#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13162	uniprotkb:Q8NBS9	intact:EBI-2211957|uniprotkb:Q6FHT3|ensembl:ENSP00000368646	intact:EBI-2510815|ensembl:ENSP00000369081|uniprotkb:Q8TCT2|uniprotkb:Q5TCQ0|uniprotkb:Q9BVH9|uniprotkb:Q8ND33|uniprotkb:B2RDM2	psi-mi:prdx4_human(display_long)|uniprotkb:PRDX4(gene name)|psi-mi:PRDX4(display_short)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym)	psi-mi:txnd5_human(display_long)|uniprotkb:TXNDC5(gene name)|psi-mi:TXNDC5(display_short)|uniprotkb:TLP46(gene name synonym)|uniprotkb:Thioredoxin-like protein p46(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 46(gene name synonym)|uniprotkb:UNQ364/PRO700(orf name)	psi-mi:"MI:0415"(enzymatic study)	Tavender et al. (2010)	pubmed:21057456|imex:IM-15309|mint:MINT-8090267|doi:10.1038/emboj.2010.273	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8501829|mint:MINT-8090275|imex:IM-15309-1	-	-	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006397.1|ensembl:ENSG00000123131(gene)|ensembl:ENST00000379341(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:Q13162|rcsb pdb:2PN8|rcsb pdb:3TJB|rcsb pdb:3TJF|rcsb pdb:3TJG|rcsb pdb:3TJJ|rcsb pdb:3TJK|rcsb pdb:3TKP|rcsb pdb:3TKQ|rcsb pdb:3TKR|rcsb pdb:3TKS|rcsb pdb:4RQX|rcsb pdb:5HQP|reactome:R-HSA-6798695|mint:MINT-8090277(identity)	ensembl:ENSG00000239264(gene)|ensembl:ENST00000379757(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|rcsb pdb:2DIZ|rcsb pdb:3UJ1|rcsb pdb:3UVT|rcsb pdb:3WGD|rcsb pdb:3WGE|rcsb pdb:3WGX|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6798695|refseq:NP_001139021.1|refseq:NP_110437.2|dip:DIP-53700N|mint:MINT-8090278(identity)	-	-	-	figure legend:f2c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/07	2014/10/16	rogid:5KWl3YuUpRDrSUxWlJS6sP7CLAs9606	rogid:bz5VVWMPFLTRKwph60UFASjsFN49606	intact-crc:25F37DF247905C0A|rigid:dLgrZi3qGeWZsY3HGhyBXL5JbPw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07237	uniprotkb:Q13162	intact:EBI-395883|uniprotkb:P30037|uniprotkb:P32079|uniprotkb:Q15205|uniprotkb:Q6LDE5|uniprotkb:B2RDQ2|ensembl:ENSP00000327801	intact:EBI-2211957|uniprotkb:Q6FHT3|ensembl:ENSP00000368646	psi-mi:pdia1_human(display_long)|uniprotkb:P4HB(gene name)|psi-mi:P4HB(display_short)|uniprotkb:PDI(gene name synonym)|uniprotkb:PDIA1(gene name synonym)|uniprotkb:PO4DB(gene name synonym)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:ERBA2L(gene name synonym)	psi-mi:prdx4_human(display_long)|uniprotkb:PRDX4(gene name)|psi-mi:PRDX4(display_short)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Tavender et al. (2010)	pubmed:21057456|imex:IM-15309|mint:MINT-8090267|doi:10.1038/emboj.2010.273	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8501877|mint:MINT-8091005|imex:IM-15309-5	-	-	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000909.2|ensembl:ENSG00000185624(gene)|ensembl:ENST00000331483(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042470"(melanosome)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P07237|rcsb pdb:1BJX|rcsb pdb:1MEK|rcsb pdb:1X5C|rcsb pdb:2BJX|rcsb pdb:2K18|rcsb pdb:3BJ5|rcsb pdb:3UEM|rcsb pdb:4EKZ|rcsb pdb:4EL1|rcsb pdb:4JU5|rcsb pdb:6I7S|reactome:R-HSA-1650814|reactome:R-HSA-3299685|reactome:R-HSA-381426|reactome:R-HSA-5358346|reactome:R-HSA-8866423|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-32979N|mint:MINT-8091009(identity)	refseq:NP_006397.1|ensembl:ENSG00000123131(gene)|ensembl:ENST00000379341(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:Q13162|rcsb pdb:2PN8|rcsb pdb:3TJB|rcsb pdb:3TJF|rcsb pdb:3TJG|rcsb pdb:3TJJ|rcsb pdb:3TJK|rcsb pdb:3TKP|rcsb pdb:3TKQ|rcsb pdb:3TKR|rcsb pdb:3TKS|rcsb pdb:4RQX|rcsb pdb:5HQP|reactome:R-HSA-6798695|mint:MINT-8091007(identity)	-	-	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/07	2014/10/16	rogid:rh0B38TSfTX+lvU5OyBwEbVndFA9606	rogid:5KWl3YuUpRDrSUxWlJS6sP7CLAs9606	intact-crc:7265ECDC2FC1E75F|rigid:xgO0ReyQzwU42D9kz7BnQ+SXAXI	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q13162	uniprotkb:P30101	intact:EBI-2211957|uniprotkb:Q6FHT3|ensembl:ENSP00000368646	intact:EBI-979862|uniprotkb:Q13453|uniprotkb:Q14255|uniprotkb:Q8IYF8|uniprotkb:Q9UMU7|ensembl:ENSP00000300289	psi-mi:prdx4_human(display_long)|uniprotkb:PRDX4(gene name)|psi-mi:PRDX4(display_short)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym)	psi-mi:pdia3_human(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP60(gene name synonym)|uniprotkb:GRP58(gene name synonym)|uniprotkb:ERP57(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Tavender et al. (2010)	pubmed:21057456|imex:IM-15309|mint:MINT-8090267|doi:10.1038/emboj.2010.273	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8501841|mint:MINT-8090942|imex:IM-15309-2	-	-	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006397.1|ensembl:ENSG00000123131(gene)|ensembl:ENST00000379341(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:Q13162|rcsb pdb:2PN8|rcsb pdb:3TJB|rcsb pdb:3TJF|rcsb pdb:3TJG|rcsb pdb:3TJJ|rcsb pdb:3TJK|rcsb pdb:3TKP|rcsb pdb:3TKQ|rcsb pdb:3TKR|rcsb pdb:3TKS|rcsb pdb:4RQX|rcsb pdb:5HQP|reactome:R-HSA-6798695|mint:MINT-8090944(identity)	interpro:IPR036249|interpro:IPR041868|mint:P30101|rcsb pdb:2ALB|rcsb pdb:2DMM|rcsb pdb:2H8L|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-901042|reactome:R-HSA-983170|interpro:IPR017937|ensembl:ENSG00000167004(gene)|ensembl:ENST00000300289(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005304.3|dip:DIP-29132N|mint:MINT-8090946(identity)	-	-	-	figure legend:f2c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/07	2014/10/16	rogid:5KWl3YuUpRDrSUxWlJS6sP7CLAs9606	rogid:N/XktiLWB/cPju9nCq6yeyXnO1Q9606	intact-crc:B55AAE45B7990BE3|rigid:H6CMJT8zVWq7isPBi6bG+D0smhI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13162	uniprotkb:P30101	intact:EBI-2211957|uniprotkb:Q6FHT3|ensembl:ENSP00000368646	intact:EBI-979862|uniprotkb:Q13453|uniprotkb:Q14255|uniprotkb:Q8IYF8|uniprotkb:Q9UMU7|ensembl:ENSP00000300289	psi-mi:prdx4_human(display_long)|uniprotkb:PRDX4(gene name)|psi-mi:PRDX4(display_short)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym)	psi-mi:pdia3_human(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP60(gene name synonym)|uniprotkb:GRP58(gene name synonym)|uniprotkb:ERP57(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Tavender et al. (2010)	pubmed:21057456|imex:IM-15309|mint:MINT-8090267|doi:10.1038/emboj.2010.273	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8501853|mint:MINT-8090965|imex:IM-15309-3	-	-	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006397.1|ensembl:ENSG00000123131(gene)|ensembl:ENST00000379341(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:Q13162|rcsb pdb:2PN8|rcsb pdb:3TJB|rcsb pdb:3TJF|rcsb pdb:3TJG|rcsb pdb:3TJJ|rcsb pdb:3TJK|rcsb pdb:3TKP|rcsb pdb:3TKQ|rcsb pdb:3TKR|rcsb pdb:3TKS|rcsb pdb:4RQX|rcsb pdb:5HQP|reactome:R-HSA-6798695|mint:MINT-8090967(identity)	interpro:IPR036249|interpro:IPR041868|mint:P30101|rcsb pdb:2ALB|rcsb pdb:2DMM|rcsb pdb:2H8L|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-901042|reactome:R-HSA-983170|interpro:IPR017937|ensembl:ENSG00000167004(gene)|ensembl:ENST00000300289(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005304.3|dip:DIP-29132N|mint:MINT-8090969(identity)	-	-	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/07	2014/10/16	rogid:5KWl3YuUpRDrSUxWlJS6sP7CLAs9606	rogid:N/XktiLWB/cPju9nCq6yeyXnO1Q9606	intact-crc:0C6F50412B51923A|rigid:H6CMJT8zVWq7isPBi6bG+D0smhI	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q8NBS9	uniprotkb:Q13162	intact:EBI-2510815|ensembl:ENSP00000369081|uniprotkb:Q8TCT2|uniprotkb:Q5TCQ0|uniprotkb:Q9BVH9|uniprotkb:Q8ND33|uniprotkb:B2RDM2	intact:EBI-2211957|uniprotkb:Q6FHT3|ensembl:ENSP00000368646	psi-mi:txnd5_human(display_long)|uniprotkb:TXNDC5(gene name)|psi-mi:TXNDC5(display_short)|uniprotkb:TLP46(gene name synonym)|uniprotkb:Thioredoxin-like protein p46(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 46(gene name synonym)|uniprotkb:UNQ364/PRO700(orf name)	psi-mi:prdx4_human(display_long)|uniprotkb:PRDX4(gene name)|psi-mi:PRDX4(display_short)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Tavender et al. (2010)	pubmed:21057456|imex:IM-15309|mint:MINT-8090267|doi:10.1038/emboj.2010.273	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8501865|mint:MINT-8090993|imex:IM-15309-4	-	-	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000239264(gene)|ensembl:ENST00000379757(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|rcsb pdb:2DIZ|rcsb pdb:3UJ1|rcsb pdb:3UVT|rcsb pdb:3WGD|rcsb pdb:3WGE|rcsb pdb:3WGX|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6798695|refseq:NP_001139021.1|refseq:NP_110437.2|dip:DIP-53700N|mint:MINT-8090997(identity)	refseq:NP_006397.1|ensembl:ENSG00000123131(gene)|ensembl:ENST00000379341(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:Q13162|rcsb pdb:2PN8|rcsb pdb:3TJB|rcsb pdb:3TJF|rcsb pdb:3TJG|rcsb pdb:3TJJ|rcsb pdb:3TJK|rcsb pdb:3TKP|rcsb pdb:3TKQ|rcsb pdb:3TKR|rcsb pdb:3TKS|rcsb pdb:4RQX|rcsb pdb:5HQP|reactome:R-HSA-6798695|mint:MINT-8090995(identity)	-	-	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/07	2014/10/16	rogid:bz5VVWMPFLTRKwph60UFASjsFN49606	rogid:5KWl3YuUpRDrSUxWlJS6sP7CLAs9606	intact-crc:662806FD6BF07038|rigid:dLgrZi3qGeWZsY3HGhyBXL5JbPw	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q13162	uniprotkb:Q15084	intact:EBI-2211957|uniprotkb:Q6FHT3|ensembl:ENSP00000368646	intact:EBI-1043087|uniprotkb:Q6ZSH5|ensembl:ENSP00000272227|uniprotkb:B3KY95|uniprotkb:B5MCQ5|uniprotkb:B7Z4M8|uniprotkb:F8WA83|uniprotkb:B7Z254|uniprotkb:Q99778|uniprotkb:Q53RC7	psi-mi:prdx4_human(display_long)|uniprotkb:PRDX4(gene name)|psi-mi:PRDX4(display_short)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym)	psi-mi:pdia6_human(display_long)|uniprotkb:PDIA6(gene name)|psi-mi:PDIA6(display_short)|uniprotkb:TXNDC7(gene name synonym)|uniprotkb:Protein disulfide isomerase P5(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 7(gene name synonym)|uniprotkb:ERP5(gene name synonym)|uniprotkb:P5(gene name synonym)|uniprotkb:Endoplasmic reticulum protein 5(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Tavender et al. (2010)	pubmed:21057456|imex:IM-15309|mint:MINT-8090267|doi:10.1038/emboj.2010.273	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8501913|mint:MINT-8091095|imex:IM-15309-8	-	-	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006397.1|ensembl:ENSG00000123131(gene)|ensembl:ENST00000379341(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:Q13162|rcsb pdb:2PN8|rcsb pdb:3TJB|rcsb pdb:3TJF|rcsb pdb:3TJG|rcsb pdb:3TJJ|rcsb pdb:3TJK|rcsb pdb:3TKP|rcsb pdb:3TKQ|rcsb pdb:3TKR|rcsb pdb:3TKS|rcsb pdb:4RQX|rcsb pdb:5HQP|reactome:R-HSA-6798695|mint:MINT-8091097(identity)	refseq:NP_001269633.1|refseq:NP_001269634.1|refseq:NP_001269635.1|refseq:NP_001269636.1|interpro:IPR036249|interpro:IPR044569|mint:Q15084|rcsb pdb:1X5D|rcsb pdb:3VWW|rcsb pdb:3W8J|rcsb pdb:4EF0|rcsb pdb:4GWR|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-8957275|interpro:IPR017937|ensembl:ENSG00000143870(gene)|ensembl:ENST00000272227(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042470"(melanosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005733.1|mint:MINT-8091099(identity)	-	-	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/07	2014/10/16	rogid:5KWl3YuUpRDrSUxWlJS6sP7CLAs9606	rogid:411bo7TdfeCtMvUqyBb7bofi5To9606	intact-crc:BF50F864B68ADC31|rigid:lk6UDtKQ5fDPj+uzcKVwK3RBXm8	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P07237	uniprotkb:Q13162	intact:EBI-395883|uniprotkb:P30037|uniprotkb:P32079|uniprotkb:Q15205|uniprotkb:Q6LDE5|uniprotkb:B2RDQ2|ensembl:ENSP00000327801	intact:EBI-2211957|uniprotkb:Q6FHT3|ensembl:ENSP00000368646	psi-mi:pdia1_human(display_long)|uniprotkb:P4HB(gene name)|psi-mi:P4HB(display_short)|uniprotkb:PDI(gene name synonym)|uniprotkb:PDIA1(gene name synonym)|uniprotkb:PO4DB(gene name synonym)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:ERBA2L(gene name synonym)	psi-mi:prdx4_human(display_long)|uniprotkb:PRDX4(gene name)|psi-mi:PRDX4(display_short)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Tavender et al. (2010)	pubmed:21057456|imex:IM-15309|mint:MINT-8090267|doi:10.1038/emboj.2010.273	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8501889|mint:MINT-8091054|imex:IM-15309-6	-	-	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000909.2|ensembl:ENSG00000185624(gene)|ensembl:ENST00000331483(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042470"(melanosome)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P07237|rcsb pdb:1BJX|rcsb pdb:1MEK|rcsb pdb:1X5C|rcsb pdb:2BJX|rcsb pdb:2K18|rcsb pdb:3BJ5|rcsb pdb:3UEM|rcsb pdb:4EKZ|rcsb pdb:4EL1|rcsb pdb:4JU5|rcsb pdb:6I7S|reactome:R-HSA-1650814|reactome:R-HSA-3299685|reactome:R-HSA-381426|reactome:R-HSA-5358346|reactome:R-HSA-8866423|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-32979N|mint:MINT-8091058(identity)	refseq:NP_006397.1|ensembl:ENSG00000123131(gene)|ensembl:ENST00000379341(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:Q13162|rcsb pdb:2PN8|rcsb pdb:3TJB|rcsb pdb:3TJF|rcsb pdb:3TJG|rcsb pdb:3TJJ|rcsb pdb:3TJK|rcsb pdb:3TKP|rcsb pdb:3TKQ|rcsb pdb:3TKR|rcsb pdb:3TKS|rcsb pdb:4RQX|rcsb pdb:5HQP|reactome:R-HSA-6798695|mint:MINT-8091056(identity)	-	-	-	figure legend:f2c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/07	2014/10/16	rogid:rh0B38TSfTX+lvU5OyBwEbVndFA9606	rogid:5KWl3YuUpRDrSUxWlJS6sP7CLAs9606	intact-crc:CB5012D8B3097E86|rigid:xgO0ReyQzwU42D9kz7BnQ+SXAXI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13162	uniprotkb:Q15084	intact:EBI-2211957|uniprotkb:Q6FHT3|ensembl:ENSP00000368646	intact:EBI-1043087|uniprotkb:Q6ZSH5|ensembl:ENSP00000272227|uniprotkb:B3KY95|uniprotkb:B5MCQ5|uniprotkb:B7Z4M8|uniprotkb:F8WA83|uniprotkb:B7Z254|uniprotkb:Q99778|uniprotkb:Q53RC7	psi-mi:prdx4_human(display_long)|uniprotkb:PRDX4(gene name)|psi-mi:PRDX4(display_short)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym)	psi-mi:pdia6_human(display_long)|uniprotkb:PDIA6(gene name)|psi-mi:PDIA6(display_short)|uniprotkb:TXNDC7(gene name synonym)|uniprotkb:Protein disulfide isomerase P5(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 7(gene name synonym)|uniprotkb:ERP5(gene name synonym)|uniprotkb:P5(gene name synonym)|uniprotkb:Endoplasmic reticulum protein 5(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Tavender et al. (2010)	pubmed:21057456|imex:IM-15309|mint:MINT-8090267|doi:10.1038/emboj.2010.273	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8501901|mint:MINT-8091076|imex:IM-15309-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006397.1|ensembl:ENSG00000123131(gene)|ensembl:ENST00000379341(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:Q13162|rcsb pdb:2PN8|rcsb pdb:3TJB|rcsb pdb:3TJF|rcsb pdb:3TJG|rcsb pdb:3TJJ|rcsb pdb:3TJK|rcsb pdb:3TKP|rcsb pdb:3TKQ|rcsb pdb:3TKR|rcsb pdb:3TKS|rcsb pdb:4RQX|rcsb pdb:5HQP|reactome:R-HSA-6798695|mint:MINT-8091080(identity)	refseq:NP_001269633.1|refseq:NP_001269634.1|refseq:NP_001269635.1|refseq:NP_001269636.1|interpro:IPR036249|interpro:IPR044569|mint:Q15084|rcsb pdb:1X5D|rcsb pdb:3VWW|rcsb pdb:3W8J|rcsb pdb:4EF0|rcsb pdb:4GWR|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-8957275|interpro:IPR017937|ensembl:ENSG00000143870(gene)|ensembl:ENST00000272227(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042470"(melanosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005733.1|mint:MINT-8091078(identity)	-	-	-	figure legend:f2c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/07	2014/10/16	rogid:5KWl3YuUpRDrSUxWlJS6sP7CLAs9606	rogid:411bo7TdfeCtMvUqyBb7bofi5To9606	intact-crc:8C5431D8CB8B11AA|rigid:lk6UDtKQ5fDPj+uzcKVwK3RBXm8	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0113"(western blot)