#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P28562	uniprotkb:Q91Y86	intact:EBI-975493|ensembl:ENSP00000239223|uniprotkb:Q2V508|uniprotkb:D3DQL9	intact:EBI-298784|ensembl:ENSMUSP00000107576	psi-mi:dus1_human(display_long)|uniprotkb:Mitogen-activated protein kinase phosphatase 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase CL100(gene name synonym)|uniprotkb:Dual specificity protein phosphatase hVH1(gene name synonym)|uniprotkb:DUSP1(gene name)|psi-mi:DUSP1(display_short)|uniprotkb:CL100(gene name synonym)|uniprotkb:MKP1(gene name synonym)|uniprotkb:PTPN10(gene name synonym)|uniprotkb:VH1(gene name synonym)	psi-mi:mk08_mouse(display_long)|uniprotkb:Mapk8(gene name)|psi-mi:Mapk8(display_short)|uniprotkb:Jnk1(gene name synonym)|uniprotkb:Prkm8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Patterson et al. (2010)	pubmed:20347885|mint:MINT-8288600|doi:10.1016/j.bbamcr.2010.03.014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7888293|mint:MINT-8288617	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000120129(gene)|ensembl:ENST00000239223(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0001706"(endoderm formation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0008330"(protein tyrosine/threonine phosphatase activity)|go:"GO:0009416"(response to light stimulus)|go:"GO:0017017"(MAP kinase tyrosine/serine/threonine phosphatase activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0032355"(response to estradiol)|interpro:IPR020422|interpro:IPR029021|interpro:IPR036873|go:"GO:0032526"(response to retinoic acid)|mint:P28562|rcsb pdb:6APX|rcsb pdb:6D65|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|rcsb pdb:6D66|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|rcsb pdb:6D67|go:"GO:0042542"(response to hydrogen peroxide)|reactome:R-HSA-112409|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-HSA-5675221|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR008343(MAP kinase phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|refseq:NP_004408.1|mint:MINT-8288620(identity)	go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902595"(regulation of DNA replication origin binding)|go:"GO:1904809"(regulation of dense core granule transport)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001224"(positive regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:Q91Y86|reactome:R-MMU-139910|reactome:R-MMU-193648|reactome:R-MMU-2559580|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-450321|reactome:R-MMU-450341|reactome:R-MMU-5693565|reactome:R-MMU-9007892|reactome:R-MMU-111446|ensembl:ENSMUSG00000021936(gene)|ensembl:ENSMUST00000111945(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009408"(response to heat)|refseq:NP_057909.1|dip:DIP-31075N|mint:MINT-8288619(identity)	-	-	comment:"Resulting Phenotypic qualities (properties)[PATO]: PATO:0002263 (dephosphorylated)"	figure legend:f2|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/08	2014/10/16	rogid:HWv2ngjp+me3PbYUNexMd0viYPw9606	rogid:PF6G6rHf26jidt+Mg3aFCvCm7pU10090	intact-crc:F577D68D9F11C79E|rigid:9uku52uAvwxF0gQlSm/LzrVlEPo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16539	uniprotkb:P28562	intact:EBI-73946|uniprotkb:A8K6P4|uniprotkb:B0LPH0|uniprotkb:A6ZJ92|uniprotkb:O60776|uniprotkb:Q13083|uniprotkb:Q14084|uniprotkb:Q8TDX0|uniprotkb:B5TY32|ensembl:ENSP00000229794	intact:EBI-975493|ensembl:ENSP00000239223|uniprotkb:Q2V508|uniprotkb:D3DQL9	psi-mi:mk14_human(display_long)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:Cytokine suppressive anti-inflammatory drug-binding protein(gene name synonym)|uniprotkb:MAX-interacting protein 2(gene name synonym)|uniprotkb:MAP kinase MXI2(gene name synonym)|uniprotkb:SAPK2A(gene name synonym)|uniprotkb:MAPK14(gene name)|psi-mi:MAPK14(display_short)|uniprotkb:CSBP(gene name synonym)|uniprotkb:CSBP1(gene name synonym)|uniprotkb:CSBP2(gene name synonym)|uniprotkb:CSPB1(gene name synonym)|uniprotkb:MXI2(gene name synonym)|uniprotkb:Stress-activated protein kinase 2a(gene name synonym)	psi-mi:dus1_human(display_long)|uniprotkb:Mitogen-activated protein kinase phosphatase 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase CL100(gene name synonym)|uniprotkb:Dual specificity protein phosphatase hVH1(gene name synonym)|uniprotkb:DUSP1(gene name)|psi-mi:DUSP1(display_short)|uniprotkb:CL100(gene name synonym)|uniprotkb:MKP1(gene name synonym)|uniprotkb:PTPN10(gene name synonym)|uniprotkb:VH1(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Patterson et al. (2010)	pubmed:20347885|mint:MINT-8288600|doi:10.1016/j.bbamcr.2010.03.014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7888271|mint:MINT-8288609	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306.1|refseq:NP_620581.1|refseq:NP_620582.1|refseq:NP_620583.1|dip:DIP-30987N|ensembl:ENSG00000112062(gene)|ensembl:ENST00000229794(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:Q16539|rcsb pdb:1A9U|rcsb pdb:1BL6|rcsb pdb:1BL7|rcsb pdb:1BMK|rcsb pdb:1DI9|rcsb pdb:1IAN|rcsb pdb:1KV1|rcsb pdb:1KV2|rcsb pdb:1M7Q|rcsb pdb:1OUK|rcsb pdb:1OUY|rcsb pdb:1OVE|rcsb pdb:1OZ1|rcsb pdb:1R39|rcsb pdb:1R3C|rcsb pdb:1W7H|rcsb pdb:1W82|rcsb pdb:1W83|rcsb pdb:1W84|rcsb pdb:1WBN|rcsb pdb:1WBO|rcsb pdb:1WBS|rcsb pdb:1WBT|rcsb pdb:1WBV|rcsb pdb:1WBW|rcsb pdb:1WFC|rcsb pdb:1YQJ|rcsb pdb:1ZYJ|rcsb pdb:1ZZ2|rcsb pdb:1ZZL|rcsb pdb:2BAJ|rcsb pdb:2BAK|rcsb pdb:2BAL|rcsb pdb:2BAQ|rcsb pdb:2FSL|rcsb pdb:2FSM|rcsb pdb:2FSO|rcsb pdb:2FST|rcsb pdb:2GFS|rcsb pdb:2I0H|rcsb pdb:2LGC|rcsb pdb:2NPQ|rcsb pdb:2OKR|rcsb pdb:2ONL|rcsb pdb:2QD9|rcsb pdb:2RG5|rcsb pdb:2RG6|rcsb pdb:2Y8O|rcsb pdb:2YIS|rcsb pdb:2YIW|rcsb pdb:2YIX|rcsb pdb:2ZAZ|rcsb pdb:2ZB0|rcsb pdb:2ZB1|rcsb pdb:3BV2|rcsb pdb:3BV3|rcsb pdb:3BX5|rcsb pdb:3C5U|rcsb pdb:3CTQ|rcsb pdb:3D7Z|rcsb pdb:3D83|rcsb pdb:3DS6|rcsb pdb:3DT1|rcsb pdb:3E92|rcsb pdb:3E93|rcsb pdb:3FC1|rcsb pdb:3FI4|rcsb pdb:3FKL|rcsb pdb:3FKN|rcsb pdb:3FKO|rcsb pdb:3FL4|rcsb pdb:3FLN|rcsb pdb:3FLQ|rcsb pdb:3FLS|rcsb pdb:3FLW|rcsb pdb:3FLY|rcsb pdb:3FLZ|rcsb pdb:3FMH|rcsb pdb:3FMJ|rcsb pdb:3FMK|rcsb pdb:3FML|rcsb pdb:3FMM|rcsb pdb:3FMN|rcsb pdb:3FSF|rcsb pdb:3FSK|rcsb pdb:3GC7|rcsb pdb:3GCP|rcsb pdb:3GCQ|rcsb pdb:3GCS|rcsb pdb:3GCU|rcsb pdb:3GCV|rcsb pdb:3GFE|rcsb pdb:3GI3|rcsb pdb:3HA8|rcsb pdb:3HEC|rcsb pdb:3HEG|rcsb pdb:3HL7|rcsb pdb:3HLL|rcsb pdb:3HP2|rcsb pdb:3HP5|rcsb pdb:3HRB|rcsb pdb:3HUB|rcsb pdb:3HUC|rcsb pdb:3HV3|rcsb pdb:3HV4|rcsb pdb:3HV5|rcsb pdb:3HV6|rcsb pdb:3HV7|rcsb pdb:3HVC|rcsb pdb:3IPH|rcsb pdb:3ITZ|rcsb pdb:3IW5|rcsb pdb:3IW6|rcsb pdb:3IW7|rcsb pdb:3IW8|rcsb pdb:3K3I|rcsb pdb:3K3J|rcsb pdb:3KF7|rcsb pdb:3KQ7|rcsb pdb:3L8S|rcsb pdb:3L8X|rcsb pdb:3LFA|rcsb pdb:3LFB|rcsb pdb:3LFC|rcsb pdb:3LFD|rcsb pdb:3LFE|rcsb pdb:3LFF|rcsb pdb:3LHJ|rcsb pdb:3MGY|rcsb pdb:3MH0|rcsb pdb:3MH1|rcsb pdb:3MH2|rcsb pdb:3MH3|rcsb pdb:3MPA|rcsb pdb:3MPT|rcsb pdb:3MVL|rcsb pdb:3MVM|rcsb pdb:3MW1|rcsb pdb:3NEW|rcsb pdb:3NNU|rcsb pdb:3NNV|rcsb pdb:3NNW|rcsb pdb:3NNX|rcsb pdb:3NWW|rcsb pdb:3O8P|rcsb pdb:3O8T|rcsb pdb:3O8U|rcsb pdb:3OBG|rcsb pdb:3OBJ|rcsb pdb:3OC1|rcsb pdb:3OCG|rcsb pdb:3OD6|rcsb pdb:3ODY|rcsb pdb:3ODZ|rcsb pdb:3OEF|rcsb pdb:3PG3|rcsb pdb:3QUD|rcsb pdb:3QUE|rcsb pdb:3RIN|rcsb pdb:3ROC|rcsb pdb:3S3I|rcsb pdb:3S4Q|rcsb pdb:3U8W|rcsb pdb:3UVP|rcsb pdb:3UVQ|rcsb pdb:3UVR|rcsb pdb:3ZS5|rcsb pdb:3ZSG|rcsb pdb:3ZSH|rcsb pdb:3ZSI|rcsb pdb:3ZYA|rcsb pdb:4A9Y|rcsb pdb:4AA0|rcsb pdb:4AA4|rcsb pdb:4AA5|rcsb pdb:4AAC|rcsb pdb:4DLI|rcsb pdb:4DLJ|rcsb pdb:4E5A|rcsb pdb:4E5B|rcsb pdb:4E6A|rcsb pdb:4E6C|rcsb pdb:4E8A|rcsb pdb:4EH2|rcsb pdb:4EH3|rcsb pdb:4EH4|rcsb pdb:4EH5|rcsb pdb:4EH6|rcsb pdb:4EH7|rcsb pdb:4EH8|rcsb pdb:4EH9|rcsb pdb:4EHV|rcsb pdb:4EWQ|rcsb pdb:4F9W|rcsb pdb:4F9Y|rcsb pdb:4FA2|rcsb pdb:4GEO|rcsb pdb:4KIN|rcsb pdb:4KIP|rcsb pdb:4KIQ|rcsb pdb:4L8M|rcsb pdb:4R3C|rcsb pdb:4ZTH|rcsb pdb:5ETA|rcsb pdb:5ETC|rcsb pdb:5ETF|rcsb pdb:5ETI|rcsb pdb:5ML5|rcsb pdb:5MTX|rcsb pdb:5MTY|rcsb pdb:5MZ3|rcsb pdb:5N63|rcsb pdb:5N64|rcsb pdb:5N65|rcsb pdb:5N66|rcsb pdb:5N67|rcsb pdb:5N68|rcsb pdb:5O8U|rcsb pdb:5O8V|rcsb pdb:5OMG|rcsb pdb:5OMH|rcsb pdb:5TBE|rcsb pdb:5TCO|rcsb pdb:5WJJ|rcsb pdb:5XYX|rcsb pdb:5XYY|rcsb pdb:6ANL|rcsb pdb:6HWT|rcsb pdb:6HWU|rcsb pdb:6HWV|rcsb pdb:6M95|rcsb pdb:6M9L|rcsb pdb:6OHD|rcsb pdb:6QDZ|rcsb pdb:6QE1|rcsb pdb:6QYX|rcsb pdb:6RFO|rcsb pdb:6SFI|rcsb pdb:6SFJ|rcsb pdb:6SFK|rcsb pdb:6SFO|rcsb pdb:6TCA|rcsb pdb:6ZQS|rcsb pdb:6ZWP|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-198753|reactome:R-HSA-2151209|reactome:R-HSA-2559580|reactome:R-HSA-376172|reactome:R-HSA-418592|reactome:R-HSA-432142|reactome:R-HSA-4420097|reactome:R-HSA-450302|reactome:R-HSA-450341|reactome:R-HSA-450604|reactome:R-HSA-525793|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-9662834|mint:MINT-8288611(identity)	ensembl:ENSG00000120129(gene)|ensembl:ENST00000239223(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0001706"(endoderm formation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0008330"(protein tyrosine/threonine phosphatase activity)|go:"GO:0009416"(response to light stimulus)|go:"GO:0017017"(MAP kinase tyrosine/serine/threonine phosphatase activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0032355"(response to estradiol)|interpro:IPR020422|interpro:IPR029021|interpro:IPR036873|go:"GO:0032526"(response to retinoic acid)|mint:P28562|rcsb pdb:6APX|rcsb pdb:6D65|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|rcsb pdb:6D66|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|rcsb pdb:6D67|go:"GO:0042542"(response to hydrogen peroxide)|reactome:R-HSA-112409|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-HSA-5675221|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR008343(MAP kinase phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|refseq:NP_004408.1|mint:MINT-8288612(identity)	-	comment:"Resulting Phenotypic qualities (properties)[PATO]: PATO:0002263 (dephosphorylated)"	-	figure legend:f2|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/08	2014/10/16	rogid:oI6EOrCDVMQ6FDVBHSiYYoKZHns9606	rogid:HWv2ngjp+me3PbYUNexMd0viYPw9606	intact-crc:C741F30A0C62988C|rigid:I/iiGWwbC58fZqsMpLnbI+P0qyI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05923	uniprotkb:P27361	intact:EBI-7888328|intact:MINT-8214530|uniprotkb:Q53T45|ensembl:ENSP00000288943	intact:EBI-73995|uniprotkb:B0LPG3|uniprotkb:A8CZ58|uniprotkb:Q8NHX1|ensembl:ENSP00000263025	psi-mi:dus2_human(display_long)|uniprotkb:DUSP2(gene name)|psi-mi:DUSP2(display_short)|uniprotkb:Dual specificity protein phosphatase PAC-1(gene name synonym)|uniprotkb:PAC1(gene name synonym)	psi-mi:mk03_human(display_long)|uniprotkb:ERT2(gene name synonym)|uniprotkb:MAP kinase isoform p44(gene name synonym)|uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)|uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)|uniprotkb:p44-ERK1(gene name synonym)|uniprotkb:MAPK3(gene name)|psi-mi:MAPK3(display_short)|uniprotkb:ERK1(gene name synonym)|uniprotkb:PRKM3(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Patterson et al. (2010)	pubmed:20347885|mint:MINT-8288600|doi:10.1016/j.bbamcr.2010.03.014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7888323|mint:MINT-8288639	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004409.1|ensembl:ENSG00000158050(gene)|ensembl:ENST00000288943(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0001706"(endoderm formation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008330"(protein tyrosine/threonine phosphatase activity)|go:"GO:0017017"(MAP kinase tyrosine/serine/threonine phosphatase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR008343(MAP kinase phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR036873|rcsb pdb:1M3G|reactome:R-HSA-112409|reactome:R-HSA-5675221|mint:MINT-8288641(identity)	refseq:NP_001035145.1|refseq:NP_001103361.1|refseq:NP_002737.2|dip:DIP-30985N|ensembl:ENSG00000102882(gene)|ensembl:ENST00000263025(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000657"(negative regulation of apolipoprotein binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P27361|rcsb pdb:2ZOQ|rcsb pdb:4QTB|rcsb pdb:6GES|reactome:R-HSA-110056|reactome:R-HSA-112409|reactome:R-HSA-1169408|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-73728|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|mint:MINT-8288642(identity)	-	comment:mint|comment:homomint	comment:"Resulting Phenotypic qualities (properties)[PATO]: PATO:0002263 (dephosphorylated)"	figure legend:f1e|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/08	2014/10/16	rogid:R8pslcKV5ENWwNyAJKqhQIUM7w09606	rogid:PGxmRMz0kOsJTfdn21FBiF33YwI9606	intact-crc:044F32C2C7FB49AD|rigid:Q8kCPUgi47K2jjbOr/zwzWNRI/8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28562	uniprotkb:P27361	intact:EBI-975493|ensembl:ENSP00000239223|uniprotkb:Q2V508|uniprotkb:D3DQL9	intact:EBI-73995|uniprotkb:B0LPG3|uniprotkb:A8CZ58|uniprotkb:Q8NHX1|ensembl:ENSP00000263025	psi-mi:dus1_human(display_long)|uniprotkb:Mitogen-activated protein kinase phosphatase 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase CL100(gene name synonym)|uniprotkb:Dual specificity protein phosphatase hVH1(gene name synonym)|uniprotkb:DUSP1(gene name)|psi-mi:DUSP1(display_short)|uniprotkb:CL100(gene name synonym)|uniprotkb:MKP1(gene name synonym)|uniprotkb:PTPN10(gene name synonym)|uniprotkb:VH1(gene name synonym)	psi-mi:mk03_human(display_long)|uniprotkb:ERT2(gene name synonym)|uniprotkb:MAP kinase isoform p44(gene name synonym)|uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)|uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)|uniprotkb:p44-ERK1(gene name synonym)|uniprotkb:MAPK3(gene name)|psi-mi:MAPK3(display_short)|uniprotkb:ERK1(gene name synonym)|uniprotkb:PRKM3(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Patterson et al. (2010)	pubmed:20347885|mint:MINT-8288600|doi:10.1016/j.bbamcr.2010.03.014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7888313|mint:MINT-8288630	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000120129(gene)|ensembl:ENST00000239223(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0001706"(endoderm formation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0008330"(protein tyrosine/threonine phosphatase activity)|go:"GO:0009416"(response to light stimulus)|go:"GO:0017017"(MAP kinase tyrosine/serine/threonine phosphatase activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0032355"(response to estradiol)|interpro:IPR020422|interpro:IPR029021|interpro:IPR036873|go:"GO:0032526"(response to retinoic acid)|mint:P28562|rcsb pdb:6APX|rcsb pdb:6D65|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|rcsb pdb:6D66|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|rcsb pdb:6D67|go:"GO:0042542"(response to hydrogen peroxide)|reactome:R-HSA-112409|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-HSA-5675221|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR008343(MAP kinase phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|refseq:NP_004408.1|mint:MINT-8288632(identity)	refseq:NP_001035145.1|refseq:NP_001103361.1|refseq:NP_002737.2|dip:DIP-30985N|ensembl:ENSG00000102882(gene)|ensembl:ENST00000263025(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000657"(negative regulation of apolipoprotein binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P27361|rcsb pdb:2ZOQ|rcsb pdb:4QTB|rcsb pdb:6GES|reactome:R-HSA-110056|reactome:R-HSA-112409|reactome:R-HSA-1169408|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-73728|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|mint:MINT-8288633(identity)	-	-	comment:"Resulting Phenotypic qualities (properties)[PATO]: PATO:0002263 (dephosphorylated)"	figure legend:f2|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/08	2014/10/16	rogid:HWv2ngjp+me3PbYUNexMd0viYPw9606	rogid:PGxmRMz0kOsJTfdn21FBiF33YwI9606	intact-crc:77E39BF8767191C9|rigid:k6CCSDYuZrVmrB9thabdZhm/eTY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)