:ENSMUSP00000027189|ensembl:ENSMUSP00000127375	psi-mi:tr10b_mouse(display_long)|uniprotkb:Tnfrsf10b(gene name)|psi-mi:Tnfrsf10b(display_short)|uniprotkb:Dr5(gene name synonym)|uniprotkb:Killer(gene name synonym)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:MK(gene name synonym)	psi-mi:casp8_mouse(display_long)|uniprotkb:Casp8(gene name)|psi-mi:Casp8(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2011)	pubmed:21251615|imex:IM-15767	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3623839|imex:IM-15767-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064671.2|ensembl:ENSMUSG00000022074(gene)|ensembl:ENSMUST00000022663(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|reactome:R-MMU-202733|reactome:R-MMU-3371378|reactome:R-MMU-5218900|reactome:R-MMU-69416|reactome:R-MMU-75158	refseq:NP_001073595.1|refseq:NP_033942.1|dip:DIP-37435N|reactome:R-MMU-3371378|reactome:R-MMU-5218900|reactome:R-MMU-5357905|reactome:R-MMU-5660668|reactome:R-MMU-5675482|reactome:R-MMU-69416|reactome:R-MMU-75108|reactome:R-MMU-75153|reactome:R-MMU-75157|reactome:R-MMU-75158|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:O89110|reactome:R-MMU-111465|reactome:R-MMU-140534|reactome:R-MMU-168638|reactome:R-MMU-2562578|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070243"(regulation of thymocyte apoptotic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097342"(ripoptosome)|ensembl:ENSMUST00000027189(transcript)|ensembl:ENSMUST00000165549(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001841"(neural tube formation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016485"(protein processing)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030690"(Noc1p-Noc2p complex)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|ensembl:ENSMUSG00000026029(gene)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048738"(cardiac muscle tissue development)|reactome:R-MMU-264870	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1H.|comment:Caspase-8 recruitment was evident within 60 min of WT drozitumab treatment, with substantial processing and appearance of the p18 catalytic subunit by 180 min.|agonist:"drozitumab and to a lesser extent DANA-drozitumab  (mutant of IgG1 Fc region (D265A and N297A)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2011/02/15	2014/10/16	rogid:cMcw4yZ+qM6o4A4BazMt05xv2BU10090	rogid:cugP6s7CldE0MbwvCxTcams7feA10090	intact-crc:915953393F98F090|rigid:ESfGoJ8q19XnO8YzUKUTJJsndtw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)