#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P98161	uniprotkb:O15259	intact:EBI-1752013|uniprotkb:Q15140|uniprotkb:Q15141|intact:EBI-28973367|ensembl:ENSP00000262304	intact:EBI-953828|uniprotkb:O14837|ensembl:ENSP00000376953	psi-mi:pkd1_human(display_long)|uniprotkb:PKD1(gene name)|psi-mi:PKD1(display_short)|uniprotkb:Autosomal dominant polycystic kidney disease 1 protein(gene name synonym)	psi-mi:nphp1_human(display_long)|uniprotkb:Juvenile nephronophthisis 1 protein(gene name synonym)|uniprotkb:NPHP1(gene name)|psi-mi:NPHP1(display_short)|uniprotkb:NPH1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Wodarczyk et al. (2010)	pubmed:20856870|mint:MINT-8109633|doi:10.1371/journal.pone.0012719	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8305824|mint:MINT-8109642	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000262304|ensembl:ENST00000423118|ensembl:ENSP00000399501|refseq:NP_000287.3|refseq:NP_001009944.2|dip:DIP-52317N|ensembl:ENSG00000008710(gene)|ensembl:ENST00000262304(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002133"(polycystin complex)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007507"(heart development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034703"(cation channel complex)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036303"(lymph vessel morphogenesis)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043588"(skin development)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048806"(genitalia development)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051216"(cartilage development)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072237"(metanephric proximal tubule development)|go:"GO:0072287"(metanephric distal tubule morphogenesis)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000203(GPS)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000434(Polycystic kidney disease type 1 protein)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000601(PKD)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001304(C-type lectin)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002859(PKD/REJ-like protein)|interpro:IPR002889(Carbohydrate-binding WSC)|interpro:IPR006228(Polycystin cation channel)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014010(Egg jelly receptor, REJ-like)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR022409|interpro:IPR032675|interpro:IPR035986|interpro:IPR036392|interpro:IPR042060|mint:P98161|rcsb pdb:1B4R|rcsb pdb:6A70|reactome:R-HSA-5620916|interpro:IPR003591(Leucine-rich repeat, typical subtype)|mint:MINT-8109649(identity)|uniprotkb:P98161(original identifier)	refseq:NP_000263.2|refseq:NP_001121650.1|refseq:NP_001121651.1|refseq:NP_997064.2|ensembl:ENSG00000144061(gene)|ensembl:ENST00000393272(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0007588"(excretion)|go:"GO:0007632"(visual behavior)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090251"(protein localization involved in establishment of planar polarity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR030642|interpro:IPR036028|interpro:IPR039687|mint:O15259|rcsb pdb:1S1N|rcsb pdb:6O1Q|reactome:R-HSA-5620912|mint:MINT-8109643(identity)|uniprotkb:O15259(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:ST1 F2B F2C F2D F3A F3B|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/18	2014/10/16	rogid:5sjZUQZacorsQPt5nSELPNsvfX09606	rogid:OPdzsagqWWni+dWU+VLoygacfcg9606	intact-crc:6C51A57ABDEAB06B|rigid:SsX7l46bcwpjzIaSmuVMS3Cyb4k	false	binding-associated region:4264-4267(MINT-8109652)	binding-associated region:155-211(MINT-8109646)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P98161	uniprotkb:O15259	intact:EBI-1752013|uniprotkb:Q15140|uniprotkb:Q15141|intact:EBI-28973367|ensembl:ENSP00000262304	intact:EBI-953828|uniprotkb:O14837|ensembl:ENSP00000376953	psi-mi:pkd1_human(display_long)|uniprotkb:PKD1(gene name)|psi-mi:PKD1(display_short)|uniprotkb:Autosomal dominant polycystic kidney disease 1 protein(gene name synonym)	psi-mi:nphp1_human(display_long)|uniprotkb:Juvenile nephronophthisis 1 protein(gene name synonym)|uniprotkb:NPHP1(gene name)|psi-mi:NPHP1(display_short)|uniprotkb:NPH1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Wodarczyk et al. (2010)	pubmed:20856870|mint:MINT-8109633|doi:10.1371/journal.pone.0012719	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8305855|mint:MINT-8109661	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000262304|ensembl:ENST00000423118|ensembl:ENSP00000399501|refseq:NP_000287.3|refseq:NP_001009944.2|dip:DIP-52317N|ensembl:ENSG00000008710(gene)|ensembl:ENST00000262304(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002133"(polycystin complex)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007507"(heart development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034703"(cation channel complex)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036303"(lymph vessel morphogenesis)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043588"(skin development)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048806"(genitalia development)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051216"(cartilage development)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072237"(metanephric proximal tubule development)|go:"GO:0072287"(metanephric distal tubule morphogenesis)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000203(GPS)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000434(Polycystic kidney disease type 1 protein)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000601(PKD)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001304(C-type lectin)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002859(PKD/REJ-like protein)|interpro:IPR002889(Carbohydrate-binding WSC)|interpro:IPR006228(Polycystin cation channel)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014010(Egg jelly receptor, REJ-like)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR022409|interpro:IPR032675|interpro:IPR035986|interpro:IPR036392|interpro:IPR042060|mint:P98161|rcsb pdb:1B4R|rcsb pdb:6A70|reactome:R-HSA-5620916|interpro:IPR003591(Leucine-rich repeat, typical subtype)|mint:MINT-8109673(identity)|uniprotkb:P98161(original identifier)	refseq:NP_000263.2|refseq:NP_001121650.1|refseq:NP_001121651.1|refseq:NP_997064.2|ensembl:ENSG00000144061(gene)|ensembl:ENST00000393272(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0007588"(excretion)|go:"GO:0007632"(visual behavior)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090251"(protein localization involved in establishment of planar polarity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR030642|interpro:IPR036028|interpro:IPR039687|mint:O15259|rcsb pdb:1S1N|rcsb pdb:6O1Q|reactome:R-HSA-5620912|mint:MINT-8109662(identity)|uniprotkb:O15259(original identifier)	-	-	-	figure legend:SF3A|comment:homomint|comment:domino|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/02/18	2014/10/16	rogid:5sjZUQZacorsQPt5nSELPNsvfX09606	rogid:OPdzsagqWWni+dWU+VLoygacfcg9606	intact-crc:BEDA59BA536FF066|rigid:SsX7l46bcwpjzIaSmuVMS3Cyb4k	false	binding-associated region:4264-4267(MINT-8109676)	binding-associated region:155-211(MINT-8109665)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)