#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q15363 uniprotkb:P25116 intact:EBI-998485|ensembl:ENSP00000262225 intact:EBI-2803960|ensembl:ENSP00000321326|uniprotkb:Q53XV0|uniprotkb:Q9BUN4|uniprotkb:Q96RF7 psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym) psi-mi:par1_human(display_long)|uniprotkb:CF2R(gene name synonym)|uniprotkb:PAR1(gene name synonym)|uniprotkb:TR(gene name synonym)|uniprotkb:Coagulation factor II receptor(gene name synonym)|uniprotkb:Thrombin receptor(gene name synonym)|uniprotkb:F2R(gene name)|psi-mi:F2R(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Luo et al. (2011) pubmed:21219331 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-4392507 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1 ensembl:ENSG00000181104(gene)|ensembl:ENST00000319211(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003105"(negative regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|refseq:NP_001983.2|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:1900134"(negative regulation of renin secretion into blood stream)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000935(Thrombin receptor)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|rcsb pdb:3HKI|rcsb pdb:3HKJ|rcsb pdb:3LU9|rcsb pdb:3VW7|reactome:R-HSA-140875|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-456926|rcsb pdb:1NRR|rcsb pdb:3BEF|refseq:NP_001298242.1|dip:DIP-29703N - - - figure legend:1a|curation depth:mimix curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/08/26 2014/10/16 rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606 rogid:XDyq4uaI8bttpcddguVYWbFJ9PA9606 intact-crc:B7760F2B53B49C26|rigid:+63P9ATLnGHRvU0FBO9t2cHYCkI false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q15363 uniprotkb:P51582 intact:EBI-998485|ensembl:ENSP00000262225 intact:EBI-4392513|uniprotkb:Q4VBB7|uniprotkb:Q4VBB8|uniprotkb:Q502W2|uniprotkb:Q5JT22|ensembl:ENSP00000363643 psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym) psi-mi:p2ry4_human(display_long)|uniprotkb:P2RY4(gene name)|psi-mi:P2RY4(display_short)|uniprotkb:NRU(gene name synonym)|uniprotkb:P2P(gene name synonym)|uniprotkb:Uridine nucleotide receptor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Luo et al. (2011) pubmed:21219331 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-4392511 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1 refseq:NP_002556.1|ensembl:ENSG00000186912(gene)|ensembl:ENST00000374519(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0045028"(G protein-coupled purinergic nucleotide receptor activity)|go:"GO:0045030"(G protein-coupled UTP receptor activity)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099509"(regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000018(P2Y4 purinoceptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2B6Q|reactome:R-HSA-417957|reactome:R-HSA-418594 - - - figure legend:1b and 4|curation depth:mimix curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/08/26 2014/10/16 rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606 rogid:LFPoHuU3CWxmWnh6TBZxBXdU0a09606 intact-crc:CE0011B025ED9753|rigid:34qIqm83v+waz2T48StdhHvr4As false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q15363 uniprotkb:Q96G91 intact:EBI-998485|ensembl:ENSP00000262225 intact:EBI-4392539|uniprotkb:B2R8X9|uniprotkb:O43190|uniprotkb:Q9BYU4|uniprotkb:Q9H170|ensembl:ENSP00000323872 psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym) psi-mi:p2y11_human(display_long)|uniprotkb:P2RY11(gene name)|psi-mi:P2RY11(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Luo et al. (2011) pubmed:21219331 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-4392563 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1 refseq:NP_002557.2|ensembl:ENSG00000244165(gene)|ensembl:ENST00000321826(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0023041"(neuronal signal transduction)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045031"(G protein-coupled ATP receptor activity)|go:"GO:0071318"(cellular response to ATP)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR027677|rcsb pdb:2B6S|reactome:R-HSA-416476|reactome:R-HSA-417957|reactome:R-HSA-418555|reactome:R-HSA-9660821 - - - figure legend:1c and 3|curation depth:mimix curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/08/26 2014/10/16 rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606 rogid:h0b6QFOIgmDok81PYLBtnBIE03w9606 intact-crc:B3F0A527B07BD41F|rigid:Ohdvlq0Sw6XYvDxYyC0gTGnKIlQ false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P33535-4 uniprotkb:Q15363 intact:EBI-5281984 intact:EBI-998485|ensembl:ENSP00000262225 psi-mi:p33535-4(display_long)|uniprotkb:MOR1B(isoform synonym)|uniprotkb:Oprm1(gene name)|psi-mi:Oprm1(display_short)|uniprotkb:Ror-b(gene name synonym)|uniprotkb:Opioid receptor B(gene name synonym) psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Luo et al. (2011) pubmed:21219331 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-4392567 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-4392569(isoform-parent) ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1 - - - figure legend:1d|curation depth:mimix curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/08/26 2014/10/16 rogid:MtslGjkSkH83hpS8kjTX/5md+No10116 rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606 intact-crc:4A718045E5D5F30A|rigid:vqFtyyRYkJ+oUa/OBn5sW7Lw1q0 false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P49755 uniprotkb:P55085 intact:EBI-998422|uniprotkb:Q15602|uniprotkb:Q16536|uniprotkb:Q86TC2|uniprotkb:Q86TS5|uniprotkb:B2R605|intact:EBI-1058680|ensembl:ENSP00000303145 intact:EBI-4303189|uniprotkb:Q13317|uniprotkb:Q13346|ensembl:ENSP00000296677|uniprotkb:Q53XJ8 psi-mi:tmeda_human(display_long)|uniprotkb:21 kDa transmembrane-trafficking protein(gene name synonym)|uniprotkb:Transmembrane protein Tmp21(gene name synonym)|uniprotkb:Tmp-21-I(gene name synonym)|uniprotkb:p24delta(gene name synonym)|uniprotkb:S31III125(gene name synonym)|uniprotkb:TMED10(gene name)|psi-mi:TMED10(display_short)|uniprotkb:TMP21(gene name synonym)|uniprotkb:p23(gene name synonym)|uniprotkb:p24 family protein delta-1(gene name synonym)|uniprotkb:S31I125(gene name synonym) psi-mi:par2_human(display_long)|uniprotkb:F2RL1(gene name)|psi-mi:F2RL1(display_short)|uniprotkb:GPR11(gene name synonym)|uniprotkb:PAR2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor 11(gene name synonym)|uniprotkb:Thrombin receptor-like 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Luo et al. (2011) pubmed:21219331 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-4394487 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007030"(Golgi organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0035964"(COPI-coated vesicle budding)|go:"GO:0042470"(melanosome)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0048199"(vesicle targeting, to, from or within Golgi)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0106272"(protein localization to ERGIC)|go:"GO:0106273"(cytosol to ERGIC protein transport)|go:"GO:1902003"(regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|mint:P49755|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|reactome:R-HSA-6811434|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|ensembl:ENSG00000170348(gene)|ensembl:ENST00000303575(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|refseq:NP_006818.3 refseq:NP_005233.3|ensembl:ENSG00000164251(gene)|ensembl:ENST00000296677(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042311"(vasodilation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070661"(leukocyte proliferation)|go:"GO:0070963"(positive regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002281(Protease-activated receptor 2)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P55085|rcsb pdb:5NDD|rcsb pdb:5NDZ|rcsb pdb:5NJ6|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|dip:DIP-42044N - - - figure legend:5a|curation depth:mimix curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/08/26 2014/10/16 rogid:Sj4B0x1qf0VJmI1aDFaw2/PiTxM9606 rogid:j9cMnyj9C74tReGYkQvGFy+cez49606 intact-crc:C149492466D1D658|rigid:K0KrQHMNmtWGejM3gkoGupc6nR8 false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P55085 uniprotkb:Q15363 intact:EBI-4303189|uniprotkb:Q13317|uniprotkb:Q13346|ensembl:ENSP00000296677|uniprotkb:Q53XJ8 intact:EBI-998485|ensembl:ENSP00000262225 psi-mi:par2_human(display_long)|uniprotkb:F2RL1(gene name)|psi-mi:F2RL1(display_short)|uniprotkb:GPR11(gene name synonym)|uniprotkb:PAR2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor 11(gene name synonym)|uniprotkb:Thrombin receptor-like 1(gene name synonym) psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym) psi-mi:"MI:0096"(pull down) Luo et al. (2011) pubmed:21219331 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-4394482 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005233.3|ensembl:ENSG00000164251(gene)|ensembl:ENST00000296677(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042311"(vasodilation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070661"(leukocyte proliferation)|go:"GO:0070963"(positive regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002281(Protease-activated receptor 2)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P55085|rcsb pdb:5NDD|rcsb pdb:5NDZ|rcsb pdb:5NJ6|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|dip:DIP-42044N ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1 - - - figure legend:2a|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/26 2014/10/16 rogid:j9cMnyj9C74tReGYkQvGFy+cez49606 rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606 intact-crc:625A9108B88DBF60|rigid:/aPmLNbHnQZdetE7giYdPhqnKDw false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P49755 uniprotkb:P55085 intact:EBI-998422|uniprotkb:Q15602|uniprotkb:Q16536|uniprotkb:Q86TC2|uniprotkb:Q86TS5|uniprotkb:B2R605|intact:EBI-1058680|ensembl:ENSP00000303145 intact:EBI-4303189|uniprotkb:Q13317|uniprotkb:Q13346|ensembl:ENSP00000296677|uniprotkb:Q53XJ8 psi-mi:tmeda_human(display_long)|uniprotkb:21 kDa transmembrane-trafficking protein(gene name synonym)|uniprotkb:Transmembrane protein Tmp21(gene name synonym)|uniprotkb:Tmp-21-I(gene name synonym)|uniprotkb:p24delta(gene name synonym)|uniprotkb:S31III125(gene name synonym)|uniprotkb:TMED10(gene name)|psi-mi:TMED10(display_short)|uniprotkb:TMP21(gene name synonym)|uniprotkb:p23(gene name synonym)|uniprotkb:p24 family protein delta-1(gene name synonym)|uniprotkb:S31I125(gene name synonym) psi-mi:par2_human(display_long)|uniprotkb:F2RL1(gene name)|psi-mi:F2RL1(display_short)|uniprotkb:GPR11(gene name synonym)|uniprotkb:PAR2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor 11(gene name synonym)|uniprotkb:Thrombin receptor-like 1(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Luo et al. (2011) pubmed:21219331 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-4394500 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007030"(Golgi organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0035964"(COPI-coated vesicle budding)|go:"GO:0042470"(melanosome)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0048199"(vesicle targeting, to, from or within Golgi)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0106272"(protein localization to ERGIC)|go:"GO:0106273"(cytosol to ERGIC protein transport)|go:"GO:1902003"(regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|mint:P49755|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|reactome:R-HSA-6811434|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|ensembl:ENSG00000170348(gene)|ensembl:ENST00000303575(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|refseq:NP_006818.3 refseq:NP_005233.3|ensembl:ENSG00000164251(gene)|ensembl:ENST00000296677(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042311"(vasodilation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070661"(leukocyte proliferation)|go:"GO:0070963"(positive regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002281(Protease-activated receptor 2)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P55085|rcsb pdb:5NDD|rcsb pdb:5NDZ|rcsb pdb:5NJ6|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|dip:DIP-42044N go:"GO:0005829"(cytosol)|go:"GO:0005794"(Golgi apparatus) - - figure legend:5b|curation depth:mimix curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/08/26 2014/10/16 rogid:Sj4B0x1qf0VJmI1aDFaw2/PiTxM9606 rogid:j9cMnyj9C74tReGYkQvGFy+cez49606 intact-crc:E2DDC16FCA61D771|rigid:K0KrQHMNmtWGejM3gkoGupc6nR8 false - - - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:P33535-4 uniprotkb:Q15363 intact:EBI-5281984 intact:EBI-998485|ensembl:ENSP00000262225 psi-mi:p33535-4(display_long)|uniprotkb:MOR1B(isoform synonym)|uniprotkb:Oprm1(gene name)|psi-mi:Oprm1(display_short)|uniprotkb:Ror-b(gene name synonym)|uniprotkb:Opioid receptor B(gene name synonym) psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Luo et al. (2011) pubmed:21219331 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-4394512 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-4392569(isoform-parent) ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1 go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol) - - figure legend:6a|curation depth:mimix curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/08/26 2014/10/16 rogid:MtslGjkSkH83hpS8kjTX/5md+No10116 rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606 intact-crc:ECB2B4978835B097|rigid:vqFtyyRYkJ+oUa/OBn5sW7Lw1q0 false - - - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining)