#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9ULV1	uniprotkb:O14745	intact:EBI-2466380|ensembl:ENSP00000434034|uniprotkb:A8K9Q3|uniprotkb:Q14C97|uniprotkb:Q6S9E4	intact:EBI-349787|uniprotkb:O43552|uniprotkb:Q86WQ5|ensembl:ENSP00000262613|uniprotkb:B3KY21|intact:EBI-15579389	psi-mi:fzd4_human(display_long)|uniprotkb:FZD4(gene name)|psi-mi:FZD4(display_short)|uniprotkb:FzE4(gene name synonym)	psi-mi:nhrf1_human(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Wheeler et al. (2011)	imex:IM-15760|pubmed:20802536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-3504957|imex:IM-15760-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-8856828|reactome:R-HSA-8856825|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000174804(gene)|ensembl:ENST00000531380(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|rcsb pdb:5BPB|rcsb pdb:5BPQ|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|rcsb pdb:5CM4|rcsb pdb:5UWG|go:"GO:0060070"(canonical Wnt signaling pathway)|rcsb pdb:6BD4|rcsb pdb:6NE1|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5099900|reactome:R-HSA-5340588|refseq:NP_036325.2	refseq:NP_004243.1|ensembl:ENSG00000109062(gene)|ensembl:ENST00000262613(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0031982"(vesicle)|go:"GO:0032415"("regulation of sodium:proton antiporter activity")|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|interpro:IPR041489|mint:O14745|rcsb pdb:1G9O|rcsb pdb:1GQ4|rcsb pdb:1GQ5|rcsb pdb:1I92|rcsb pdb:1SGH|rcsb pdb:2D10|rcsb pdb:2JXO|rcsb pdb:2KJD|rcsb pdb:2KRG|rcsb pdb:2M0T|rcsb pdb:2M0U|rcsb pdb:2M0V|rcsb pdb:2OZF|rcsb pdb:4JL7|rcsb pdb:4LMM|rcsb pdb:4N6X|rcsb pdb:4PQW|rcsb pdb:4Q3H|rcsb pdb:6RQR|rcsb pdb:4MPA|dip:DIP-29092N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1d|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/24	2014/10/16	rogid:AMa+JdoYYdqHGs85YaqVNE+YGAY9606	rogid:03E30U6coFBcC3BeKOYnInfG/BI9606	intact-crc:4A744BBC0A5B3D05|rigid:bSkt7YL1syUkO6f19PGMPr5uHOc	false	ha tag:?-?|mutation decreasing interaction:537-537	his tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q9ULV1	uniprotkb:G3GTH2	intact:EBI-2466380|ensembl:ENSP00000434034|uniprotkb:A8K9Q3|uniprotkb:Q14C97|uniprotkb:Q6S9E4	intact:EBI-3504975|ensembl:ENSCGRP00001026101|ensembl:ENSCGRP00015013247	psi-mi:fzd4_human(display_long)|uniprotkb:FZD4(gene name)|psi-mi:FZD4(display_short)|uniprotkb:FzE4(gene name synonym)	psi-mi:g3gth2_crigr(display_long)|uniprotkb:I79_000956(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wheeler et al. (2011)	imex:IM-15760|pubmed:20802536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-3504985|imex:IM-15760-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-8856828|reactome:R-HSA-8856825|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000174804(gene)|ensembl:ENST00000531380(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|rcsb pdb:5BPB|rcsb pdb:5BPQ|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|rcsb pdb:5CM4|rcsb pdb:5UWG|go:"GO:0060070"(canonical Wnt signaling pathway)|rcsb pdb:6BD4|rcsb pdb:6NE1|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5099900|reactome:R-HSA-5340588|refseq:NP_036325.2	ensembl:ENSCGRG00001023524(gene)|ensembl:ENSCGRG00015010149(gene)|ensembl:ENSCGRT00001030347(transcript)|ensembl:ENSCGRT00015016206(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005576"(extracellular region)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|refseq:XP_007641362.1|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1b|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2011/01/24	2014/10/16	rogid:AMa+JdoYYdqHGs85YaqVNE+YGAY9606	rogid:rBfgtZXe3c10O0PqZOhfXDqG56I10029	intact-crc:15F0423BF3C032BD|rigid:MlEumMGvu7m1xwcVTSIDJQgBlF0	false	ha tag:?-?|mutation decreasing interaction:537-537	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60838	uniprotkb:Q9ULV1	intact:EBI-641940|uniprotkb:Q7TN14|ensembl:ENSMUSP00000099635|ensembl:ENSMUSP00000140073|ensembl:ENSMUSP00000019362	intact:EBI-2466380|ensembl:ENSP00000434034|uniprotkb:A8K9Q3|uniprotkb:Q14C97|uniprotkb:Q6S9E4	psi-mi:dvl2_mouse(display_long)|uniprotkb:Dvl2(gene name)|psi-mi:Dvl2(display_short)|uniprotkb:DSH homolog 2(gene name synonym)	psi-mi:fzd4_human(display_long)|uniprotkb:FZD4(gene name)|psi-mi:FZD4(display_short)|uniprotkb:FzE4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wheeler et al. (2011)	imex:IM-15760|pubmed:20802536	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-3505001|imex:IM-15760-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031914.3|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q60838|rcsb pdb:3ML6|rcsb pdb:6VCC|reactome:R-MMU-201688|reactome:R-MMU-2028269|reactome:R-MMU-4086400|reactome:R-MMU-4608870|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5099900|reactome:R-MMU-5663220|reactome:R-MMU-8856825|reactome:R-MMU-8856828|ensembl:ENSMUST00000019362(transcript)|ensembl:ENSMUST00000102575(transcript)|ensembl:ENSMUST00000190940(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035282"(segmentation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060029"(convergent extension involved in organogenesis)|ensembl:ENSMUSG00000020888(gene)|dip:DIP-29399N	reactome:R-HSA-8856828|reactome:R-HSA-8856825|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000174804(gene)|ensembl:ENST00000531380(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|rcsb pdb:5BPB|rcsb pdb:5BPQ|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|rcsb pdb:5CM4|rcsb pdb:5UWG|go:"GO:0060070"(canonical Wnt signaling pathway)|rcsb pdb:6BD4|rcsb pdb:6NE1|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5099900|reactome:R-HSA-5340588|refseq:NP_036325.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6a|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2011/01/24	2014/10/16	rogid:bFjXy0cGGbY8YE60qW3+0NLpqNs10090	rogid:AMa+JdoYYdqHGs85YaqVNE+YGAY9606	intact-crc:090D158D33C84E40|rigid:nlJJ23MZKX+hhMO1Uidw6zy3bdc	false	myc tag:?-?	ha tag:?-?|mutation decreasing interaction:537-537	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9ULV1	uniprotkb:G3GTH2	intact:EBI-2466380|ensembl:ENSP00000434034|uniprotkb:A8K9Q3|uniprotkb:Q14C97|uniprotkb:Q6S9E4	intact:EBI-3504975|ensembl:ENSCGRP00001026101|ensembl:ENSCGRP00015013247	psi-mi:fzd4_human(display_long)|uniprotkb:FZD4(gene name)|psi-mi:FZD4(display_short)|uniprotkb:FzE4(gene name synonym)	psi-mi:g3gth2_crigr(display_long)|uniprotkb:I79_000956(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wheeler et al. (2011)	imex:IM-15760|pubmed:20802536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-3504993|imex:IM-15760-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-8856828|reactome:R-HSA-8856825|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000174804(gene)|ensembl:ENST00000531380(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|rcsb pdb:5BPB|rcsb pdb:5BPQ|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|rcsb pdb:5CM4|rcsb pdb:5UWG|go:"GO:0060070"(canonical Wnt signaling pathway)|rcsb pdb:6BD4|rcsb pdb:6NE1|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5099900|reactome:R-HSA-5340588|refseq:NP_036325.2	ensembl:ENSCGRG00001023524(gene)|ensembl:ENSCGRG00015010149(gene)|ensembl:ENSCGRT00001030347(transcript)|ensembl:ENSCGRT00015016206(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005576"(extracellular region)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|refseq:XP_007641362.1|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1c, S3|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2011/01/24	2014/10/16	rogid:AMa+JdoYYdqHGs85YaqVNE+YGAY9606	rogid:rBfgtZXe3c10O0PqZOhfXDqG56I10029	intact-crc:499A62D692BB4EF6|rigid:MlEumMGvu7m1xwcVTSIDJQgBlF0	false	ha tag:?-?	mutation decreasing interaction:167-167,164-164|mutation disrupting interaction:24-24,26-26,164-164,167-167	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)