#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O95786	uniprotkb:O95786	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Hayakawa et al. (2011)	pubmed:21102435|imex:IM-16538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3867888|imex:IM-16538-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4F|stimulant:NDV infection 16h|inhibition:siZAPS3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/03/24	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	intact-crc:522A6D652E9BB45C|rigid:KxURc/EOhcG7wpqcyebnGRmipQU	false	flag tag:?-?	flag tag:?-?	2	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q14653	uniprotkb:Q14653	intact:EBI-2650369|uniprotkb:Q5FBY1|uniprotkb:Q5FBY2|uniprotkb:Q7Z5G6|uniprotkb:A8K7L2|uniprotkb:B2RAZ3|ensembl:ENSP00000310127|ensembl:ENSP00000366344|ensembl:ENSP00000469113|uniprotkb:Q5FBY4	intact:EBI-2650369|uniprotkb:Q5FBY1|uniprotkb:Q5FBY2|uniprotkb:Q7Z5G6|uniprotkb:A8K7L2|uniprotkb:B2RAZ3|ensembl:ENSP00000310127|ensembl:ENSP00000366344|ensembl:ENSP00000469113|uniprotkb:Q5FBY4	psi-mi:irf3_human(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short)	psi-mi:irf3_human(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Hayakawa et al. (2011)	pubmed:21102435|imex:IM-16538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3863338|imex:IM-16538-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001562.1|refseq:NP_001184053.1|ensembl:ENSG00000126456(gene)|ensembl:ENST00000309877(transcript)|ensembl:ENST00000377139(transcript)|ensembl:ENST00000597198(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071888"(macrophage apoptotic process)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|mint:Q14653|rcsb pdb:1J2F|rcsb pdb:1QWT|rcsb pdb:1T2K|rcsb pdb:1ZOQ|rcsb pdb:2O61|rcsb pdb:2O6G|rcsb pdb:2PI0|rcsb pdb:3A77|rcsb pdb:3QU6|rcsb pdb:5JEJ|rcsb pdb:5JEK|rcsb pdb:5JEL|rcsb pdb:5JEM|rcsb pdb:5JEO|rcsb pdb:5JER|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:7JFL|reactome:R-HSA-1169408|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3270619|reactome:R-HSA-877300|reactome:R-HSA-3134973|reactome:R-HSA-9013973|reactome:R-HSA-909733|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:NP_001184051.1|refseq:NP_001184052.1|refseq:NP_001184054.1|refseq:NP_001184055.1|refseq:NP_001184056.1|refseq:NP_001184057.1|refseq:XP_006723260.1|refseq:XP_006723261.1|refseq:XP_016882255.1|refseq:XP_016882256.1|dip:DIP-41448N	refseq:NP_001562.1|refseq:NP_001184053.1|ensembl:ENSG00000126456(gene)|ensembl:ENST00000309877(transcript)|ensembl:ENST00000377139(transcript)|ensembl:ENST00000597198(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071888"(macrophage apoptotic process)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|mint:Q14653|rcsb pdb:1J2F|rcsb pdb:1QWT|rcsb pdb:1T2K|rcsb pdb:1ZOQ|rcsb pdb:2O61|rcsb pdb:2O6G|rcsb pdb:2PI0|rcsb pdb:3A77|rcsb pdb:3QU6|rcsb pdb:5JEJ|rcsb pdb:5JEK|rcsb pdb:5JEL|rcsb pdb:5JEM|rcsb pdb:5JEO|rcsb pdb:5JER|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:7JFL|reactome:R-HSA-1169408|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3270619|reactome:R-HSA-877300|reactome:R-HSA-3134973|reactome:R-HSA-9013973|reactome:R-HSA-909733|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:NP_001184051.1|refseq:NP_001184052.1|refseq:NP_001184054.1|refseq:NP_001184055.1|refseq:NP_001184056.1|refseq:NP_001184057.1|refseq:XP_006723260.1|refseq:XP_006723261.1|refseq:XP_016882255.1|refseq:XP_016882256.1|dip:DIP-41448N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3D|stimulant:1-10ug/mL 3pRNA|inhibition:siZAPS3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/03/24	2014/10/16	rogid:hQC59YXQ7BOkhZzKbxYHcu1YWFA9606	rogid:hQC59YXQ7BOkhZzKbxYHcu1YWFA9606	intact-crc:CACECE4E03805E24|rigid:y/wjSxLhOsf5dKzciLRCT0YH2Ho	false	-	-	2	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95786	uniprotkb:Q7Z2W4-2	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-922559|ensembl:ENSP00000419855	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:q7z2w4-2(display_long)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:ZAPS(isoform synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Hayakawa et al. (2011)	pubmed:21102435|imex:IM-16538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3863359|imex:IM-16538-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	intact:EBI-922540(zcc2_human)|ensembl:ENSG00000105939(gene)|ensembl:ENST00000471652(transcript)|uniprotkb:Q7Z2W4-2(isoform-parent)	psi-mi:"MI:0469"(intact)	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 4A|stimulant:4h 3pRNA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2011/03/24	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:iYC6SVjVUbaBJ7RnzFluOsH9UAQ9606	intact-crc:142B55AFEEC5D1B1|rigid:KSRH4ZrY26Js7OvzFAHn9Tq68LA	false	flag tag:?-?	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O95786	uniprotkb:Q7Z2W4-2	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-922559|ensembl:ENSP00000419855	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:q7z2w4-2(display_long)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:ZAPS(isoform synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Hayakawa et al. (2011)	pubmed:21102435|imex:IM-16538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3863374|imex:IM-16538-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0865"(fluorescence acceptor donor pair)	psi-mi:"MI:0865"(fluorescence acceptor donor pair)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	intact:EBI-922540(zcc2_human)|ensembl:ENSG00000105939(gene)|ensembl:ENST00000471652(transcript)|uniprotkb:Q7Z2W4-2(isoform-parent)	psi-mi:"MI:0469"(intact)	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 4B|stimulant:3pRNA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2011/03/24	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:iYC6SVjVUbaBJ7RnzFluOsH9UAQ9606	intact-crc:8D9ACED98C4A1AA5|rigid:KSRH4ZrY26Js7OvzFAHn9Tq68LA	false	flag tag:?-?	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O95786	uniprotkb:Q7Z2W4-2	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-922559|ensembl:ENSP00000419855	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:q7z2w4-2(display_long)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:ZAPS(isoform synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hayakawa et al. (2011)	pubmed:21102435|imex:IM-16538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3863393|imex:IM-16538-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	intact:EBI-922540(zcc2_human)|ensembl:ENSG00000105939(gene)|ensembl:ENST00000471652(transcript)|uniprotkb:Q7Z2W4-2(isoform-parent)	psi-mi:"MI:0469"(intact)	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 4C, 4E, S4B, S4D|stimulant:3pRNA, NDV infection, Flu vRNA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/03/24	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:iYC6SVjVUbaBJ7RnzFluOsH9UAQ9606	intact-crc:839717DBBD993D97|rigid:KSRH4ZrY26Js7OvzFAHn9Tq68LA	false	sufficient binding region:194-791|flag tag:?-?	necessary binding region:1-194(IPR000571)|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95786	uniprotkb:O95786	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hayakawa et al. (2011)	pubmed:21102435|imex:IM-16538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3863419|imex:IM-16538-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S4F|stimulant:3pRNA|inhibition:siZAPS3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/03/24	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	intact-crc:A754368BD66559BF|rigid:OZVe60LnUSlsyENCBLOufBCH66U	false	yellow fluorescent protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95786	uniprotkb:Q7Z434	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hayakawa et al. (2011)	pubmed:21102435|imex:IM-16538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3863409|imex:IM-16538-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4H|stimulant:3pRNA|inhibition:siZAPS3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/03/24	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	intact-crc:25EEBB12145D0E4E|rigid:obR2EHoHumN9pPBg9pR31HUKako	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95786	uniprotkb:Q7Z2W4	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-922540|uniprotkb:Q8TAJ3|uniprotkb:Q96N79|uniprotkb:Q9H8R9|uniprotkb:Q9P0Y7|uniprotkb:Q8IW57|uniprotkb:A4D1R2|uniprotkb:A4D1S4|ensembl:ENSP00000242351	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:zcchv_human(display_long)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hayakawa et al. (2011)	pubmed:21102435|imex:IM-16538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3863798|imex:IM-16538-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	refseq:NP_064504.2|refseq:NP_078901.3|ensembl:ENSG00000105939(gene)|ensembl:ENST00000242351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q7Z2W4|rcsb pdb:2X5Y|rcsb pdb:4X52|rcsb pdb:6UEI|rcsb pdb:6UEJ|reactome:R-HSA-6802952|dip:DIP-37896N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|stimulant:"3pRNA (6hr)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2011/03/24	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:iJy4W/YX/vVXGbFd+GnfoKlo8aA9606	intact-crc:D513558309AB6464|rigid:bo28uDbUaHprWeDfyGEklZ7LBLs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95786	uniprotkb:Q7Z2W4	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-922540|uniprotkb:Q8TAJ3|uniprotkb:Q96N79|uniprotkb:Q9H8R9|uniprotkb:Q9P0Y7|uniprotkb:Q8IW57|uniprotkb:A4D1R2|uniprotkb:A4D1S4|ensembl:ENSP00000242351	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:zcchv_human(display_long)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hayakawa et al. (2011)	pubmed:21102435|imex:IM-16538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3863828|imex:IM-16538-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	refseq:NP_064504.2|refseq:NP_078901.3|ensembl:ENSG00000105939(gene)|ensembl:ENST00000242351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q7Z2W4|rcsb pdb:2X5Y|rcsb pdb:4X52|rcsb pdb:6UEI|rcsb pdb:6UEJ|reactome:R-HSA-6802952|dip:DIP-37896N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S4C|stimulant:"3pRNA (6hr)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line)	-	2011/03/24	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:iJy4W/YX/vVXGbFd+GnfoKlo8aA9606	intact-crc:DABEB298579791DC|rigid:bo28uDbUaHprWeDfyGEklZ7LBLs	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95786	uniprotkb:Q7Z2W4-2	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-922559|ensembl:ENSP00000419855	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:q7z2w4-2(display_long)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:ZAPS(isoform synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hayakawa et al. (2011)	pubmed:21102435|imex:IM-16538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3863844|imex:IM-16538-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	intact:EBI-922540(zcc2_human)|ensembl:ENSG00000105939(gene)|ensembl:ENST00000471652(transcript)|uniprotkb:Q7Z2W4-2(isoform-parent)	psi-mi:"MI:0469"(intact)	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. S4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:116.0x10^-9(molar)	2011/03/24	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:iYC6SVjVUbaBJ7RnzFluOsH9UAQ9606	intact-crc:45102A87A3E913D1|rigid:KSRH4ZrY26Js7OvzFAHn9Tq68LA	false	glutathione s tranferase tag:?-?|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95786	uniprotkb:Q7Z2W4	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-922540|uniprotkb:Q8TAJ3|uniprotkb:Q96N79|uniprotkb:Q9H8R9|uniprotkb:Q9P0Y7|uniprotkb:Q8IW57|uniprotkb:A4D1R2|uniprotkb:A4D1S4|ensembl:ENSP00000242351	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:zcchv_human(display_long)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hayakawa et al. (2011)	pubmed:21102435|imex:IM-16538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3863812|imex:IM-16538-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	refseq:NP_064504.2|refseq:NP_078901.3|ensembl:ENSG00000105939(gene)|ensembl:ENST00000242351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q7Z2W4|rcsb pdb:2X5Y|rcsb pdb:4X52|rcsb pdb:6UEI|rcsb pdb:6UEJ|reactome:R-HSA-6802952|dip:DIP-37896N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S4A|stimulant:flu vRNA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/03/24	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:iJy4W/YX/vVXGbFd+GnfoKlo8aA9606	intact-crc:7E27771A14D3E47C|rigid:bo28uDbUaHprWeDfyGEklZ7LBLs	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)