#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q06330 uniprotkb:Q96K30 intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22 intact:EBI-2836148|uniprotkb:F8VRG5|uniprotkb:Q96K25|uniprotkb:Q53GM3|uniprotkb:B3KVZ4|uniprotkb:C9JIN1|ensembl:ENSP00000448289|ensembl:ENSP00000449841 psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym) psi-mi:rita1_human(display_long)|uniprotkb:RITA1(gene name)|psi-mi:RITA1(display_short)|uniprotkb:C12orf52(gene name synonym)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:RITA(gene name synonym)|uniprotkb:PSEC0043(orf name) psi-mi:"MI:0018"(two hybrid) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8517086|mint:MINT-8094354|imex:IM-15396-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N|mint:MINT-8094357(identity) refseq:NP_001273144.1|go:"GO:0051168"(nuclear export)|interpro:IPR031418|rcsb pdb:5EG6|refseq:NP_116237.1|refseq:XP_005254029.1|ensembl:ENSG00000139405(gene)|ensembl:ENST00000548278(transcript)|ensembl:ENST00000549621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|mint:MINT-8094356(identity) - - - figure legend:nfa|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2011/02/14 2014/10/16 rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606 rogid:Ei2Oioh5EFhjPi7wMQq7d5D7rwc9606 intact-crc:68AA48C4B6837D9B|rigid:/DIsEi802/iwX4yTOsQsIzfwhhE false fusion protein:?-?(MINT-8094372)|binding-associated region:?-?(MINT-8094375) fusion protein:?-?(MINT-8094368) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96T58 uniprotkb:Q06330 intact:EBI-765739|uniprotkb:Q9UQ01|uniprotkb:Q9Y556|uniprotkb:Q9H9A8|uniprotkb:Q9NWH5|intact:EBI-28975565|ensembl:ENSP00000364912 intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22 psi-mi:mint_human(display_long)|uniprotkb:SPEN homolog(gene name synonym)|uniprotkb:SMART/HDAC1-associated repressor protein(gene name synonym)|uniprotkb:KIAA0929(gene name synonym)|uniprotkb:MINT(gene name synonym)|uniprotkb:SHARP(gene name synonym)|uniprotkb:SPEN(gene name)|psi-mi:SPEN(display_short) psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym) psi-mi:"MI:0096"(pull down) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517134|mint:MINT-8094394|imex:IM-15396-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055816.2|ensembl:ENSP00000364912|dip:DIP-34569N|ensembl:ENSG00000065526(gene)|ensembl:ENST00000375759(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR010912(Spen paralogue and orthologue C-terminal, metazoa)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012921(Spen paralogue and orthologue C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR034172|interpro:IPR034173|interpro:IPR034174|interpro:IPR034175|interpro:IPR035979|mint:Q96T58|rcsb pdb:1OW1|rcsb pdb:2RT5|rcsb pdb:4P6Q|reactome:R-HSA-9013422|go:"GO:0005654"(nucleoplasm)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|mint:MINT-8094396(identity) refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N|mint:MINT-8094400(identity) - - - figure legend:f1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/14 2014/10/16 rogid:m7bdkKVATaG4dkFG/BYXRn4jOIk9606 rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606 intact-crc:CE220793C0A803C2|rigid:f559tRQayT/XN000m9x3g7Rrcm4 false binding-associated region:2002-3664(MINT-8094405)|glutathione s tranferase tag:?-?(MINT-8094397) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q96K30 uniprotkb:Q06330 intact:EBI-2836148|uniprotkb:F8VRG5|uniprotkb:Q96K25|uniprotkb:Q53GM3|uniprotkb:B3KVZ4|uniprotkb:C9JIN1|ensembl:ENSP00000448289|ensembl:ENSP00000449841 intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22 psi-mi:rita1_human(display_long)|uniprotkb:RITA1(gene name)|psi-mi:RITA1(display_short)|uniprotkb:C12orf52(gene name synonym)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:RITA(gene name synonym)|uniprotkb:PSEC0043(orf name) psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym) psi-mi:"MI:0096"(pull down) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517119|mint:MINT-8094378|imex:IM-15396-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273144.1|go:"GO:0051168"(nuclear export)|interpro:IPR031418|rcsb pdb:5EG6|refseq:NP_116237.1|refseq:XP_005254029.1|ensembl:ENSG00000139405(gene)|ensembl:ENST00000548278(transcript)|ensembl:ENST00000549621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|mint:MINT-8094380(identity) refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N|mint:MINT-8094384(identity) - - - figure legend:f1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/14 2014/10/16 rogid:Ei2Oioh5EFhjPi7wMQq7d5D7rwc9606 rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606 intact-crc:17B0A5B18BB93928|rigid:/DIsEi802/iwX4yTOsQsIzfwhhE false glutathione s tranferase tag:?-?(MINT-8094381) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q06330 uniprotkb:Q01705 intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22 intact:EBI-1392707|uniprotkb:Q06007|uniprotkb:Q61905|uniprotkb:Q99JC2|uniprotkb:Q9QW58|uniprotkb:Q9R0X7|uniprotkb:Q3TZW2|uniprotkb:Q3U3Y2|uniprotkb:Q7TQ50|uniprotkb:Q7TQ51|uniprotkb:Q7TQ52|uniprotkb:Q8K428|ensembl:ENSMUSP00000028288 psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym) psi-mi:notc1_mouse(display_long)|uniprotkb:Notch1(gene name)|psi-mi:Notch1(display_short)|uniprotkb:Motch(gene name synonym)|uniprotkb:Motch A(gene name synonym)|uniprotkb:p300(gene name synonym)|uniprotkb:mT14(gene name synonym) psi-mi:"MI:0096"(pull down) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517152|mint:MINT-8094803|imex:IM-15396-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N|mint:MINT-8094805(identity) refseq:NP_032740.3|dip:DIP-214N|ensembl:ENSMUSG00000026923(gene)|ensembl:ENSMUST00000028288(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003264"(regulation of cardioblast proliferation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045607"(regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|rcsb pdb:1YMP|rcsb pdb:2QC9|rcsb pdb:2RQZ|rcsb pdb:2RR0|rcsb pdb:2RR2|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:5KY0|rcsb pdb:5KY4|rcsb pdb:5KY8|rcsb pdb:5KY9|reactome:R-MMU-1912420|reactome:R-MMU-2122947|reactome:R-MMU-2122948|reactome:R-MMU-350054|reactome:R-MMU-8941856|mint:MINT-8094807(identity) - - - comment:mint|figure legend:sf2c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/14 2014/10/16 rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606 rogid:VOWlSJ0z/YkR4qWQ6MHjD/CVitg10090 intact-crc:D8D7687F040F2253|rigid:G2asopYbgdrkBNF3b7Bu8CnlHgQ false binding-associated region:166-334(MINT-8150941) glutathione s tranferase tag:?-?(MINT-8094808) - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q06330 uniprotkb:Q96K30 intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22 intact:EBI-2836148|uniprotkb:F8VRG5|uniprotkb:Q96K25|uniprotkb:Q53GM3|uniprotkb:B3KVZ4|uniprotkb:C9JIN1|ensembl:ENSP00000448289|ensembl:ENSP00000449841 psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym) psi-mi:rita1_human(display_long)|uniprotkb:RITA1(gene name)|psi-mi:RITA1(display_short)|uniprotkb:C12orf52(gene name synonym)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:RITA(gene name synonym)|uniprotkb:PSEC0043(orf name) psi-mi:"MI:0096"(pull down) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517169|mint:MINT-8094859|imex:IM-15396-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N|mint:MINT-8094861(identity) refseq:NP_001273144.1|go:"GO:0051168"(nuclear export)|interpro:IPR031418|rcsb pdb:5EG6|refseq:NP_116237.1|refseq:XP_005254029.1|ensembl:ENSG00000139405(gene)|ensembl:ENST00000548278(transcript)|ensembl:ENST00000549621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|mint:MINT-8094863(identity) - - - comment:homomint|comment:mint|figure legend:sf2d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/14 2014/10/16 rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606 rogid:Ei2Oioh5EFhjPi7wMQq7d5D7rwc9606 intact-crc:28724FD076DB6A7E|rigid:/DIsEi802/iwX4yTOsQsIzfwhhE false binding-associated region:166-334(MINT-8150937) glutathione s tranferase tag:?-?(MINT-8094864) - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0CJ62 uniprotkb:Q06330 intact:EBI-8517225|intact:MINT-8094751 intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22 psi-mi:rita1_xenla(display_long)|uniprotkb:rita1(gene name)|psi-mi:rita1(display_short)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:rita(gene name synonym) psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym) psi-mi:"MI:0096"(pull down) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517253|mint:MINT-8094999|imex:IM-15396-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR031418|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0051168"(nuclear export)|mint:MINT-8095003(identity) refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N|mint:MINT-8095001(identity) - comment:mint - comment:mint|figure legend:sf7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/14 2014/10/16 rogid:Lg5rqWe24787EoMrYamESztEp608355 rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606 intact-crc:546F7513A11643AF|rigid:9EwM9B0RAO3lMcwOAae1ZQNaj48 false glutathione s tranferase tag:?-?(MINT-8095004) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q91880 uniprotkb:Q96K30 intact:EBI-8517187|intact:UNK-5980176|uniprotkb:Q91881 intact:EBI-2836148|uniprotkb:F8VRG5|uniprotkb:Q96K25|uniprotkb:Q53GM3|uniprotkb:B3KVZ4|uniprotkb:C9JIN1|ensembl:ENSP00000448289|ensembl:ENSP00000449841 psi-mi:suh_xenla(display_long)|uniprotkb:rbpj(gene name)|psi-mi:rbpj(display_short)|uniprotkb:rbpsuh(gene name synonym)|uniprotkb:suh(gene name synonym)|uniprotkb:"X-Su(H)"(gene name synonym) psi-mi:rita1_human(display_long)|uniprotkb:RITA1(gene name)|psi-mi:RITA1(display_short)|uniprotkb:C12orf52(gene name synonym)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:RITA(gene name synonym)|uniprotkb:PSEC0043(orf name) psi-mi:"MI:0096"(pull down) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517211|mint:MINT-8094979|imex:IM-15396-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015350(Beta-trefoil)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR015351(LAG1, DNA binding)|refseq:NP_001084347.1|interpro:IPR040159|interpro:IPR038007|interpro:IPR036358|interpro:IPR037095|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|mint:MINT-8094985(identity) refseq:NP_001273144.1|go:"GO:0051168"(nuclear export)|interpro:IPR031418|rcsb pdb:5EG6|refseq:NP_116237.1|refseq:XP_005254029.1|ensembl:ENSG00000139405(gene)|ensembl:ENST00000548278(transcript)|ensembl:ENST00000549621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|mint:MINT-8094981(identity) - comment:mint|function:"Transcriptional regulator wich plays a central role in Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes (By similarity). Required for the transcriptional activation of ESR1, suggesting that it is required during primary neurogenesis in embryos" - comment:mint|figure legend:sf7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/14 2014/10/16 rogid:XXPlZvCMK+Ly/gtJ5fa5reQHA3g8355 rogid:Ei2Oioh5EFhjPi7wMQq7d5D7rwc9606 intact-crc:A63CB081D89B060E|rigid:mS5e+PVhj0+7GXhxvLh+dNRJ7zk false - glutathione s tranferase tag:?-?(MINT-8094982) - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q91880 uniprotkb:P0CJ62 intact:EBI-8517187|intact:UNK-5980176|uniprotkb:Q91881 intact:EBI-8517225|intact:MINT-8094751 psi-mi:suh_xenla(display_long)|uniprotkb:rbpj(gene name)|psi-mi:rbpj(display_short)|uniprotkb:rbpsuh(gene name synonym)|uniprotkb:suh(gene name synonym)|uniprotkb:"X-Su(H)"(gene name synonym) psi-mi:rita1_xenla(display_long)|uniprotkb:rita1(gene name)|psi-mi:rita1(display_short)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:rita(gene name synonym) psi-mi:"MI:0096"(pull down) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517239|mint:MINT-8094990|imex:IM-15396-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015350(Beta-trefoil)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR015351(LAG1, DNA binding)|refseq:NP_001084347.1|interpro:IPR040159|interpro:IPR038007|interpro:IPR036358|interpro:IPR037095|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|mint:MINT-8094996(identity) interpro:IPR031418|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0051168"(nuclear export)|mint:MINT-8094992(identity) - comment:mint|function:"Transcriptional regulator wich plays a central role in Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes (By similarity). Required for the transcriptional activation of ESR1, suggesting that it is required during primary neurogenesis in embryos" comment:mint comment:mint|figure legend:sf7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/14 2014/10/16 rogid:XXPlZvCMK+Ly/gtJ5fa5reQHA3g8355 rogid:Lg5rqWe24787EoMrYamESztEp608355 intact-crc:5D0605DC52EC2A69|rigid:Wn0qcG91wQRVH0HPdFKS+XQjUoA false - glutathione s tranferase tag:?-?(MINT-8094993) - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q01705 uniprotkb:P28159 intact:EBI-1392707|uniprotkb:Q06007|uniprotkb:Q61905|uniprotkb:Q99JC2|uniprotkb:Q9QW58|uniprotkb:Q9R0X7|uniprotkb:Q3TZW2|uniprotkb:Q3U3Y2|uniprotkb:Q7TQ50|uniprotkb:Q7TQ51|uniprotkb:Q7TQ52|uniprotkb:Q8K428|ensembl:ENSMUSP00000028288 intact:EBI-92180|uniprotkb:Q3S1M8|uniprotkb:Q9TVK8|uniprotkb:Q9TVY7|uniprotkb:Q9TW34|uniprotkb:Q9U8F9|uniprotkb:Q9V446|ensemblmetazoa:FBpp0080261|ensemblmetazoa:FBpp0312201 psi-mi:notc1_mouse(display_long)|uniprotkb:Notch1(gene name)|psi-mi:Notch1(display_short)|uniprotkb:Motch(gene name synonym)|uniprotkb:Motch A(gene name synonym)|uniprotkb:p300(gene name synonym)|uniprotkb:mT14(gene name synonym) psi-mi:suh_drome(display_long)|uniprotkb:"Su(H)"(gene name)|psi-mi:"Su(H)"(display_short)|uniprotkb:dRBP-JK(gene name synonym)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CG3497(orf name) psi-mi:"MI:0096"(pull down) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517267|mint:MINT-8095018|imex:IM-15396-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032740.3|dip:DIP-214N|ensembl:ENSMUSG00000026923(gene)|ensembl:ENSMUST00000028288(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003264"(regulation of cardioblast proliferation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045607"(regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|rcsb pdb:1YMP|rcsb pdb:2QC9|rcsb pdb:2RQZ|rcsb pdb:2RR0|rcsb pdb:2RR2|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:5KY0|rcsb pdb:5KY4|rcsb pdb:5KY8|rcsb pdb:5KY9|reactome:R-MMU-1912420|reactome:R-MMU-2122947|reactome:R-MMU-2122948|reactome:R-MMU-350054|reactome:R-MMU-8941856|mint:MINT-8095022(identity) refseq:NP_001285948.1|refseq:NP_476868.1|flybase:FBgn0004837|ensemblmetazoa:FBgn0004837(gene)|ensemblmetazoa:FBtr0080700(transcript)|ensemblmetazoa:FBtr0346621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001709"(cell fate determination)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0007616"(long-term memory)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042683"(negative regulation of compound eye cone cell fate specification)|go:"GO:0042688"(crystal cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1990433"(CSL-Notch-Mastermind transcription factor complex)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|rcsb pdb:5E24|dip:DIP-177N|mint:MINT-8095020(identity) - - - comment:mint|figure legend:sf5d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/14 2014/10/16 rogid:VOWlSJ0z/YkR4qWQ6MHjD/CVitg10090 rogid:3NFMvvrfh1WC+s9QwiDW5BCUr5I7227 intact-crc:87C729EB354FCD4D|rigid:QVczLdr0c04Vam6a074T6HGK5wc false glutathione s tranferase tag:?-?(MINT-8095023) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:B3RLH1 uniprotkb:Q96K30 intact:EBI-8517301|intact:MINT-8095056|ensemblmetazoa:TriadP49676 intact:EBI-2836148|uniprotkb:F8VRG5|uniprotkb:Q96K25|uniprotkb:Q53GM3|uniprotkb:B3KVZ4|uniprotkb:C9JIN1|ensembl:ENSP00000448289|ensembl:ENSP00000449841 psi-mi:b3rlh1_triad(display_long)|uniprotkb:TRIADDRAFT_49676(orf name) psi-mi:rita1_human(display_long)|uniprotkb:RITA1(gene name)|psi-mi:RITA1(display_short)|uniprotkb:C12orf52(gene name synonym)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:RITA(gene name synonym)|uniprotkb:PSEC0043(orf name) psi-mi:"MI:0096"(pull down) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:10228(triad)|taxid:10228(Trichoplax adhaerens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517296|mint:MINT-8095045|imex:IM-15396-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015350(Beta-trefoil)|refseq:XP_002107974.1|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR040159|interpro:IPR036358|interpro:IPR037095|ensemblmetazoa:TriadG49676(gene)|ensemblmetazoa:TriadT49676(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|mint:MINT-8095047(identity) refseq:NP_001273144.1|go:"GO:0051168"(nuclear export)|interpro:IPR031418|rcsb pdb:5EG6|refseq:NP_116237.1|refseq:XP_005254029.1|ensembl:ENSG00000139405(gene)|ensembl:ENST00000548278(transcript)|ensembl:ENST00000549621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|mint:MINT-8095049(identity) - comment:mint - comment:mint|figure legend:sf5b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/14 2014/10/16 rogid:s0LCVzYnOvpsXkwFcz/iaWhb1AM10228 rogid:Ei2Oioh5EFhjPi7wMQq7d5D7rwc9606 intact-crc:4CEE25FD3850E497|rigid:E4ZundgKe8YwKKSgfIYQSqsSIOk false - glutathione s tranferase tag:?-?(MINT-8095050) - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B3RLH1 uniprotkb:B3S297 intact:EBI-8517301|intact:MINT-8095056|ensemblmetazoa:TriadP49676 intact:EBI-8517330|intact:MINT-8095081|ensemblmetazoa:TriadP58426 psi-mi:b3rlh1_triad(display_long)|uniprotkb:TRIADDRAFT_49676(orf name) psi-mi:b3s297_triad(display_long)|uniprotkb:RBPJ-interacting and tubulin-associated protein 1(gene name synonym)|uniprotkb:TRIADDRAFT_58426(orf name) psi-mi:"MI:0096"(pull down) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:10228(triad)|taxid:10228(Trichoplax adhaerens) taxid:10228(triad)|taxid:10228(Trichoplax adhaerens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517325|mint:MINT-8095072|imex:IM-15396-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015350(Beta-trefoil)|refseq:XP_002107974.1|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR040159|interpro:IPR036358|interpro:IPR037095|ensemblmetazoa:TriadG49676(gene)|ensemblmetazoa:TriadT49676(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|mint:MINT-8095078(identity) interpro:IPR031418|refseq:XP_002114203.1|ensemblmetazoa:TriadG58426(gene)|ensemblmetazoa:TriadT58426(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0051168"(nuclear export)|mint:MINT-8095074(identity) - comment:mint comment:mint comment:mint|figure legend:sf5b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/14 2014/10/16 rogid:s0LCVzYnOvpsXkwFcz/iaWhb1AM10228 rogid:tthh/bLnD1o1mcdZlTZUGGJJ03s10228 intact-crc:09D4BE87E55244DE|rigid:c9alUosMUGvSZexlMf4P8srexfw false - glutathione s tranferase tag:?-?(MINT-8095075) - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96K30 uniprotkb:P28159 intact:EBI-2836148|uniprotkb:F8VRG5|uniprotkb:Q96K25|uniprotkb:Q53GM3|uniprotkb:B3KVZ4|uniprotkb:C9JIN1|ensembl:ENSP00000448289|ensembl:ENSP00000449841 intact:EBI-92180|uniprotkb:Q3S1M8|uniprotkb:Q9TVK8|uniprotkb:Q9TVY7|uniprotkb:Q9TW34|uniprotkb:Q9U8F9|uniprotkb:Q9V446|ensemblmetazoa:FBpp0080261|ensemblmetazoa:FBpp0312201 psi-mi:rita1_human(display_long)|uniprotkb:RITA1(gene name)|psi-mi:RITA1(display_short)|uniprotkb:C12orf52(gene name synonym)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:RITA(gene name synonym)|uniprotkb:PSEC0043(orf name) psi-mi:suh_drome(display_long)|uniprotkb:"Su(H)"(gene name)|psi-mi:"Su(H)"(display_short)|uniprotkb:dRBP-JK(gene name synonym)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CG3497(orf name) psi-mi:"MI:0096"(pull down) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517281|mint:MINT-8095034|imex:IM-15396-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273144.1|go:"GO:0051168"(nuclear export)|interpro:IPR031418|rcsb pdb:5EG6|refseq:NP_116237.1|refseq:XP_005254029.1|ensembl:ENSG00000139405(gene)|ensembl:ENST00000548278(transcript)|ensembl:ENST00000549621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|mint:MINT-8095036(identity) refseq:NP_001285948.1|refseq:NP_476868.1|flybase:FBgn0004837|ensemblmetazoa:FBgn0004837(gene)|ensemblmetazoa:FBtr0080700(transcript)|ensemblmetazoa:FBtr0346621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001709"(cell fate determination)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0007616"(long-term memory)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042683"(negative regulation of compound eye cone cell fate specification)|go:"GO:0042688"(crystal cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1990433"(CSL-Notch-Mastermind transcription factor complex)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|rcsb pdb:5E24|dip:DIP-177N|mint:MINT-8095040(identity) - - - comment:homomint|comment:mint|figure legend:sf5d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/14 2014/10/16 rogid:Ei2Oioh5EFhjPi7wMQq7d5D7rwc9606 rogid:3NFMvvrfh1WC+s9QwiDW5BCUr5I7227 intact-crc:25D35AE59B5979EB|rigid:vqD16DlLy2v1kM0qPSPHf29KRr8 false glutathione s tranferase tag:?-?(MINT-8095037) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q06330 uniprotkb:Q96K30 intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22 intact:EBI-2836148|uniprotkb:F8VRG5|uniprotkb:Q96K25|uniprotkb:Q53GM3|uniprotkb:B3KVZ4|uniprotkb:C9JIN1|ensembl:ENSP00000448289|ensembl:ENSP00000449841 psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym) psi-mi:rita1_human(display_long)|uniprotkb:RITA1(gene name)|psi-mi:RITA1(display_short)|uniprotkb:C12orf52(gene name synonym)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:RITA(gene name synonym)|uniprotkb:PSEC0043(orf name) psi-mi:"MI:0096"(pull down) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517361|mint:MINT-8150964|imex:IM-15396-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N|mint:MINT-8150970(identity) refseq:NP_001273144.1|go:"GO:0051168"(nuclear export)|interpro:IPR031418|rcsb pdb:5EG6|refseq:NP_116237.1|refseq:XP_005254029.1|ensembl:ENSG00000139405(gene)|ensembl:ENST00000548278(transcript)|ensembl:ENST00000549621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|mint:MINT-8150966(identity) - - - comment:homomint|comment:mint|figure legend:sf7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/14 2014/10/16 rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606 rogid:Ei2Oioh5EFhjPi7wMQq7d5D7rwc9606 intact-crc:A4605D1562C70CBD|rigid:/DIsEi802/iwX4yTOsQsIzfwhhE false - glutathione s tranferase tag:?-?(MINT-8150967) - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q06330 uniprotkb:Q96K30 intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22 intact:EBI-2836148|uniprotkb:F8VRG5|uniprotkb:Q96K25|uniprotkb:Q53GM3|uniprotkb:B3KVZ4|uniprotkb:C9JIN1|ensembl:ENSP00000448289|ensembl:ENSP00000449841 psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym) psi-mi:rita1_human(display_long)|uniprotkb:RITA1(gene name)|psi-mi:RITA1(display_short)|uniprotkb:C12orf52(gene name synonym)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:RITA(gene name synonym)|uniprotkb:PSEC0043(orf name) psi-mi:"MI:0096"(pull down) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8517346|mint:MINT-8150902|imex:IM-15396-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N|mint:MINT-8150910(identity) refseq:NP_001273144.1|go:"GO:0051168"(nuclear export)|interpro:IPR031418|rcsb pdb:5EG6|refseq:NP_116237.1|refseq:XP_005254029.1|ensembl:ENSG00000139405(gene)|ensembl:ENST00000548278(transcript)|ensembl:ENST00000549621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|mint:MINT-8150904(identity) - - - figure legend:f3b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/14 2014/10/16 rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606 rogid:Ei2Oioh5EFhjPi7wMQq7d5D7rwc9606 intact-crc:7910B82F1D99755D|rigid:/DIsEi802/iwX4yTOsQsIzfwhhE false - glutathione s tranferase tag:?-?(MINT-8150907) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q06330 uniprotkb:Q96K30 intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22 intact:EBI-2836148|uniprotkb:F8VRG5|uniprotkb:Q96K25|uniprotkb:Q53GM3|uniprotkb:B3KVZ4|uniprotkb:C9JIN1|ensembl:ENSP00000448289|ensembl:ENSP00000449841 psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym) psi-mi:rita1_human(display_long)|uniprotkb:RITA1(gene name)|psi-mi:RITA1(display_short)|uniprotkb:C12orf52(gene name synonym)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:RITA(gene name synonym)|uniprotkb:PSEC0043(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8517455|mint:MINT-8094611|imex:IM-15396-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N|mint:MINT-8094617(identity) refseq:NP_001273144.1|go:"GO:0051168"(nuclear export)|interpro:IPR031418|rcsb pdb:5EG6|refseq:NP_116237.1|refseq:XP_005254029.1|ensembl:ENSG00000139405(gene)|ensembl:ENST00000548278(transcript)|ensembl:ENST00000549621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|mint:MINT-8094613(identity) - - - figure legend:f1b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2011/02/14 2014/10/16 rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606 rogid:Ei2Oioh5EFhjPi7wMQq7d5D7rwc9606 intact-crc:934FAB8EC93F4CF9|rigid:/DIsEi802/iwX4yTOsQsIzfwhhE false - binding-associated region:65-155(MINT-8150895)|flag tag:?-?(MINT-8094614) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P0CJ62 uniprotkb:Q06330 intact:EBI-8517225|intact:MINT-8094751 intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22 psi-mi:rita1_xenla(display_long)|uniprotkb:rita1(gene name)|psi-mi:rita1(display_short)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:rita(gene name synonym) psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8517491|mint:MINT-8094695|imex:IM-15396-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR031418|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0051168"(nuclear export)|mint:MINT-8094697(identity) refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N|mint:MINT-8094703(identity) - comment:mint - comment:mint|figure legend:sf7b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2011/02/14 2014/10/16 rogid:Lg5rqWe24787EoMrYamESztEp608355 rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606 intact-crc:E490182FEC695285|rigid:9EwM9B0RAO3lMcwOAae1ZQNaj48 false green fluorescent protein tag:?-?(MINT-8094700) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0113"(western blot) uniprotkb:Q96K30 uniprotkb:Q06330 intact:EBI-2836148|uniprotkb:F8VRG5|uniprotkb:Q96K25|uniprotkb:Q53GM3|uniprotkb:B3KVZ4|uniprotkb:C9JIN1|ensembl:ENSP00000448289|ensembl:ENSP00000449841 intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22 psi-mi:rita1_human(display_long)|uniprotkb:RITA1(gene name)|psi-mi:RITA1(display_short)|uniprotkb:C12orf52(gene name synonym)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:RITA(gene name synonym)|uniprotkb:PSEC0043(orf name) psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8517473|mint:MINT-8094668|imex:IM-15396-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273144.1|go:"GO:0051168"(nuclear export)|interpro:IPR031418|rcsb pdb:5EG6|refseq:NP_116237.1|refseq:XP_005254029.1|ensembl:ENSG00000139405(gene)|ensembl:ENST00000548278(transcript)|ensembl:ENST00000549621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|mint:MINT-8094670(identity) refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N|mint:MINT-8094674(identity) - - - figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2011/02/14 2014/10/16 rogid:Ei2Oioh5EFhjPi7wMQq7d5D7rwc9606 rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606 intact-crc:1CB78E07D01B3C46|rigid:/DIsEi802/iwX4yTOsQsIzfwhhE false binding-associated region:128-156(MINT-8094688)|green fluorescent protein tag:?-?(MINT-8094671) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q01705 uniprotkb:Q06330 intact:EBI-1392707|uniprotkb:Q06007|uniprotkb:Q61905|uniprotkb:Q99JC2|uniprotkb:Q9QW58|uniprotkb:Q9R0X7|uniprotkb:Q3TZW2|uniprotkb:Q3U3Y2|uniprotkb:Q7TQ50|uniprotkb:Q7TQ51|uniprotkb:Q7TQ52|uniprotkb:Q8K428|ensembl:ENSMUSP00000028288 intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22 psi-mi:notc1_mouse(display_long)|uniprotkb:Notch1(gene name)|psi-mi:Notch1(display_short)|uniprotkb:Motch(gene name synonym)|uniprotkb:Motch A(gene name synonym)|uniprotkb:p300(gene name synonym)|uniprotkb:mT14(gene name synonym) psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8517505|mint:MINT-8094765|imex:IM-15396-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032740.3|dip:DIP-214N|ensembl:ENSMUSG00000026923(gene)|ensembl:ENSMUST00000028288(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003264"(regulation of cardioblast proliferation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045607"(regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|rcsb pdb:1YMP|rcsb pdb:2QC9|rcsb pdb:2RQZ|rcsb pdb:2RR0|rcsb pdb:2RR2|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:5KY0|rcsb pdb:5KY4|rcsb pdb:5KY8|rcsb pdb:5KY9|reactome:R-MMU-1912420|reactome:R-MMU-2122947|reactome:R-MMU-2122948|reactome:R-MMU-350054|reactome:R-MMU-8941856|mint:MINT-8094767(identity) refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N|mint:MINT-8094771(identity) - - - comment:mint|figure legend:sf7b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2011/02/14 2014/10/16 rogid:VOWlSJ0z/YkR4qWQ6MHjD/CVitg10090 rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606 intact-crc:E0BF184BFD6970D5|rigid:G2asopYbgdrkBNF3b7Bu8CnlHgQ false green fluorescent protein tag:?-?(MINT-8094768) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0113"(western blot) uniprotkb:Q01705 uniprotkb:Q06330 intact:EBI-1392707|uniprotkb:Q06007|uniprotkb:Q61905|uniprotkb:Q99JC2|uniprotkb:Q9QW58|uniprotkb:Q9R0X7|uniprotkb:Q3TZW2|uniprotkb:Q3U3Y2|uniprotkb:Q7TQ50|uniprotkb:Q7TQ51|uniprotkb:Q7TQ52|uniprotkb:Q8K428|ensembl:ENSMUSP00000028288 intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22 psi-mi:notc1_mouse(display_long)|uniprotkb:Notch1(gene name)|psi-mi:Notch1(display_short)|uniprotkb:Motch(gene name synonym)|uniprotkb:Motch A(gene name synonym)|uniprotkb:p300(gene name synonym)|uniprotkb:mT14(gene name synonym) psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517528|mint:MINT-8094775|imex:IM-15396-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032740.3|dip:DIP-214N|ensembl:ENSMUSG00000026923(gene)|ensembl:ENSMUST00000028288(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003264"(regulation of cardioblast proliferation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045607"(regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|rcsb pdb:1YMP|rcsb pdb:2QC9|rcsb pdb:2RQZ|rcsb pdb:2RR0|rcsb pdb:2RR2|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:5KY0|rcsb pdb:5KY4|rcsb pdb:5KY8|rcsb pdb:5KY9|reactome:R-MMU-1912420|reactome:R-MMU-2122947|reactome:R-MMU-2122948|reactome:R-MMU-350054|reactome:R-MMU-8941856|mint:MINT-8094779(identity) refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N|mint:MINT-8094777(identity) - - - comment:mint|figure legend:sf4b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/02/14 2014/10/16 rogid:VOWlSJ0z/YkR4qWQ6MHjD/CVitg10090 rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606 intact-crc:1777E498AE8C0819|rigid:G2asopYbgdrkBNF3b7Bu8CnlHgQ false flag tag:?-?(MINT-8094780) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:O95613 uniprotkb:Q96K30 intact:EBI-530012|uniprotkb:O43152|uniprotkb:Q7Z7C9|intact:EBI-28971202|ensembl:ENSP00000352572 intact:EBI-2836148|uniprotkb:F8VRG5|uniprotkb:Q96K25|uniprotkb:Q53GM3|uniprotkb:B3KVZ4|uniprotkb:C9JIN1|ensembl:ENSP00000448289|ensembl:ENSP00000449841 psi-mi:pcnt_human(display_long)|uniprotkb:Pericentrin-B(gene name synonym)|uniprotkb:Kendrin(gene name synonym)|uniprotkb:PCNT(gene name)|psi-mi:PCNT(display_short)|uniprotkb:KIAA0402(gene name synonym)|uniprotkb:PCNT2(gene name synonym) psi-mi:rita1_human(display_long)|uniprotkb:RITA1(gene name)|psi-mi:RITA1(display_short)|uniprotkb:C12orf52(gene name synonym)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:RITA(gene name synonym)|uniprotkb:PSEC0043(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8517568|mint:MINT-8094907|imex:IM-15396-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000352572|refseq:NP_006022.3|refseq:NP_001302458.1|ensembl:ENSG00000160299(gene)|ensembl:ENST00000359568(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|interpro:IPR019528|interpro:IPR028745|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|dip:DIP-33829N|mint:MINT-8094916(identity) refseq:NP_001273144.1|go:"GO:0051168"(nuclear export)|interpro:IPR031418|rcsb pdb:5EG6|refseq:NP_116237.1|refseq:XP_005254029.1|ensembl:ENSG00000139405(gene)|ensembl:ENST00000548278(transcript)|ensembl:ENST00000549621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|mint:MINT-8094910(identity) go:"GO:0005813"(centrosome) - - figure legend:f4a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/02/14 2014/10/16 rogid:8YHnOQE3b77ocsel2oAdsqvE+js9606 rogid:Ei2Oioh5EFhjPi7wMQq7d5D7rwc9606 intact-crc:321F85C69D1A53CA|rigid:FArx/R4cUvZoXMZi3vejnqCmh4Q false - green fluorescent protein tag:?-?(MINT-8094911) - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q96K30 uniprotkb:P51955 intact:EBI-2836148|uniprotkb:F8VRG5|uniprotkb:Q96K25|uniprotkb:Q53GM3|uniprotkb:B3KVZ4|uniprotkb:C9JIN1|ensembl:ENSP00000448289|ensembl:ENSP00000449841 intact:EBI-633182|uniprotkb:Q53FD6|uniprotkb:Q5VXZ1|intact:EBI-4311380|uniprotkb:Q5I1Z9|uniprotkb:Q6NZX8|uniprotkb:Q7Z634|uniprotkb:Q86XH2|uniprotkb:Q96QN9|ensembl:ENSP00000355966 psi-mi:rita1_human(display_long)|uniprotkb:RITA1(gene name)|psi-mi:RITA1(display_short)|uniprotkb:C12orf52(gene name synonym)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:RITA(gene name synonym)|uniprotkb:PSEC0043(orf name) psi-mi:nek2_human(display_long)|uniprotkb:NEK2A(gene name synonym)|uniprotkb:NimA-like protein kinase 1(gene name synonym)|uniprotkb:HSPK 21(gene name synonym)|uniprotkb:NEK2(gene name)|psi-mi:NEK2(display_short)|uniprotkb:NLK1(gene name synonym)|uniprotkb:Never in mitosis A-related kinase 2(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8517552|mint:MINT-8094886|imex:IM-15396-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273144.1|go:"GO:0051168"(nuclear export)|interpro:IPR031418|rcsb pdb:5EG6|refseq:NP_116237.1|refseq:XP_005254029.1|ensembl:ENSG00000139405(gene)|ensembl:ENST00000548278(transcript)|ensembl:ENST00000549621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|mint:MINT-8094890(identity) refseq:NP_001191111.1|refseq:NP_001191112.1|refseq:NP_002488.1|ensembl:ENSG00000117650(gene)|ensembl:ENST00000366999(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000922"(spindle pole)|go:"GO:0001824"(blastocyst development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030496"(midbody)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0046602"(regulation of mitotic centrosome separation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051299"(centrosome separation)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903126"(negative regulation of centriole-centriole cohesion)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:P51955|rcsb pdb:2JAV|rcsb pdb:2W5A|rcsb pdb:2W5B|rcsb pdb:2W5H|rcsb pdb:2WQO|rcsb pdb:2XK3|rcsb pdb:2XK4|rcsb pdb:2XK6|rcsb pdb:2XK7|rcsb pdb:2XK8|rcsb pdb:2XKC|rcsb pdb:2XKD|rcsb pdb:2XKE|rcsb pdb:2XKF|rcsb pdb:2XNM|rcsb pdb:2XNN|rcsb pdb:2XNO|rcsb pdb:2XNP|rcsb pdb:4A4X|rcsb pdb:4AFE|rcsb pdb:5M51|rcsb pdb:5M53|rcsb pdb:5M55|rcsb pdb:5M57|rcsb pdb:6SGD|rcsb pdb:6SGH|rcsb pdb:6SGI|rcsb pdb:6SGK|rcsb pdb:6SK9|rcsb pdb:6TM5|reactome:R-HSA-179409|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:XP_005273204.1|mint:MINT-8094888(identity) go:"GO:0005813"(centrosome) - - figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/02/14 2014/10/16 rogid:Ei2Oioh5EFhjPi7wMQq7d5D7rwc9606 rogid:7iozc82+IF+sGyerzvp571Uc1RM9606 intact-crc:6C78512864C1293C|rigid:z8rF4W6SH1SkOBn8e5O2ERUozmw false green fluorescent protein tag:?-?(MINT-8094893) - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q96K30 uniprotkb:Q06330 intact:EBI-2836148|uniprotkb:F8VRG5|uniprotkb:Q96K25|uniprotkb:Q53GM3|uniprotkb:B3KVZ4|uniprotkb:C9JIN1|ensembl:ENSP00000448289|ensembl:ENSP00000449841 intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22 psi-mi:rita1_human(display_long)|uniprotkb:RITA1(gene name)|psi-mi:RITA1(display_short)|uniprotkb:C12orf52(gene name synonym)|uniprotkb:RBPJ-interacting and tubulin-associated protein(gene name synonym)|uniprotkb:RITA(gene name synonym)|uniprotkb:PSEC0043(orf name) psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Wacker et al. (2011) mint:MINT-8094313|pubmed:21102556|imex:IM-15396|doi:10.1038/emboj.2010.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8517595|mint:MINT-8094949|imex:IM-15396-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273144.1|go:"GO:0051168"(nuclear export)|interpro:IPR031418|rcsb pdb:5EG6|refseq:NP_116237.1|refseq:XP_005254029.1|ensembl:ENSG00000139405(gene)|ensembl:ENST00000548278(transcript)|ensembl:ENST00000549621(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|mint:MINT-8094952(identity) refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N|mint:MINT-8094956(identity) go:"GO:0005634"(nucleus) - - figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/02/14 2014/10/16 rogid:Ei2Oioh5EFhjPi7wMQq7d5D7rwc9606 rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606 intact-crc:DE9550784B0B0491|rigid:/DIsEi802/iwX4yTOsQsIzfwhhE false green fluorescent protein tag:?-?(MINT-8094953) fusion protein:?-?(MINT-8094957) - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)