#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O35228	uniprotkb:P43431	intact:EBI-3862967|ensembl:ENSMUSP00000003274	intact:EBI-3862959|ensembl:ENSMUSP00000103446	psi-mi:il27b_mouse(display_long)|uniprotkb:Ebi3(gene name)|psi-mi:Ebi3(display_short)|uniprotkb:Epstein-Barr virus-induced gene 3 protein homolog(gene name synonym)|uniprotkb:Il27b(gene name synonym)	psi-mi:il12a_mouse(display_long)|uniprotkb:Il12a(gene name)|psi-mi:Il12a(display_short)|uniprotkb:Cytotoxic lymphocyte maturation factor 35 kDa subunit(gene name synonym)|uniprotkb:IL-12 subunit p35(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Collison et al. (2010)	pubmed:20953201|imex:IM-17016	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3862962|imex:IM-17016-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056581.1|dip:DIP-60364N|ensembl:ENSMUSG00000003206(gene)|ensembl:ENSMUST00000003274(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043235"(receptor complex)|go:"GO:0045523"(interleukin-27 receptor binding)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|reactome:R-MMU-8984722|reactome:R-MMU-9020956	refseq:NP_032377.1|refseq:NP_001152896.1|dip:DIP-60363N|ensembl:ENSMUSG00000027776(gene)|ensembl:ENSMUST00000107816(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005125"(cytokine activity)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010224"(response to UV-B)|go:"GO:0016477"(cell migration)|go:"GO:0031904"(endosome lumen)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042163"(interleukin-12 beta subunit binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043514"(interleukin-12 complex)|go:"GO:0045513"(interleukin-27 binding)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR004281(Interleukin-12 alpha subunit)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0032729"(positive regulation of interferon-gamma production)	-	-	-	figure legend:Fig. 2B, 5C, 6G|agonist:IL-35|complex-synonym:IL-35|comment:interaction not detected in Foxp3-/- splenic T cells, however, the interaction was present in Foxp3-/- tumour cells|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2011/03/24	2016/03/31	rogid:H+LUzFqTegEwUrrxFjtLJlwhYY410090	rogid:q+Zpf9e28d8/LZqf/CvuEYRXLSs10090	intact-crc:3FB59561E7AC1681|rigid:gyLhPfe03EwQelteT/55KhSlWJY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)