#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43156	uniprotkb:Q13315	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	intact:EBI-495465|uniprotkb:O15429|uniprotkb:Q12758|uniprotkb:Q16551|uniprotkb:Q93007|uniprotkb:Q9NP02|uniprotkb:Q9UCX7|intact:EBI-1059333|uniprotkb:B2RNX5|intact:EBI-28985245|ensembl:ENSP00000278616|ensembl:ENSP00000388058|ensembl:ENSP00000501606	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:atm_human(display_long)|uniprotkb:ATM(gene name)|psi-mi:ATM(display_short)|uniprotkb:Ataxia telangiectasia mutated(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4565670	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	refseq:NP_000042.3|refseq:XP_011541142.1|ensembl:ENSP00000501606|ensembl:ENSP00000278616|ensembl:ENSP00000388058|refseq:XP_005271618.2|refseq:XP_005271619.2|refseq:XP_006718906.1|refseq:XP_006718908.1|dip:DIP-182N|refseq:XP_016873278.1|refseq:XP_016873279.1|ensembl:ENSG00000149311(gene)|ensembl:ENST00000452508(transcript)|ensembl:ENST00000675843(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007165"(signal transduction)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|go:"GO:1990391"(DNA repair complex)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR015519(Ataxia-Telangiectasia Mutated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021668|interpro:IPR036940|interpro:IPR044107|ensembl:ENST00000278616(transcript)|mint:Q13315|rcsb pdb:5NP0|rcsb pdb:5NP1|rcsb pdb:6HKA|rcsb pdb:6K9K|rcsb pdb:6K9L|reactome:R-HSA-2559586|reactome:R-HSA-3371453|reactome:R-HSA-349425|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803207|reactome:R-HSA-6804756|reactome:R-HSA-6804760|reactome:R-HSA-69473|reactome:R-HSA-69541|reactome:R-HSA-912446|reactome:R-HSA-9664873|reactome:R-HSA-6804757	-	-	-	figure legend:5c|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/17	2014/10/16	rogid:64WoojA64oXXnupzAKEbytnly1s9606	rogid:d/FYo7KdBblfR/inXUZpFlWTfoo9606	intact-crc:52D499D3E10BA9FB|rigid:dYjbNAYhUFwq2B77HlyOEv8eJh4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43156	uniprotkb:P42345	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	intact:EBI-359260|uniprotkb:Q5TER1|uniprotkb:Q4LE76|uniprotkb:Q6LE87|uniprotkb:Q96QG3|uniprotkb:Q9Y4I3|ensembl:ENSP00000354558|intact:EBI-28989074	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:mtor_human(display_long)|uniprotkb:MTOR(gene name)|psi-mi:MTOR(display_short)|uniprotkb:FRAP(gene name synonym)|uniprotkb:FRAP2(gene name synonym)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:FRAP1(gene name synonym)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)|uniprotkb:RAFT1(gene name synonym)|uniprotkb:RAPT1(gene name synonym)|uniprotkb:Rapamycin and FKBP12 target 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4565670	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	ensembl:ENSG00000198793(gene)|refseq:NP_004949.1|ensembl:ENST00000361445(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005764"(lysosome)|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043276"(anoikis)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904690"(positive regulation of cytoplasmic translational initiation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|mint:P42345|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|rcsb pdb:1FAP|rcsb pdb:1NSG|rcsb pdb:2FAP|rcsb pdb:2GAQ|rcsb pdb:2NPU|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:3JBZ|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRJ|rcsb pdb:4FAP|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5GPG|rcsb pdb:5H64|rcsb pdb:5WBH|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:1AUE|rcsb pdb:6BCX|rcsb pdb:6M4U|rcsb pdb:6M4W|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSP00000354558|refseq:XP_005263495.1|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0008361"(regulation of cell size)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|dip:DIP-790N	-	-	-	figure legend:5c|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/17	2014/10/16	rogid:64WoojA64oXXnupzAKEbytnly1s9606	rogid:z6uJxqv906jKZ7IqoavN5JTWJs09606	intact-crc:52D499D3E10BA9FB|rigid:dYjbNAYhUFwq2B77HlyOEv8eJh4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43156	uniprotkb:Q13535	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	intact:EBI-968983|ensembl:ENSP00000343741|uniprotkb:Q7KYL3|uniprotkb:Q93051|uniprotkb:Q9BXK4|uniprotkb:Q59HB2	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:atr_human(display_long)|uniprotkb:ATR(gene name)|psi-mi:ATR(display_short)|uniprotkb:FRP1(gene name synonym)|uniprotkb:Ataxia telangiectasia and Rad3-related protein(gene name synonym)|uniprotkb:FRAP-related protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4565670	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	ensembl:ENSG00000175054(gene)|ensembl:ENST00000350721(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031297"(replication fork processing)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042493"|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012993(UME)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021133|interpro:IPR036940|mint:Q13535|rcsb pdb:5YZ0|reactome:R-HSA-1221632|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-5685938|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6783310|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|refseq:NP_001175.2|refseq:XP_016862132.1|dip:DIP-35308N	-	-	-	figure legend:5c|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/17	2014/10/16	rogid:64WoojA64oXXnupzAKEbytnly1s9606	rogid:ZYzDNmnxcK+RJN42KfgQZlxGACU9606	intact-crc:52D499D3E10BA9FB|rigid:dYjbNAYhUFwq2B77HlyOEv8eJh4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43156	uniprotkb:P78527	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4565670	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	-	-	-	figure legend:5c|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/17	2014/10/16	rogid:64WoojA64oXXnupzAKEbytnly1s9606	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	intact-crc:52D499D3E10BA9FB|rigid:dYjbNAYhUFwq2B77HlyOEv8eJh4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43156	uniprotkb:Q96Q15	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	intact:EBI-1049832|uniprotkb:O43305|uniprotkb:Q13284|uniprotkb:Q8NFX2|uniprotkb:Q96QV0|uniprotkb:Q96RW3|ensembl:ENSP00000402515	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:smg1_human(display_long)|uniprotkb:Lambda/iota protein kinase C-interacting protein(gene name synonym)|uniprotkb:61E3.4(gene name synonym)|uniprotkb:SMG1(gene name)|psi-mi:SMG1(display_short)|uniprotkb:ATX(gene name synonym)|uniprotkb:KIAA0421(gene name synonym)|uniprotkb:LIP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4565670	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	refseq:NP_055907.3|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR031559|interpro:IPR035175|interpro:IPR036940|interpro:IPR039414|mint:Q96Q15|rcsb pdb:6L53|rcsb pdb:6L54|rcsb pdb:6SYT|rcsb pdb:6Z3R|reactome:R-HSA-975957|ensembl:ENSG00000157106(gene)|ensembl:ENST00000446231(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032204"(regulation of telomere maintenance)	-	-	-	figure legend:5c|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/17	2014/10/16	rogid:64WoojA64oXXnupzAKEbytnly1s9606	rogid:u7doCYezlcCUKq//xhk0TZ2TD009606	intact-crc:52D499D3E10BA9FB|rigid:dYjbNAYhUFwq2B77HlyOEv8eJh4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6NXR4	uniprotkb:Q9Y4R8	intact:EBI-4566107|uniprotkb:D3DSV7|uniprotkb:Q96IM2|uniprotkb:Q9H5N4|ensembl:ENSP00000353971|ensembl:ENSP00000411169|ensembl:ENSP00000478396	intact:EBI-1043674|uniprotkb:O75168|uniprotkb:Q7LDV4|uniprotkb:Q9BR21|intact:EBI-725566|intact:EBI-1047721|ensembl:ENSP00000262319|uniprotkb:D3DU73	psi-mi:tti2_human(display_long)|uniprotkb:TTI2(gene name)|psi-mi:TTI2(display_short)|uniprotkb:C8orf41(gene name synonym)	psi-mi:telo2_human(display_long)|uniprotkb:TELO2(gene name)|psi-mi:TELO2(display_short)|uniprotkb:KIAA0683(gene name synonym)|uniprotkb:Protein clk-2 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4566979	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001095871.1|refseq:NP_079391.2|refseq:NP_001252510.1|ensembl:ENSG00000129696(gene)|ensembl:ENST00000360742(transcript)|ensembl:ENST00000431156(transcript)|ensembl:ENST00000613904(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018870|go:"GO:0005813"(centrosome)	ensembl:ENSG00000100726(gene)|ensembl:ENST00000262319(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070209"(ASTRA complex)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019337|interpro:IPR038528|mint:Q9Y4R8|rcsb pdb:4PSI|refseq:NP_057195.2|refseq:XP_016879403.1|dip:DIP-40568N	-	-	-	figure legend:6f|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/17	2014/10/16	rogid:CK+55nt5IJEfNNFXWqo9MPSA3bo9606	rogid:AnKk5b5Bc/tzEEz+p68m5uQUZVY9606	intact-crc:BBDF3B4E0BAF74DB|rigid:lbNNRsgB6IfsQPHoh8XD98CyIJY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6NXR4	uniprotkb:O43156	intact:EBI-4566107|uniprotkb:D3DSV7|uniprotkb:Q96IM2|uniprotkb:Q9H5N4|ensembl:ENSP00000353971|ensembl:ENSP00000411169|ensembl:ENSP00000478396	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	psi-mi:tti2_human(display_long)|uniprotkb:TTI2(gene name)|psi-mi:TTI2(display_short)|uniprotkb:C8orf41(gene name synonym)	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4566979	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001095871.1|refseq:NP_079391.2|refseq:NP_001252510.1|ensembl:ENSG00000129696(gene)|ensembl:ENST00000360742(transcript)|ensembl:ENST00000431156(transcript)|ensembl:ENST00000613904(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018870|go:"GO:0005813"(centrosome)	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	-	-	-	figure legend:6f|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/17	2014/10/16	rogid:CK+55nt5IJEfNNFXWqo9MPSA3bo9606	rogid:64WoojA64oXXnupzAKEbytnly1s9606	intact-crc:BBDF3B4E0BAF74DB|rigid:lbNNRsgB6IfsQPHoh8XD98CyIJY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13315	uniprotkb:O43156	intact:EBI-495465|uniprotkb:O15429|uniprotkb:Q12758|uniprotkb:Q16551|uniprotkb:Q93007|uniprotkb:Q9NP02|uniprotkb:Q9UCX7|intact:EBI-1059333|uniprotkb:B2RNX5|intact:EBI-28985245|ensembl:ENSP00000278616|ensembl:ENSP00000388058|ensembl:ENSP00000501606	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	psi-mi:atm_human(display_long)|uniprotkb:ATM(gene name)|psi-mi:ATM(display_short)|uniprotkb:Ataxia telangiectasia mutated(gene name synonym)	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4591512	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000042.3|refseq:XP_011541142.1|ensembl:ENSP00000501606|ensembl:ENSP00000278616|ensembl:ENSP00000388058|refseq:XP_005271618.2|refseq:XP_005271619.2|refseq:XP_006718906.1|refseq:XP_006718908.1|dip:DIP-182N|refseq:XP_016873278.1|refseq:XP_016873279.1|ensembl:ENSG00000149311(gene)|ensembl:ENST00000452508(transcript)|ensembl:ENST00000675843(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007165"(signal transduction)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|go:"GO:1990391"(DNA repair complex)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR015519(Ataxia-Telangiectasia Mutated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021668|interpro:IPR036940|interpro:IPR044107|ensembl:ENST00000278616(transcript)|mint:Q13315|rcsb pdb:5NP0|rcsb pdb:5NP1|rcsb pdb:6HKA|rcsb pdb:6K9K|rcsb pdb:6K9L|reactome:R-HSA-2559586|reactome:R-HSA-3371453|reactome:R-HSA-349425|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803207|reactome:R-HSA-6804756|reactome:R-HSA-6804760|reactome:R-HSA-69473|reactome:R-HSA-69541|reactome:R-HSA-912446|reactome:R-HSA-9664873|reactome:R-HSA-6804757	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	-	-	-	figure legend:S9|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/17	2014/10/16	rogid:d/FYo7KdBblfR/inXUZpFlWTfoo9606	rogid:64WoojA64oXXnupzAKEbytnly1s9606	intact-crc:0E04F8D763B32011|rigid:IHjUyVu6w+ByUZZIZCt6XG/KjN4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13315	uniprotkb:O43156	intact:EBI-495465|uniprotkb:O15429|uniprotkb:Q12758|uniprotkb:Q16551|uniprotkb:Q93007|uniprotkb:Q9NP02|uniprotkb:Q9UCX7|intact:EBI-1059333|uniprotkb:B2RNX5|intact:EBI-28985245|ensembl:ENSP00000278616|ensembl:ENSP00000388058|ensembl:ENSP00000501606	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	psi-mi:atm_human(display_long)|uniprotkb:ATM(gene name)|psi-mi:ATM(display_short)|uniprotkb:Ataxia telangiectasia mutated(gene name synonym)	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4568017	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000042.3|refseq:XP_011541142.1|ensembl:ENSP00000501606|ensembl:ENSP00000278616|ensembl:ENSP00000388058|refseq:XP_005271618.2|refseq:XP_005271619.2|refseq:XP_006718906.1|refseq:XP_006718908.1|dip:DIP-182N|refseq:XP_016873278.1|refseq:XP_016873279.1|ensembl:ENSG00000149311(gene)|ensembl:ENST00000452508(transcript)|ensembl:ENST00000675843(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007165"(signal transduction)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|go:"GO:1990391"(DNA repair complex)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR015519(Ataxia-Telangiectasia Mutated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021668|interpro:IPR036940|interpro:IPR044107|ensembl:ENST00000278616(transcript)|mint:Q13315|rcsb pdb:5NP0|rcsb pdb:5NP1|rcsb pdb:6HKA|rcsb pdb:6K9K|rcsb pdb:6K9L|reactome:R-HSA-2559586|reactome:R-HSA-3371453|reactome:R-HSA-349425|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803207|reactome:R-HSA-6804756|reactome:R-HSA-6804760|reactome:R-HSA-69473|reactome:R-HSA-69541|reactome:R-HSA-912446|reactome:R-HSA-9664873|reactome:R-HSA-6804757	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	-	-	-	figure legend:5f|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/17	2014/10/16	rogid:d/FYo7KdBblfR/inXUZpFlWTfoo9606	rogid:64WoojA64oXXnupzAKEbytnly1s9606	intact-crc:479B75EF1C89F789|rigid:IHjUyVu6w+ByUZZIZCt6XG/KjN4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13315	uniprotkb:O43156	intact:EBI-495465|uniprotkb:O15429|uniprotkb:Q12758|uniprotkb:Q16551|uniprotkb:Q93007|uniprotkb:Q9NP02|uniprotkb:Q9UCX7|intact:EBI-1059333|uniprotkb:B2RNX5|intact:EBI-28985245|ensembl:ENSP00000278616|ensembl:ENSP00000388058|ensembl:ENSP00000501606	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	psi-mi:atm_human(display_long)|uniprotkb:ATM(gene name)|psi-mi:ATM(display_short)|uniprotkb:Ataxia telangiectasia mutated(gene name synonym)	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4568007	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000042.3|refseq:XP_011541142.1|ensembl:ENSP00000501606|ensembl:ENSP00000278616|ensembl:ENSP00000388058|refseq:XP_005271618.2|refseq:XP_005271619.2|refseq:XP_006718906.1|refseq:XP_006718908.1|dip:DIP-182N|refseq:XP_016873278.1|refseq:XP_016873279.1|ensembl:ENSG00000149311(gene)|ensembl:ENST00000452508(transcript)|ensembl:ENST00000675843(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007165"(signal transduction)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|go:"GO:1990391"(DNA repair complex)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR015519(Ataxia-Telangiectasia Mutated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021668|interpro:IPR036940|interpro:IPR044107|ensembl:ENST00000278616(transcript)|mint:Q13315|rcsb pdb:5NP0|rcsb pdb:5NP1|rcsb pdb:6HKA|rcsb pdb:6K9K|rcsb pdb:6K9L|reactome:R-HSA-2559586|reactome:R-HSA-3371453|reactome:R-HSA-349425|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803207|reactome:R-HSA-6804756|reactome:R-HSA-6804760|reactome:R-HSA-69473|reactome:R-HSA-69541|reactome:R-HSA-912446|reactome:R-HSA-9664873|reactome:R-HSA-6804757	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	-	-	-	figure legend:5d|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/17	2014/10/16	rogid:d/FYo7KdBblfR/inXUZpFlWTfoo9606	rogid:64WoojA64oXXnupzAKEbytnly1s9606	intact-crc:F6D61D9B9BC7A30D|rigid:IHjUyVu6w+ByUZZIZCt6XG/KjN4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43156	uniprotkb:Q13535	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	intact:EBI-968983|ensembl:ENSP00000343741|uniprotkb:Q7KYL3|uniprotkb:Q93051|uniprotkb:Q9BXK4|uniprotkb:Q59HB2	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:atr_human(display_long)|uniprotkb:ATR(gene name)|psi-mi:ATR(display_short)|uniprotkb:FRP1(gene name synonym)|uniprotkb:Ataxia telangiectasia and Rad3-related protein(gene name synonym)|uniprotkb:FRAP-related protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4568012	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	ensembl:ENSG00000175054(gene)|ensembl:ENST00000350721(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031297"(replication fork processing)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042493"|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012993(UME)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021133|interpro:IPR036940|mint:Q13535|rcsb pdb:5YZ0|reactome:R-HSA-1221632|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-5685938|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6783310|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|refseq:NP_001175.2|refseq:XP_016862132.1|dip:DIP-35308N	-	-	-	figure legend:5e|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/17	2014/10/16	rogid:64WoojA64oXXnupzAKEbytnly1s9606	rogid:ZYzDNmnxcK+RJN42KfgQZlxGACU9606	intact-crc:C577AD9B74CD09A6|rigid:ZpRDQMUf/VoWEPeml25tXx4tIHc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4R8	uniprotkb:O43156	intact:EBI-1043674|uniprotkb:O75168|uniprotkb:Q7LDV4|uniprotkb:Q9BR21|intact:EBI-725566|intact:EBI-1047721|ensembl:ENSP00000262319|uniprotkb:D3DU73	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	psi-mi:telo2_human(display_long)|uniprotkb:TELO2(gene name)|psi-mi:TELO2(display_short)|uniprotkb:KIAA0683(gene name synonym)|uniprotkb:Protein clk-2 homolog(gene name synonym)	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4597071	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100726(gene)|ensembl:ENST00000262319(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070209"(ASTRA complex)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019337|interpro:IPR038528|mint:Q9Y4R8|rcsb pdb:4PSI|refseq:NP_057195.2|refseq:XP_016879403.1|dip:DIP-40568N	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	-	-	-	figure legend:S10|curation depth:mimix curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2011/10/17	2014/10/16	rogid:AnKk5b5Bc/tzEEz+p68m5uQUZVY9606	rogid:64WoojA64oXXnupzAKEbytnly1s9606	intact-crc:C0C0CB08CD43204F|rigid:V+VoR3jhQgR8mGHoTbkWDN3q5pc	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y4R8	uniprotkb:O43156	intact:EBI-1043674|uniprotkb:O75168|uniprotkb:Q7LDV4|uniprotkb:Q9BR21|intact:EBI-725566|intact:EBI-1047721|ensembl:ENSP00000262319|uniprotkb:D3DU73	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	psi-mi:telo2_human(display_long)|uniprotkb:TELO2(gene name)|psi-mi:TELO2(display_short)|uniprotkb:KIAA0683(gene name synonym)|uniprotkb:Protein clk-2 homolog(gene name synonym)	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4565739	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100726(gene)|ensembl:ENST00000262319(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070209"(ASTRA complex)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019337|interpro:IPR038528|mint:Q9Y4R8|rcsb pdb:4PSI|refseq:NP_057195.2|refseq:XP_016879403.1|dip:DIP-40568N	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	-	-	-	figure legend:6a|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2011/10/17	2014/10/16	rogid:AnKk5b5Bc/tzEEz+p68m5uQUZVY9606	rogid:64WoojA64oXXnupzAKEbytnly1s9606	intact-crc:3B8DAC4DF2D41DE7|rigid:V+VoR3jhQgR8mGHoTbkWDN3q5pc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6NXR4	uniprotkb:O43156	intact:EBI-4566107|uniprotkb:D3DSV7|uniprotkb:Q96IM2|uniprotkb:Q9H5N4|ensembl:ENSP00000353971|ensembl:ENSP00000411169|ensembl:ENSP00000478396	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	psi-mi:tti2_human(display_long)|uniprotkb:TTI2(gene name)|psi-mi:TTI2(display_short)|uniprotkb:C8orf41(gene name synonym)	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4568058	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001095871.1|refseq:NP_079391.2|refseq:NP_001252510.1|ensembl:ENSG00000129696(gene)|ensembl:ENST00000360742(transcript)|ensembl:ENST00000431156(transcript)|ensembl:ENST00000613904(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018870|go:"GO:0005813"(centrosome)	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	-	-	-	figure legend:6d|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2011/10/17	2014/10/16	rogid:CK+55nt5IJEfNNFXWqo9MPSA3bo9606	rogid:64WoojA64oXXnupzAKEbytnly1s9606	intact-crc:1CC25DA898BD7EB0|rigid:lbNNRsgB6IfsQPHoh8XD98CyIJY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6NXR4	uniprotkb:Q9Y4R8	intact:EBI-4566107|uniprotkb:D3DSV7|uniprotkb:Q96IM2|uniprotkb:Q9H5N4|ensembl:ENSP00000353971|ensembl:ENSP00000411169|ensembl:ENSP00000478396	intact:EBI-1043674|uniprotkb:O75168|uniprotkb:Q7LDV4|uniprotkb:Q9BR21|intact:EBI-725566|intact:EBI-1047721|ensembl:ENSP00000262319|uniprotkb:D3DU73	psi-mi:tti2_human(display_long)|uniprotkb:TTI2(gene name)|psi-mi:TTI2(display_short)|uniprotkb:C8orf41(gene name synonym)	psi-mi:telo2_human(display_long)|uniprotkb:TELO2(gene name)|psi-mi:TELO2(display_short)|uniprotkb:KIAA0683(gene name synonym)|uniprotkb:Protein clk-2 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4568058	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001095871.1|refseq:NP_079391.2|refseq:NP_001252510.1|ensembl:ENSG00000129696(gene)|ensembl:ENST00000360742(transcript)|ensembl:ENST00000431156(transcript)|ensembl:ENST00000613904(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018870|go:"GO:0005813"(centrosome)	ensembl:ENSG00000100726(gene)|ensembl:ENST00000262319(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070209"(ASTRA complex)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019337|interpro:IPR038528|mint:Q9Y4R8|rcsb pdb:4PSI|refseq:NP_057195.2|refseq:XP_016879403.1|dip:DIP-40568N	-	-	-	figure legend:6d|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2011/10/17	2014/10/16	rogid:CK+55nt5IJEfNNFXWqo9MPSA3bo9606	rogid:AnKk5b5Bc/tzEEz+p68m5uQUZVY9606	intact-crc:1CC25DA898BD7EB0|rigid:lbNNRsgB6IfsQPHoh8XD98CyIJY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4R8	uniprotkb:O43156	intact:EBI-1043674|uniprotkb:O75168|uniprotkb:Q7LDV4|uniprotkb:Q9BR21|intact:EBI-725566|intact:EBI-1047721|ensembl:ENSP00000262319|uniprotkb:D3DU73	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	psi-mi:telo2_human(display_long)|uniprotkb:TELO2(gene name)|psi-mi:TELO2(display_short)|uniprotkb:KIAA0683(gene name synonym)|uniprotkb:Protein clk-2 homolog(gene name synonym)	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4566935	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100726(gene)|ensembl:ENST00000262319(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070209"(ASTRA complex)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019337|interpro:IPR038528|mint:Q9Y4R8|rcsb pdb:4PSI|refseq:NP_057195.2|refseq:XP_016879403.1|dip:DIP-40568N	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	-	-	-	figure legend:6e|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/17	2014/10/16	rogid:AnKk5b5Bc/tzEEz+p68m5uQUZVY9606	rogid:64WoojA64oXXnupzAKEbytnly1s9606	intact-crc:31575830150E0709|rigid:lbNNRsgB6IfsQPHoh8XD98CyIJY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4R8	uniprotkb:Q6NXR4	intact:EBI-1043674|uniprotkb:O75168|uniprotkb:Q7LDV4|uniprotkb:Q9BR21|intact:EBI-725566|intact:EBI-1047721|ensembl:ENSP00000262319|uniprotkb:D3DU73	intact:EBI-4566107|uniprotkb:D3DSV7|uniprotkb:Q96IM2|uniprotkb:Q9H5N4|ensembl:ENSP00000353971|ensembl:ENSP00000411169|ensembl:ENSP00000478396	psi-mi:telo2_human(display_long)|uniprotkb:TELO2(gene name)|psi-mi:TELO2(display_short)|uniprotkb:KIAA0683(gene name synonym)|uniprotkb:Protein clk-2 homolog(gene name synonym)	psi-mi:tti2_human(display_long)|uniprotkb:TTI2(gene name)|psi-mi:TTI2(display_short)|uniprotkb:C8orf41(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4566935	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100726(gene)|ensembl:ENST00000262319(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070209"(ASTRA complex)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019337|interpro:IPR038528|mint:Q9Y4R8|rcsb pdb:4PSI|refseq:NP_057195.2|refseq:XP_016879403.1|dip:DIP-40568N	refseq:NP_001095871.1|refseq:NP_079391.2|refseq:NP_001252510.1|ensembl:ENSG00000129696(gene)|ensembl:ENST00000360742(transcript)|ensembl:ENST00000431156(transcript)|ensembl:ENST00000613904(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018870|go:"GO:0005813"(centrosome)	-	-	-	figure legend:6e|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/17	2014/10/16	rogid:AnKk5b5Bc/tzEEz+p68m5uQUZVY9606	rogid:CK+55nt5IJEfNNFXWqo9MPSA3bo9606	intact-crc:31575830150E0709|rigid:lbNNRsgB6IfsQPHoh8XD98CyIJY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43156	uniprotkb:Q9Y4R8	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	intact:EBI-1043674|uniprotkb:O75168|uniprotkb:Q7LDV4|uniprotkb:Q9BR21|intact:EBI-725566|intact:EBI-1047721|ensembl:ENSP00000262319|uniprotkb:D3DU73	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:telo2_human(display_long)|uniprotkb:TELO2(gene name)|psi-mi:TELO2(display_short)|uniprotkb:KIAA0683(gene name synonym)|uniprotkb:Protein clk-2 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4568048	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	ensembl:ENSG00000100726(gene)|ensembl:ENST00000262319(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070209"(ASTRA complex)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019337|interpro:IPR038528|mint:Q9Y4R8|rcsb pdb:4PSI|refseq:NP_057195.2|refseq:XP_016879403.1|dip:DIP-40568N	-	-	-	figure legend:6b|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/17	2014/10/16	rogid:64WoojA64oXXnupzAKEbytnly1s9606	rogid:AnKk5b5Bc/tzEEz+p68m5uQUZVY9606	intact-crc:21E94D395FD17838|rigid:V+VoR3jhQgR8mGHoTbkWDN3q5pc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43156	uniprotkb:Q13315	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	intact:EBI-495465|uniprotkb:O15429|uniprotkb:Q12758|uniprotkb:Q16551|uniprotkb:Q93007|uniprotkb:Q9NP02|uniprotkb:Q9UCX7|intact:EBI-1059333|uniprotkb:B2RNX5|intact:EBI-28985245|ensembl:ENSP00000278616|ensembl:ENSP00000388058|ensembl:ENSP00000501606	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:atm_human(display_long)|uniprotkb:ATM(gene name)|psi-mi:ATM(display_short)|uniprotkb:Ataxia telangiectasia mutated(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-5242252	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	refseq:NP_000042.3|refseq:XP_011541142.1|ensembl:ENSP00000501606|ensembl:ENSP00000278616|ensembl:ENSP00000388058|refseq:XP_005271618.2|refseq:XP_005271619.2|refseq:XP_006718906.1|refseq:XP_006718908.1|dip:DIP-182N|refseq:XP_016873278.1|refseq:XP_016873279.1|ensembl:ENSG00000149311(gene)|ensembl:ENST00000452508(transcript)|ensembl:ENST00000675843(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007165"(signal transduction)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|go:"GO:1990391"(DNA repair complex)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR015519(Ataxia-Telangiectasia Mutated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021668|interpro:IPR036940|interpro:IPR044107|ensembl:ENST00000278616(transcript)|mint:Q13315|rcsb pdb:5NP0|rcsb pdb:5NP1|rcsb pdb:6HKA|rcsb pdb:6K9K|rcsb pdb:6K9L|reactome:R-HSA-2559586|reactome:R-HSA-3371453|reactome:R-HSA-349425|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803207|reactome:R-HSA-6804756|reactome:R-HSA-6804760|reactome:R-HSA-69473|reactome:R-HSA-69541|reactome:R-HSA-912446|reactome:R-HSA-9664873|reactome:R-HSA-6804757	-	-	-	figure legend:"7F (left panel)"|curation depth:mimix curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2011/10/17	2014/10/16	rogid:64WoojA64oXXnupzAKEbytnly1s9606	rogid:d/FYo7KdBblfR/inXUZpFlWTfoo9606	intact-crc:CE7CDF37ECD13B5C|rigid:FAhogxKifTFSMUEROh8iEbHmZdA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43156	uniprotkb:Q6NXR4	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	intact:EBI-4566107|uniprotkb:D3DSV7|uniprotkb:Q96IM2|uniprotkb:Q9H5N4|ensembl:ENSP00000353971|ensembl:ENSP00000411169|ensembl:ENSP00000478396	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:tti2_human(display_long)|uniprotkb:TTI2(gene name)|psi-mi:TTI2(display_short)|uniprotkb:C8orf41(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-5242252	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	refseq:NP_001095871.1|refseq:NP_079391.2|refseq:NP_001252510.1|ensembl:ENSG00000129696(gene)|ensembl:ENST00000360742(transcript)|ensembl:ENST00000431156(transcript)|ensembl:ENST00000613904(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018870|go:"GO:0005813"(centrosome)	-	-	-	figure legend:"7F (left panel)"|curation depth:mimix curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2011/10/17	2014/10/16	rogid:64WoojA64oXXnupzAKEbytnly1s9606	rogid:CK+55nt5IJEfNNFXWqo9MPSA3bo9606	intact-crc:CE7CDF37ECD13B5C|rigid:FAhogxKifTFSMUEROh8iEbHmZdA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6NXR4	uniprotkb:Q13315	intact:EBI-4566107|uniprotkb:D3DSV7|uniprotkb:Q96IM2|uniprotkb:Q9H5N4|ensembl:ENSP00000353971|ensembl:ENSP00000411169|ensembl:ENSP00000478396	intact:EBI-495465|uniprotkb:O15429|uniprotkb:Q12758|uniprotkb:Q16551|uniprotkb:Q93007|uniprotkb:Q9NP02|uniprotkb:Q9UCX7|intact:EBI-1059333|uniprotkb:B2RNX5|intact:EBI-28985245|ensembl:ENSP00000278616|ensembl:ENSP00000388058|ensembl:ENSP00000501606	psi-mi:tti2_human(display_long)|uniprotkb:TTI2(gene name)|psi-mi:TTI2(display_short)|uniprotkb:C8orf41(gene name synonym)	psi-mi:atm_human(display_long)|uniprotkb:ATM(gene name)|psi-mi:ATM(display_short)|uniprotkb:Ataxia telangiectasia mutated(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-5242259	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001095871.1|refseq:NP_079391.2|refseq:NP_001252510.1|ensembl:ENSG00000129696(gene)|ensembl:ENST00000360742(transcript)|ensembl:ENST00000431156(transcript)|ensembl:ENST00000613904(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018870|go:"GO:0005813"(centrosome)	refseq:NP_000042.3|refseq:XP_011541142.1|ensembl:ENSP00000501606|ensembl:ENSP00000278616|ensembl:ENSP00000388058|refseq:XP_005271618.2|refseq:XP_005271619.2|refseq:XP_006718906.1|refseq:XP_006718908.1|dip:DIP-182N|refseq:XP_016873278.1|refseq:XP_016873279.1|ensembl:ENSG00000149311(gene)|ensembl:ENST00000452508(transcript)|ensembl:ENST00000675843(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007165"(signal transduction)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|go:"GO:1990391"(DNA repair complex)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR015519(Ataxia-Telangiectasia Mutated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021668|interpro:IPR036940|interpro:IPR044107|ensembl:ENST00000278616(transcript)|mint:Q13315|rcsb pdb:5NP0|rcsb pdb:5NP1|rcsb pdb:6HKA|rcsb pdb:6K9K|rcsb pdb:6K9L|reactome:R-HSA-2559586|reactome:R-HSA-3371453|reactome:R-HSA-349425|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803207|reactome:R-HSA-6804756|reactome:R-HSA-6804760|reactome:R-HSA-69473|reactome:R-HSA-69541|reactome:R-HSA-912446|reactome:R-HSA-9664873|reactome:R-HSA-6804757	-	-	-	figure legend:"7F (right panel)"|curation depth:mimix curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2011/10/17	2014/10/16	rogid:CK+55nt5IJEfNNFXWqo9MPSA3bo9606	rogid:d/FYo7KdBblfR/inXUZpFlWTfoo9606	intact-crc:A1D3A4EA7D7CC4E6|rigid:FAhogxKifTFSMUEROh8iEbHmZdA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6NXR4	uniprotkb:O43156	intact:EBI-4566107|uniprotkb:D3DSV7|uniprotkb:Q96IM2|uniprotkb:Q9H5N4|ensembl:ENSP00000353971|ensembl:ENSP00000411169|ensembl:ENSP00000478396	intact:EBI-1055680|uniprotkb:Q5JX67|uniprotkb:Q96A38|uniprotkb:Q9BR47|uniprotkb:Q9H4K0|uniprotkb:D6W4K3|ensembl:ENSP00000362546|ensembl:ENSP00000362547|ensembl:ENSP00000407270	psi-mi:tti2_human(display_long)|uniprotkb:TTI2(gene name)|psi-mi:TTI2(display_short)|uniprotkb:C8orf41(gene name synonym)	psi-mi:tti1_human(display_long)|uniprotkb:TTI1(gene name)|psi-mi:TTI1(display_short)|uniprotkb:KIAA0406(gene name synonym)|uniprotkb:SMG10(gene name synonym)|uniprotkb:Protein SMG10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hurov et al. (2010)	pubmed:20810650	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-5242259	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001095871.1|refseq:NP_079391.2|refseq:NP_001252510.1|ensembl:ENSG00000129696(gene)|ensembl:ENST00000360742(transcript)|ensembl:ENST00000431156(transcript)|ensembl:ENST00000613904(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0070209"(ASTRA complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018870|go:"GO:0005813"(centrosome)	refseq:NP_001290386.1|refseq:NP_055472.1|ensembl:ENSG00000101407(gene)|ensembl:ENST00000373447(transcript)|ensembl:ENST00000373448(transcript)|ensembl:ENST00000449821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0070209"(ASTRA complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016441(Uncharacterised conserved protein UCP005250)|dip:DIP-50660N	-	-	-	figure legend:"7F (right panel)"|curation depth:mimix curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2011/10/17	2014/10/16	rogid:CK+55nt5IJEfNNFXWqo9MPSA3bo9606	rogid:64WoojA64oXXnupzAKEbytnly1s9606	intact-crc:A1D3A4EA7D7CC4E6|rigid:FAhogxKifTFSMUEROh8iEbHmZdA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)