#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P50591	uniprotkb:O00220	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-518861|uniprotkb:Q96E62|ensembl:ENSP00000221132|uniprotkb:A8K5I4|uniprotkb:Q53Y72	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:tr10a_human(display_long)|uniprotkb:Death receptor 4(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 1(gene name synonym)|uniprotkb:TNFRSF10A(gene name)|psi-mi:TNFRSF10A(display_short)|uniprotkb:APO2(gene name synonym)|uniprotkb:DR4(gene name synonym)|uniprotkb:TRAILR1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274550|imex:IM-17240-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|mint:O00220|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENSG00000104689(gene)|ensembl:ENST00000221132(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005035"(death receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045569"(TRAIL binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|refseq:NP_003835.3	-	-	-	figure legend:1b and S1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:utFDDi1uRCNlMUCt29SYzzar6Sc9606	intact-crc:5066DB7B63F02BEC|rigid:R16+JHTWrZ4m8AJetK9DdzTr1xo	false	his tag:n-n	fc-igg tag:c-c|sufficient binding region:24-239	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	uniprotkb:Q9UBN6	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-1044859|uniprotkb:Q9Y6Q4|uniprotkb:B2R8W0|ensembl:ENSP00000310263	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:tr10d_human(display_long)|uniprotkb:Decoy receptor 2(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 4(gene name synonym)|uniprotkb:TRAIL receptor with a truncated death domain(gene name synonym)|uniprotkb:TNFRSF10D(gene name)|psi-mi:TNFRSF10D(display_short)|uniprotkb:DCR2(gene name synonym)|uniprotkb:TRAILR4(gene name synonym)|uniprotkb:TRUNDD(gene name synonym)|uniprotkb:UNQ251/PRO288(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274611|imex:IM-17240-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	ensembl:ENSG00000173530(gene)|ensembl:ENST00000312584(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045569"(TRAIL binding)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020465|interpro:IPR034024|reactome:R-HSA-202733|reactome:R-HSA-6803211|reactome:R-HSA-75158|refseq:NP_003831.2|dip:DIP-6231N	-	-	-	figure legend:1b and S1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:/kgIqAOa08imPgqFsHZUB+ps4wc9606	intact-crc:D53EA5C541E79B51|rigid:lm9Zl10jFZS4VPl2v8jx2ukwRYE	false	his tag:n-n	sufficient binding region:56-212|fc-igg tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	intact:EBI-5274645	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	-	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:trailmim/dr5 2m(display_short)|psi-mi:EBI-5274645(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275024|imex:IM-17240-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	-	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:32.4x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:9IRdIbj6Q+WCKY9Bddm9SLTJXsU-1	intact-crc:8498826AD0370BF2|rigid:nQAi9WBdMt0UqU4CFYyGr5jTGgw	false	his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	uniprotkb:O14763	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275024|imex:IM-17240-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:32.4x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:8498826AD0370BF2|rigid:nQAi9WBdMt0UqU4CFYyGr5jTGgw	false	his tag:n-n	sufficient binding region:52-212|fc-igg tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	intact:EBI-5274631	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	-	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:trailmim/dr5 1d(display_short)|psi-mi:EBI-5274631(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274997|imex:IM-17240-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	-	-	-	isoform-comment:2xtrailmim/dr5 1m linked through K15 using bis-succunimidyl carboxymehtoxyacetate.	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:1.8x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:kup1tItLsGCDtVizMP9g1FdxLTU-1	intact-crc:B1A15CEE9B556B38|rigid:v8OQPGDdik4iKF/V8Z3lDRht2wY	false	his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	uniprotkb:O14763	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274997|imex:IM-17240-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:1.8x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:B1A15CEE9B556B38|rigid:v8OQPGDdik4iKF/V8Z3lDRht2wY	false	his tag:n-n	fc-igg tag:c-c|sufficient binding region:52-212	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	intact:EBI-5274637	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	-	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:trailmim/dr5 2t(display_short)|psi-mi:EBI-5274637(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275048|imex:IM-17240-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	-	-	-	isoform-comment:3xtrailmim/dr5 2m linked through an adamantyl core.	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:2.47x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:9IRdIbj6Q+WCKY9Bddm9SLTJXsU-1	intact-crc:8498826AD0370BF2|rigid:nQAi9WBdMt0UqU4CFYyGr5jTGgw	false	his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	uniprotkb:O14763	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275048|imex:IM-17240-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:2.47x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:8498826AD0370BF2|rigid:nQAi9WBdMt0UqU4CFYyGr5jTGgw	false	his tag:n-n	fc-igg tag:c-c|sufficient binding region:52-212	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	intact:EBI-5274640	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	-	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:trailmim/dr5 2d(display_short)|psi-mi:EBI-5274640(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275036|imex:IM-17240-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	-	-	-	isoform-comment:2xtrailmim/dr5 2m linked through K10 using bis-succunimidyl carboxymehtoxyacetate.	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:2.47x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:9IRdIbj6Q+WCKY9Bddm9SLTJXsU-1	intact-crc:8498826AD0370BF2|rigid:nQAi9WBdMt0UqU4CFYyGr5jTGgw	false	his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	uniprotkb:O14763	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275036|imex:IM-17240-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:2.47x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:8498826AD0370BF2|rigid:nQAi9WBdMt0UqU4CFYyGr5jTGgw	false	his tag:n-n	fc-igg tag:c-c|sufficient binding region:52-212	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	intact:EBI-5274643	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	-	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:trailmim/dr5 3m(display_short)|psi-mi:EBI-5274643(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275060|imex:IM-17240-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	-	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:8.9x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:C0Xc+g1WuX0UDtioUdl1MHFEPbA-1	intact-crc:769BCB8EF5E90BDF|rigid:rjUkBfyULh7cDUzdGYEwjKRd9jo	false	his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	uniprotkb:O14763	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275060|imex:IM-17240-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:8.9x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:769BCB8EF5E90BDF|rigid:rjUkBfyULh7cDUzdGYEwjKRd9jo	false	his tag:n-n	fc-igg tag:c-c|sufficient binding region:52-212	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	intact:EBI-5274650	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	-	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:trailmim/dr5 3t(display_short)|psi-mi:EBI-5274650(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275084|imex:IM-17240-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	-	-	-	isoform-comment:3xtrailmim/dr5 3m linked through an adamantyl core.	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:0.49x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:C0Xc+g1WuX0UDtioUdl1MHFEPbA-1	intact-crc:769BCB8EF5E90BDF|rigid:rjUkBfyULh7cDUzdGYEwjKRd9jo	false	his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	uniprotkb:O14763	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275084|imex:IM-17240-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:0.49x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:769BCB8EF5E90BDF|rigid:rjUkBfyULh7cDUzdGYEwjKRd9jo	false	his tag:n-n	fc-igg tag:c-c|sufficient binding region:52-212	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-5274643	uniprotkb:O14763	-	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:trailmim/dr5 3m(display_short)|psi-mi:EBI-5274643(display_long)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274669|imex:IM-17240-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	figure legend:1b and S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:226.0x10^-9 ~5.64(molar)	2011/11/24	2014/10/16	rogid:C0Xc+g1WuX0UDtioUdl1MHFEPbA-1	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:4F100B3990060AA5|rigid:VZZB/ZuHcGaA1aTLEIJes/H3uOs	false	-	fc-igg tag:c-c|sufficient binding region:52-212	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14763	intact:EBI-5274629	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	-	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:trailmim/dr5 1m(display_short)|psi-mi:EBI-5274629(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274719|imex:IM-17240-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	-	figure legend:1b and S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:129.0x10^-9 ~3.68(molar)	2011/11/24	2014/10/16	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	rogid:kup1tItLsGCDtVizMP9g1FdxLTU-1	intact-crc:683B572A717F6ADD|rigid:e1gzfOCCiWO4Zz5HmkrmnUeKC/Q	false	sufficient binding region:52-212|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14763	uniprotkb:P50591	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274568|imex:IM-17240-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	-	-	-	figure legend:1b and S1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.27x10^-9 ~0.06(molar)	2011/11/24	2014/10/16	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	intact-crc:695F2CFC405BC003|rigid:THL/KoVweAL56Qb8mew0UpwoU08	false	fc-igg tag:c-c|sufficient binding region:52-212	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-5274631	uniprotkb:O14763	-	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:trailmim/dr5 1d(display_short)|psi-mi:EBI-5274631(display_long)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274727|imex:IM-17240-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	isoform-comment:2xtrailmim/dr5 1m linked through K15 using bis-succunimidyl carboxymehtoxyacetate.	-	figure legend:S1 and S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.24x10^-9 ~0.05(molar)	2011/11/24	2014/10/16	rogid:kup1tItLsGCDtVizMP9g1FdxLTU-1	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:2EB79D2A717F6ADD|rigid:e1gzfOCCiWO4Zz5HmkrmnUeKC/Q	false	-	fc-igg tag:c-c|sufficient binding region:52-212	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	intact:EBI-5274629	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	-	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:trailmim/dr5 1m(display_short)|psi-mi:EBI-5274629(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274985|imex:IM-17240-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	-	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:4.9x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:kup1tItLsGCDtVizMP9g1FdxLTU-1	intact-crc:B1A15CEE9B556B38|rigid:v8OQPGDdik4iKF/V8Z3lDRht2wY	false	his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	uniprotkb:O14763	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274985|imex:IM-17240-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:4.9x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:B1A15CEE9B556B38|rigid:v8OQPGDdik4iKF/V8Z3lDRht2wY	false	his tag:n-n	fc-igg tag:c-c|sufficient binding region:52-212	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	intact:EBI-5274647	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	-	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:trailmim/dr5 3d(display_short)|psi-mi:EBI-5274647(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275072|imex:IM-17240-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	-	-	-	isoform-comment:2xtrailmim/dr5 3m linked through K7 using bis-succunimidyl carboxymehtoxyacetate.	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:1.42x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:C0Xc+g1WuX0UDtioUdl1MHFEPbA-1	intact-crc:769BCB8EF5E90BDF|rigid:rjUkBfyULh7cDUzdGYEwjKRd9jo	false	his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50591	uniprotkb:O14763	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275072|imex:IM-17240-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:1.42x10^-9(molar)	2011/11/24	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:769BCB8EF5E90BDF|rigid:rjUkBfyULh7cDUzdGYEwjKRd9jo	false	his tag:n-n	fc-igg tag:c-c|sufficient binding region:52-212	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-5274647	uniprotkb:O14763	-	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:trailmim/dr5 3d(display_short)|psi-mi:EBI-5274647(display_long)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274976|imex:IM-17240-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	isoform-comment:2xtrailmim/dr5 3m linked through K7 using bis-succunimidyl carboxymehtoxyacetate.	-	figure legend:S1 and S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.29x10^-9 ~0.06(molar)	2011/11/24	2014/10/16	rogid:C0Xc+g1WuX0UDtioUdl1MHFEPbA-1	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:099CC13990060AA5|rigid:VZZB/ZuHcGaA1aTLEIJes/H3uOs	false	-	sufficient binding region:52-212|fc-igg tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-5274640	uniprotkb:O14763	-	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:trailmim/dr5 2d(display_short)|psi-mi:EBI-5274640(display_long)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274684|imex:IM-17240-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	isoform-comment:2xtrailmim/dr5 2m linked through K10 using bis-succunimidyl carboxymehtoxyacetate.	-	figure legend:S1 and S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.114x10^-9 ~0.005(molar)	2011/11/24	2014/10/16	rogid:9IRdIbj6Q+WCKY9Bddm9SLTJXsU-1	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:3C229AD879017E56|rigid:EP5vDMzQeOVXqiHXUMK1oWgmmjE	false	-	fc-igg tag:c-c|sufficient binding region:52-212	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14763	intact:EBI-5274637	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	-	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:trailmim/dr5 2t(display_short)|psi-mi:EBI-5274637(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274707|imex:IM-17240-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	isoform-comment:3xtrailmim/dr5 2m linked through an adamantyl core.	figure legend:S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.539x10^-9 ~0.007(molar)	2011/11/24	2014/10/16	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	rogid:9IRdIbj6Q+WCKY9Bddm9SLTJXsU-1	intact-crc:2A136F373277E1C1|rigid:EP5vDMzQeOVXqiHXUMK1oWgmmjE	false	sufficient binding region:52-212|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-5274634	uniprotkb:O14763	-	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:trailmim/dr5 1t(display_short)|psi-mi:EBI-5274634(display_long)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274653|imex:IM-17240-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	isoform-comment:3xtrailmim/dr5 1m linked through an adamantyl core.	-	figure legend:S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.88x10^-9 ~0.03(molar)	2011/11/24	2014/10/16	rogid:kup1tItLsGCDtVizMP9g1FdxLTU-1	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:410C69E9BFCF5DAB|rigid:e1gzfOCCiWO4Zz5HmkrmnUeKC/Q	false	-	fc-igg tag:c-c|sufficient binding region:52-212	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-5274645	uniprotkb:O14763	-	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:trailmim/dr5 2m(display_short)|psi-mi:EBI-5274645(display_long)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274661|imex:IM-17240-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	figure legend:1b and S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:664.0x10^-9 ~18.0(molar)	2011/11/24	2014/10/16	rogid:9IRdIbj6Q+WCKY9Bddm9SLTJXsU-1	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:7AAE50D879017E56|rigid:EP5vDMzQeOVXqiHXUMK1oWgmmjE	false	-	fc-igg tag:c-c|sufficient binding region:52-212	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14798	uniprotkb:P50591	intact:EBI-717441|uniprotkb:O14755|uniprotkb:Q08AS6|uniprotkb:Q6UXM5|uniprotkb:Q6FH98|ensembl:ENSP00000349324	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	psi-mi:tr10c_human(display_long)|uniprotkb:Decoy receptor 1(gene name synonym)|uniprotkb:Decoy TRAIL receptor without death domain(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 3(gene name synonym)|uniprotkb:TRAIL receptor without an intracellular domain(gene name synonym)|uniprotkb:Lymphocyte inhibitor of TRAIL(gene name synonym)|uniprotkb:Antagonist decoy receptor for TRAIL/Apo-2L(gene name synonym)|uniprotkb:DCR1(gene name synonym)|uniprotkb:LIT(gene name synonym)|uniprotkb:TRAILR3(gene name synonym)|uniprotkb:TRID(gene name synonym)|uniprotkb:UNQ321/PRO366(orf name)|uniprotkb:TNFRSF10C(gene name)|psi-mi:TNFRSF10C(display_short)	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274587|imex:IM-17240-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003832.2|go:"GO:0009986"(cell surface)|ensembl:ENSG00000173535(gene)|ensembl:ENST00000356864(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045569"(TRAIL binding)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020465|interpro:IPR034024|reactome:R-HSA-6803211|dip:DIP-6242N	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	-	-	-	figure legend:1b and S1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/24	2014/10/16	rogid:LeVKmKs1A2D3p4A8O4wFVCyohvg9606	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	intact-crc:2D51E47BA0F73453|rigid:gfYsG8KpUnFGbXp0XcaCc9CnKjY	false	fc-igg tag:c-c|sufficient binding region:25-240	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-5274650	uniprotkb:O14763	-	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:trailmim/dr5 3t(display_short)|psi-mi:EBI-5274650(display_long)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5274692|imex:IM-17240-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	isoform-comment:3xtrailmim/dr5 3m linked through an adamantyl core.	-	figure legend:S1 and S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.05x10^-9 ~0.003(molar)	2011/11/24	2014/10/16	rogid:C0Xc+g1WuX0UDtioUdl1MHFEPbA-1	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:099CC13990060AA5|rigid:VZZB/ZuHcGaA1aTLEIJes/H3uOs	false	-	fc-igg tag:c-c|sufficient binding region:52-212	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01375	uniprotkb:P19438	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5276325|imex:IM-17240-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	-	-	-	figure legend:S1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/24	2014/10/16	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	intact-crc:A6B6F1BFC22B2704|rigid:32KHgWVN+wBPmLhbQAGiLF/P/xk	false	-	fc-igg tag:c-c|sufficient binding region:1-211	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14790	uniprotkb:O00220	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	intact:EBI-518861|uniprotkb:Q96E62|ensembl:ENSP00000221132|uniprotkb:A8K5I4|uniprotkb:Q53Y72	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:tr10a_human(display_long)|uniprotkb:Death receptor 4(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 1(gene name synonym)|uniprotkb:TNFRSF10A(gene name)|psi-mi:TNFRSF10A(display_short)|uniprotkb:APO2(gene name synonym)|uniprotkb:DR4(gene name synonym)|uniprotkb:TRAILR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275161|imex:IM-17240-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|mint:O00220|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENSG00000104689(gene)|ensembl:ENST00000221132(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005035"(death receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045569"(TRAIL binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|refseq:NP_003835.3	-	-	-	figure legend:2b|agonist:"The interaction depends on TNFSF10 (TRAIL) treatment of the cells."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bjab)|taxid:9606(Homo sapiens B-cell lymphoma cell line)	-	2011/11/24	2014/10/16	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rogid:utFDDi1uRCNlMUCt29SYzzar6Sc9606	intact-crc:F7E8F69D42035314|rigid:nxrAq0fsZGgDgs8XrP14WNLNQCY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14790	uniprotkb:O14763	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275161|imex:IM-17240-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	figure legend:2b|agonist:"The interaction depends on TNFSF10 (TRAIL) treatment of the cells."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bjab)|taxid:9606(Homo sapiens B-cell lymphoma cell line)	-	2011/11/24	2014/10/16	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:F7E8F69D42035314|rigid:nxrAq0fsZGgDgs8XrP14WNLNQCY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14790	uniprotkb:Q13158	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	intact:EBI-494804|uniprotkb:Q14866|uniprotkb:Q6IBR4|ensembl:ENSP00000301838	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:fadd_human(display_long)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)|uniprotkb:Mediator of receptor induced toxicity(gene name synonym)|uniprotkb:FADD(gene name)|psi-mi:FADD(display_short)|uniprotkb:MORT1(gene name synonym)|uniprotkb:GIG3(orf name)|uniprotkb:Growth-inhibiting gene 3 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275161|imex:IM-17240-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	refseq:NP_003815.1|dip:DIP-286N|ensembl:ENSG00000168040(gene)|ensembl:ENST00000301838(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002020"(protease binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0089720"(caspase binding)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097342"(ripoptosome)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2000454"(positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR016729(FADD)|mint:Q13158|rcsb pdb:1A1W|rcsb pdb:1A1Z|rcsb pdb:1E3Y|rcsb pdb:1E41|rcsb pdb:2GF5|rcsb pdb:3EZQ|rcsb pdb:3OQ9|rcsb pdb:6ACI|reactome:R-HSA-140534|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9693928	-	-	-	figure legend:2b|agonist:"The interaction depends on TNFSF10 (TRAIL) treatment of the cells."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bjab)|taxid:9606(Homo sapiens B-cell lymphoma cell line)	-	2011/11/24	2014/10/16	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rogid:DzaWyJjHDsNt8nMWLbv6GYa0Ri49606	intact-crc:F7E8F69D42035314|rigid:nxrAq0fsZGgDgs8XrP14WNLNQCY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14790	uniprotkb:Q13158	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	intact:EBI-494804|uniprotkb:Q14866|uniprotkb:Q6IBR4|ensembl:ENSP00000301838	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:fadd_human(display_long)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)|uniprotkb:Mediator of receptor induced toxicity(gene name synonym)|uniprotkb:FADD(gene name)|psi-mi:FADD(display_short)|uniprotkb:MORT1(gene name synonym)|uniprotkb:GIG3(orf name)|uniprotkb:Growth-inhibiting gene 3 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275168|imex:IM-17240-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	refseq:NP_003815.1|dip:DIP-286N|ensembl:ENSG00000168040(gene)|ensembl:ENST00000301838(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002020"(protease binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0089720"(caspase binding)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097342"(ripoptosome)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2000454"(positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR016729(FADD)|mint:Q13158|rcsb pdb:1A1W|rcsb pdb:1A1Z|rcsb pdb:1E3Y|rcsb pdb:1E41|rcsb pdb:2GF5|rcsb pdb:3EZQ|rcsb pdb:3OQ9|rcsb pdb:6ACI|reactome:R-HSA-140534|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9693928	-	-	-	figure legend:2b|agonist:"The interaction depends on treatment of the cells with TRAILmim/DR5 peptides (1m, 1d, 1t, 2d, 2t, 3m, 3d and 3t)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bjab)|taxid:9606(Homo sapiens B-cell lymphoma cell line)	-	2011/11/24	2014/10/16	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rogid:DzaWyJjHDsNt8nMWLbv6GYa0Ri49606	intact-crc:19B8FE477D93A8C9|rigid:Wyxyuomuc4cvLa8Uu33iprNpZRU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14790	uniprotkb:O14763	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275168|imex:IM-17240-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	figure legend:2b|agonist:"The interaction depends on treatment of the cells with TRAILmim/DR5 peptides (1m, 1d, 1t, 2d, 2t, 3m, 3d and 3t)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bjab)|taxid:9606(Homo sapiens B-cell lymphoma cell line)	-	2011/11/24	2014/10/16	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:19B8FE477D93A8C9|rigid:Wyxyuomuc4cvLa8Uu33iprNpZRU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14790	uniprotkb:Q13158	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	intact:EBI-494804|uniprotkb:Q14866|uniprotkb:Q6IBR4|ensembl:ENSP00000301838	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:fadd_human(display_long)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)|uniprotkb:Mediator of receptor induced toxicity(gene name synonym)|uniprotkb:FADD(gene name)|psi-mi:FADD(display_short)|uniprotkb:MORT1(gene name synonym)|uniprotkb:GIG3(orf name)|uniprotkb:Growth-inhibiting gene 3 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275182|imex:IM-17240-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	refseq:NP_003815.1|dip:DIP-286N|ensembl:ENSG00000168040(gene)|ensembl:ENST00000301838(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002020"(protease binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0089720"(caspase binding)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097342"(ripoptosome)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2000454"(positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR016729(FADD)|mint:Q13158|rcsb pdb:1A1W|rcsb pdb:1A1Z|rcsb pdb:1E3Y|rcsb pdb:1E41|rcsb pdb:2GF5|rcsb pdb:3EZQ|rcsb pdb:3OQ9|rcsb pdb:6ACI|reactome:R-HSA-140534|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9693928	-	-	-	figure legend:2b|agonist:"The interaction depends on TNFSF10 (TRAIL) treatment of the cells."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bjab)|taxid:9606(Homo sapiens B-cell lymphoma cell line)	-	2011/11/24	2014/10/16	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rogid:DzaWyJjHDsNt8nMWLbv6GYa0Ri49606	intact-crc:23690B7541E8E17D|rigid:Dt6f1O4XmyyM6U/UmFNMsZi1FYM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14790	uniprotkb:O00220	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	intact:EBI-518861|uniprotkb:Q96E62|ensembl:ENSP00000221132|uniprotkb:A8K5I4|uniprotkb:Q53Y72	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:tr10a_human(display_long)|uniprotkb:Death receptor 4(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 1(gene name synonym)|uniprotkb:TNFRSF10A(gene name)|psi-mi:TNFRSF10A(display_short)|uniprotkb:APO2(gene name synonym)|uniprotkb:DR4(gene name synonym)|uniprotkb:TRAILR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pavet et al. (2010)	pubmed:20103630|imex:IM-17240	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5275182|imex:IM-17240-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|mint:O00220|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENSG00000104689(gene)|ensembl:ENST00000221132(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005035"(death receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045569"(TRAIL binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|refseq:NP_003835.3	-	-	-	figure legend:2b|agonist:"The interaction depends on TNFSF10 (TRAIL) treatment of the cells."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bjab)|taxid:9606(Homo sapiens B-cell lymphoma cell line)	-	2011/11/24	2014/10/16	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rogid:utFDDi1uRCNlMUCt29SYzzar6Sc9606	intact-crc:23690B7541E8E17D|rigid:Dt6f1O4XmyyM6U/UmFNMsZi1FYM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)