#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q92133 uniprotkb:Q9GYI0 intact:EBI-3508838 intact:EBI-3508849|uniprotkb:Q9BI67|ensemblmetazoa:F29B9.2a.1 psi-mi:q92133_xenla(display_long)|uniprotkb:h3c8.S(gene name)|psi-mi:h3c8.S(display_short)|uniprotkb:H3l(gene name synonym)|uniprotkb:h3c8(gene name synonym)|uniprotkb:hist1h3g(gene name synonym) psi-mi:kdm7_caeel(display_long)|uniprotkb:jmjd-1.2(gene name)|psi-mi:jmjd-1.2(display_short)|uniprotkb:JmjC domain-containing protein 1.2(gene name synonym)|uniprotkb:PHD finger protein 8 homolog(gene name synonym)|uniprotkb:PHF8 homolog(gene name synonym)|uniprotkb:F29B9.2(orf name) psi-mi:"MI:0870"(demethylase assay) Xu et al. (2011) pubmed:21251613|imex:IM-15765 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0871"(demethylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3508840|imex:IM-15765-1 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091119.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:2L1B|rcsb pdb:3GL6|rcsb pdb:3H91|rcsb pdb:3ME9|rcsb pdb:3MEA|rcsb pdb:3MET|rcsb pdb:3MEU|rcsb pdb:3MEV|rcsb pdb:3O7A|rcsb pdb:4HSU|rcsb pdb:6G0L|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6VZ4|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|dip:DIP-60191N reactome:R-CEL-8951664|reactome:R-CEL-983168|refseq:NP_500610.1|refseq:NP_500611.1|wormbase:F29B9.2a|wormbase:F29B9.2b|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR019786|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:3N9L|rcsb pdb:3N9M|rcsb pdb:3N9N|rcsb pdb:3N9O|rcsb pdb:3N9P|rcsb pdb:3N9Q|rcsb pdb:3PUQ|rcsb pdb:3PUR|ensemblmetazoa:F29B9.2a.1(transcript)|ensemblmetazoa:WBGene00017920(gene)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042393"(histone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|reactome:R-CEL-2299718|reactome:R-CEL-3214842|interpro:IPR041070 psi-mi:"MI:0469"(intact) - - inhibition:2-hydroxyglutarate, D>Lform.|figure legend:Fig 1A, 1B, S1.|stimulant:α-ketoglutarate|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:fAFhGVLDAjIscuN8aazYlT6fqng8355 rogid:nnRt20IEzY7g0e8PdVuAaAPM0VI6239 intact-crc:9AAEDCC098B9E9B3|rigid:64suVszJx5pbBVESCm2wSDqYyKA false sufficient binding region:2-16|methylated lysine:10-10 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08898 uniprotkb:Q9GYI0 intact:EBI-3508991|uniprotkb:Q9TW44|ensemblmetazoa:F07B7.5.1|ensemblmetazoa:F08G2.3.1|ensemblmetazoa:F17E9.10.1|ensemblmetazoa:F22B3.2.1|ensemblmetazoa:F45F2.13.1|ensemblmetazoa:B0035.10.1|ensemblmetazoa:F54E12.1.1|ensemblmetazoa:F55G1.2.1|ensemblmetazoa:K06C4.13.1|ensemblmetazoa:K06C4.5.1|ensemblmetazoa:T10C6.13.1|ensemblmetazoa:ZK131.2.1|ensemblmetazoa:ZK131.3.1|ensemblmetazoa:ZK131.7.1 intact:EBI-3508849|uniprotkb:Q9BI67|ensemblmetazoa:F29B9.2a.1 psi-mi:h3_caeel(display_long)|uniprotkb:his-2(gene name)|psi-mi:his-2(display_short)|uniprotkb:his-6(gene name)|psi-mi:his-6(display_short)|uniprotkb:his-9(gene name)|psi-mi:his-9(display_short)|uniprotkb:his-13(gene name)|psi-mi:his-13(display_short)|uniprotkb:his-17(gene name)|psi-mi:his-17(display_short)|uniprotkb:his-25(gene name)|psi-mi:his-25(display_short)|uniprotkb:his-27(gene name)|psi-mi:his-27(display_short)|uniprotkb:his-32(gene name)|psi-mi:his-32(display_short)|uniprotkb:his-42(gene name)|psi-mi:his-42(display_short)|uniprotkb:his-45(gene name)|psi-mi:his-45(display_short)|uniprotkb:his-49(gene name)|psi-mi:his-49(display_short)|uniprotkb:his-55(gene name)|psi-mi:his-55(display_short)|uniprotkb:his-59(gene name)|psi-mi:his-59(display_short)|uniprotkb:his-63(gene name)|psi-mi:his-63(display_short)|uniprotkb:T10C6.13(orf name)|uniprotkb:F45F2.13(orf name)|uniprotkb:ZK131.3(orf name)|uniprotkb:ZK131.7(orf name)|uniprotkb:K06C4.5(orf name)|uniprotkb:ZK131.2(orf name)|uniprotkb:K06C4.13(orf name)|uniprotkb:F17E9.10(orf name)|uniprotkb:F08G2.3(orf name)|uniprotkb:B0035.10(orf name)|uniprotkb:F07B7.5(orf name)|uniprotkb:F54E12.1(orf name)|uniprotkb:F55G1.2(orf name)|uniprotkb:F22B3.2(orf name) psi-mi:kdm7_caeel(display_long)|uniprotkb:jmjd-1.2(gene name)|psi-mi:jmjd-1.2(display_short)|uniprotkb:JmjC domain-containing protein 1.2(gene name synonym)|uniprotkb:PHD finger protein 8 homolog(gene name synonym)|uniprotkb:PHF8 homolog(gene name synonym)|uniprotkb:F29B9.2(orf name) psi-mi:"MI:0870"(demethylase assay) Xu et al. (2011) pubmed:21251613|imex:IM-15765 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0871"(demethylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-3508993|imex:IM-15765-2 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001263958.1|refseq:NP_496890.1|refseq:NP_496894.1|refseq:NP_496895.1|refseq:NP_501204.1|refseq:NP_501407.1|refseq:NP_502134.1|refseq:NP_502138.1|refseq:NP_502153.1|refseq:NP_505199.1|refseq:NP_505276.1|refseq:NP_505292.1|refseq:NP_505297.1|refseq:NP_507033.1|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|wormbase:B0035.10|wormbase:F07B7.5|wormbase:F08G2.3|wormbase:F17E9.10|wormbase:F22B3.2|wormbase:F45F2.13|wormbase:F54E12.1|wormbase:F55G1.2|wormbase:K06C4.13|wormbase:K06C4.5|wormbase:T10C6.13|wormbase:ZK131.2|wormbase:ZK131.3|wormbase:ZK131.7|rcsb pdb:3N9L|rcsb pdb:3N9N|rcsb pdb:3N9O|rcsb pdb:3N9P|rcsb pdb:3N9Q|ensemblmetazoa:B0035.10.1(transcript)|ensemblmetazoa:F07B7.5.1(transcript)|ensemblmetazoa:F08G2.3.1(transcript)|ensemblmetazoa:F17E9.10.1(transcript)|ensemblmetazoa:F22B3.2.1(transcript)|ensemblmetazoa:F45F2.13.1(transcript)|ensemblmetazoa:F54E12.1.1(transcript)|ensemblmetazoa:F55G1.2.1(transcript)|ensemblmetazoa:K06C4.13.1(transcript)|ensemblmetazoa:K06C4.5.1(transcript)|ensemblmetazoa:T10C6.13.1(transcript)|ensemblmetazoa:WBGene00001876(gene)|ensemblmetazoa:WBGene00001880(gene)|ensemblmetazoa:WBGene00001883(gene)|ensemblmetazoa:WBGene00001887(gene)|ensemblmetazoa:WBGene00001891(gene)|ensemblmetazoa:WBGene00001899(gene)|ensemblmetazoa:WBGene00001901(gene)|ensemblmetazoa:WBGene00001906(gene)|ensemblmetazoa:WBGene00001916(gene)|ensemblmetazoa:WBGene00001919(gene)|ensemblmetazoa:WBGene00001923(gene)|ensemblmetazoa:WBGene00001933(gene)|ensemblmetazoa:WBGene00001937(gene)|ensemblmetazoa:WBGene00001929(gene)|ensemblmetazoa:ZK131.2.1(transcript)|ensemblmetazoa:ZK131.3.1(transcript)|ensemblmetazoa:ZK131.7.1(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_496899.1 reactome:R-CEL-8951664|reactome:R-CEL-983168|refseq:NP_500610.1|refseq:NP_500611.1|wormbase:F29B9.2a|wormbase:F29B9.2b|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR019786|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:3N9L|rcsb pdb:3N9M|rcsb pdb:3N9N|rcsb pdb:3N9O|rcsb pdb:3N9P|rcsb pdb:3N9Q|rcsb pdb:3PUQ|rcsb pdb:3PUR|ensemblmetazoa:F29B9.2a.1(transcript)|ensemblmetazoa:WBGene00017920(gene)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042393"(histone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|reactome:R-CEL-2299718|reactome:R-CEL-3214842|interpro:IPR041070 psi-mi:"MI:0469"(intact) - - inhibition:2-hydroxyglutarate, D>Lform.|figure legend:Fig 1A, 1B, S1.|stimulant:α-ketoglutarate|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 rogid:KENDX1+w1fQI+PTl/NNgdaKTzbw6239 rogid:nnRt20IEzY7g0e8PdVuAaAPM0VI6239 intact-crc:DABAC30FB614E125|rigid:YDwbZaQOE/YJkNQBhXc9huxoI5g false methylated lysine:28-28|sufficient binding region:20-33 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) chebi:"CHEBI:30915" chebi:"CHEBI:29033" intact:EBI-3513856 intact:EBI-2929936 psi-mi:a-kg(display_short)|psi-mi:"CHEBI:30915"(display_long) psi-mi:iron2plus(display_short)|psi-mi:"CHEBI:29033"(display_long) psi-mi:"MI:0114"(x-ray crystallography) Xu et al. (2011) pubmed:21251613|imex:IM-15765 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3513842|pdbe:3puq|imex:IM-15765-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - - - - figure legend:Fig 2B, Table 1.|3d-r-factors:"Working R factor of 18.75%, Free R-factor: 22.36%."|3d-resolution:2.25A.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 - - intact-crc:A82354598AE40B0D false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:30915" uniprotkb:Q9GYI0 intact:EBI-3513856 intact:EBI-3508849|uniprotkb:Q9BI67|ensemblmetazoa:F29B9.2a.1 psi-mi:a-kg(display_short)|psi-mi:"CHEBI:30915"(display_long) psi-mi:kdm7_caeel(display_long)|uniprotkb:jmjd-1.2(gene name)|psi-mi:jmjd-1.2(display_short)|uniprotkb:JmjC domain-containing protein 1.2(gene name synonym)|uniprotkb:PHD finger protein 8 homolog(gene name synonym)|uniprotkb:PHF8 homolog(gene name synonym)|uniprotkb:F29B9.2(orf name) psi-mi:"MI:0114"(x-ray crystallography) Xu et al. (2011) pubmed:21251613|imex:IM-15765 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3513842|pdbe:3puq|imex:IM-15765-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - reactome:R-CEL-8951664|reactome:R-CEL-983168|refseq:NP_500610.1|refseq:NP_500611.1|wormbase:F29B9.2a|wormbase:F29B9.2b|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR019786|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:3N9L|rcsb pdb:3N9M|rcsb pdb:3N9N|rcsb pdb:3N9O|rcsb pdb:3N9P|rcsb pdb:3N9Q|rcsb pdb:3PUQ|rcsb pdb:3PUR|ensemblmetazoa:F29B9.2a.1(transcript)|ensemblmetazoa:WBGene00017920(gene)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042393"(histone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|reactome:R-CEL-2299718|reactome:R-CEL-3214842|interpro:IPR041070 - - - figure legend:Fig 2B, Table 1.|3d-r-factors:"Working R factor of 18.75%, Free R-factor: 22.36%."|3d-resolution:2.25A.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 - rogid:nnRt20IEzY7g0e8PdVuAaAPM0VI6239 intact-crc:A82354598AE40B0D false - sufficient binding region:441..441-612..612|binding-associated region:497-497 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:30915" chebi:"CHEBI:29105" intact:EBI-3513856 intact:EBI-968340 psi-mi:a-kg(display_short)|psi-mi:"CHEBI:30915"(display_long) psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long) psi-mi:"MI:0114"(x-ray crystallography) Xu et al. (2011) pubmed:21251613|imex:IM-15765 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3513842|pdbe:3puq|imex:IM-15765-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - - - - figure legend:Fig 2B, Table 1.|3d-r-factors:"Working R factor of 18.75%, Free R-factor: 22.36%."|3d-resolution:2.25A.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 - - intact-crc:A82354598AE40B0D false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:29033" uniprotkb:Q9GYI0 intact:EBI-2929936 intact:EBI-3508849|uniprotkb:Q9BI67|ensemblmetazoa:F29B9.2a.1 psi-mi:iron2plus(display_short)|psi-mi:"CHEBI:29033"(display_long) psi-mi:kdm7_caeel(display_long)|uniprotkb:jmjd-1.2(gene name)|psi-mi:jmjd-1.2(display_short)|uniprotkb:JmjC domain-containing protein 1.2(gene name synonym)|uniprotkb:PHD finger protein 8 homolog(gene name synonym)|uniprotkb:PHF8 homolog(gene name synonym)|uniprotkb:F29B9.2(orf name) psi-mi:"MI:0114"(x-ray crystallography) Xu et al. (2011) pubmed:21251613|imex:IM-15765 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3509117|pdbe:3pur|imex:IM-15765-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - reactome:R-CEL-8951664|reactome:R-CEL-983168|refseq:NP_500610.1|refseq:NP_500611.1|wormbase:F29B9.2a|wormbase:F29B9.2b|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR019786|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:3N9L|rcsb pdb:3N9M|rcsb pdb:3N9N|rcsb pdb:3N9O|rcsb pdb:3N9P|rcsb pdb:3N9Q|rcsb pdb:3PUQ|rcsb pdb:3PUR|ensemblmetazoa:F29B9.2a.1(transcript)|ensemblmetazoa:WBGene00017920(gene)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042393"(histone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|reactome:R-CEL-2299718|reactome:R-CEL-3214842|interpro:IPR041070 - - - figure legend:Fig 2A, Table 1, Fig S2.|3d-r-factors:"Working R factor of 21.4%, Free R-factor: 25.05%."|3d-resolution:2.1A.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 - rogid:nnRt20IEzY7g0e8PdVuAaAPM0VI6239 intact-crc:A6AB6E6094C7FFCD false - sufficient binding region:441..441-612..612|binding-associated region:497-497,497-497 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:29033" chebi:"CHEBI:32796" intact:EBI-2929936 intact:EBI-3509206 psi-mi:iron2plus(display_short)|psi-mi:"CHEBI:29033"(display_long) psi-mi:r-2-hg(display_short)|psi-mi:"CHEBI:32796"(display_long) psi-mi:"MI:0114"(x-ray crystallography) Xu et al. (2011) pubmed:21251613|imex:IM-15765 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3509117|pdbe:3pur|imex:IM-15765-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - - - - figure legend:Fig 2A, Table 1, Fig S2.|3d-r-factors:"Working R factor of 21.4%, Free R-factor: 25.05%."|3d-resolution:2.1A.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 - - intact-crc:A6AB6E6094C7FFCD false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:29033" chebi:"CHEBI:29105" intact:EBI-2929936 intact:EBI-968340 psi-mi:iron2plus(display_short)|psi-mi:"CHEBI:29033"(display_long) psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long) psi-mi:"MI:0114"(x-ray crystallography) Xu et al. (2011) pubmed:21251613|imex:IM-15765 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3509117|pdbe:3pur|imex:IM-15765-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - - - - figure legend:Fig 2A, Table 1, Fig S2.|3d-r-factors:"Working R factor of 21.4%, Free R-factor: 25.05%."|3d-resolution:2.1A.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/08 2014/10/16 - - intact-crc:A6AB6E6094C7FFCD false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)