#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P20651 uniprotkb:Q9WVC7 intact:EBI-7400670|intact:MINT-4589009|uniprotkb:Q6LDJ7 intact:EBI-7559840|intact:MINT-4998500 psi-mi:pp2bb_rat(display_long)|uniprotkb:Ppp3cb(gene name)|psi-mi:Ppp3cb(display_short)|uniprotkb:Calmodulin-dependent calcineurin A subunit beta isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym) psi-mi:akap6_rat(display_long)|uniprotkb:Akap6(gene name)|psi-mi:Akap6(display_short)|uniprotkb:Protein kinase A-anchoring protein 6(gene name synonym)|uniprotkb:mAKAP(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Li et al. (2010) pubmed:19883655|mint:MINT-8291654|doi:10.1016/j.yjmcc.2009.10.023 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7559869|mint:MINT-8291689 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_058738.1|rgd:3383|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0034097"(response to cytokine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|dip:DIP-66N|reactome:R-RNO-2025928|reactome:R-RNO-2871809|reactome:R-RNO-4086398|reactome:R-RNO-5607763|mint:MINT-8291692(identity) interpro:IPR018159|rgd:69412|interpro:IPR002017(Spectrin repeat)|refseq:NP_072140.1|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005901"(caveola)|mint:MINT-8291691(identity) - function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin|comment:mint|comment:homomint comment:mint|comment:homomint|function:Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes figure legend:f1a|comment:homomint|comment:mint|partial coverage:partial coverage taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2011/11/14 2014/10/16 rogid:7QZadDbOncDsdFeeakxOFjchyxo10116 rogid:ljBsOY2+NPfjnIn3RHjZImS1q7010116 intact-crc:81E9241DDDE8E867|rigid:gv+aMFzVzj957wbbtvaSQ50ddp4 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9WVC7 uniprotkb:P48453 intact:EBI-7559840|intact:MINT-4998500 intact:EBI-642618|uniprotkb:Q6NZR4|ensembl:ENSMUSP00000125722 psi-mi:akap6_rat(display_long)|uniprotkb:Akap6(gene name)|psi-mi:Akap6(display_short)|uniprotkb:Protein kinase A-anchoring protein 6(gene name synonym)|uniprotkb:mAKAP(gene name synonym) psi-mi:pp2bb_mouse(display_long)|uniprotkb:Calmodulin-dependent calcineurin A subunit beta isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)|uniprotkb:Ppp3cb(gene name)|psi-mi:Ppp3cb(display_short)|uniprotkb:Calnb(gene name synonym) psi-mi:"MI:0096"(pull down) Li et al. (2010) pubmed:19883655|mint:MINT-8291654|doi:10.1016/j.yjmcc.2009.10.023 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7559943|mint:MINT-8291718 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR018159|rgd:69412|interpro:IPR002017(Spectrin repeat)|refseq:NP_072140.1|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005901"(caveola)|mint:MINT-8291720(identity) refseq:NP_032940.1|refseq:NP_001297355.1|refseq:NP_001297356.1|ensembl:ENSMUSG00000021816(gene)|ensembl:ENSMUST00000159027(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0034097"(response to cytokine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P48453|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|go:"GO:0005516"(calmodulin binding)|mint:MINT-8291721(identity) - comment:mint|comment:homomint|function:Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes - comment:homomint|comment:mint|figure legend:f2a f2d|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/11/14 2014/10/16 rogid:ljBsOY2+NPfjnIn3RHjZImS1q7010116 rogid:YD7q3dcL87htgwHRd5m5ReMlqd010090 intact-crc:D294380FED7A303E|rigid:8WNbPufFJKFm/qzD0MSj4wP0vfE false - glutathione s tranferase tag:?-?(MINT-8291722) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9WVC7 uniprotkb:P48453 intact:EBI-7559840|intact:MINT-4998500 intact:EBI-642618|uniprotkb:Q6NZR4|ensembl:ENSMUSP00000125722 psi-mi:akap6_rat(display_long)|uniprotkb:Akap6(gene name)|psi-mi:Akap6(display_short)|uniprotkb:Protein kinase A-anchoring protein 6(gene name synonym)|uniprotkb:mAKAP(gene name synonym) psi-mi:pp2bb_mouse(display_long)|uniprotkb:Calmodulin-dependent calcineurin A subunit beta isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)|uniprotkb:Ppp3cb(gene name)|psi-mi:Ppp3cb(display_short)|uniprotkb:Calnb(gene name synonym) psi-mi:"MI:0096"(pull down) Li et al. (2010) pubmed:19883655|mint:MINT-8291654|doi:10.1016/j.yjmcc.2009.10.023 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7559973|mint:MINT-8291753 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR018159|rgd:69412|interpro:IPR002017(Spectrin repeat)|refseq:NP_072140.1|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005901"(caveola)|mint:MINT-8291755(identity) refseq:NP_032940.1|refseq:NP_001297355.1|refseq:NP_001297356.1|ensembl:ENSMUSG00000021816(gene)|ensembl:ENSMUST00000159027(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0034097"(response to cytokine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P48453|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|go:"GO:0005516"(calmodulin binding)|mint:MINT-8291756(identity) - comment:mint|comment:homomint|function:Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes - comment:homomint|comment:mint|figure legend:f2a f2b f2c|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/11/14 2014/10/16 rogid:ljBsOY2+NPfjnIn3RHjZImS1q7010116 rogid:YD7q3dcL87htgwHRd5m5ReMlqd010090 intact-crc:EDC46D9B73571CDB|rigid:8WNbPufFJKFm/qzD0MSj4wP0vfE false binding-associated region:1286-1345(MINT-8291764)|glutathione s tranferase tag:?-?(MINT-8291762) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9WVC7 uniprotkb:P20651 intact:EBI-7559840|intact:MINT-4998500 intact:EBI-7400670|intact:MINT-4589009|uniprotkb:Q6LDJ7 psi-mi:akap6_rat(display_long)|uniprotkb:Akap6(gene name)|psi-mi:Akap6(display_short)|uniprotkb:Protein kinase A-anchoring protein 6(gene name synonym)|uniprotkb:mAKAP(gene name synonym) psi-mi:pp2bb_rat(display_long)|uniprotkb:Ppp3cb(gene name)|psi-mi:Ppp3cb(display_short)|uniprotkb:Calmodulin-dependent calcineurin A subunit beta isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Li et al. (2010) pubmed:19883655|mint:MINT-8291654|doi:10.1016/j.yjmcc.2009.10.023 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7560016|mint:MINT-8291696 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR018159|rgd:69412|interpro:IPR002017(Spectrin repeat)|refseq:NP_072140.1|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005901"(caveola)|mint:MINT-8291698(identity) refseq:NP_058738.1|rgd:3383|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0034097"(response to cytokine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|dip:DIP-66N|reactome:R-RNO-2025928|reactome:R-RNO-2871809|reactome:R-RNO-4086398|reactome:R-RNO-5607763|mint:MINT-8291699(identity) - comment:mint|comment:homomint|function:Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin|comment:mint|comment:homomint comment:homomint|comment:mint|figure legend:f1c f1d f1e f2e|partial coverage:partial coverage taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/11/14 2014/10/16 rogid:ljBsOY2+NPfjnIn3RHjZImS1q7010116 rogid:7QZadDbOncDsdFeeakxOFjchyxo10116 intact-crc:2E01446AD1DA40AD|rigid:gv+aMFzVzj957wbbtvaSQ50ddp4 false - ha tag:?-?(MINT-8291711) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P48453 uniprotkb:O95644 intact:EBI-642618|uniprotkb:Q6NZR4|ensembl:ENSMUSP00000125722 intact:EBI-6907210|uniprotkb:Q12865|uniprotkb:Q15793|uniprotkb:B5B2M4|uniprotkb:B5B2M5|uniprotkb:B5B2M6|uniprotkb:B5B2M7|uniprotkb:B5B2M8|uniprotkb:B5B2M9|uniprotkb:B5B2N1|uniprotkb:Q2M1S3|ensembl:ENSP00000389377 psi-mi:pp2bb_mouse(display_long)|uniprotkb:Calmodulin-dependent calcineurin A subunit beta isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)|uniprotkb:Ppp3cb(gene name)|psi-mi:Ppp3cb(display_short)|uniprotkb:Calnb(gene name synonym) psi-mi:nfac1_human(display_long)|uniprotkb:NFATC1(gene name)|psi-mi:NFATC1(display_short)|uniprotkb:NFAT2(gene name synonym)|uniprotkb:NFATC(gene name synonym)|uniprotkb:NFAT transcription complex cytosolic component(gene name synonym) psi-mi:"MI:0434"(phosphatase assay) Li et al. (2010) pubmed:19883655|mint:MINT-8291654|doi:10.1016/j.yjmcc.2009.10.023 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0203"(dephosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7560056|mint:MINT-8291767 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032940.1|refseq:NP_001297355.1|refseq:NP_001297356.1|ensembl:ENSMUSG00000021816(gene)|ensembl:ENSMUST00000159027(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0034097"(response to cytokine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P48453|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|go:"GO:0005516"(calmodulin binding)|mint:MINT-8291774(identity) refseq:NP_006153.2|refseq:NP_765975.1|refseq:NP_765976.1|refseq:NP_765977.1|refseq:NP_765978.1|refseq:NP_001265598.1|refseq:NP_001265599.1|refseq:NP_001265601.1|refseq:NP_001265602.1|refseq:NP_001265604.1|dip:DIP-44311N|ensembl:ENSG00000131196(gene)|ensembl:ENST00000427363(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016604"(nuclear body)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015647(Nuclear factor of activated T-cells 1)|interpro:IPR032397|interpro:IPR037059|mint:O95644|rcsb pdb:1A66|rcsb pdb:1NFA|rcsb pdb:5SVE|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763|mint:MINT-8291769(identity) - - comment:"Resulting Phenotypic qualities (properties)[PATO]: PATO:0002263 (dephosphorylated)" figure legend:f3|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/11/14 2014/10/16 rogid:YD7q3dcL87htgwHRd5m5ReMlqd010090 rogid:ighU5P59Gv8yTk6lwwm/Ohy3FdY9606 intact-crc:4CAE0C417F009D56|rigid:hoebN7sACYwbEt+ZOHDlALI4VgA false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)