#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P25116	uniprotkb:Q03135	intact:EBI-2803960|ensembl:ENSP00000321326|uniprotkb:Q53XV0|uniprotkb:Q9BUN4|uniprotkb:Q96RF7	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	psi-mi:par1_human(display_long)|uniprotkb:CF2R(gene name synonym)|uniprotkb:PAR1(gene name synonym)|uniprotkb:TR(gene name synonym)|uniprotkb:Coagulation factor II receptor(gene name synonym)|uniprotkb:Thrombin receptor(gene name synonym)|uniprotkb:F2R(gene name)|psi-mi:F2R(display_short)	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2010)	pubmed:20826780|imex:IM-16915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4399921|imex:IM-16915-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000181104(gene)|ensembl:ENST00000319211(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003105"(negative regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|refseq:NP_001983.2|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:1900134"(negative regulation of renin secretion into blood stream)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000935(Thrombin receptor)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|rcsb pdb:3HKI|rcsb pdb:3HKJ|rcsb pdb:3LU9|rcsb pdb:3VW7|reactome:R-HSA-140875|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-456926|rcsb pdb:1NRR|rcsb pdb:3BEF|refseq:NP_001298242.1|dip:DIP-29703N	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	-	-	-	figure legend:5b|comment:"When endothelial cells were pretreated with Factor FX (Ser195Ala),  EPCR and caveolin-1 were not co-immunoprecipitated."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926)	-	2011/07/22	2014/10/16	rogid:XDyq4uaI8bttpcddguVYWbFJ9PA9606	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	intact-crc:AE26145B55E87AD6|rigid:R1yoy/vGIZvL2J1V5NXu3SEsAHo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03135	uniprotkb:P25116	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	intact:EBI-2803960|ensembl:ENSP00000321326|uniprotkb:Q53XV0|uniprotkb:Q9BUN4|uniprotkb:Q96RF7	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:par1_human(display_long)|uniprotkb:CF2R(gene name synonym)|uniprotkb:PAR1(gene name synonym)|uniprotkb:TR(gene name synonym)|uniprotkb:Coagulation factor II receptor(gene name synonym)|uniprotkb:Thrombin receptor(gene name synonym)|uniprotkb:F2R(gene name)|psi-mi:F2R(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2010)	pubmed:20826780|imex:IM-16915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4309754|imex:IM-16915-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	ensembl:ENSG00000181104(gene)|ensembl:ENST00000319211(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003105"(negative regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|refseq:NP_001983.2|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:1900134"(negative regulation of renin secretion into blood stream)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000935(Thrombin receptor)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|rcsb pdb:3HKI|rcsb pdb:3HKJ|rcsb pdb:3LU9|rcsb pdb:3VW7|reactome:R-HSA-140875|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-456926|rcsb pdb:1NRR|rcsb pdb:3BEF|refseq:NP_001298242.1|dip:DIP-29703N	-	-	-	figure legend:5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926)	-	2011/07/22	2014/10/16	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rogid:XDyq4uaI8bttpcddguVYWbFJ9PA9606	intact-crc:335924EB92A1472B|rigid:ZEvhQYcnfNvd+2fD1I8ZPuc+jl8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03135	uniprotkb:Q9UNN8	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	intact:EBI-719705|uniprotkb:Q14218|uniprotkb:Q6IB56|uniprotkb:Q96CB3|uniprotkb:Q9ULX1|uniprotkb:B2RC04|ensembl:ENSP00000216968	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:epcr_human(display_long)|uniprotkb:Endothelial cell protein C receptor(gene name synonym)|uniprotkb:Activated protein C receptor(gene name synonym)|uniprotkb:PROCR(gene name)|psi-mi:PROCR(display_short)|uniprotkb:EPCR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2010)	pubmed:20826780|imex:IM-16915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4309754|imex:IM-16915-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	refseq:NP_006395.2|ensembl:ENSG00000101000(gene)|ensembl:ENST00000216968(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007596"(blood coagulation)|go:"GO:0009986"(cell surface)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050819"(negative regulation of coagulation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR015669(Endothelial protein C receptor)|interpro:IPR037055|rcsb pdb:1L8J|rcsb pdb:1LQV|rcsb pdb:3JTC|rcsb pdb:4V3D|rcsb pdb:4V3E|rcsb pdb:6SNY|reactome:R-HSA-140875|reactome:R-HSA-202733|dip:DIP-48671N	-	-	-	figure legend:5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926)	-	2011/07/22	2014/10/16	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rogid:E5YufhPX46Id1xm4YN03ZG+UYPU9606	intact-crc:335924EB92A1472B|rigid:ZEvhQYcnfNvd+2fD1I8ZPuc+jl8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25116	uniprotkb:Q9UNN8	intact:EBI-2803960|ensembl:ENSP00000321326|uniprotkb:Q53XV0|uniprotkb:Q9BUN4|uniprotkb:Q96RF7	intact:EBI-719705|uniprotkb:Q14218|uniprotkb:Q6IB56|uniprotkb:Q96CB3|uniprotkb:Q9ULX1|uniprotkb:B2RC04|ensembl:ENSP00000216968	psi-mi:par1_human(display_long)|uniprotkb:CF2R(gene name synonym)|uniprotkb:PAR1(gene name synonym)|uniprotkb:TR(gene name synonym)|uniprotkb:Coagulation factor II receptor(gene name synonym)|uniprotkb:Thrombin receptor(gene name synonym)|uniprotkb:F2R(gene name)|psi-mi:F2R(display_short)	psi-mi:epcr_human(display_long)|uniprotkb:Endothelial cell protein C receptor(gene name synonym)|uniprotkb:Activated protein C receptor(gene name synonym)|uniprotkb:PROCR(gene name)|psi-mi:PROCR(display_short)|uniprotkb:EPCR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2010)	pubmed:20826780|imex:IM-16915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4399916|imex:IM-16915-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000181104(gene)|ensembl:ENST00000319211(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003105"(negative regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|refseq:NP_001983.2|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:1900134"(negative regulation of renin secretion into blood stream)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000935(Thrombin receptor)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|rcsb pdb:3HKI|rcsb pdb:3HKJ|rcsb pdb:3LU9|rcsb pdb:3VW7|reactome:R-HSA-140875|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-456926|rcsb pdb:1NRR|rcsb pdb:3BEF|refseq:NP_001298242.1|dip:DIP-29703N	refseq:NP_006395.2|ensembl:ENSG00000101000(gene)|ensembl:ENST00000216968(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007596"(blood coagulation)|go:"GO:0009986"(cell surface)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050819"(negative regulation of coagulation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR015669(Endothelial protein C receptor)|interpro:IPR037055|rcsb pdb:1L8J|rcsb pdb:1LQV|rcsb pdb:3JTC|rcsb pdb:4V3D|rcsb pdb:4V3E|rcsb pdb:6SNY|reactome:R-HSA-140875|reactome:R-HSA-202733|dip:DIP-48671N	-	-	-	figure legend:5c|comment:"When endothelial cells were pretreated with Factor FX (Ser195Ala),  EPCR and caveolin-1 were not co-immunoprecipitated."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926)	-	2011/07/22	2014/10/16	rogid:XDyq4uaI8bttpcddguVYWbFJ9PA9606	rogid:E5YufhPX46Id1xm4YN03ZG+UYPU9606	intact-crc:8644D5BD428B3563|rigid:va8VWAaX2G0x9EnuYP9lq6B21uc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25116	uniprotkb:Q9UNN8	intact:EBI-2803960|ensembl:ENSP00000321326|uniprotkb:Q53XV0|uniprotkb:Q9BUN4|uniprotkb:Q96RF7	intact:EBI-719705|uniprotkb:Q14218|uniprotkb:Q6IB56|uniprotkb:Q96CB3|uniprotkb:Q9ULX1|uniprotkb:B2RC04|ensembl:ENSP00000216968	psi-mi:par1_human(display_long)|uniprotkb:CF2R(gene name synonym)|uniprotkb:PAR1(gene name synonym)|uniprotkb:TR(gene name synonym)|uniprotkb:Coagulation factor II receptor(gene name synonym)|uniprotkb:Thrombin receptor(gene name synonym)|uniprotkb:F2R(gene name)|psi-mi:F2R(display_short)	psi-mi:epcr_human(display_long)|uniprotkb:Endothelial cell protein C receptor(gene name synonym)|uniprotkb:Activated protein C receptor(gene name synonym)|uniprotkb:PROCR(gene name)|psi-mi:PROCR(display_short)|uniprotkb:EPCR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2010)	pubmed:20826780|imex:IM-16915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4309749|imex:IM-16915-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000181104(gene)|ensembl:ENST00000319211(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003105"(negative regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|refseq:NP_001983.2|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:1900134"(negative regulation of renin secretion into blood stream)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000935(Thrombin receptor)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|rcsb pdb:3HKI|rcsb pdb:3HKJ|rcsb pdb:3LU9|rcsb pdb:3VW7|reactome:R-HSA-140875|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-456926|rcsb pdb:1NRR|rcsb pdb:3BEF|refseq:NP_001298242.1|dip:DIP-29703N	refseq:NP_006395.2|ensembl:ENSG00000101000(gene)|ensembl:ENST00000216968(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007596"(blood coagulation)|go:"GO:0009986"(cell surface)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050819"(negative regulation of coagulation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR015669(Endothelial protein C receptor)|interpro:IPR037055|rcsb pdb:1L8J|rcsb pdb:1LQV|rcsb pdb:3JTC|rcsb pdb:4V3D|rcsb pdb:4V3E|rcsb pdb:6SNY|reactome:R-HSA-140875|reactome:R-HSA-202733|dip:DIP-48671N	-	-	-	figure legend:5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926)	-	2011/07/22	2014/10/16	rogid:XDyq4uaI8bttpcddguVYWbFJ9PA9606	rogid:E5YufhPX46Id1xm4YN03ZG+UYPU9606	intact-crc:35FBFA81DEAB87CF|rigid:ZEvhQYcnfNvd+2fD1I8ZPuc+jl8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25116	uniprotkb:Q03135	intact:EBI-2803960|ensembl:ENSP00000321326|uniprotkb:Q53XV0|uniprotkb:Q9BUN4|uniprotkb:Q96RF7	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	psi-mi:par1_human(display_long)|uniprotkb:CF2R(gene name synonym)|uniprotkb:PAR1(gene name synonym)|uniprotkb:TR(gene name synonym)|uniprotkb:Coagulation factor II receptor(gene name synonym)|uniprotkb:Thrombin receptor(gene name synonym)|uniprotkb:F2R(gene name)|psi-mi:F2R(display_short)	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2010)	pubmed:20826780|imex:IM-16915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4309749|imex:IM-16915-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000181104(gene)|ensembl:ENST00000319211(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003105"(negative regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|refseq:NP_001983.2|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:1900134"(negative regulation of renin secretion into blood stream)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000935(Thrombin receptor)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|rcsb pdb:3HKI|rcsb pdb:3HKJ|rcsb pdb:3LU9|rcsb pdb:3VW7|reactome:R-HSA-140875|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-456926|rcsb pdb:1NRR|rcsb pdb:3BEF|refseq:NP_001298242.1|dip:DIP-29703N	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	-	-	-	figure legend:5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926)	-	2011/07/22	2014/10/16	rogid:XDyq4uaI8bttpcddguVYWbFJ9PA9606	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	intact-crc:35FBFA81DEAB87CF|rigid:ZEvhQYcnfNvd+2fD1I8ZPuc+jl8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UNN8	uniprotkb:P25116	intact:EBI-719705|uniprotkb:Q14218|uniprotkb:Q6IB56|uniprotkb:Q96CB3|uniprotkb:Q9ULX1|uniprotkb:B2RC04|ensembl:ENSP00000216968	intact:EBI-2803960|ensembl:ENSP00000321326|uniprotkb:Q53XV0|uniprotkb:Q9BUN4|uniprotkb:Q96RF7	psi-mi:epcr_human(display_long)|uniprotkb:Endothelial cell protein C receptor(gene name synonym)|uniprotkb:Activated protein C receptor(gene name synonym)|uniprotkb:PROCR(gene name)|psi-mi:PROCR(display_short)|uniprotkb:EPCR(gene name synonym)	psi-mi:par1_human(display_long)|uniprotkb:CF2R(gene name synonym)|uniprotkb:PAR1(gene name synonym)|uniprotkb:TR(gene name synonym)|uniprotkb:Coagulation factor II receptor(gene name synonym)|uniprotkb:Thrombin receptor(gene name synonym)|uniprotkb:F2R(gene name)|psi-mi:F2R(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2010)	pubmed:20826780|imex:IM-16915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4309759|imex:IM-16915-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006395.2|ensembl:ENSG00000101000(gene)|ensembl:ENST00000216968(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007596"(blood coagulation)|go:"GO:0009986"(cell surface)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050819"(negative regulation of coagulation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR015669(Endothelial protein C receptor)|interpro:IPR037055|rcsb pdb:1L8J|rcsb pdb:1LQV|rcsb pdb:3JTC|rcsb pdb:4V3D|rcsb pdb:4V3E|rcsb pdb:6SNY|reactome:R-HSA-140875|reactome:R-HSA-202733|dip:DIP-48671N	ensembl:ENSG00000181104(gene)|ensembl:ENST00000319211(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003105"(negative regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|refseq:NP_001983.2|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:1900134"(negative regulation of renin secretion into blood stream)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000935(Thrombin receptor)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|rcsb pdb:3HKI|rcsb pdb:3HKJ|rcsb pdb:3LU9|rcsb pdb:3VW7|reactome:R-HSA-140875|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-456926|rcsb pdb:1NRR|rcsb pdb:3BEF|refseq:NP_001298242.1|dip:DIP-29703N	-	-	-	figure legend:5c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926)	-	2011/07/22	2014/10/16	rogid:E5YufhPX46Id1xm4YN03ZG+UYPU9606	rogid:XDyq4uaI8bttpcddguVYWbFJ9PA9606	intact-crc:0E498E0B7C23A9C9|rigid:ZEvhQYcnfNvd+2fD1I8ZPuc+jl8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UNN8	uniprotkb:Q03135	intact:EBI-719705|uniprotkb:Q14218|uniprotkb:Q6IB56|uniprotkb:Q96CB3|uniprotkb:Q9ULX1|uniprotkb:B2RC04|ensembl:ENSP00000216968	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	psi-mi:epcr_human(display_long)|uniprotkb:Endothelial cell protein C receptor(gene name synonym)|uniprotkb:Activated protein C receptor(gene name synonym)|uniprotkb:PROCR(gene name)|psi-mi:PROCR(display_short)|uniprotkb:EPCR(gene name synonym)	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2010)	pubmed:20826780|imex:IM-16915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4309759|imex:IM-16915-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006395.2|ensembl:ENSG00000101000(gene)|ensembl:ENST00000216968(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007596"(blood coagulation)|go:"GO:0009986"(cell surface)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050819"(negative regulation of coagulation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR015669(Endothelial protein C receptor)|interpro:IPR037055|rcsb pdb:1L8J|rcsb pdb:1LQV|rcsb pdb:3JTC|rcsb pdb:4V3D|rcsb pdb:4V3E|rcsb pdb:6SNY|reactome:R-HSA-140875|reactome:R-HSA-202733|dip:DIP-48671N	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	-	-	-	figure legend:5c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926)	-	2011/07/22	2014/10/16	rogid:E5YufhPX46Id1xm4YN03ZG+UYPU9606	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	intact-crc:0E498E0B7C23A9C9|rigid:ZEvhQYcnfNvd+2fD1I8ZPuc+jl8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14868	uniprotkb:P55085	intact:EBI-4309771	intact:EBI-4303189|uniprotkb:Q13317|uniprotkb:Q13346|ensembl:ENSP00000296677|uniprotkb:Q53XJ8	psi-mi:q14868_human(display_long)|uniprotkb:EPR-1(gene name)|psi-mi:EPR-1(display_short)	psi-mi:par2_human(display_long)|uniprotkb:F2RL1(gene name)|psi-mi:F2RL1(display_short)|uniprotkb:GPR11(gene name synonym)|uniprotkb:PAR2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor 11(gene name synonym)|uniprotkb:Thrombin receptor-like 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2010)	pubmed:20826780|imex:IM-16915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4396218|imex:IM-16915-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)	refseq:NP_005233.3|ensembl:ENSG00000164251(gene)|ensembl:ENST00000296677(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042311"(vasodilation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070661"(leukocyte proliferation)|go:"GO:0070963"(positive regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002281(Protease-activated receptor 2)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P55085|rcsb pdb:5NDD|rcsb pdb:5NDZ|rcsb pdb:5NJ6|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|dip:DIP-42044N	-	-	-	figure legend:6c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926)	-	2011/07/22	2014/10/16	rogid:ioAnAqZf7LzIXKBClZw/eTxbg349606	rogid:j9cMnyj9C74tReGYkQvGFy+cez49606	intact-crc:1D63436903A99E17|rigid:yMMXdA6R6vW9LZnBq0CFCEIR7js	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P55085	uniprotkb:Q14868	intact:EBI-4303189|uniprotkb:Q13317|uniprotkb:Q13346|ensembl:ENSP00000296677|uniprotkb:Q53XJ8	intact:EBI-4309771	psi-mi:par2_human(display_long)|uniprotkb:F2RL1(gene name)|psi-mi:F2RL1(display_short)|uniprotkb:GPR11(gene name synonym)|uniprotkb:PAR2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor 11(gene name synonym)|uniprotkb:Thrombin receptor-like 1(gene name synonym)	psi-mi:q14868_human(display_long)|uniprotkb:EPR-1(gene name)|psi-mi:EPR-1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2010)	pubmed:20826780|imex:IM-16915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4396216|imex:IM-16915-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005233.3|ensembl:ENSG00000164251(gene)|ensembl:ENST00000296677(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042311"(vasodilation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070661"(leukocyte proliferation)|go:"GO:0070963"(positive regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002281(Protease-activated receptor 2)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P55085|rcsb pdb:5NDD|rcsb pdb:5NDZ|rcsb pdb:5NJ6|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|dip:DIP-42044N	go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)	-	-	-	figure legend:6c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926)	-	2011/07/22	2014/10/16	rogid:j9cMnyj9C74tReGYkQvGFy+cez49606	rogid:ioAnAqZf7LzIXKBClZw/eTxbg349606	intact-crc:5AD5E009D784590B|rigid:yMMXdA6R6vW9LZnBq0CFCEIR7js	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14868	uniprotkb:P55085	intact:EBI-4309771	intact:EBI-4303189|uniprotkb:Q13317|uniprotkb:Q13346|ensembl:ENSP00000296677|uniprotkb:Q53XJ8	psi-mi:q14868_human(display_long)|uniprotkb:EPR-1(gene name)|psi-mi:EPR-1(display_short)	psi-mi:par2_human(display_long)|uniprotkb:F2RL1(gene name)|psi-mi:F2RL1(display_short)|uniprotkb:GPR11(gene name synonym)|uniprotkb:PAR2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor 11(gene name synonym)|uniprotkb:Thrombin receptor-like 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2010)	pubmed:20826780|imex:IM-16915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4309785|imex:IM-16915-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)	refseq:NP_005233.3|ensembl:ENSG00000164251(gene)|ensembl:ENST00000296677(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042311"(vasodilation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070661"(leukocyte proliferation)|go:"GO:0070963"(positive regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002281(Protease-activated receptor 2)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P55085|rcsb pdb:5NDD|rcsb pdb:5NDZ|rcsb pdb:5NJ6|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|dip:DIP-42044N	-	-	-	figure legend:6c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2011/07/22	2014/10/16	rogid:ioAnAqZf7LzIXKBClZw/eTxbg349606	rogid:j9cMnyj9C74tReGYkQvGFy+cez49606	intact-crc:DEEF936C92E086CF|rigid:yMMXdA6R6vW9LZnBq0CFCEIR7js	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P55085	uniprotkb:Q14868	intact:EBI-4303189|uniprotkb:Q13317|uniprotkb:Q13346|ensembl:ENSP00000296677|uniprotkb:Q53XJ8	intact:EBI-4309771	psi-mi:par2_human(display_long)|uniprotkb:F2RL1(gene name)|psi-mi:F2RL1(display_short)|uniprotkb:GPR11(gene name synonym)|uniprotkb:PAR2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor 11(gene name synonym)|uniprotkb:Thrombin receptor-like 1(gene name synonym)	psi-mi:q14868_human(display_long)|uniprotkb:EPR-1(gene name)|psi-mi:EPR-1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2010)	pubmed:20826780|imex:IM-16915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4309781|imex:IM-16915-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005233.3|ensembl:ENSG00000164251(gene)|ensembl:ENST00000296677(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042311"(vasodilation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070661"(leukocyte proliferation)|go:"GO:0070963"(positive regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002281(Protease-activated receptor 2)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P55085|rcsb pdb:5NDD|rcsb pdb:5NDZ|rcsb pdb:5NJ6|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|dip:DIP-42044N	go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)	-	-	-	figure legend:6c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2011/07/22	2014/10/16	rogid:j9cMnyj9C74tReGYkQvGFy+cez49606	rogid:ioAnAqZf7LzIXKBClZw/eTxbg349606	intact-crc:A305360E181B6C6E|rigid:yMMXdA6R6vW9LZnBq0CFCEIR7js	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)