#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49767	uniprotkb:P35916	intact:EBI-3405539|ensembl:ENSP00000480043|uniprotkb:B2R9Q8	intact:EBI-1005467|uniprotkb:Q16067|uniprotkb:Q86W07|uniprotkb:A8K6L4|uniprotkb:B5A926|uniprotkb:Q86W08|ensembl:ENSP00000261937	psi-mi:vegfc_human(display_long)|uniprotkb:VEGFC(gene name)|psi-mi:VEGFC(display_short)|uniprotkb:Flt4 ligand(gene name synonym)|uniprotkb:Vascular endothelial growth factor-related protein(gene name synonym)	psi-mi:vgfr3_human(display_long)|uniprotkb:Tyrosine-protein kinase receptor FLT4(gene name synonym)|uniprotkb:FLT4(gene name)|psi-mi:FLT4(display_short)|uniprotkb:Fms-like tyrosine kinase 4(gene name synonym)|uniprotkb:VEGFR3(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Tvorogov et al. (2010)	imex:IM-15305|pubmed:21130043	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3405538|imex:IM-15305-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000150630(gene)|ensembl:ENST00000618562(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|interpro:IPR004153(CXCXC repeat)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031093"(platelet alpha granule lumen)|interpro:IPR023581|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|interpro:IPR029034|rcsb pdb:2X1W|rcsb pdb:2X1X|go:"GO:0042493"|rcsb pdb:4BSK|rcsb pdb:6TJT|go:"GO:0043185"(vascular endothelial growth factor receptor 3 binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|reactome:R-HSA-114608|reactome:R-HSA-194313|go:"GO:0045766"(positive regulation of angiogenesis)|reactome:R-HSA-195399|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:1901492"(positive regulation of lymphangiogenesis)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|dip:DIP-5738N|refseq:NP_005420.1	refseq:NP_002011.2|refseq:NP_891555.2|dip:DIP-5739N|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009137(Vascular endothelial growth factor receptor 3, VEGFR3, N-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|mint:P35916|rcsb pdb:4BSJ|rcsb pdb:4BSK|reactome:R-HSA-195399|reactome:R-HSA-9013695|ensembl:ENSG00000037280(gene)|ensembl:ENST00000261937(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001944"(vasculature development)|go:"GO:0001945"(lymph vessel development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003016"(respiratory system process)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C|comment:Unlike the 3C5 antibody, the 2E11 antibody did not block the binding of VEGFR-3 extracellular domain to immobilized VEGF-C.|antagonist:3C5 antibody|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/07	2014/10/16	rogid:qMYdLp3lRJMwHapcAarA3gsEtlQ9606	rogid:daBgkt907Q/5VJ/nuDyeSNZMNf09606	intact-crc:1FF1093C352A2150|rigid:ghMKVHh3DqfPImmkMSRYZb25zZs	false	his tag:c-c|sufficient binding region:103-215	sufficient binding region:25-774	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35916	uniprotkb:P35968	intact:EBI-1005467|uniprotkb:Q16067|uniprotkb:Q86W07|uniprotkb:A8K6L4|uniprotkb:B5A926|uniprotkb:Q86W08|ensembl:ENSP00000261937	intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0	psi-mi:vgfr3_human(display_long)|uniprotkb:Tyrosine-protein kinase receptor FLT4(gene name synonym)|uniprotkb:FLT4(gene name)|psi-mi:FLT4(display_short)|uniprotkb:Fms-like tyrosine kinase 4(gene name synonym)|uniprotkb:VEGFR3(gene name synonym)	psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tvorogov et al. (2010)	imex:IM-15305|pubmed:21130043	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3509024|imex:IM-15305-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002011.2|refseq:NP_891555.2|dip:DIP-5739N|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009137(Vascular endothelial growth factor receptor 3, VEGFR3, N-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|mint:P35916|rcsb pdb:4BSJ|rcsb pdb:4BSK|reactome:R-HSA-195399|reactome:R-HSA-9013695|ensembl:ENSG00000037280(gene)|ensembl:ENST00000261937(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001944"(vasculature development)|go:"GO:0001945"(lymph vessel development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003016"(respiratory system process)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)	refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 4A.|agonist:VEGF-C|antagonist:Antibodies 2E11 and 3C5 inhibit  the formation of VEGFR-2/VEGFR-3 heterodimers.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-endothelium)|taxid:9606(Homo sapiens endothelail cells/endothelium)	-	2011/01/07	2014/10/16	rogid:daBgkt907Q/5VJ/nuDyeSNZMNf09606	rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606	intact-crc:9E2304ED24FAC89C|rigid:rymRtJrbJsk5z1zihTBgWT6bXZc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49767	uniprotkb:P35916	intact:EBI-3405539|ensembl:ENSP00000480043|uniprotkb:B2R9Q8	intact:EBI-1005467|uniprotkb:Q16067|uniprotkb:Q86W07|uniprotkb:A8K6L4|uniprotkb:B5A926|uniprotkb:Q86W08|ensembl:ENSP00000261937	psi-mi:vegfc_human(display_long)|uniprotkb:VEGFC(gene name)|psi-mi:VEGFC(display_short)|uniprotkb:Flt4 ligand(gene name synonym)|uniprotkb:Vascular endothelial growth factor-related protein(gene name synonym)	psi-mi:vgfr3_human(display_long)|uniprotkb:Tyrosine-protein kinase receptor FLT4(gene name synonym)|uniprotkb:FLT4(gene name)|psi-mi:FLT4(display_short)|uniprotkb:Fms-like tyrosine kinase 4(gene name synonym)|uniprotkb:VEGFR3(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Tvorogov et al. (2010)	imex:IM-15305|pubmed:21130043	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3505628|imex:IM-15305-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000150630(gene)|ensembl:ENST00000618562(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|interpro:IPR004153(CXCXC repeat)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031093"(platelet alpha granule lumen)|interpro:IPR023581|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|interpro:IPR029034|rcsb pdb:2X1W|rcsb pdb:2X1X|go:"GO:0042493"|rcsb pdb:4BSK|rcsb pdb:6TJT|go:"GO:0043185"(vascular endothelial growth factor receptor 3 binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|reactome:R-HSA-114608|reactome:R-HSA-194313|go:"GO:0045766"(positive regulation of angiogenesis)|reactome:R-HSA-195399|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:1901492"(positive regulation of lymphangiogenesis)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|dip:DIP-5738N|refseq:NP_005420.1	refseq:NP_002011.2|refseq:NP_891555.2|dip:DIP-5739N|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009137(Vascular endothelial growth factor receptor 3, VEGFR3, N-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|mint:P35916|rcsb pdb:4BSJ|rcsb pdb:4BSK|reactome:R-HSA-195399|reactome:R-HSA-9013695|ensembl:ENSG00000037280(gene)|ensembl:ENST00000261937(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001944"(vasculature development)|go:"GO:0001945"(lymph vessel development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003016"(respiratory system process)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1D|comment:Unlike the 3C5 antibody, the 2E11 antibody did not block the binding of VEGFR-3 extracellular domain to immobilized VEGF-C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/07	2014/10/16	rogid:qMYdLp3lRJMwHapcAarA3gsEtlQ9606	rogid:daBgkt907Q/5VJ/nuDyeSNZMNf09606	intact-crc:459464A9117A35F1|rigid:ghMKVHh3DqfPImmkMSRYZb25zZs	false	sufficient binding region:103-215|his tag:c-c	alkaline phosphatase tag:?-?|sufficient binding region:25-775	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)