#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O88871	uniprotkb:Q9Z0U4	intact:EBI-7090239|intact:MINT-1889821|uniprotkb:Q9QWU2|uniprotkb:Q9JK36	intact:EBI-7090268|intact:UNK-5560925|uniprotkb:Q9Z0F9|uniprotkb:O08620|uniprotkb:O08621|uniprotkb:Q9Z308	psi-mi:gabr2_rat(display_long)|uniprotkb:Gabbr2(gene name)|psi-mi:Gabbr2(display_short)|uniprotkb:Gpr51(gene name synonym)|uniprotkb:G-protein coupled receptor 51(gene name synonym)	psi-mi:gabr1_rat(display_long)|uniprotkb:Gabbr1(gene name)|psi-mi:Gabbr1(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Monnier et al. (2011)	pubmed:21063387|imex:IM-15325|mint:MINT-8091814|doi:10.1038/emboj.2010.270	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-8502160|mint:MINT-8091825|imex:IM-15325-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O88871|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|go:"GO:0005737"(cytoplasm)|interpro:IPR017978|refseq:NP_113990.1|rgd:619864|interpro:IPR017979|interpro:IPR028082|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR041689|mint:MINT-8091828(identity)	mint:Q9Z0U4|refseq:XP_006255941.1|interpro:IPR002456(GPCR, family 3, gamma-aminobutyric acid receptor, type B1)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014053"(negative regulation of gamma-aminobutyric acid secretion)|go:"GO:0016020"(membrane)|go:"GO:0030673"(axolemma)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1990430"(extracellular matrix protein binding)|rcsb pdb:1SRZ|rcsb pdb:1SS2|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|interpro:IPR017978|refseq:NP_112290.2|interpro:IPR000436(Sushi/SCR/CCP)|rgd:621537|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR028082|interpro:IPR035976|mint:MINT-8091827(identity)	go:"GO:0005886"(plasma membrane)	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	comment:homomint|comment:mint|figure legend:F1B F1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/02/09	2014/10/16	rogid:2KtIPgSLdOYAmc34lA/U+dOtAow10116	rogid:3x+mBvnwGiR6R8XPKUvTCDovYxM10116	intact-crc:CC562A3057C3F155|rigid:O3861JHjgRBPK+39UGnRoXk7yxk	false	fusion protein:?-?(MINT-8091834)	fusion protein:?-?(MINT-8091830)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)