#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NWT6	uniprotkb:Q9H2K2	intact:EBI-745632|uniprotkb:Q969Q7|uniprotkb:Q9NPV5|uniprotkb:Q5W147|ensembl:ENSP00000299163|uniprotkb:D3DR69	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:hif1n_human(display_long)|uniprotkb:Hypoxia-inducible factor asparagine hydroxylase(gene name synonym)|uniprotkb:Factor inhibiting HIF-1(gene name synonym)|uniprotkb:HIF1AN(gene name)|psi-mi:HIF1AN(display_short)|uniprotkb:FIH1(gene name synonym)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Yang et al. (2011)	mint:MINT-8084809|pubmed:21251231|doi:10.1111/j.1742-4658.2011.08022|mint:fj-10-1159	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8565642|mint:MINT-8084814	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060372.2|ensembl:ENSG00000166135(gene)|ensembl:ENST00000299163(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0036138"(peptidyl-histidine hydroxylation)|go:"GO:0036139"(peptidyl-histidine dioxygenase activity)|go:"GO:0036140"(peptidyl-asparagine 3-dioxygenase activity)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0042265"(peptidyl-asparagine hydroxylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0102113"(hypoxia-inducible factor-asparagine oxygenase activity)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR027445|interpro:IPR027452|interpro:IPR041667|mint:Q9NWT6|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1H2N|rcsb pdb:1IZ3|rcsb pdb:1MZE|rcsb pdb:1MZF|rcsb pdb:1YCI|rcsb pdb:2CGN|rcsb pdb:2CGO|rcsb pdb:2ILM|rcsb pdb:2W0X|rcsb pdb:2WA3|rcsb pdb:2WA4|rcsb pdb:2XUM|rcsb pdb:2Y0I|rcsb pdb:2YC0|rcsb pdb:2YDE|rcsb pdb:3D8C|rcsb pdb:3KCX|rcsb pdb:3KCY|rcsb pdb:3OD4|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:4AI8|rcsb pdb:4B7E|rcsb pdb:4B7K|rcsb pdb:4BIO|rcsb pdb:4JAA|rcsb pdb:4NR1|rcsb pdb:4Z1V|rcsb pdb:4Z2W|rcsb pdb:5JWK|rcsb pdb:5JWL|rcsb pdb:5JWP|rcsb pdb:5OP6|rcsb pdb:6H9J|rcsb pdb:6HA6|rcsb pdb:6HC8|rcsb pdb:6HKP|rcsb pdb:6HL5|rcsb pdb:6HL6|rcsb pdb:6RUJ|reactome:R-HSA-1234174|rcsb pdb:5OP8|rcsb pdb:5OPC|dip:DIP-35527N|mint:MINT-8084816(identity)	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM|mint:MINT-8084817(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f5a f5b st1	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/11	2014/10/16	rogid:lvPtfqlB1+hOcdCAwcopj/Yl+3Y9606	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:1BE350F86C3A936E|rigid:OjSiBwUCOHwYqo3ObPtHkrHbuUg	false	-	binding-associated region:538-558(MINT-8084823)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q9NWT6	uniprotkb:Q9H2K2	intact:EBI-745632|uniprotkb:Q969Q7|uniprotkb:Q9NPV5|uniprotkb:Q5W147|ensembl:ENSP00000299163|uniprotkb:D3DR69	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:hif1n_human(display_long)|uniprotkb:Hypoxia-inducible factor asparagine hydroxylase(gene name synonym)|uniprotkb:Factor inhibiting HIF-1(gene name synonym)|uniprotkb:HIF1AN(gene name)|psi-mi:HIF1AN(display_short)|uniprotkb:FIH1(gene name synonym)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Yang et al. (2011)	mint:MINT-8084809|pubmed:21251231|doi:10.1111/j.1742-4658.2011.08022|mint:fj-10-1159	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0210"(hydroxylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8565717|mint:MINT-8084841	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060372.2|ensembl:ENSG00000166135(gene)|ensembl:ENST00000299163(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0036138"(peptidyl-histidine hydroxylation)|go:"GO:0036139"(peptidyl-histidine dioxygenase activity)|go:"GO:0036140"(peptidyl-asparagine 3-dioxygenase activity)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0042265"(peptidyl-asparagine hydroxylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0102113"(hypoxia-inducible factor-asparagine oxygenase activity)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR027445|interpro:IPR027452|interpro:IPR041667|mint:Q9NWT6|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1H2N|rcsb pdb:1IZ3|rcsb pdb:1MZE|rcsb pdb:1MZF|rcsb pdb:1YCI|rcsb pdb:2CGN|rcsb pdb:2CGO|rcsb pdb:2ILM|rcsb pdb:2W0X|rcsb pdb:2WA3|rcsb pdb:2WA4|rcsb pdb:2XUM|rcsb pdb:2Y0I|rcsb pdb:2YC0|rcsb pdb:2YDE|rcsb pdb:3D8C|rcsb pdb:3KCX|rcsb pdb:3KCY|rcsb pdb:3OD4|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:4AI8|rcsb pdb:4B7E|rcsb pdb:4B7K|rcsb pdb:4BIO|rcsb pdb:4JAA|rcsb pdb:4NR1|rcsb pdb:4Z1V|rcsb pdb:4Z2W|rcsb pdb:5JWK|rcsb pdb:5JWL|rcsb pdb:5JWP|rcsb pdb:5OP6|rcsb pdb:6H9J|rcsb pdb:6HA6|rcsb pdb:6HC8|rcsb pdb:6HKP|rcsb pdb:6HL5|rcsb pdb:6HL6|rcsb pdb:6RUJ|reactome:R-HSA-1234174|rcsb pdb:5OP8|rcsb pdb:5OPC|dip:DIP-35527N|mint:MINT-8084843(identity)	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM|mint:MINT-8084844(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1b sf1 f4 sf5	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/11	2014/10/16	rogid:lvPtfqlB1+hOcdCAwcopj/Yl+3Y9606	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:9F14C4D344D49FFD|rigid:OjSiBwUCOHwYqo3ObPtHkrHbuUg	false	-	binding-associated region:538-558(MINT-8084847)|dihydroxylated residue:553-553(MINT-8084845)|mutation increasing interaction:553-553(MINT-8084953)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9H2K2	uniprotkb:Q9NWT6	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	intact:EBI-745632|uniprotkb:Q969Q7|uniprotkb:Q9NPV5|uniprotkb:Q5W147|ensembl:ENSP00000299163|uniprotkb:D3DR69	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:hif1n_human(display_long)|uniprotkb:Hypoxia-inducible factor asparagine hydroxylase(gene name synonym)|uniprotkb:Factor inhibiting HIF-1(gene name synonym)|uniprotkb:HIF1AN(gene name)|psi-mi:HIF1AN(display_short)|uniprotkb:FIH1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Yang et al. (2011)	mint:MINT-8084809|pubmed:21251231|doi:10.1111/j.1742-4658.2011.08022|mint:fj-10-1159	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0210"(hydroxylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8565664|mint:MINT-8084829	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM|mint:MINT-8084831(identity)	refseq:NP_060372.2|ensembl:ENSG00000166135(gene)|ensembl:ENST00000299163(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0036138"(peptidyl-histidine hydroxylation)|go:"GO:0036139"(peptidyl-histidine dioxygenase activity)|go:"GO:0036140"(peptidyl-asparagine 3-dioxygenase activity)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0042265"(peptidyl-asparagine hydroxylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0102113"(hypoxia-inducible factor-asparagine oxygenase activity)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR027445|interpro:IPR027452|interpro:IPR041667|mint:Q9NWT6|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1H2N|rcsb pdb:1IZ3|rcsb pdb:1MZE|rcsb pdb:1MZF|rcsb pdb:1YCI|rcsb pdb:2CGN|rcsb pdb:2CGO|rcsb pdb:2ILM|rcsb pdb:2W0X|rcsb pdb:2WA3|rcsb pdb:2WA4|rcsb pdb:2XUM|rcsb pdb:2Y0I|rcsb pdb:2YC0|rcsb pdb:2YDE|rcsb pdb:3D8C|rcsb pdb:3KCX|rcsb pdb:3KCY|rcsb pdb:3OD4|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:4AI8|rcsb pdb:4B7E|rcsb pdb:4B7K|rcsb pdb:4BIO|rcsb pdb:4JAA|rcsb pdb:4NR1|rcsb pdb:4Z1V|rcsb pdb:4Z2W|rcsb pdb:5JWK|rcsb pdb:5JWL|rcsb pdb:5JWP|rcsb pdb:5OP6|rcsb pdb:6H9J|rcsb pdb:6HA6|rcsb pdb:6HC8|rcsb pdb:6HKP|rcsb pdb:6HL5|rcsb pdb:6HL6|rcsb pdb:6RUJ|reactome:R-HSA-1234174|rcsb pdb:5OP8|rcsb pdb:5OPC|dip:DIP-35527N|mint:MINT-8084832(identity)	-	-	-	figure legend:f1b|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/11	2014/10/16	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	rogid:lvPtfqlB1+hOcdCAwcopj/Yl+3Y9606	intact-crc:9599C8624C182E23|rigid:OjSiBwUCOHwYqo3ObPtHkrHbuUg	false	binding-associated region:223-243(MINT-8084835)|dihydroxylated residue:238-238(MINT-8084838)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95271	uniprotkb:Q9NWT6	intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579	intact:EBI-745632|uniprotkb:Q969Q7|uniprotkb:Q9NPV5|uniprotkb:Q5W147|ensembl:ENSP00000299163|uniprotkb:D3DR69	psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)	psi-mi:hif1n_human(display_long)|uniprotkb:Hypoxia-inducible factor asparagine hydroxylase(gene name synonym)|uniprotkb:Factor inhibiting HIF-1(gene name synonym)|uniprotkb:HIF1AN(gene name)|psi-mi:HIF1AN(display_short)|uniprotkb:FIH1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Yang et al. (2011)	mint:MINT-8084809|pubmed:21251231|doi:10.1111/j.1742-4658.2011.08022|mint:fj-10-1159	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0210"(hydroxylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8565753|mint:MINT-8084923	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N|mint:MINT-8084925(identity)	refseq:NP_060372.2|ensembl:ENSG00000166135(gene)|ensembl:ENST00000299163(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0036138"(peptidyl-histidine hydroxylation)|go:"GO:0036139"(peptidyl-histidine dioxygenase activity)|go:"GO:0036140"(peptidyl-asparagine 3-dioxygenase activity)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0042265"(peptidyl-asparagine hydroxylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0102113"(hypoxia-inducible factor-asparagine oxygenase activity)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR027445|interpro:IPR027452|interpro:IPR041667|mint:Q9NWT6|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1H2N|rcsb pdb:1IZ3|rcsb pdb:1MZE|rcsb pdb:1MZF|rcsb pdb:1YCI|rcsb pdb:2CGN|rcsb pdb:2CGO|rcsb pdb:2ILM|rcsb pdb:2W0X|rcsb pdb:2WA3|rcsb pdb:2WA4|rcsb pdb:2XUM|rcsb pdb:2Y0I|rcsb pdb:2YC0|rcsb pdb:2YDE|rcsb pdb:3D8C|rcsb pdb:3KCX|rcsb pdb:3KCY|rcsb pdb:3OD4|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:4AI8|rcsb pdb:4B7E|rcsb pdb:4B7K|rcsb pdb:4BIO|rcsb pdb:4JAA|rcsb pdb:4NR1|rcsb pdb:4Z1V|rcsb pdb:4Z2W|rcsb pdb:5JWK|rcsb pdb:5JWL|rcsb pdb:5JWP|rcsb pdb:5OP6|rcsb pdb:6H9J|rcsb pdb:6HA6|rcsb pdb:6HC8|rcsb pdb:6HKP|rcsb pdb:6HL5|rcsb pdb:6HL6|rcsb pdb:6RUJ|reactome:R-HSA-1234174|rcsb pdb:5OP8|rcsb pdb:5OPC|dip:DIP-35527N|mint:MINT-8084929(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f6c sf3	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/11	2014/10/16	rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606	rogid:lvPtfqlB1+hOcdCAwcopj/Yl+3Y9606	intact-crc:8377FEA4B5083B9C|rigid:uo+nX1QQF3F5zIyarBpF6+wLvPI	false	dihydroxylated residue:711-711(MINT-8084937)|binding-associated region:696-715(MINT-8084926)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NWT6	uniprotkb:O95271	intact:EBI-745632|uniprotkb:Q969Q7|uniprotkb:Q9NPV5|uniprotkb:Q5W147|ensembl:ENSP00000299163|uniprotkb:D3DR69	intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579	psi-mi:hif1n_human(display_long)|uniprotkb:Hypoxia-inducible factor asparagine hydroxylase(gene name synonym)|uniprotkb:Factor inhibiting HIF-1(gene name synonym)|uniprotkb:HIF1AN(gene name)|psi-mi:HIF1AN(display_short)|uniprotkb:FIH1(gene name synonym)	psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Yang et al. (2011)	mint:MINT-8084809|pubmed:21251231|doi:10.1111/j.1742-4658.2011.08022|mint:fj-10-1159	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0210"(hydroxylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8565739|mint:MINT-8084882	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060372.2|ensembl:ENSG00000166135(gene)|ensembl:ENST00000299163(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0036138"(peptidyl-histidine hydroxylation)|go:"GO:0036139"(peptidyl-histidine dioxygenase activity)|go:"GO:0036140"(peptidyl-asparagine 3-dioxygenase activity)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0042265"(peptidyl-asparagine hydroxylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0102113"(hypoxia-inducible factor-asparagine oxygenase activity)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR027445|interpro:IPR027452|interpro:IPR041667|mint:Q9NWT6|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1H2N|rcsb pdb:1IZ3|rcsb pdb:1MZE|rcsb pdb:1MZF|rcsb pdb:1YCI|rcsb pdb:2CGN|rcsb pdb:2CGO|rcsb pdb:2ILM|rcsb pdb:2W0X|rcsb pdb:2WA3|rcsb pdb:2WA4|rcsb pdb:2XUM|rcsb pdb:2Y0I|rcsb pdb:2YC0|rcsb pdb:2YDE|rcsb pdb:3D8C|rcsb pdb:3KCX|rcsb pdb:3KCY|rcsb pdb:3OD4|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:4AI8|rcsb pdb:4B7E|rcsb pdb:4B7K|rcsb pdb:4BIO|rcsb pdb:4JAA|rcsb pdb:4NR1|rcsb pdb:4Z1V|rcsb pdb:4Z2W|rcsb pdb:5JWK|rcsb pdb:5JWL|rcsb pdb:5JWP|rcsb pdb:5OP6|rcsb pdb:6H9J|rcsb pdb:6HA6|rcsb pdb:6HC8|rcsb pdb:6HKP|rcsb pdb:6HL5|rcsb pdb:6HL6|rcsb pdb:6RUJ|reactome:R-HSA-1234174|rcsb pdb:5OP8|rcsb pdb:5OPC|dip:DIP-35527N|mint:MINT-8084885(identity)	refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N|mint:MINT-8084884(identity)	-	-	-	figure legend:f6b|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/11	2014/10/16	rogid:lvPtfqlB1+hOcdCAwcopj/Yl+3Y9606	rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606	intact-crc:FB6A325DF07B2DD6|rigid:uo+nX1QQF3F5zIyarBpF6+wLvPI	false	-	binding-associated region:381-400(MINT-8084916)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q8TAK5	uniprotkb:Q9NWT6	intact:EBI-8468945|intact:MINT-6778891|uniprotkb:D3DV14|uniprotkb:B1AVJ8|uniprotkb:Q8NAR5|ensembl:ENSP00000357914	intact:EBI-745632|uniprotkb:Q969Q7|uniprotkb:Q9NPV5|uniprotkb:Q5W147|ensembl:ENSP00000299163|uniprotkb:D3DR69	psi-mi:gabp2_human(display_long)|uniprotkb:GABPB2(gene name)|psi-mi:GABPB2(display_short)	psi-mi:hif1n_human(display_long)|uniprotkb:Hypoxia-inducible factor asparagine hydroxylase(gene name synonym)|uniprotkb:Factor inhibiting HIF-1(gene name synonym)|uniprotkb:HIF1AN(gene name)|psi-mi:HIF1AN(display_short)|uniprotkb:FIH1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Yang et al. (2011)	mint:MINT-8084809|pubmed:21251231|doi:10.1111/j.1742-4658.2011.08022|mint:fj-10-1159	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0210"(hydroxylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8565789|mint:MINT-8085095	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001310837.1|refseq:NP_653219.1|refseq:XP_016855738.1|ensembl:ENSG00000143458(gene)|ensembl:ENST00000368918(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q8TAK5|mint:MINT-8085098(identity)	refseq:NP_060372.2|ensembl:ENSG00000166135(gene)|ensembl:ENST00000299163(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0036138"(peptidyl-histidine hydroxylation)|go:"GO:0036139"(peptidyl-histidine dioxygenase activity)|go:"GO:0036140"(peptidyl-asparagine 3-dioxygenase activity)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0042265"(peptidyl-asparagine hydroxylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0102113"(hypoxia-inducible factor-asparagine oxygenase activity)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR027445|interpro:IPR027452|interpro:IPR041667|mint:Q9NWT6|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1H2N|rcsb pdb:1IZ3|rcsb pdb:1MZE|rcsb pdb:1MZF|rcsb pdb:1YCI|rcsb pdb:2CGN|rcsb pdb:2CGO|rcsb pdb:2ILM|rcsb pdb:2W0X|rcsb pdb:2WA3|rcsb pdb:2WA4|rcsb pdb:2XUM|rcsb pdb:2Y0I|rcsb pdb:2YC0|rcsb pdb:2YDE|rcsb pdb:3D8C|rcsb pdb:3KCX|rcsb pdb:3KCY|rcsb pdb:3OD4|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:4AI8|rcsb pdb:4B7E|rcsb pdb:4B7K|rcsb pdb:4BIO|rcsb pdb:4JAA|rcsb pdb:4NR1|rcsb pdb:4Z1V|rcsb pdb:4Z2W|rcsb pdb:5JWK|rcsb pdb:5JWL|rcsb pdb:5JWP|rcsb pdb:5OP6|rcsb pdb:6H9J|rcsb pdb:6HA6|rcsb pdb:6HC8|rcsb pdb:6HKP|rcsb pdb:6HL5|rcsb pdb:6HL6|rcsb pdb:6RUJ|reactome:R-HSA-1234174|rcsb pdb:5OP8|rcsb pdb:5OPC|dip:DIP-35527N|mint:MINT-8085097(identity)	-	function:"May function as transcription factor capable of interacting with purine rich repeats (GA repeats)"|comment:mint|comment:homomint	-	figure legend:f6d|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/11	2014/10/16	rogid:F1UTCglE16qDpbAHMtdpL/zq8XY9606	rogid:lvPtfqlB1+hOcdCAwcopj/Yl+3Y9606	intact-crc:96E9B98E67E0FD6D|rigid:1jpPhuBYNbQ/UAoCB1S9LBeltis	false	binding-associated region:115-135(MINT-8085118)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NWT6	uniprotkb:Q9HBA0	intact:EBI-745632|uniprotkb:Q969Q7|uniprotkb:Q9NPV5|uniprotkb:Q5W147|ensembl:ENSP00000299163|uniprotkb:D3DR69	intact:EBI-962786|uniprotkb:Q17R79|uniprotkb:Q2Y122|uniprotkb:Q2Y123|ensembl:ENSP00000261740|ensembl:ENSP00000406191|ensembl:ENSP00000502135|uniprotkb:Q2Y124|uniprotkb:B7ZKQ6|uniprotkb:Q86YZ6|uniprotkb:Q8NDY7|uniprotkb:Q8NG64|uniprotkb:Q96Q92|uniprotkb:Q96RS7|uniprotkb:Q9HBC0	psi-mi:hif1n_human(display_long)|uniprotkb:Hypoxia-inducible factor asparagine hydroxylase(gene name synonym)|uniprotkb:Factor inhibiting HIF-1(gene name synonym)|uniprotkb:HIF1AN(gene name)|psi-mi:HIF1AN(display_short)|uniprotkb:FIH1(gene name synonym)	psi-mi:trpv4_human(display_long)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Yang et al. (2011)	mint:MINT-8084809|pubmed:21251231|doi:10.1111/j.1742-4658.2011.08022|mint:fj-10-1159	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0210"(hydroxylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8565771|mint:MINT-8085038	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060372.2|ensembl:ENSG00000166135(gene)|ensembl:ENST00000299163(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0036138"(peptidyl-histidine hydroxylation)|go:"GO:0036139"(peptidyl-histidine dioxygenase activity)|go:"GO:0036140"(peptidyl-asparagine 3-dioxygenase activity)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0042265"(peptidyl-asparagine hydroxylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0102113"(hypoxia-inducible factor-asparagine oxygenase activity)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR027445|interpro:IPR027452|interpro:IPR041667|mint:Q9NWT6|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1H2N|rcsb pdb:1IZ3|rcsb pdb:1MZE|rcsb pdb:1MZF|rcsb pdb:1YCI|rcsb pdb:2CGN|rcsb pdb:2CGO|rcsb pdb:2ILM|rcsb pdb:2W0X|rcsb pdb:2WA3|rcsb pdb:2WA4|rcsb pdb:2XUM|rcsb pdb:2Y0I|rcsb pdb:2YC0|rcsb pdb:2YDE|rcsb pdb:3D8C|rcsb pdb:3KCX|rcsb pdb:3KCY|rcsb pdb:3OD4|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:4AI8|rcsb pdb:4B7E|rcsb pdb:4B7K|rcsb pdb:4BIO|rcsb pdb:4JAA|rcsb pdb:4NR1|rcsb pdb:4Z1V|rcsb pdb:4Z2W|rcsb pdb:5JWK|rcsb pdb:5JWL|rcsb pdb:5JWP|rcsb pdb:5OP6|rcsb pdb:6H9J|rcsb pdb:6HA6|rcsb pdb:6HC8|rcsb pdb:6HKP|rcsb pdb:6HL5|rcsb pdb:6HL6|rcsb pdb:6RUJ|reactome:R-HSA-1234174|rcsb pdb:5OP8|rcsb pdb:5OPC|dip:DIP-35527N|mint:MINT-8085041(identity)	go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:0050891"(multicellular organismal water homeostasis)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|rcsb pdb:4DX1|rcsb pdb:4DX2|reactome:R-HSA-3295583|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|ensembl:ENSG00000111199(gene)|ensembl:ENST00000261740(transcript)|ensembl:ENST00000418703(transcript)|ensembl:ENST00000675670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0032587"(ruffle membrane)|refseq:NP_671737.1|refseq:NP_001170899.1|refseq:NP_001170902.1|refseq:NP_001170904.1|refseq:NP_067638.3|refseq:XP_016875263.1|refseq:XP_005253975.1|dip:DIP-35702N|mint:MINT-8085040(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f6e sf4	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/11	2014/10/16	rogid:lvPtfqlB1+hOcdCAwcopj/Yl+3Y9606	rogid:R4tV4g+95OnxFkwxAKG51FeKNZA9606	intact-crc:916269A72CE571A6|rigid:+Sea0kEU+1oDnbfl+MoWMHvipzs	false	-	binding-associated region:249-269(MINT-8085058)|dihydroxylated residue:265-265(MINT-8085060)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)