#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q00975	uniprotkb:Q9JIR4	intact:EBI-1055161|uniprotkb:B1AQK5|ensembl:ENSP00000360423	intact:EBI-3507436|uniprotkb:O35168	psi-mi:cac1b_human(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 5(gene name synonym)|uniprotkb:Brain calcium channel III(gene name synonym)|uniprotkb:CACNA1B(gene name)|psi-mi:CACNA1B(display_short)|uniprotkb:CACH5(gene name synonym)|uniprotkb:CACNL1A5(gene name synonym)	psi-mi:rims1_rat(display_long)|uniprotkb:Rims1(gene name)|psi-mi:Rims1(display_short)|uniprotkb:Rim1(gene name synonym)|uniprotkb:Rab-3-interacting molecule 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kaeser et al. (2011)	pubmed:21241895|imex:IM-15334	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3507439|imex:IM-15334-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000709.1|refseq:NP_001230741.1|ensembl:ENSG00000148408(gene)|ensembl:ENST00000371372(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0045202"(synapse)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:1904645"(response to amyloid-beta)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005447(Voltage-dependent calcium channel, N-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR043203|rcsb pdb:2LCM|reactome:R-HSA-112308	rgd:620000|refseq:NP_439894.1|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035892|interpro:IPR036034|interpro:IPR039032|interpro:IPR041282|rcsb pdb:1ZUB|rcsb pdb:2Q3X|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-888590|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010808"(positive regulation of synaptic vesicle priming)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031632"(positive regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0060077"(inhibitory synapse)|mint:Q9JIR4|dip:DIP-41432N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/02/04	2014/10/16	rogid:R7OVT/57HywIdiczIgCa+cjqifA9606	rogid:Qk1J57peZ9ZCLtiLg1v5R4LAlF410116	intact-crc:834FAE6A2F3B0D43|rigid:0F6v0hEPory+eFFAV43mOQfudnE	false	sufficient binding region:2163-2339	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIR1	uniprotkb:P54282	intact:EBI-3507405	intact:EBI-3507416|uniprotkb:Q01541	psi-mi:rimb2_rat(display_long)|uniprotkb:Rimbp2(gene name)|psi-mi:Rimbp2(display_short)|uniprotkb:Rbp2(gene name synonym)	psi-mi:cac1a_rat(display_long)|uniprotkb:Cacna1a(gene name)|psi-mi:Cacna1a(display_short)|uniprotkb:Cach4(gene name synonym)|uniprotkb:Cacn3(gene name synonym)|uniprotkb:Cacnl1a4(gene name synonym)|uniprotkb:Brain calcium channel I(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 4(gene name synonym)|uniprotkb:Rat brain class A(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kaeser et al. (2011)	pubmed:21241895|imex:IM-15334	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3507407|imex:IM-15334-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:708533|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR001452(Src homology-3)|interpro:IPR035519|go:"GO:0005886"(plasma membrane)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|interpro:IPR035753|interpro:IPR035755|interpro:IPR036028|interpro:IPR036116|interpro:IPR040325	rgd:2244|refseq:NP_037050.2|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008219"(cell death)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031335"(regulation of sulfur amino acid metabolic process)|go:"GO:0032353"(negative regulation of hormone biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0019905"(syntaxin binding)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0021590"(cerebellum maturation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050877"(nervous system process)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005448(Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|go:"GO:0021679"(cerebellar molecular layer development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|dip:DIP-29638N|reactome:R-RNO-112308|reactome:R-RNO-422356	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/02/04	2014/10/16	rogid:ew9AJ8wG4GGfVL5sidbjPsnIq7010116	rogid:Y8URBT6cAl9zeiwhdcvRNWDUrxY10116	intact-crc:FDB651595E5B9609|rigid:BDgiHEzr2GStxrpQ/RNZLm2qmZM	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q00975	uniprotkb:Q9JIR1	intact:EBI-1055161|uniprotkb:B1AQK5|ensembl:ENSP00000360423	intact:EBI-3507405	psi-mi:cac1b_human(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 5(gene name synonym)|uniprotkb:Brain calcium channel III(gene name synonym)|uniprotkb:CACNA1B(gene name)|psi-mi:CACNA1B(display_short)|uniprotkb:CACH5(gene name synonym)|uniprotkb:CACNL1A5(gene name synonym)	psi-mi:rimb2_rat(display_long)|uniprotkb:Rimbp2(gene name)|psi-mi:Rimbp2(display_short)|uniprotkb:Rbp2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kaeser et al. (2011)	pubmed:21241895|imex:IM-15334	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3507421|imex:IM-15334-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000709.1|refseq:NP_001230741.1|ensembl:ENSG00000148408(gene)|ensembl:ENST00000371372(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0045202"(synapse)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:1904645"(response to amyloid-beta)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005447(Voltage-dependent calcium channel, N-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR043203|rcsb pdb:2LCM|reactome:R-HSA-112308	rgd:708533|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR001452(Src homology-3)|interpro:IPR035519|go:"GO:0005886"(plasma membrane)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|interpro:IPR035753|interpro:IPR035755|interpro:IPR036028|interpro:IPR036116|interpro:IPR040325	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/02/04	2014/10/16	rogid:R7OVT/57HywIdiczIgCa+cjqifA9606	rogid:ew9AJ8wG4GGfVL5sidbjPsnIq7010116	intact-crc:05AB1E6B2E6E0D41|rigid:BGwuQNHrE+dQ1AAG++i7EVk8n4A	false	sufficient binding region:2163-2339	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P54282	uniprotkb:Q9JIR4	intact:EBI-3507416|uniprotkb:Q01541	intact:EBI-3507436|uniprotkb:O35168	psi-mi:cac1a_rat(display_long)|uniprotkb:Cacna1a(gene name)|psi-mi:Cacna1a(display_short)|uniprotkb:Cach4(gene name synonym)|uniprotkb:Cacn3(gene name synonym)|uniprotkb:Cacnl1a4(gene name synonym)|uniprotkb:Brain calcium channel I(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 4(gene name synonym)|uniprotkb:Rat brain class A(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.1(gene name synonym)	psi-mi:rims1_rat(display_long)|uniprotkb:Rims1(gene name)|psi-mi:Rims1(display_short)|uniprotkb:Rim1(gene name synonym)|uniprotkb:Rab-3-interacting molecule 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kaeser et al. (2011)	pubmed:21241895|imex:IM-15334	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3507431|imex:IM-15334-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2244|refseq:NP_037050.2|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008219"(cell death)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031335"(regulation of sulfur amino acid metabolic process)|go:"GO:0032353"(negative regulation of hormone biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0019905"(syntaxin binding)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0021590"(cerebellum maturation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050877"(nervous system process)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005448(Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|go:"GO:0021679"(cerebellar molecular layer development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|dip:DIP-29638N|reactome:R-RNO-112308|reactome:R-RNO-422356	rgd:620000|refseq:NP_439894.1|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035892|interpro:IPR036034|interpro:IPR039032|interpro:IPR041282|rcsb pdb:1ZUB|rcsb pdb:2Q3X|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-888590|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010808"(positive regulation of synaptic vesicle priming)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031632"(positive regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0060077"(inhibitory synapse)|mint:Q9JIR4|dip:DIP-41432N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/02/04	2014/10/16	rogid:Y8URBT6cAl9zeiwhdcvRNWDUrxY10116	rogid:Qk1J57peZ9ZCLtiLg1v5R4LAlF410116	intact-crc:7B52E1585F0E960B|rigid:vx90r4a+DAlQ0SAzgHxi09jK8+Q	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIR4	uniprotkb:P54282	intact:EBI-3507436|uniprotkb:O35168	intact:EBI-3507416|uniprotkb:Q01541	psi-mi:rims1_rat(display_long)|uniprotkb:Rims1(gene name)|psi-mi:Rims1(display_short)|uniprotkb:Rim1(gene name synonym)|uniprotkb:Rab-3-interacting molecule 1(gene name synonym)	psi-mi:cac1a_rat(display_long)|uniprotkb:Cacna1a(gene name)|psi-mi:Cacna1a(display_short)|uniprotkb:Cach4(gene name synonym)|uniprotkb:Cacn3(gene name synonym)|uniprotkb:Cacnl1a4(gene name synonym)|uniprotkb:Brain calcium channel I(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 4(gene name synonym)|uniprotkb:Rat brain class A(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kaeser et al. (2011)	pubmed:21241895|imex:IM-15334	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3507453|imex:IM-15334-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620000|refseq:NP_439894.1|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035892|interpro:IPR036034|interpro:IPR039032|interpro:IPR041282|rcsb pdb:1ZUB|rcsb pdb:2Q3X|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-888590|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010808"(positive regulation of synaptic vesicle priming)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031632"(positive regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0060077"(inhibitory synapse)|mint:Q9JIR4|dip:DIP-41432N	rgd:2244|refseq:NP_037050.2|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008219"(cell death)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031335"(regulation of sulfur amino acid metabolic process)|go:"GO:0032353"(negative regulation of hormone biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0019905"(syntaxin binding)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0021590"(cerebellum maturation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050877"(nervous system process)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005448(Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|go:"GO:0021679"(cerebellar molecular layer development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|dip:DIP-29638N|reactome:R-RNO-112308|reactome:R-RNO-422356	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/02/04	2014/10/16	rogid:Qk1J57peZ9ZCLtiLg1v5R4LAlF410116	rogid:Y8URBT6cAl9zeiwhdcvRNWDUrxY10116	intact-crc:74B8FF44E388C0F7|rigid:vx90r4a+DAlQ0SAzgHxi09jK8+Q	false	sufficient binding region:572-1614	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00975	uniprotkb:Q9JIR4	intact:EBI-1055161|uniprotkb:B1AQK5|ensembl:ENSP00000360423	intact:EBI-3507436|uniprotkb:O35168	psi-mi:cac1b_human(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 5(gene name synonym)|uniprotkb:Brain calcium channel III(gene name synonym)|uniprotkb:CACNA1B(gene name)|psi-mi:CACNA1B(display_short)|uniprotkb:CACH5(gene name synonym)|uniprotkb:CACNL1A5(gene name synonym)	psi-mi:rims1_rat(display_long)|uniprotkb:Rims1(gene name)|psi-mi:Rims1(display_short)|uniprotkb:Rim1(gene name synonym)|uniprotkb:Rab-3-interacting molecule 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kaeser et al. (2011)	pubmed:21241895|imex:IM-15334	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3507463|imex:IM-15334-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000709.1|refseq:NP_001230741.1|ensembl:ENSG00000148408(gene)|ensembl:ENST00000371372(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0045202"(synapse)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:1904645"(response to amyloid-beta)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005447(Voltage-dependent calcium channel, N-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR043203|rcsb pdb:2LCM|reactome:R-HSA-112308	rgd:620000|refseq:NP_439894.1|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035892|interpro:IPR036034|interpro:IPR039032|interpro:IPR041282|rcsb pdb:1ZUB|rcsb pdb:2Q3X|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-888590|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010808"(positive regulation of synaptic vesicle priming)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031632"(positive regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0060077"(inhibitory synapse)|mint:Q9JIR4|dip:DIP-41432N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/02/04	2014/10/16	rogid:R7OVT/57HywIdiczIgCa+cjqifA9606	rogid:Qk1J57peZ9ZCLtiLg1v5R4LAlF410116	intact-crc:0CF754B5979EB4F4|rigid:0F6v0hEPory+eFFAV43mOQfudnE	false	necessary binding region:2336-2339	sufficient binding region:572-1614	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JIR4	uniprotkb:P54282	intact:EBI-3507436|uniprotkb:O35168	intact:EBI-3507416|uniprotkb:Q01541	psi-mi:rims1_rat(display_long)|uniprotkb:Rims1(gene name)|psi-mi:Rims1(display_short)|uniprotkb:Rim1(gene name synonym)|uniprotkb:Rab-3-interacting molecule 1(gene name synonym)	psi-mi:cac1a_rat(display_long)|uniprotkb:Cacna1a(gene name)|psi-mi:Cacna1a(display_short)|uniprotkb:Cach4(gene name synonym)|uniprotkb:Cacn3(gene name synonym)|uniprotkb:Cacnl1a4(gene name synonym)|uniprotkb:Brain calcium channel I(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 4(gene name synonym)|uniprotkb:Rat brain class A(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Kaeser et al. (2011)	pubmed:21241895|imex:IM-15334	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3507479|imex:IM-15334-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620000|refseq:NP_439894.1|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035892|interpro:IPR036034|interpro:IPR039032|interpro:IPR041282|rcsb pdb:1ZUB|rcsb pdb:2Q3X|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-888590|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010808"(positive regulation of synaptic vesicle priming)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031632"(positive regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0060077"(inhibitory synapse)|mint:Q9JIR4|dip:DIP-41432N	rgd:2244|refseq:NP_037050.2|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008219"(cell death)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031335"(regulation of sulfur amino acid metabolic process)|go:"GO:0032353"(negative regulation of hormone biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0019905"(syntaxin binding)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0021590"(cerebellum maturation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050877"(nervous system process)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005448(Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|go:"GO:0021679"(cerebellar molecular layer development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|dip:DIP-29638N|reactome:R-RNO-112308|reactome:R-RNO-422356	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/04	2014/10/16	rogid:Qk1J57peZ9ZCLtiLg1v5R4LAlF410116	rogid:Y8URBT6cAl9zeiwhdcvRNWDUrxY10116	intact-crc:E1869508CD6A5684|rigid:vx90r4a+DAlQ0SAzgHxi09jK8+Q	false	sufficient binding region:593-708|15n label:?-?|isotope label:?-?	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q811U3	uniprotkb:Q9JIR4	intact:EBI-3507502|uniprotkb:Q8CIY9	intact:EBI-3507436|uniprotkb:O35168	psi-mi:rb6i2_rat(display_long)|uniprotkb:Erc1(gene name)|psi-mi:Erc1(display_short)|uniprotkb:Cast2(gene name synonym)|uniprotkb:Elks(gene name synonym)|uniprotkb:Rab6ip2(gene name synonym)|uniprotkb:CAZ-associated structural protein 2(gene name synonym)|uniprotkb:Rab6-interacting protein 2(gene name synonym)	psi-mi:rims1_rat(display_long)|uniprotkb:Rims1(gene name)|psi-mi:Rims1(display_short)|uniprotkb:Rim1(gene name synonym)|uniprotkb:Rab-3-interacting molecule 1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Kaeser et al. (2011)	pubmed:21241895|imex:IM-15334	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3507492|imex:IM-15334-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628733|refseq:NP_740769.2|interpro:IPR019323|rcsb pdb:1ZUB|go:"GO:0000139"(Golgi membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045202"(synapse)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048790"(maintenance of presynaptic active zone structure)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)	rgd:620000|refseq:NP_439894.1|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035892|interpro:IPR036034|interpro:IPR039032|interpro:IPR041282|rcsb pdb:1ZUB|rcsb pdb:2Q3X|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-888590|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010808"(positive regulation of synaptic vesicle priming)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031632"(positive regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0060077"(inhibitory synapse)|mint:Q9JIR4|dip:DIP-41432N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/04	2014/10/16	rogid:MmEtwA0YnPzpPTRO8H6JpP688Hs10116	rogid:Qk1J57peZ9ZCLtiLg1v5R4LAlF410116	intact-crc:5AB1953B8D936745|rigid:4GDvSt1kdeWo4YJKegKewfDAYXo	false	-	sufficient binding region:593-708|15n label:?-?|isotope label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O70368	uniprotkb:Q9JIR4	intact:EBI-3507514	intact:EBI-3507436|uniprotkb:O35168	psi-mi:o70368_rat(display_long)|uniprotkb:Cacna1a(gene name)|psi-mi:Cacna1a(display_short)|uniprotkb:BCCA1(gene name synonym)	psi-mi:rims1_rat(display_long)|uniprotkb:Rims1(gene name)|psi-mi:Rims1(display_short)|uniprotkb:Rim1(gene name synonym)|uniprotkb:Rab-3-interacting molecule 1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Kaeser et al. (2011)	pubmed:21241895|imex:IM-15334	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3507505|imex:IM-15334-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR031649|refseq:NP_037050.2|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0046872"(metal ion binding)|rgd:2244|interpro:IPR027359	rgd:620000|refseq:NP_439894.1|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035892|interpro:IPR036034|interpro:IPR039032|interpro:IPR041282|rcsb pdb:1ZUB|rcsb pdb:2Q3X|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-888590|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010808"(positive regulation of synaptic vesicle priming)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031632"(positive regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0060077"(inhibitory synapse)|mint:Q9JIR4|dip:DIP-41432N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.34x10^-5(molar)	2011/02/04	2014/10/16	rogid:LpN8bwXzEvuSB/iob/iwodnE2mA10116	rogid:Qk1J57peZ9ZCLtiLg1v5R4LAlF410116	intact-crc:0A87C05248C8B779|rigid:f6qo9Xb23ozOzb4e8AM071BP9S4	false	sufficient binding region:779-791|mutation:779-779	sufficient binding region:593-708|15n label:?-?|isotope label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O89089	uniprotkb:Q9JIR4	intact:EBI-3507539	intact:EBI-3507436|uniprotkb:O35168	psi-mi:o89089_rat(display_long)|uniprotkb:Cacna1b(gene name)|psi-mi:Cacna1b(display_short)	psi-mi:rims1_rat(display_long)|uniprotkb:Rims1(gene name)|psi-mi:Rims1(display_short)|uniprotkb:Rim1(gene name synonym)|uniprotkb:Rab-3-interacting molecule 1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Kaeser et al. (2011)	pubmed:21241895|imex:IM-15334	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3507530|imex:IM-15334-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR005447(Voltage-dependent calcium channel, N-type, alpha-1 subunit)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|refseq:NP_671482.1|interpro:IPR043203|interpro:IPR031649|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|rgd:628852|interpro:IPR027359	rgd:620000|refseq:NP_439894.1|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035892|interpro:IPR036034|interpro:IPR039032|interpro:IPR041282|rcsb pdb:1ZUB|rcsb pdb:2Q3X|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-888590|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010808"(positive regulation of synaptic vesicle priming)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031632"(positive regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0060077"(inhibitory synapse)|mint:Q9JIR4|dip:DIP-41432N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/04	2014/10/16	rogid:HY2D3fxoV7HlLTDaMRf12wsKopE10116	rogid:Qk1J57peZ9ZCLtiLg1v5R4LAlF410116	intact-crc:44FC37B560F5A5FE|rigid:QFu+mXuz67yncVIymIpUfJtpiPM	false	sufficient binding region:2321-2333	sufficient binding region:593-708|15n label:?-?|isotope label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O89089	uniprotkb:Q9JIR4	intact:EBI-3507539	intact:EBI-3507436|uniprotkb:O35168	psi-mi:o89089_rat(display_long)|uniprotkb:Cacna1b(gene name)|psi-mi:Cacna1b(display_short)	psi-mi:rims1_rat(display_long)|uniprotkb:Rims1(gene name)|psi-mi:Rims1(display_short)|uniprotkb:Rim1(gene name synonym)|uniprotkb:Rab-3-interacting molecule 1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Kaeser et al. (2011)	pubmed:21241895|imex:IM-15334	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3507829|imex:IM-15334-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR005447(Voltage-dependent calcium channel, N-type, alpha-1 subunit)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|refseq:NP_671482.1|interpro:IPR043203|interpro:IPR031649|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|rgd:628852|interpro:IPR027359	rgd:620000|refseq:NP_439894.1|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035892|interpro:IPR036034|interpro:IPR039032|interpro:IPR041282|rcsb pdb:1ZUB|rcsb pdb:2Q3X|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-888590|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010808"(positive regulation of synaptic vesicle priming)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031632"(positive regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0060077"(inhibitory synapse)|mint:Q9JIR4|dip:DIP-41432N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/04	2014/10/16	rogid:HY2D3fxoV7HlLTDaMRf12wsKopE10116	rogid:Qk1J57peZ9ZCLtiLg1v5R4LAlF410116	intact-crc:8DC6283CB8682D14|rigid:QFu+mXuz67yncVIymIpUfJtpiPM	false	sufficient binding region:2321-2333	sufficient binding region:593-708|15n label:?-?|isotope label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JIR4	uniprotkb:O70368	intact:EBI-3507436|uniprotkb:O35168	intact:EBI-3507514	psi-mi:rims1_rat(display_long)|uniprotkb:Rims1(gene name)|psi-mi:Rims1(display_short)|uniprotkb:Rim1(gene name synonym)|uniprotkb:Rab-3-interacting molecule 1(gene name synonym)	psi-mi:o70368_rat(display_long)|uniprotkb:Cacna1a(gene name)|psi-mi:Cacna1a(display_short)|uniprotkb:BCCA1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Kaeser et al. (2011)	pubmed:21241895|imex:IM-15334	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3507552|imex:IM-15334-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620000|refseq:NP_439894.1|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035892|interpro:IPR036034|interpro:IPR039032|interpro:IPR041282|rcsb pdb:1ZUB|rcsb pdb:2Q3X|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-888590|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010808"(positive regulation of synaptic vesicle priming)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031632"(positive regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0060077"(inhibitory synapse)|mint:Q9JIR4|dip:DIP-41432N	interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR031649|refseq:NP_037050.2|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0046872"(metal ion binding)|rgd:2244|interpro:IPR027359	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/04	2014/10/16	rogid:Qk1J57peZ9ZCLtiLg1v5R4LAlF410116	rogid:LpN8bwXzEvuSB/iob/iwodnE2mA10116	intact-crc:C3BEBFDB90553F93|rigid:f6qo9Xb23ozOzb4e8AM071BP9S4	false	sufficient binding region:593-708|15n label:?-?|isotope label:?-?	sufficient binding region:779-791|mutation:779-779	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54282	uniprotkb:Q9JIR1	intact:EBI-3507416|uniprotkb:Q01541	intact:EBI-3507405	psi-mi:cac1a_rat(display_long)|uniprotkb:Cacna1a(gene name)|psi-mi:Cacna1a(display_short)|uniprotkb:Cach4(gene name synonym)|uniprotkb:Cacn3(gene name synonym)|uniprotkb:Cacnl1a4(gene name synonym)|uniprotkb:Brain calcium channel I(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 4(gene name synonym)|uniprotkb:Rat brain class A(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.1(gene name synonym)	psi-mi:rimb2_rat(display_long)|uniprotkb:Rimbp2(gene name)|psi-mi:Rimbp2(display_short)|uniprotkb:Rbp2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kaeser et al. (2011)	pubmed:21241895|imex:IM-15334	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3507849|imex:IM-15334-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2244|refseq:NP_037050.2|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008219"(cell death)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031335"(regulation of sulfur amino acid metabolic process)|go:"GO:0032353"(negative regulation of hormone biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0019905"(syntaxin binding)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0021590"(cerebellum maturation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050877"(nervous system process)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005448(Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|go:"GO:0021679"(cerebellar molecular layer development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|dip:DIP-29638N|reactome:R-RNO-112308|reactome:R-RNO-422356	rgd:708533|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR001452(Src homology-3)|interpro:IPR035519|go:"GO:0005886"(plasma membrane)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|interpro:IPR035753|interpro:IPR035755|interpro:IPR036028|interpro:IPR036116|interpro:IPR040325	psi-mi:"MI:0469"(intact)	-	-	caution:Exact coordinates of RIMS-PS and RIMBP2 SH3 domain constructs not given in the publication so have been inferred from the information in the text and the UniProtKB entries.|figure legend:Supp. Fig. 8C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/02/04	2014/10/16	rogid:Y8URBT6cAl9zeiwhdcvRNWDUrxY10116	rogid:ew9AJ8wG4GGfVL5sidbjPsnIq7010116	intact-crc:0BE356ADBC1702D9|rigid:fYqKxSrAGZeMnX1VCooZWSVXOLo	false	sufficient binding region:?-?|fusion protein:?-?	sufficient binding region:164..164-1019..1019|tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P54282	uniprotkb:Q9JIR4	intact:EBI-3507416|uniprotkb:Q01541	intact:EBI-3507436|uniprotkb:O35168	psi-mi:cac1a_rat(display_long)|uniprotkb:Cacna1a(gene name)|psi-mi:Cacna1a(display_short)|uniprotkb:Cach4(gene name synonym)|uniprotkb:Cacn3(gene name synonym)|uniprotkb:Cacnl1a4(gene name synonym)|uniprotkb:Brain calcium channel I(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 4(gene name synonym)|uniprotkb:Rat brain class A(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.1(gene name synonym)	psi-mi:rims1_rat(display_long)|uniprotkb:Rims1(gene name)|psi-mi:Rims1(display_short)|uniprotkb:Rim1(gene name synonym)|uniprotkb:Rab-3-interacting molecule 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kaeser et al. (2011)	pubmed:21241895|imex:IM-15334	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3507849|imex:IM-15334-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2244|refseq:NP_037050.2|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008219"(cell death)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031335"(regulation of sulfur amino acid metabolic process)|go:"GO:0032353"(negative regulation of hormone biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0019905"(syntaxin binding)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0021590"(cerebellum maturation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050877"(nervous system process)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005448(Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|go:"GO:0021679"(cerebellar molecular layer development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|dip:DIP-29638N|reactome:R-RNO-112308|reactome:R-RNO-422356	rgd:620000|refseq:NP_439894.1|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035892|interpro:IPR036034|interpro:IPR039032|interpro:IPR041282|rcsb pdb:1ZUB|rcsb pdb:2Q3X|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-888590|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010808"(positive regulation of synaptic vesicle priming)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031632"(positive regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0060077"(inhibitory synapse)|mint:Q9JIR4|dip:DIP-41432N	psi-mi:"MI:0469"(intact)	-	-	caution:Exact coordinates of RIMS-PS and RIMBP2 SH3 domain constructs not given in the publication so have been inferred from the information in the text and the UniProtKB entries.|figure legend:Supp. Fig. 8C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/02/04	2014/10/16	rogid:Y8URBT6cAl9zeiwhdcvRNWDUrxY10116	rogid:Qk1J57peZ9ZCLtiLg1v5R4LAlF410116	intact-crc:0BE356ADBC1702D9|rigid:fYqKxSrAGZeMnX1VCooZWSVXOLo	false	sufficient binding region:?-?|fusion protein:?-?	fluorescent dye label:c-c|sufficient binding region:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)