#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P11473 uniprotkb:P26045 intact:EBI-286357|uniprotkb:Q5PSV3|uniprotkb:B2R5Q1|uniprotkb:G3V1V9|ensembl:ENSP00000378734|ensembl:ENSP00000449573 intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667 psi-mi:vdr_human(display_long)|uniprotkb:1,25-dihydroxyvitamin D3 receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group I member 1(gene name synonym)|uniprotkb:VDR(gene name)|psi-mi:VDR(display_short)|uniprotkb:NR1I1(gene name synonym) psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhi et al. (2011) pubmed:21119599|imex:IM-15787 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-3891265|imex:IM-15787-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000367.1|refseq:NP_001017535.1|refseq:NP_001017536.1|refseq:XP_006719650.1|refseq:XP_011537022.1|dip:DIP-32624N|ensembl:ENSG00000111424(gene)|ensembl:ENST00000395324(transcript)|ensembl:ENST00000549336(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007595"(lactation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038186"(lithocholic acid receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0050892"(intestinal absorption)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060558"(regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0070561"(vitamin D receptor signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902098"(calcitriol binding)|go:"GO:1902121"(lithocholic acid binding)|interpro:IPR000324(Vitamin D receptor)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR042153|mint:P11473|rcsb pdb:1DB1|rcsb pdb:1IE8|rcsb pdb:1IE9|rcsb pdb:1KB2|rcsb pdb:1KB4|rcsb pdb:1KB6|rcsb pdb:1S0Z|rcsb pdb:1S19|rcsb pdb:1TXI|rcsb pdb:1YNW|rcsb pdb:2HAM|rcsb pdb:2HAR|rcsb pdb:2HAS|rcsb pdb:2HB7|rcsb pdb:2HB8|rcsb pdb:3A2I|rcsb pdb:3A2J|rcsb pdb:3A3Z|rcsb pdb:3A40|rcsb pdb:3A78|rcsb pdb:3AUQ|rcsb pdb:3AUR|rcsb pdb:3AX8|rcsb pdb:3AZ1|rcsb pdb:3AZ2|rcsb pdb:3AZ3|rcsb pdb:3B0T|rcsb pdb:3CS4|rcsb pdb:3CS6|rcsb pdb:3KPZ|rcsb pdb:3M7R|rcsb pdb:3OGT|rcsb pdb:3P8X|rcsb pdb:3TKC|rcsb pdb:3VHW|rcsb pdb:3W0A|rcsb pdb:3W0C|rcsb pdb:3W0Y|rcsb pdb:3WGP|rcsb pdb:3WWR|rcsb pdb:3X31|rcsb pdb:3X36|rcsb pdb:4G2I|rcsb pdb:4ITE|rcsb pdb:4ITF|rcsb pdb:5GT4|rcsb pdb:5V39|rcsb pdb:5YSY|rcsb pdb:5YT2|reactome:R-HSA-196791|reactome:R-HSA-383280|reactome:R-HSA-4090294 refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N psi-mi:"MI:0469"(intact) - - figure legend:6a, S1c|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/04/21 2014/10/16 rogid:7j3KKs/nPSWIKLnb2SZqA+UAysM9606 rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606 intact-crc:FEF8434A6F491AE1|rigid:9eUF1tLc1lf9OfOryTMqomoVZZQ false v5 tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P11473 uniprotkb:P26045 intact:EBI-286357|uniprotkb:Q5PSV3|uniprotkb:B2R5Q1|uniprotkb:G3V1V9|ensembl:ENSP00000378734|ensembl:ENSP00000449573 intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667 psi-mi:vdr_human(display_long)|uniprotkb:1,25-dihydroxyvitamin D3 receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group I member 1(gene name synonym)|uniprotkb:VDR(gene name)|psi-mi:VDR(display_short)|uniprotkb:NR1I1(gene name synonym) psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhi et al. (2011) pubmed:21119599|imex:IM-15787 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-3891281|imex:IM-15787-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000367.1|refseq:NP_001017535.1|refseq:NP_001017536.1|refseq:XP_006719650.1|refseq:XP_011537022.1|dip:DIP-32624N|ensembl:ENSG00000111424(gene)|ensembl:ENST00000395324(transcript)|ensembl:ENST00000549336(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007595"(lactation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038186"(lithocholic acid receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0050892"(intestinal absorption)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060558"(regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0070561"(vitamin D receptor signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902098"(calcitriol binding)|go:"GO:1902121"(lithocholic acid binding)|interpro:IPR000324(Vitamin D receptor)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR042153|mint:P11473|rcsb pdb:1DB1|rcsb pdb:1IE8|rcsb pdb:1IE9|rcsb pdb:1KB2|rcsb pdb:1KB4|rcsb pdb:1KB6|rcsb pdb:1S0Z|rcsb pdb:1S19|rcsb pdb:1TXI|rcsb pdb:1YNW|rcsb pdb:2HAM|rcsb pdb:2HAR|rcsb pdb:2HAS|rcsb pdb:2HB7|rcsb pdb:2HB8|rcsb pdb:3A2I|rcsb pdb:3A2J|rcsb pdb:3A3Z|rcsb pdb:3A40|rcsb pdb:3A78|rcsb pdb:3AUQ|rcsb pdb:3AUR|rcsb pdb:3AX8|rcsb pdb:3AZ1|rcsb pdb:3AZ2|rcsb pdb:3AZ3|rcsb pdb:3B0T|rcsb pdb:3CS4|rcsb pdb:3CS6|rcsb pdb:3KPZ|rcsb pdb:3M7R|rcsb pdb:3OGT|rcsb pdb:3P8X|rcsb pdb:3TKC|rcsb pdb:3VHW|rcsb pdb:3W0A|rcsb pdb:3W0C|rcsb pdb:3W0Y|rcsb pdb:3WGP|rcsb pdb:3WWR|rcsb pdb:3X31|rcsb pdb:3X36|rcsb pdb:4G2I|rcsb pdb:4ITE|rcsb pdb:4ITF|rcsb pdb:5GT4|rcsb pdb:5V39|rcsb pdb:5YSY|rcsb pdb:5YT2|reactome:R-HSA-196791|reactome:R-HSA-383280|reactome:R-HSA-4090294 refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N psi-mi:"MI:0469"(intact) - - figure legend:7a|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-t47d)|taxid:9606(human breast cancer tumour cell line-epithelial cells) - 2011/04/21 2014/10/16 rogid:7j3KKs/nPSWIKLnb2SZqA+UAysM9606 rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606 intact-crc:0D6870494109D1FE|rigid:9eUF1tLc1lf9OfOryTMqomoVZZQ false v5 tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P26045 uniprotkb:P11473 intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667 intact:EBI-286357|uniprotkb:Q5PSV3|uniprotkb:B2R5Q1|uniprotkb:G3V1V9|ensembl:ENSP00000378734|ensembl:ENSP00000449573 psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym) psi-mi:vdr_human(display_long)|uniprotkb:1,25-dihydroxyvitamin D3 receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group I member 1(gene name synonym)|uniprotkb:VDR(gene name)|psi-mi:VDR(display_short)|uniprotkb:NR1I1(gene name synonym) psi-mi:"MI:0096"(pull down) Zhi et al. (2011) pubmed:21119599|imex:IM-15787 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-3891297|imex:IM-15787-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N refseq:NP_000367.1|refseq:NP_001017535.1|refseq:NP_001017536.1|refseq:XP_006719650.1|refseq:XP_011537022.1|dip:DIP-32624N|ensembl:ENSG00000111424(gene)|ensembl:ENST00000395324(transcript)|ensembl:ENST00000549336(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007595"(lactation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038186"(lithocholic acid receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0050892"(intestinal absorption)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060558"(regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0070561"(vitamin D receptor signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902098"(calcitriol binding)|go:"GO:1902121"(lithocholic acid binding)|interpro:IPR000324(Vitamin D receptor)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR042153|mint:P11473|rcsb pdb:1DB1|rcsb pdb:1IE8|rcsb pdb:1IE9|rcsb pdb:1KB2|rcsb pdb:1KB4|rcsb pdb:1KB6|rcsb pdb:1S0Z|rcsb pdb:1S19|rcsb pdb:1TXI|rcsb pdb:1YNW|rcsb pdb:2HAM|rcsb pdb:2HAR|rcsb pdb:2HAS|rcsb pdb:2HB7|rcsb pdb:2HB8|rcsb pdb:3A2I|rcsb pdb:3A2J|rcsb pdb:3A3Z|rcsb pdb:3A40|rcsb pdb:3A78|rcsb pdb:3AUQ|rcsb pdb:3AUR|rcsb pdb:3AX8|rcsb pdb:3AZ1|rcsb pdb:3AZ2|rcsb pdb:3AZ3|rcsb pdb:3B0T|rcsb pdb:3CS4|rcsb pdb:3CS6|rcsb pdb:3KPZ|rcsb pdb:3M7R|rcsb pdb:3OGT|rcsb pdb:3P8X|rcsb pdb:3TKC|rcsb pdb:3VHW|rcsb pdb:3W0A|rcsb pdb:3W0C|rcsb pdb:3W0Y|rcsb pdb:3WGP|rcsb pdb:3WWR|rcsb pdb:3X31|rcsb pdb:3X36|rcsb pdb:4G2I|rcsb pdb:4ITE|rcsb pdb:4ITF|rcsb pdb:5GT4|rcsb pdb:5V39|rcsb pdb:5YSY|rcsb pdb:5YT2|reactome:R-HSA-196791|reactome:R-HSA-383280|reactome:R-HSA-4090294 psi-mi:"MI:0469"(intact) - - figure legend:S2b|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/04/21 2014/10/16 rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606 rogid:7j3KKs/nPSWIKLnb2SZqA+UAysM9606 intact-crc:9D66BFE78E619035|rigid:9eUF1tLc1lf9OfOryTMqomoVZZQ false ha tag:?-? glutathione s tranferase tag:?-?|necessary binding region:415-427|necessary binding region:1-140 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P11473 uniprotkb:P26045 intact:EBI-286357|uniprotkb:Q5PSV3|uniprotkb:B2R5Q1|uniprotkb:G3V1V9|ensembl:ENSP00000378734|ensembl:ENSP00000449573 intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667 psi-mi:vdr_human(display_long)|uniprotkb:1,25-dihydroxyvitamin D3 receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group I member 1(gene name synonym)|uniprotkb:VDR(gene name)|psi-mi:VDR(display_short)|uniprotkb:NR1I1(gene name synonym) psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhi et al. (2011) pubmed:21119599|imex:IM-15787 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-4291551|imex:IM-15787-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000367.1|refseq:NP_001017535.1|refseq:NP_001017536.1|refseq:XP_006719650.1|refseq:XP_011537022.1|dip:DIP-32624N|ensembl:ENSG00000111424(gene)|ensembl:ENST00000395324(transcript)|ensembl:ENST00000549336(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007595"(lactation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038186"(lithocholic acid receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0050892"(intestinal absorption)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060558"(regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0070561"(vitamin D receptor signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902098"(calcitriol binding)|go:"GO:1902121"(lithocholic acid binding)|interpro:IPR000324(Vitamin D receptor)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR042153|mint:P11473|rcsb pdb:1DB1|rcsb pdb:1IE8|rcsb pdb:1IE9|rcsb pdb:1KB2|rcsb pdb:1KB4|rcsb pdb:1KB6|rcsb pdb:1S0Z|rcsb pdb:1S19|rcsb pdb:1TXI|rcsb pdb:1YNW|rcsb pdb:2HAM|rcsb pdb:2HAR|rcsb pdb:2HAS|rcsb pdb:2HB7|rcsb pdb:2HB8|rcsb pdb:3A2I|rcsb pdb:3A2J|rcsb pdb:3A3Z|rcsb pdb:3A40|rcsb pdb:3A78|rcsb pdb:3AUQ|rcsb pdb:3AUR|rcsb pdb:3AX8|rcsb pdb:3AZ1|rcsb pdb:3AZ2|rcsb pdb:3AZ3|rcsb pdb:3B0T|rcsb pdb:3CS4|rcsb pdb:3CS6|rcsb pdb:3KPZ|rcsb pdb:3M7R|rcsb pdb:3OGT|rcsb pdb:3P8X|rcsb pdb:3TKC|rcsb pdb:3VHW|rcsb pdb:3W0A|rcsb pdb:3W0C|rcsb pdb:3W0Y|rcsb pdb:3WGP|rcsb pdb:3WWR|rcsb pdb:3X31|rcsb pdb:3X36|rcsb pdb:4G2I|rcsb pdb:4ITE|rcsb pdb:4ITF|rcsb pdb:5GT4|rcsb pdb:5V39|rcsb pdb:5YSY|rcsb pdb:5YT2|reactome:R-HSA-196791|reactome:R-HSA-383280|reactome:R-HSA-4090294 refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N psi-mi:"MI:0469"(intact) - - figure legend:S2d|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/04/21 2014/10/16 rogid:7j3KKs/nPSWIKLnb2SZqA+UAysM9606 rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606 intact-crc:D0C748EE3230FB7A|rigid:9eUF1tLc1lf9OfOryTMqomoVZZQ false v5 tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)