#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10147	uniprotkb:P10147	intact:EBI-8459634|intact:MINT-103148|ensembl:ENSP00000477908|ensembl:ENSP00000480753|ensembl:ENSP00000483712	intact:EBI-8459634|intact:MINT-103148|ensembl:ENSP00000477908|ensembl:ENSP00000480753|ensembl:ENSP00000483712	psi-mi:ccl3_human(display_long)|uniprotkb:CCL3(gene name)|psi-mi:CCL3(display_short)|uniprotkb:G0S19-1(gene name synonym)|uniprotkb:MIP1A(gene name synonym)|uniprotkb:SCYA3(gene name synonym)|uniprotkb:Small-inducible cytokine A3(gene name synonym)|uniprotkb:SIS-beta(gene name synonym)|uniprotkb:PAT 464.1(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-alpha(gene name synonym)|uniprotkb:Tonsillar lymphocyte LD78 alpha protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 19-1(gene name synonym)	psi-mi:ccl3_human(display_long)|uniprotkb:CCL3(gene name)|psi-mi:CCL3(display_short)|uniprotkb:G0S19-1(gene name synonym)|uniprotkb:MIP1A(gene name synonym)|uniprotkb:SCYA3(gene name synonym)|uniprotkb:Small-inducible cytokine A3(gene name synonym)|uniprotkb:SIS-beta(gene name synonym)|uniprotkb:PAT 464.1(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-alpha(gene name synonym)|uniprotkb:Tonsillar lymphocyte LD78 alpha protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 19-1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Ren et al. (2010)	pubmed:20959807|imex:IM-15343|mint:MINT-8087523|doi:10.1038/emboj.2010.256	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8459628|mint:MINT-8087537|imex:IM-15343-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002974.1|dip:DIP-5837N|ensembl:ENSG00000274221(gene)|ensembl:ENSG00000277632(gene)|ensembl:ENSG00000278567(gene)|ensembl:ENST00000613396(transcript)|ensembl:ENST00000613922(transcript)|ensembl:ENST00000616221(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001775"(cell activation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016301"(kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0023052"(signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1B50|rcsb pdb:1B53|rcsb pdb:2X69|rcsb pdb:2X6G|rcsb pdb:3FPU|rcsb pdb:3H44|rcsb pdb:3KBX|rcsb pdb:4RA8|rcsb pdb:4ZKB|rcsb pdb:5COR|rcsb pdb:5D65|reactome:R-HSA-380108|reactome:R-HSA-6783783|mint:MINT-8087539(identity)	refseq:NP_002974.1|dip:DIP-5837N|ensembl:ENSG00000274221(gene)|ensembl:ENSG00000277632(gene)|ensembl:ENSG00000278567(gene)|ensembl:ENST00000613396(transcript)|ensembl:ENST00000613922(transcript)|ensembl:ENST00000616221(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001775"(cell activation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016301"(kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0023052"(signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1B50|rcsb pdb:1B53|rcsb pdb:2X69|rcsb pdb:2X6G|rcsb pdb:3FPU|rcsb pdb:3H44|rcsb pdb:3KBX|rcsb pdb:4RA8|rcsb pdb:4ZKB|rcsb pdb:5COR|rcsb pdb:5D65|reactome:R-HSA-380108|reactome:R-HSA-6783783|mint:MINT-8087539(identity)	-	comment:mint|function:"Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)"|comment:"Stoichiometry: 2.0"	comment:mint|function:"Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)"|comment:"Stoichiometry: 2.0"	comment:mint|figure legend:t1 f1a f1b f1c f1d f1e f1f f1g f2 sf4 st1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/27	2014/10/16	rogid:s/DqXkYebldCLlYoiA+fS1nI8TA9606	rogid:s/DqXkYebldCLlYoiA+fS1nI8TA9606	intact-crc:87AE0C1AEE904661|rigid:t9JfCvxTOq0LzJ/tYTkTvR9UUag	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10147	uniprotkb:P14735	intact:EBI-8459634|intact:MINT-103148|ensembl:ENSP00000477908|ensembl:ENSP00000480753|ensembl:ENSP00000483712	intact:EBI-2556886|uniprotkb:Q5T5N2|uniprotkb:D3DR35|ensembl:ENSP00000265986|uniprotkb:B2R721|uniprotkb:B7ZAU2	psi-mi:ccl3_human(display_long)|uniprotkb:CCL3(gene name)|psi-mi:CCL3(display_short)|uniprotkb:G0S19-1(gene name synonym)|uniprotkb:MIP1A(gene name synonym)|uniprotkb:SCYA3(gene name synonym)|uniprotkb:Small-inducible cytokine A3(gene name synonym)|uniprotkb:SIS-beta(gene name synonym)|uniprotkb:PAT 464.1(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-alpha(gene name synonym)|uniprotkb:Tonsillar lymphocyte LD78 alpha protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 19-1(gene name synonym)	psi-mi:ide_human(display_long)|uniprotkb:IDE(gene name)|psi-mi:IDE(display_short)|uniprotkb:Insulin protease(gene name synonym)|uniprotkb:Insulysin(gene name synonym)|uniprotkb:Abeta-degrading protease(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Ren et al. (2010)	pubmed:20959807|imex:IM-15343|mint:MINT-8087523|doi:10.1038/emboj.2010.256	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8459741|mint:MINT-8087747|imex:IM-15343-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002974.1|dip:DIP-5837N|ensembl:ENSG00000274221(gene)|ensembl:ENSG00000277632(gene)|ensembl:ENSG00000278567(gene)|ensembl:ENST00000613396(transcript)|ensembl:ENST00000613922(transcript)|ensembl:ENST00000616221(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001775"(cell activation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016301"(kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0023052"(signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1B50|rcsb pdb:1B53|rcsb pdb:2X69|rcsb pdb:2X6G|rcsb pdb:3FPU|rcsb pdb:3H44|rcsb pdb:3KBX|rcsb pdb:4RA8|rcsb pdb:4ZKB|rcsb pdb:5COR|rcsb pdb:5D65|reactome:R-HSA-380108|reactome:R-HSA-6783783|mint:MINT-8087750(identity)	refseq:NP_004960.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010815"(bradykinin catabolic process)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0031626"(beta-endorphin binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042447"(hormone catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000119912(gene)|ensembl:ENST00000265986(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0043559"(insulin binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR032632|mint:P14735|rcsb pdb:2G47|rcsb pdb:2G48|rcsb pdb:2G49|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2JBU|rcsb pdb:2JG4|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WK3|rcsb pdb:2YPU|rcsb pdb:3CWW|rcsb pdb:3E4A|rcsb pdb:3E4Z|rcsb pdb:3E50|rcsb pdb:3H44|rcsb pdb:3N56|rcsb pdb:3N57|rcsb pdb:3OFI|rcsb pdb:3QZ2|rcsb pdb:4DTT|rcsb pdb:4DWK|rcsb pdb:4GS8|rcsb pdb:4GSC|rcsb pdb:4GSF|rcsb pdb:4IFH|rcsb pdb:4IOF|rcsb pdb:4LTE|rcsb pdb:4M1C|rcsb pdb:4NXO|rcsb pdb:4PES|rcsb pdb:4PF7|rcsb pdb:4PF9|rcsb pdb:4PFC|rcsb pdb:4QIA|rcsb pdb:4RAL|rcsb pdb:4RE9|rcsb pdb:5CJO|rcsb pdb:3HGZ|rcsb pdb:5UOE|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6B7Y|rcsb pdb:6BF6|rcsb pdb:6BF7|rcsb pdb:6BF8|rcsb pdb:6BF9|rcsb pdb:6BFC|rcsb pdb:6BYZ|rcsb pdb:6EDS|rcsb pdb:6MQ3|reactome:R-HSA-5689880|reactome:R-HSA-9033241|rcsb pdb:6B7Z|refseq:NP_001159418.1|dip:DIP-55771N|mint:MINT-8087752(identity)	-	comment:mint|function:"Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)"	-	comment:homomint|comment:mint|figure legend:f7a f7b f7c f7d t1 sf2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/27	2014/10/16	rogid:s/DqXkYebldCLlYoiA+fS1nI8TA9606	rogid:dwngN3kUOExC5qapSgF01YhBNAM9606	intact-crc:8D1F423476DFFAA5|rigid:pKNB7JJKeB05w5NMc+lrWWlfQrw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13236	uniprotkb:P13236	intact:EBI-2873970|ensembl:ENSP00000480345|ensembl:ENSP00000482259|ensembl:ENSP00000478708|uniprotkb:P22617|uniprotkb:Q6FGI8|uniprotkb:Q3SXL8|uniprotkb:Q13704	intact:EBI-2873970|ensembl:ENSP00000480345|ensembl:ENSP00000482259|ensembl:ENSP00000478708|uniprotkb:P22617|uniprotkb:Q6FGI8|uniprotkb:Q3SXL8|uniprotkb:Q13704	psi-mi:ccl4_human(display_long)|uniprotkb:CCL4(gene name)|psi-mi:CCL4(display_short)|uniprotkb:LAG1(gene name synonym)|uniprotkb:MIP1B(gene name synonym)|uniprotkb:SCYA4(gene name synonym)|uniprotkb:G-26 T-lymphocyte-secreted protein(gene name synonym)|uniprotkb:HC21(gene name synonym)|uniprotkb:Lymphocyte activation gene 1 protein(gene name synonym)|uniprotkb:"MIP-1-beta(1-69)"(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-beta(gene name synonym)|uniprotkb:PAT 744(gene name synonym)|uniprotkb:Protein H400(gene name synonym)|uniprotkb:SIS-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine A4(gene name synonym)|uniprotkb:T-cell activation protein 2(gene name synonym)	psi-mi:ccl4_human(display_long)|uniprotkb:CCL4(gene name)|psi-mi:CCL4(display_short)|uniprotkb:LAG1(gene name synonym)|uniprotkb:MIP1B(gene name synonym)|uniprotkb:SCYA4(gene name synonym)|uniprotkb:G-26 T-lymphocyte-secreted protein(gene name synonym)|uniprotkb:HC21(gene name synonym)|uniprotkb:Lymphocyte activation gene 1 protein(gene name synonym)|uniprotkb:"MIP-1-beta(1-69)"(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-beta(gene name synonym)|uniprotkb:PAT 744(gene name synonym)|uniprotkb:Protein H400(gene name synonym)|uniprotkb:SIS-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine A4(gene name synonym)|uniprotkb:T-cell activation protein 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Ren et al. (2010)	pubmed:20959807|imex:IM-15343|mint:MINT-8087523|doi:10.1038/emboj.2010.256	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8459714|mint:MINT-8087548|imex:IM-15343-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000615863(transcript)|ensembl:ENST00000617322(transcript)|ensembl:ENST00000621600(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000275302(gene)|ensembl:ENSG00000275824(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|ensembl:ENSG00000277943(gene)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1HUM|rcsb pdb:1HUN|rcsb pdb:1JE4|rcsb pdb:2FFK|rcsb pdb:2FIN|rcsb pdb:2X6L|rcsb pdb:3TN2|rcsb pdb:4RAL|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|go:"GO:0043547"(positive regulation of GTPase activity)|refseq:NP_002975.1|refseq:NP_996890.1|dip:DIP-5840N|mint:MINT-8087550(identity)	ensembl:ENST00000615863(transcript)|ensembl:ENST00000617322(transcript)|ensembl:ENST00000621600(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000275302(gene)|ensembl:ENSG00000275824(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|ensembl:ENSG00000277943(gene)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1HUM|rcsb pdb:1HUN|rcsb pdb:1JE4|rcsb pdb:2FFK|rcsb pdb:2FIN|rcsb pdb:2X6L|rcsb pdb:3TN2|rcsb pdb:4RAL|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|go:"GO:0043547"(positive regulation of GTPase activity)|refseq:NP_002975.1|refseq:NP_996890.1|dip:DIP-5840N|mint:MINT-8087550(identity)	-	comment:"Stoichiometry: 2.0"	comment:"Stoichiometry: 2.0"	comment:mint|figure legend:t1 f1c f1d f1e f1f f1g sf4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/27	2014/10/16	rogid:EfoA+ek4mVlaReV80wgU824brpw9606	rogid:EfoA+ek4mVlaReV80wgU824brpw9606	intact-crc:89BCFAC62EB70524|rigid:7zgdZWbRn/nDEevhe/BeDRteDn4	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10147	uniprotkb:P10147	intact:EBI-8459634|intact:MINT-103148|ensembl:ENSP00000477908|ensembl:ENSP00000480753|ensembl:ENSP00000483712	intact:EBI-8459634|intact:MINT-103148|ensembl:ENSP00000477908|ensembl:ENSP00000480753|ensembl:ENSP00000483712	psi-mi:ccl3_human(display_long)|uniprotkb:CCL3(gene name)|psi-mi:CCL3(display_short)|uniprotkb:G0S19-1(gene name synonym)|uniprotkb:MIP1A(gene name synonym)|uniprotkb:SCYA3(gene name synonym)|uniprotkb:Small-inducible cytokine A3(gene name synonym)|uniprotkb:SIS-beta(gene name synonym)|uniprotkb:PAT 464.1(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-alpha(gene name synonym)|uniprotkb:Tonsillar lymphocyte LD78 alpha protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 19-1(gene name synonym)	psi-mi:ccl3_human(display_long)|uniprotkb:CCL3(gene name)|psi-mi:CCL3(display_short)|uniprotkb:G0S19-1(gene name synonym)|uniprotkb:MIP1A(gene name synonym)|uniprotkb:SCYA3(gene name synonym)|uniprotkb:Small-inducible cytokine A3(gene name synonym)|uniprotkb:SIS-beta(gene name synonym)|uniprotkb:PAT 464.1(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-alpha(gene name synonym)|uniprotkb:Tonsillar lymphocyte LD78 alpha protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 19-1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Ren et al. (2010)	pubmed:20959807|imex:IM-15343|mint:MINT-8087523|doi:10.1038/emboj.2010.256	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8459762|mint:MINT-8087563|imex:IM-15343-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002974.1|dip:DIP-5837N|ensembl:ENSG00000274221(gene)|ensembl:ENSG00000277632(gene)|ensembl:ENSG00000278567(gene)|ensembl:ENST00000613396(transcript)|ensembl:ENST00000613922(transcript)|ensembl:ENST00000616221(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001775"(cell activation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016301"(kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0023052"(signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1B50|rcsb pdb:1B53|rcsb pdb:2X69|rcsb pdb:2X6G|rcsb pdb:3FPU|rcsb pdb:3H44|rcsb pdb:3KBX|rcsb pdb:4RA8|rcsb pdb:4ZKB|rcsb pdb:5COR|rcsb pdb:5D65|reactome:R-HSA-380108|reactome:R-HSA-6783783|mint:MINT-8087565(identity)	refseq:NP_002974.1|dip:DIP-5837N|ensembl:ENSG00000274221(gene)|ensembl:ENSG00000277632(gene)|ensembl:ENSG00000278567(gene)|ensembl:ENST00000613396(transcript)|ensembl:ENST00000613922(transcript)|ensembl:ENST00000616221(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001775"(cell activation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016301"(kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0023052"(signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1B50|rcsb pdb:1B53|rcsb pdb:2X69|rcsb pdb:2X6G|rcsb pdb:3FPU|rcsb pdb:3H44|rcsb pdb:3KBX|rcsb pdb:4RA8|rcsb pdb:4ZKB|rcsb pdb:5COR|rcsb pdb:5D65|reactome:R-HSA-380108|reactome:R-HSA-6783783|mint:MINT-8087565(identity)	-	comment:mint|function:"Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)"|comment:"Stoichiometry: 2.0"	comment:mint|function:"Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)"|comment:"Stoichiometry: 2.0"	comment:mint|figure legend:f3a sf7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/27	2014/10/16	rogid:s/DqXkYebldCLlYoiA+fS1nI8TA9606	rogid:s/DqXkYebldCLlYoiA+fS1nI8TA9606	intact-crc:D57DE8E3527B608E|rigid:t9JfCvxTOq0LzJ/tYTkTvR9UUag	false	mutation decreasing interaction:27-27(MINT-8142402)	mutation decreasing interaction:27-27(MINT-8142402)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13236	uniprotkb:P13236	intact:EBI-2873970|ensembl:ENSP00000480345|ensembl:ENSP00000482259|ensembl:ENSP00000478708|uniprotkb:P22617|uniprotkb:Q6FGI8|uniprotkb:Q3SXL8|uniprotkb:Q13704	intact:EBI-2873970|ensembl:ENSP00000480345|ensembl:ENSP00000482259|ensembl:ENSP00000478708|uniprotkb:P22617|uniprotkb:Q6FGI8|uniprotkb:Q3SXL8|uniprotkb:Q13704	psi-mi:ccl4_human(display_long)|uniprotkb:CCL4(gene name)|psi-mi:CCL4(display_short)|uniprotkb:LAG1(gene name synonym)|uniprotkb:MIP1B(gene name synonym)|uniprotkb:SCYA4(gene name synonym)|uniprotkb:G-26 T-lymphocyte-secreted protein(gene name synonym)|uniprotkb:HC21(gene name synonym)|uniprotkb:Lymphocyte activation gene 1 protein(gene name synonym)|uniprotkb:"MIP-1-beta(1-69)"(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-beta(gene name synonym)|uniprotkb:PAT 744(gene name synonym)|uniprotkb:Protein H400(gene name synonym)|uniprotkb:SIS-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine A4(gene name synonym)|uniprotkb:T-cell activation protein 2(gene name synonym)	psi-mi:ccl4_human(display_long)|uniprotkb:CCL4(gene name)|psi-mi:CCL4(display_short)|uniprotkb:LAG1(gene name synonym)|uniprotkb:MIP1B(gene name synonym)|uniprotkb:SCYA4(gene name synonym)|uniprotkb:G-26 T-lymphocyte-secreted protein(gene name synonym)|uniprotkb:HC21(gene name synonym)|uniprotkb:Lymphocyte activation gene 1 protein(gene name synonym)|uniprotkb:"MIP-1-beta(1-69)"(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-beta(gene name synonym)|uniprotkb:PAT 744(gene name synonym)|uniprotkb:Protein H400(gene name synonym)|uniprotkb:SIS-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine A4(gene name synonym)|uniprotkb:T-cell activation protein 2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Ren et al. (2010)	pubmed:20959807|imex:IM-15343|mint:MINT-8087523|doi:10.1038/emboj.2010.256	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8459776|mint:MINT-8087568|imex:IM-15343-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000615863(transcript)|ensembl:ENST00000617322(transcript)|ensembl:ENST00000621600(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000275302(gene)|ensembl:ENSG00000275824(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|ensembl:ENSG00000277943(gene)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1HUM|rcsb pdb:1HUN|rcsb pdb:1JE4|rcsb pdb:2FFK|rcsb pdb:2FIN|rcsb pdb:2X6L|rcsb pdb:3TN2|rcsb pdb:4RAL|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|go:"GO:0043547"(positive regulation of GTPase activity)|refseq:NP_002975.1|refseq:NP_996890.1|dip:DIP-5840N|mint:MINT-8087570(identity)	ensembl:ENST00000615863(transcript)|ensembl:ENST00000617322(transcript)|ensembl:ENST00000621600(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000275302(gene)|ensembl:ENSG00000275824(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|ensembl:ENSG00000277943(gene)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1HUM|rcsb pdb:1HUN|rcsb pdb:1JE4|rcsb pdb:2FFK|rcsb pdb:2FIN|rcsb pdb:2X6L|rcsb pdb:3TN2|rcsb pdb:4RAL|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|go:"GO:0043547"(positive regulation of GTPase activity)|refseq:NP_002975.1|refseq:NP_996890.1|dip:DIP-5840N|mint:MINT-8087570(identity)	-	comment:"Stoichiometry: 2.0"	comment:"Stoichiometry: 2.0"	comment:mint|figure legend:f3a sf7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/27	2014/10/16	rogid:EfoA+ek4mVlaReV80wgU824brpw9606	rogid:EfoA+ek4mVlaReV80wgU824brpw9606	intact-crc:80BDC1E847E7BE85|rigid:7zgdZWbRn/nDEevhe/BeDRteDn4	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13236	uniprotkb:P13236	intact:EBI-2873970|ensembl:ENSP00000480345|ensembl:ENSP00000482259|ensembl:ENSP00000478708|uniprotkb:P22617|uniprotkb:Q6FGI8|uniprotkb:Q3SXL8|uniprotkb:Q13704	intact:EBI-2873970|ensembl:ENSP00000480345|ensembl:ENSP00000482259|ensembl:ENSP00000478708|uniprotkb:P22617|uniprotkb:Q6FGI8|uniprotkb:Q3SXL8|uniprotkb:Q13704	psi-mi:ccl4_human(display_long)|uniprotkb:CCL4(gene name)|psi-mi:CCL4(display_short)|uniprotkb:LAG1(gene name synonym)|uniprotkb:MIP1B(gene name synonym)|uniprotkb:SCYA4(gene name synonym)|uniprotkb:G-26 T-lymphocyte-secreted protein(gene name synonym)|uniprotkb:HC21(gene name synonym)|uniprotkb:Lymphocyte activation gene 1 protein(gene name synonym)|uniprotkb:"MIP-1-beta(1-69)"(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-beta(gene name synonym)|uniprotkb:PAT 744(gene name synonym)|uniprotkb:Protein H400(gene name synonym)|uniprotkb:SIS-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine A4(gene name synonym)|uniprotkb:T-cell activation protein 2(gene name synonym)	psi-mi:ccl4_human(display_long)|uniprotkb:CCL4(gene name)|psi-mi:CCL4(display_short)|uniprotkb:LAG1(gene name synonym)|uniprotkb:MIP1B(gene name synonym)|uniprotkb:SCYA4(gene name synonym)|uniprotkb:G-26 T-lymphocyte-secreted protein(gene name synonym)|uniprotkb:HC21(gene name synonym)|uniprotkb:Lymphocyte activation gene 1 protein(gene name synonym)|uniprotkb:"MIP-1-beta(1-69)"(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-beta(gene name synonym)|uniprotkb:PAT 744(gene name synonym)|uniprotkb:Protein H400(gene name synonym)|uniprotkb:SIS-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine A4(gene name synonym)|uniprotkb:T-cell activation protein 2(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Ren et al. (2010)	pubmed:20959807|imex:IM-15343|mint:MINT-8087523|doi:10.1038/emboj.2010.256	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8459795|mint:MINT-8087579|imex:IM-15343-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000615863(transcript)|ensembl:ENST00000617322(transcript)|ensembl:ENST00000621600(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000275302(gene)|ensembl:ENSG00000275824(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|ensembl:ENSG00000277943(gene)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1HUM|rcsb pdb:1HUN|rcsb pdb:1JE4|rcsb pdb:2FFK|rcsb pdb:2FIN|rcsb pdb:2X6L|rcsb pdb:3TN2|rcsb pdb:4RAL|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|go:"GO:0043547"(positive regulation of GTPase activity)|refseq:NP_002975.1|refseq:NP_996890.1|dip:DIP-5840N|mint:MINT-8087581(identity)	ensembl:ENST00000615863(transcript)|ensembl:ENST00000617322(transcript)|ensembl:ENST00000621600(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000275302(gene)|ensembl:ENSG00000275824(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|ensembl:ENSG00000277943(gene)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1HUM|rcsb pdb:1HUN|rcsb pdb:1JE4|rcsb pdb:2FFK|rcsb pdb:2FIN|rcsb pdb:2X6L|rcsb pdb:3TN2|rcsb pdb:4RAL|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|go:"GO:0043547"(positive regulation of GTPase activity)|refseq:NP_002975.1|refseq:NP_996890.1|dip:DIP-5840N|mint:MINT-8087581(identity)	-	comment:"Stoichiometry: 2.0"	comment:"Stoichiometry: 2.0"	comment:mint|figure legend:f3b sf6 st2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/27	2014/10/16	rogid:EfoA+ek4mVlaReV80wgU824brpw9606	rogid:EfoA+ek4mVlaReV80wgU824brpw9606	intact-crc:8EB7256A5B30A59E|rigid:7zgdZWbRn/nDEevhe/BeDRteDn4	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10147	uniprotkb:P10147	intact:EBI-8459634|intact:MINT-103148|ensembl:ENSP00000477908|ensembl:ENSP00000480753|ensembl:ENSP00000483712	intact:EBI-8459634|intact:MINT-103148|ensembl:ENSP00000477908|ensembl:ENSP00000480753|ensembl:ENSP00000483712	psi-mi:ccl3_human(display_long)|uniprotkb:CCL3(gene name)|psi-mi:CCL3(display_short)|uniprotkb:G0S19-1(gene name synonym)|uniprotkb:MIP1A(gene name synonym)|uniprotkb:SCYA3(gene name synonym)|uniprotkb:Small-inducible cytokine A3(gene name synonym)|uniprotkb:SIS-beta(gene name synonym)|uniprotkb:PAT 464.1(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-alpha(gene name synonym)|uniprotkb:Tonsillar lymphocyte LD78 alpha protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 19-1(gene name synonym)	psi-mi:ccl3_human(display_long)|uniprotkb:CCL3(gene name)|psi-mi:CCL3(display_short)|uniprotkb:G0S19-1(gene name synonym)|uniprotkb:MIP1A(gene name synonym)|uniprotkb:SCYA3(gene name synonym)|uniprotkb:Small-inducible cytokine A3(gene name synonym)|uniprotkb:SIS-beta(gene name synonym)|uniprotkb:PAT 464.1(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-alpha(gene name synonym)|uniprotkb:Tonsillar lymphocyte LD78 alpha protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 19-1(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Ren et al. (2010)	pubmed:20959807|imex:IM-15343|mint:MINT-8087523|doi:10.1038/emboj.2010.256	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8459822|mint:MINT-8087584|imex:IM-15343-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002974.1|dip:DIP-5837N|ensembl:ENSG00000274221(gene)|ensembl:ENSG00000277632(gene)|ensembl:ENSG00000278567(gene)|ensembl:ENST00000613396(transcript)|ensembl:ENST00000613922(transcript)|ensembl:ENST00000616221(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001775"(cell activation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016301"(kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0023052"(signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1B50|rcsb pdb:1B53|rcsb pdb:2X69|rcsb pdb:2X6G|rcsb pdb:3FPU|rcsb pdb:3H44|rcsb pdb:3KBX|rcsb pdb:4RA8|rcsb pdb:4ZKB|rcsb pdb:5COR|rcsb pdb:5D65|reactome:R-HSA-380108|reactome:R-HSA-6783783|mint:MINT-8087586(identity)	refseq:NP_002974.1|dip:DIP-5837N|ensembl:ENSG00000274221(gene)|ensembl:ENSG00000277632(gene)|ensembl:ENSG00000278567(gene)|ensembl:ENST00000613396(transcript)|ensembl:ENST00000613922(transcript)|ensembl:ENST00000616221(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001775"(cell activation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016301"(kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0023052"(signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1B50|rcsb pdb:1B53|rcsb pdb:2X69|rcsb pdb:2X6G|rcsb pdb:3FPU|rcsb pdb:3H44|rcsb pdb:3KBX|rcsb pdb:4RA8|rcsb pdb:4ZKB|rcsb pdb:5COR|rcsb pdb:5D65|reactome:R-HSA-380108|reactome:R-HSA-6783783|mint:MINT-8087586(identity)	-	comment:mint|function:"Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)"|comment:"Stoichiometry: 2.0"	comment:mint|function:"Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)"|comment:"Stoichiometry: 2.0"	comment:mint|figure legend:f3b sf6 st2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/27	2014/10/16	rogid:s/DqXkYebldCLlYoiA+fS1nI8TA9606	rogid:s/DqXkYebldCLlYoiA+fS1nI8TA9606	intact-crc:715B62CDE9A8BDD3|rigid:t9JfCvxTOq0LzJ/tYTkTvR9UUag	false	mutation decreasing interaction:27-27(MINT-8142411)	mutation decreasing interaction:27-27(MINT-8142411)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10147	uniprotkb:P14735	intact:EBI-8459634|intact:MINT-103148|ensembl:ENSP00000477908|ensembl:ENSP00000480753|ensembl:ENSP00000483712	intact:EBI-2556886|uniprotkb:Q5T5N2|uniprotkb:D3DR35|ensembl:ENSP00000265986|uniprotkb:B2R721|uniprotkb:B7ZAU2	psi-mi:ccl3_human(display_long)|uniprotkb:CCL3(gene name)|psi-mi:CCL3(display_short)|uniprotkb:G0S19-1(gene name synonym)|uniprotkb:MIP1A(gene name synonym)|uniprotkb:SCYA3(gene name synonym)|uniprotkb:Small-inducible cytokine A3(gene name synonym)|uniprotkb:SIS-beta(gene name synonym)|uniprotkb:PAT 464.1(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-alpha(gene name synonym)|uniprotkb:Tonsillar lymphocyte LD78 alpha protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 19-1(gene name synonym)	psi-mi:ide_human(display_long)|uniprotkb:IDE(gene name)|psi-mi:IDE(display_short)|uniprotkb:Insulin protease(gene name synonym)|uniprotkb:Insulysin(gene name synonym)|uniprotkb:Abeta-degrading protease(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Ren et al. (2010)	pubmed:20959807|imex:IM-15343|mint:MINT-8087523|doi:10.1038/emboj.2010.256	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8459846|mint:MINT-8087595|imex:IM-15343-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002974.1|dip:DIP-5837N|ensembl:ENSG00000274221(gene)|ensembl:ENSG00000277632(gene)|ensembl:ENSG00000278567(gene)|ensembl:ENST00000613396(transcript)|ensembl:ENST00000613922(transcript)|ensembl:ENST00000616221(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001775"(cell activation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016301"(kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0023052"(signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1B50|rcsb pdb:1B53|rcsb pdb:2X69|rcsb pdb:2X6G|rcsb pdb:3FPU|rcsb pdb:3H44|rcsb pdb:3KBX|rcsb pdb:4RA8|rcsb pdb:4ZKB|rcsb pdb:5COR|rcsb pdb:5D65|reactome:R-HSA-380108|reactome:R-HSA-6783783|mint:MINT-8087597(identity)	refseq:NP_004960.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010815"(bradykinin catabolic process)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0031626"(beta-endorphin binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042447"(hormone catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000119912(gene)|ensembl:ENST00000265986(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0043559"(insulin binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR032632|mint:P14735|rcsb pdb:2G47|rcsb pdb:2G48|rcsb pdb:2G49|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2JBU|rcsb pdb:2JG4|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WK3|rcsb pdb:2YPU|rcsb pdb:3CWW|rcsb pdb:3E4A|rcsb pdb:3E4Z|rcsb pdb:3E50|rcsb pdb:3H44|rcsb pdb:3N56|rcsb pdb:3N57|rcsb pdb:3OFI|rcsb pdb:3QZ2|rcsb pdb:4DTT|rcsb pdb:4DWK|rcsb pdb:4GS8|rcsb pdb:4GSC|rcsb pdb:4GSF|rcsb pdb:4IFH|rcsb pdb:4IOF|rcsb pdb:4LTE|rcsb pdb:4M1C|rcsb pdb:4NXO|rcsb pdb:4PES|rcsb pdb:4PF7|rcsb pdb:4PF9|rcsb pdb:4PFC|rcsb pdb:4QIA|rcsb pdb:4RAL|rcsb pdb:4RE9|rcsb pdb:5CJO|rcsb pdb:3HGZ|rcsb pdb:5UOE|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6B7Y|rcsb pdb:6BF6|rcsb pdb:6BF7|rcsb pdb:6BF8|rcsb pdb:6BF9|rcsb pdb:6BFC|rcsb pdb:6BYZ|rcsb pdb:6EDS|rcsb pdb:6MQ3|reactome:R-HSA-5689880|reactome:R-HSA-9033241|rcsb pdb:6B7Z|refseq:NP_001159418.1|dip:DIP-55771N|mint:MINT-8087609(identity)	-	comment:mint|function:"Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)"	-	comment:homomint|comment:mint|figure legend:f5b sf10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/27	2014/10/16	rogid:s/DqXkYebldCLlYoiA+fS1nI8TA9606	rogid:dwngN3kUOExC5qapSgF01YhBNAM9606	intact-crc:99FD140878D42664|rigid:pKNB7JJKeB05w5NMc+lrWWlfQrw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14735	uniprotkb:P13236	intact:EBI-2556886|uniprotkb:Q5T5N2|uniprotkb:D3DR35|ensembl:ENSP00000265986|uniprotkb:B2R721|uniprotkb:B7ZAU2	intact:EBI-2873970|ensembl:ENSP00000480345|ensembl:ENSP00000482259|ensembl:ENSP00000478708|uniprotkb:P22617|uniprotkb:Q6FGI8|uniprotkb:Q3SXL8|uniprotkb:Q13704	psi-mi:ide_human(display_long)|uniprotkb:IDE(gene name)|psi-mi:IDE(display_short)|uniprotkb:Insulin protease(gene name synonym)|uniprotkb:Insulysin(gene name synonym)|uniprotkb:Abeta-degrading protease(gene name synonym)	psi-mi:ccl4_human(display_long)|uniprotkb:CCL4(gene name)|psi-mi:CCL4(display_short)|uniprotkb:LAG1(gene name synonym)|uniprotkb:MIP1B(gene name synonym)|uniprotkb:SCYA4(gene name synonym)|uniprotkb:G-26 T-lymphocyte-secreted protein(gene name synonym)|uniprotkb:HC21(gene name synonym)|uniprotkb:Lymphocyte activation gene 1 protein(gene name synonym)|uniprotkb:"MIP-1-beta(1-69)"(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-beta(gene name synonym)|uniprotkb:PAT 744(gene name synonym)|uniprotkb:Protein H400(gene name synonym)|uniprotkb:SIS-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine A4(gene name synonym)|uniprotkb:T-cell activation protein 2(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Ren et al. (2010)	pubmed:20959807|imex:IM-15343|mint:MINT-8087523|doi:10.1038/emboj.2010.256	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8459859|mint:MINT-8087616|imex:IM-15343-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004960.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010815"(bradykinin catabolic process)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0031626"(beta-endorphin binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042447"(hormone catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000119912(gene)|ensembl:ENST00000265986(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0043559"(insulin binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR032632|mint:P14735|rcsb pdb:2G47|rcsb pdb:2G48|rcsb pdb:2G49|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2JBU|rcsb pdb:2JG4|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WK3|rcsb pdb:2YPU|rcsb pdb:3CWW|rcsb pdb:3E4A|rcsb pdb:3E4Z|rcsb pdb:3E50|rcsb pdb:3H44|rcsb pdb:3N56|rcsb pdb:3N57|rcsb pdb:3OFI|rcsb pdb:3QZ2|rcsb pdb:4DTT|rcsb pdb:4DWK|rcsb pdb:4GS8|rcsb pdb:4GSC|rcsb pdb:4GSF|rcsb pdb:4IFH|rcsb pdb:4IOF|rcsb pdb:4LTE|rcsb pdb:4M1C|rcsb pdb:4NXO|rcsb pdb:4PES|rcsb pdb:4PF7|rcsb pdb:4PF9|rcsb pdb:4PFC|rcsb pdb:4QIA|rcsb pdb:4RAL|rcsb pdb:4RE9|rcsb pdb:5CJO|rcsb pdb:3HGZ|rcsb pdb:5UOE|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6B7Y|rcsb pdb:6BF6|rcsb pdb:6BF7|rcsb pdb:6BF8|rcsb pdb:6BF9|rcsb pdb:6BFC|rcsb pdb:6BYZ|rcsb pdb:6EDS|rcsb pdb:6MQ3|reactome:R-HSA-5689880|reactome:R-HSA-9033241|rcsb pdb:6B7Z|refseq:NP_001159418.1|dip:DIP-55771N|mint:MINT-8087618(identity)	ensembl:ENST00000615863(transcript)|ensembl:ENST00000617322(transcript)|ensembl:ENST00000621600(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000275302(gene)|ensembl:ENSG00000275824(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|ensembl:ENSG00000277943(gene)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1HUM|rcsb pdb:1HUN|rcsb pdb:1JE4|rcsb pdb:2FFK|rcsb pdb:2FIN|rcsb pdb:2X6L|rcsb pdb:3TN2|rcsb pdb:4RAL|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|go:"GO:0043547"(positive regulation of GTPase activity)|refseq:NP_002975.1|refseq:NP_996890.1|dip:DIP-5840N|mint:MINT-8087620(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f5b sf10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/27	2014/10/16	rogid:dwngN3kUOExC5qapSgF01YhBNAM9606	rogid:EfoA+ek4mVlaReV80wgU824brpw9606	intact-crc:5CFDC8A045530638|rigid:ilJ6NNb8Q5l2OFRgdV0ZDNJPwbI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P10147	uniprotkb:P14735	intact:EBI-8459634|intact:MINT-103148|ensembl:ENSP00000477908|ensembl:ENSP00000480753|ensembl:ENSP00000483712	intact:EBI-2556886|uniprotkb:Q5T5N2|uniprotkb:D3DR35|ensembl:ENSP00000265986|uniprotkb:B2R721|uniprotkb:B7ZAU2	psi-mi:ccl3_human(display_long)|uniprotkb:CCL3(gene name)|psi-mi:CCL3(display_short)|uniprotkb:G0S19-1(gene name synonym)|uniprotkb:MIP1A(gene name synonym)|uniprotkb:SCYA3(gene name synonym)|uniprotkb:Small-inducible cytokine A3(gene name synonym)|uniprotkb:SIS-beta(gene name synonym)|uniprotkb:PAT 464.1(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-alpha(gene name synonym)|uniprotkb:Tonsillar lymphocyte LD78 alpha protein(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 19-1(gene name synonym)	psi-mi:ide_human(display_long)|uniprotkb:IDE(gene name)|psi-mi:IDE(display_short)|uniprotkb:Insulin protease(gene name synonym)|uniprotkb:Insulysin(gene name synonym)|uniprotkb:Abeta-degrading protease(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Ren et al. (2010)	pubmed:20959807|imex:IM-15343|mint:MINT-8087523|doi:10.1038/emboj.2010.256	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8459881|mint:MINT-8087623|imex:IM-15343-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002974.1|dip:DIP-5837N|ensembl:ENSG00000274221(gene)|ensembl:ENSG00000277632(gene)|ensembl:ENSG00000278567(gene)|ensembl:ENST00000613396(transcript)|ensembl:ENST00000613922(transcript)|ensembl:ENST00000616221(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001775"(cell activation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016301"(kinase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0023052"(signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1B50|rcsb pdb:1B53|rcsb pdb:2X69|rcsb pdb:2X6G|rcsb pdb:3FPU|rcsb pdb:3H44|rcsb pdb:3KBX|rcsb pdb:4RA8|rcsb pdb:4ZKB|rcsb pdb:5COR|rcsb pdb:5D65|reactome:R-HSA-380108|reactome:R-HSA-6783783|mint:MINT-8087627(identity)	refseq:NP_004960.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010815"(bradykinin catabolic process)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0031626"(beta-endorphin binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042447"(hormone catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000119912(gene)|ensembl:ENST00000265986(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0043559"(insulin binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR032632|mint:P14735|rcsb pdb:2G47|rcsb pdb:2G48|rcsb pdb:2G49|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2JBU|rcsb pdb:2JG4|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WK3|rcsb pdb:2YPU|rcsb pdb:3CWW|rcsb pdb:3E4A|rcsb pdb:3E4Z|rcsb pdb:3E50|rcsb pdb:3H44|rcsb pdb:3N56|rcsb pdb:3N57|rcsb pdb:3OFI|rcsb pdb:3QZ2|rcsb pdb:4DTT|rcsb pdb:4DWK|rcsb pdb:4GS8|rcsb pdb:4GSC|rcsb pdb:4GSF|rcsb pdb:4IFH|rcsb pdb:4IOF|rcsb pdb:4LTE|rcsb pdb:4M1C|rcsb pdb:4NXO|rcsb pdb:4PES|rcsb pdb:4PF7|rcsb pdb:4PF9|rcsb pdb:4PFC|rcsb pdb:4QIA|rcsb pdb:4RAL|rcsb pdb:4RE9|rcsb pdb:5CJO|rcsb pdb:3HGZ|rcsb pdb:5UOE|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6B7Y|rcsb pdb:6BF6|rcsb pdb:6BF7|rcsb pdb:6BF8|rcsb pdb:6BF9|rcsb pdb:6BFC|rcsb pdb:6BYZ|rcsb pdb:6EDS|rcsb pdb:6MQ3|reactome:R-HSA-5689880|reactome:R-HSA-9033241|rcsb pdb:6B7Z|refseq:NP_001159418.1|dip:DIP-55771N|mint:MINT-8087625(identity)	-	comment:mint|function:"Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)"	-	figure legend:f6a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:170.0x10^-9(molar)	2011/01/27	2014/10/16	rogid:s/DqXkYebldCLlYoiA+fS1nI8TA9606	rogid:dwngN3kUOExC5qapSgF01YhBNAM9606	intact-crc:5E7715D14D37941F|rigid:pKNB7JJKeB05w5NMc+lrWWlfQrw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)