#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9NS37 uniprotkb:P62508 intact:EBI-632965|ensembl:ENSP00000433459|ensembl:ENSP00000434281|uniprotkb:Q52LT3|uniprotkb:B2R8Q9|uniprotkb:Q0P5U9 intact:EBI-2834260|uniprotkb:Q9UNJ4|uniprotkb:O96021|uniprotkb:A8K6I2|uniprotkb:Q68DA0|uniprotkb:Q6TS38|uniprotkb:O75454|uniprotkb:Q6PK28|uniprotkb:A8K4I0|uniprotkb:Q9R1F3|uniprotkb:Q6P274|ensembl:ENSP00000386171|uniprotkb:B3KY84|uniprotkb:E9PGB7|uniprotkb:F8W8J3 psi-mi:zhang_human(display_long)|uniprotkb:Host cell factor-binding transcription factor Zhangfei(gene name synonym)|uniprotkb:CREBZF(gene name)|psi-mi:CREBZF(display_short)|uniprotkb:ZF(gene name synonym) psi-mi:err3_human(display_long)|uniprotkb:ESRRG(gene name)|psi-mi:ESRRG(display_short)|uniprotkb:ERR3(gene name synonym)|uniprotkb:ERRG2(gene name synonym)|uniprotkb:KIAA0832(gene name synonym)|uniprotkb:NR3B3(gene name synonym)|uniprotkb:ERR gamma-2(gene name synonym)|uniprotkb:Estrogen receptor-related protein 3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Xie et al. (2009) pubmed:19690166 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5273985 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000137504(gene)|ensembl:ENST00000490820(transcript)|ensembl:ENST00000527447(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|refseq:NP_001034707.1|refseq:XP_016873577.1|refseq:XP_016873578.1|refseq:XP_016873579.1|refseq:XP_016873580.1|refseq:XP_016873581.1|refseq:XP_011543497.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|mint:Q9NS37|dip:DIP-33934N refseq:XP_011507569.1|refseq:XP_011507570.1|refseq:XP_011507571.1|refseq:XP_011507576.1|refseq:XP_011507577.1|refseq:XP_011507578.1|refseq:XP_011507579.1|refseq:XP_011507580.1|refseq:XP_011507581.1|refseq:XP_011507582.1|refseq:XP_016856120.1|refseq:NP_001230434.1|refseq:NP_001230435.1|refseq:NP_001230436.1|refseq:NP_001230447.1|refseq:XP_016856121.1|ensembl:ENSG00000196482(gene)|ensembl:ENST00000408911(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|mint:P62508|rcsb pdb:1KV6|rcsb pdb:1TFC|rcsb pdb:1VJB|rcsb pdb:2E2R|rcsb pdb:2EWP|rcsb pdb:2GP7|rcsb pdb:2GPO|rcsb pdb:2GPP|rcsb pdb:2GPU|rcsb pdb:2GPV|rcsb pdb:2P7A|rcsb pdb:2P7G|rcsb pdb:2P7Z|rcsb pdb:2ZAS|rcsb pdb:2ZBS|rcsb pdb:2ZKC|rcsb pdb:5YSO|rcsb pdb:6A6K|rcsb pdb:6I61|rcsb pdb:6I62|rcsb pdb:6I63|rcsb pdb:6I64|rcsb pdb:6I65|rcsb pdb:6I66|rcsb pdb:6I67|rcsb pdb:6K3N|rcsb pdb:6KNR|rcsb pdb:6XXC|rcsb pdb:6XY5|rcsb pdb:6Y18|rcsb pdb:6Y1D|rcsb pdb:6Y3W|rcsb pdb:6Y58|reactome:R-HSA-383280|go:"GO:0005654"(nucleoplasm)|refseq:NP_001127757.1|refseq:NP_001230438.1|refseq:NP_001230439.1|refseq:NP_001230440.1|refseq:NP_001230441.1|refseq:NP_001230442.1|refseq:NP_001230443.1|refseq:NP_001230444.1|refseq:NP_001230448.1|refseq:NP_001429.2|refseq:NP_996317.1|refseq:NP_996318.1|refseq:XP_016856122.1|refseq:XP_016856123.1|refseq:XP_016856124.1|refseq:XP_016856125.1|refseq:XP_016856126.1|refseq:XP_016856127.1|refseq:XP_016856128.1|refseq:XP_016856130.1|refseq:XP_016856133.1|refseq:XP_016856134.1|refseq:XP_016856129.1|refseq:XP_016856131.1|refseq:XP_016856132.1|refseq:XP_016856135.1|refseq:XP_016856136.1|refseq:XP_016856137.1|refseq:XP_016856138.1 - - - figure legend:1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|curation depth:mimix curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2011/11/24 2014/10/16 rogid:f4aOJ/8bwzLv6oFRz6dERW2dUIA9606 rogid:BMdGghKpGbkmaSL6DR6ApJU6Exk9606 intact-crc:3DBC487C81E08D7C|rigid:Al0noCDVN7h8TnyXOuxtxxDvf0U false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96EB6 uniprotkb:Q9NS37 intact:EBI-1802965|uniprotkb:Q2XNF6|uniprotkb:Q5JVQ0|uniprotkb:Q9GZR9|uniprotkb:Q9Y6F0|ensembl:ENSP00000212015 intact:EBI-632965|ensembl:ENSP00000433459|ensembl:ENSP00000434281|uniprotkb:Q52LT3|uniprotkb:B2R8Q9|uniprotkb:Q0P5U9 psi-mi:sir1_human(display_long)|uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym)|uniprotkb:SIRT1(gene name)|psi-mi:SIRT1(display_short)|uniprotkb:SIR2L1(gene name synonym)|uniprotkb:SIR2-like protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym) psi-mi:zhang_human(display_long)|uniprotkb:Host cell factor-binding transcription factor Zhangfei(gene name synonym)|uniprotkb:CREBZF(gene name)|psi-mi:CREBZF(display_short)|uniprotkb:ZF(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Xie et al. (2009) pubmed:19690166 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5274143 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001135970.1|refseq:NP_036370.2|refseq:NP_001300978.1|dip:DIP-29757N|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q96EB6|rcsb pdb:4I5I|rcsb pdb:4IF6|rcsb pdb:4IG9|rcsb pdb:4KXQ|rcsb pdb:4ZZH|rcsb pdb:4ZZI|rcsb pdb:4ZZJ|rcsb pdb:5BTR|reactome:R-HSA-3371453|reactome:R-HSA-400253|reactome:R-HSA-427359|reactome:R-HSA-9617629|reactome:R-HSA-9707616|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000096717(gene)|ensembl:ENST00000212015(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001650"(fibrillar center)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002039"(p53 binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031393"(negative regulation of prostaglandin biosynthetic process)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035358"(regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042393"(histone binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042595"(behavioral response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0044321"(response to leptin)|go:"GO:0071441"(negative regulation of histone H3-K14 acetylation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0106230"(protein depropionylation)|go:"GO:0106231"(protein-propionyllysine depropionylase activity)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2000655"(negative regulation of cellular response to testosterone stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor) ensembl:ENSG00000137504(gene)|ensembl:ENST00000490820(transcript)|ensembl:ENST00000527447(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|refseq:NP_001034707.1|refseq:XP_016873577.1|refseq:XP_016873578.1|refseq:XP_016873579.1|refseq:XP_016873580.1|refseq:XP_016873581.1|refseq:XP_011543497.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|mint:Q9NS37|dip:DIP-33934N - - - figure legend:5G|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|curation depth:mimix curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2011/11/24 2014/10/16 rogid:h3zVepuhRhzlINCluVuAn71Btjc9606 rogid:f4aOJ/8bwzLv6oFRz6dERW2dUIA9606 intact-crc:8C6AE3AD090C0B7B|rigid:zrsZyAiVBgWKwp5/IlmuecfsFAw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P62509 uniprotkb:Q91ZR3 intact:EBI-5274019|uniprotkb:O75454|uniprotkb:O96021|uniprotkb:Q8CHC9|uniprotkb:Q9R1F3|ensembl:ENSMUSP00000027906 intact:EBI-5274001|uniprotkb:Q91Y72|ensembl:ENSMUSP00000050972 psi-mi:err3_mouse(display_long)|uniprotkb:Esrrg(gene name)|psi-mi:Esrrg(display_short)|uniprotkb:Err3(gene name synonym)|uniprotkb:Kiaa0832(gene name synonym)|uniprotkb:Nr3b3(gene name synonym)|uniprotkb:Estrogen receptor-related protein 3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 3(gene name synonym) psi-mi:zhang_mouse(display_long)|uniprotkb:Crebzf(gene name)|psi-mi:Crebzf(display_short)|uniprotkb:Zf(gene name synonym)|uniprotkb:Host cell factor-binding transcription factor Zhangfei(gene name synonym)|uniprotkb:Tyrosine kinase-associated leucine zipper protein LAZip(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Xie et al. (2009) pubmed:19690166 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5273999 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230721.1|refseq:NP_036065.1|refseq:XP_006497227.1|refseq:XP_006497228.1|refseq:XP_006497230.1|refseq:XP_006497233.1|ensembl:ENSMUSG00000026610(gene)|ensembl:ENSMUST00000027906(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1S9P|rcsb pdb:1S9Q|reactome:R-MMU-383280 refseq:NP_660133.2|refseq:XP_006507669.1|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|ensembl:ENSMUSG00000051451(gene)|ensembl:ENSMUST00000061767(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity) - - - figure legend:1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|curation depth:mimix curation taxid:10090(mouse-liver)|taxid:10090(Mus musculus) - 2011/11/24 2014/10/16 rogid:BMdGghKpGbkmaSL6DR6ApJU6Exk10090 rogid:dK6LjlzlJPPGMgwkiVxgXP9epg010090 intact-crc:9C4294F14AA1FCD9|rigid:BfjmOYLGxtyjhJoJvJtQk/C0nUI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P62509 uniprotkb:Q91ZR3 intact:EBI-5274019|uniprotkb:O75454|uniprotkb:O96021|uniprotkb:Q8CHC9|uniprotkb:Q9R1F3|ensembl:ENSMUSP00000027906 intact:EBI-5274001|uniprotkb:Q91Y72|ensembl:ENSMUSP00000050972 psi-mi:err3_mouse(display_long)|uniprotkb:Esrrg(gene name)|psi-mi:Esrrg(display_short)|uniprotkb:Err3(gene name synonym)|uniprotkb:Kiaa0832(gene name synonym)|uniprotkb:Nr3b3(gene name synonym)|uniprotkb:Estrogen receptor-related protein 3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 3(gene name synonym) psi-mi:zhang_mouse(display_long)|uniprotkb:Crebzf(gene name)|psi-mi:Crebzf(display_short)|uniprotkb:Zf(gene name synonym)|uniprotkb:Host cell factor-binding transcription factor Zhangfei(gene name synonym)|uniprotkb:Tyrosine kinase-associated leucine zipper protein LAZip(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Xie et al. (2009) pubmed:19690166 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5274067 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230721.1|refseq:NP_036065.1|refseq:XP_006497227.1|refseq:XP_006497228.1|refseq:XP_006497230.1|refseq:XP_006497233.1|ensembl:ENSMUSG00000026610(gene)|ensembl:ENSMUST00000027906(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1S9P|rcsb pdb:1S9Q|reactome:R-MMU-383280 refseq:NP_660133.2|refseq:XP_006507669.1|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|ensembl:ENSMUSG00000051451(gene)|ensembl:ENSMUST00000061767(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity) - - - figure legend:1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|curation depth:mimix curation taxid:10090(mouse-heart)|taxid:10090(Mus musculus heart [Cardiac; Cardiac tissue]) - 2011/11/24 2014/10/16 rogid:BMdGghKpGbkmaSL6DR6ApJU6Exk10090 rogid:dK6LjlzlJPPGMgwkiVxgXP9epg010090 intact-crc:09C31D85E26429A0|rigid:BfjmOYLGxtyjhJoJvJtQk/C0nUI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q91ZR3 uniprotkb:P62509 intact:EBI-5274001|uniprotkb:Q91Y72|ensembl:ENSMUSP00000050972 intact:EBI-5274019|uniprotkb:O75454|uniprotkb:O96021|uniprotkb:Q8CHC9|uniprotkb:Q9R1F3|ensembl:ENSMUSP00000027906 psi-mi:zhang_mouse(display_long)|uniprotkb:Crebzf(gene name)|psi-mi:Crebzf(display_short)|uniprotkb:Zf(gene name synonym)|uniprotkb:Host cell factor-binding transcription factor Zhangfei(gene name synonym)|uniprotkb:Tyrosine kinase-associated leucine zipper protein LAZip(gene name synonym) psi-mi:err3_mouse(display_long)|uniprotkb:Esrrg(gene name)|psi-mi:Esrrg(display_short)|uniprotkb:Err3(gene name synonym)|uniprotkb:Kiaa0832(gene name synonym)|uniprotkb:Nr3b3(gene name synonym)|uniprotkb:Estrogen receptor-related protein 3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Xie et al. (2009) pubmed:19690166 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5277987 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660133.2|refseq:XP_006507669.1|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|ensembl:ENSMUSG00000051451(gene)|ensembl:ENSMUST00000061767(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity) refseq:NP_001230721.1|refseq:NP_036065.1|refseq:XP_006497227.1|refseq:XP_006497228.1|refseq:XP_006497230.1|refseq:XP_006497233.1|ensembl:ENSMUSG00000026610(gene)|ensembl:ENSMUST00000027906(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1S9P|rcsb pdb:1S9Q|reactome:R-MMU-383280 - - - figure legend:1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|curation depth:mimix curation taxid:10090(mouse-kidney)|taxid:10090(Mus musculus) - 2011/11/24 2014/10/16 rogid:dK6LjlzlJPPGMgwkiVxgXP9epg010090 rogid:BMdGghKpGbkmaSL6DR6ApJU6Exk10090 intact-crc:541C5E3746DF558A|rigid:BfjmOYLGxtyjhJoJvJtQk/C0nUI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P62509 uniprotkb:Q9NS37 intact:EBI-5274019|uniprotkb:O75454|uniprotkb:O96021|uniprotkb:Q8CHC9|uniprotkb:Q9R1F3|ensembl:ENSMUSP00000027906 intact:EBI-632965|ensembl:ENSP00000433459|ensembl:ENSP00000434281|uniprotkb:Q52LT3|uniprotkb:B2R8Q9|uniprotkb:Q0P5U9 psi-mi:err3_mouse(display_long)|uniprotkb:Esrrg(gene name)|psi-mi:Esrrg(display_short)|uniprotkb:Err3(gene name synonym)|uniprotkb:Kiaa0832(gene name synonym)|uniprotkb:Nr3b3(gene name synonym)|uniprotkb:Estrogen receptor-related protein 3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 3(gene name synonym) psi-mi:zhang_human(display_long)|uniprotkb:Host cell factor-binding transcription factor Zhangfei(gene name synonym)|uniprotkb:CREBZF(gene name)|psi-mi:CREBZF(display_short)|uniprotkb:ZF(gene name synonym) psi-mi:"MI:0096"(pull down) Xie et al. (2009) pubmed:19690166 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5274099 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230721.1|refseq:NP_036065.1|refseq:XP_006497227.1|refseq:XP_006497228.1|refseq:XP_006497230.1|refseq:XP_006497233.1|ensembl:ENSMUSG00000026610(gene)|ensembl:ENSMUST00000027906(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1S9P|rcsb pdb:1S9Q|reactome:R-MMU-383280 ensembl:ENSG00000137504(gene)|ensembl:ENST00000490820(transcript)|ensembl:ENST00000527447(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|refseq:NP_001034707.1|refseq:XP_016873577.1|refseq:XP_016873578.1|refseq:XP_016873579.1|refseq:XP_016873580.1|refseq:XP_016873581.1|refseq:XP_011543497.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|mint:Q9NS37|dip:DIP-33934N - - - figure legend:1A and 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/11/24 2014/10/16 rogid:BMdGghKpGbkmaSL6DR6ApJU6Exk10090 rogid:f4aOJ/8bwzLv6oFRz6dERW2dUIA9606 intact-crc:E6100BBB63268402|rigid:kHUyrrjC+kR9EiJsP8NCIvhKr0Y false - - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q96EB6 uniprotkb:Q9NS37 intact:EBI-1802965|uniprotkb:Q2XNF6|uniprotkb:Q5JVQ0|uniprotkb:Q9GZR9|uniprotkb:Q9Y6F0|ensembl:ENSP00000212015 intact:EBI-632965|ensembl:ENSP00000433459|ensembl:ENSP00000434281|uniprotkb:Q52LT3|uniprotkb:B2R8Q9|uniprotkb:Q0P5U9 psi-mi:sir1_human(display_long)|uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym)|uniprotkb:SIRT1(gene name)|psi-mi:SIRT1(display_short)|uniprotkb:SIR2L1(gene name synonym)|uniprotkb:SIR2-like protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym) psi-mi:zhang_human(display_long)|uniprotkb:Host cell factor-binding transcription factor Zhangfei(gene name synonym)|uniprotkb:CREBZF(gene name)|psi-mi:CREBZF(display_short)|uniprotkb:ZF(gene name synonym) psi-mi:"MI:0096"(pull down) Xie et al. (2009) pubmed:19690166 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5274134 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001135970.1|refseq:NP_036370.2|refseq:NP_001300978.1|dip:DIP-29757N|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q96EB6|rcsb pdb:4I5I|rcsb pdb:4IF6|rcsb pdb:4IG9|rcsb pdb:4KXQ|rcsb pdb:4ZZH|rcsb pdb:4ZZI|rcsb pdb:4ZZJ|rcsb pdb:5BTR|reactome:R-HSA-3371453|reactome:R-HSA-400253|reactome:R-HSA-427359|reactome:R-HSA-9617629|reactome:R-HSA-9707616|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000096717(gene)|ensembl:ENST00000212015(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001650"(fibrillar center)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002039"(p53 binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031393"(negative regulation of prostaglandin biosynthetic process)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035358"(regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042393"(histone binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042595"(behavioral response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0044321"(response to leptin)|go:"GO:0071441"(negative regulation of histone H3-K14 acetylation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0106230"(protein depropionylation)|go:"GO:0106231"(protein-propionyllysine depropionylase activity)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2000655"(negative regulation of cellular response to testosterone stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor) ensembl:ENSG00000137504(gene)|ensembl:ENST00000490820(transcript)|ensembl:ENST00000527447(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|refseq:NP_001034707.1|refseq:XP_016873577.1|refseq:XP_016873578.1|refseq:XP_016873579.1|refseq:XP_016873580.1|refseq:XP_016873581.1|refseq:XP_011543497.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|mint:Q9NS37|dip:DIP-33934N - - - figure legend:5E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/11/24 2014/10/16 rogid:h3zVepuhRhzlINCluVuAn71Btjc9606 rogid:f4aOJ/8bwzLv6oFRz6dERW2dUIA9606 intact-crc:E3873D4313D0162D|rigid:zrsZyAiVBgWKwp5/IlmuecfsFAw false - - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9NS37 uniprotkb:P62509 intact:EBI-632965|ensembl:ENSP00000433459|ensembl:ENSP00000434281|uniprotkb:Q52LT3|uniprotkb:B2R8Q9|uniprotkb:Q0P5U9 intact:EBI-5274019|uniprotkb:O75454|uniprotkb:O96021|uniprotkb:Q8CHC9|uniprotkb:Q9R1F3|ensembl:ENSMUSP00000027906 psi-mi:zhang_human(display_long)|uniprotkb:Host cell factor-binding transcription factor Zhangfei(gene name synonym)|uniprotkb:CREBZF(gene name)|psi-mi:CREBZF(display_short)|uniprotkb:ZF(gene name synonym) psi-mi:err3_mouse(display_long)|uniprotkb:Esrrg(gene name)|psi-mi:Esrrg(display_short)|uniprotkb:Err3(gene name synonym)|uniprotkb:Kiaa0832(gene name synonym)|uniprotkb:Nr3b3(gene name synonym)|uniprotkb:Estrogen receptor-related protein 3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 3(gene name synonym) psi-mi:"MI:0096"(pull down) Xie et al. (2009) pubmed:19690166 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5274130 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000137504(gene)|ensembl:ENST00000490820(transcript)|ensembl:ENST00000527447(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|refseq:NP_001034707.1|refseq:XP_016873577.1|refseq:XP_016873578.1|refseq:XP_016873579.1|refseq:XP_016873580.1|refseq:XP_016873581.1|refseq:XP_011543497.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|mint:Q9NS37|dip:DIP-33934N refseq:NP_001230721.1|refseq:NP_036065.1|refseq:XP_006497227.1|refseq:XP_006497228.1|refseq:XP_006497230.1|refseq:XP_006497233.1|ensembl:ENSMUSG00000026610(gene)|ensembl:ENSMUST00000027906(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1S9P|rcsb pdb:1S9Q|reactome:R-MMU-383280 - - - figure legend:3D, 6C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|curation depth:mimix curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2011/11/24 2014/10/16 rogid:f4aOJ/8bwzLv6oFRz6dERW2dUIA9606 rogid:BMdGghKpGbkmaSL6DR6ApJU6Exk10090 intact-crc:F26855BA0CC655F5|rigid:kHUyrrjC+kR9EiJsP8NCIvhKr0Y false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96EB6 uniprotkb:Q9NS37 intact:EBI-1802965|uniprotkb:Q2XNF6|uniprotkb:Q5JVQ0|uniprotkb:Q9GZR9|uniprotkb:Q9Y6F0|ensembl:ENSP00000212015 intact:EBI-632965|ensembl:ENSP00000433459|ensembl:ENSP00000434281|uniprotkb:Q52LT3|uniprotkb:B2R8Q9|uniprotkb:Q0P5U9 psi-mi:sir1_human(display_long)|uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym)|uniprotkb:SIRT1(gene name)|psi-mi:SIRT1(display_short)|uniprotkb:SIR2L1(gene name synonym)|uniprotkb:SIR2-like protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym) psi-mi:zhang_human(display_long)|uniprotkb:Host cell factor-binding transcription factor Zhangfei(gene name synonym)|uniprotkb:CREBZF(gene name)|psi-mi:CREBZF(display_short)|uniprotkb:ZF(gene name synonym) psi-mi:"MI:0096"(pull down) Xie et al. (2009) pubmed:19690166 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5274139 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001135970.1|refseq:NP_036370.2|refseq:NP_001300978.1|dip:DIP-29757N|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q96EB6|rcsb pdb:4I5I|rcsb pdb:4IF6|rcsb pdb:4IG9|rcsb pdb:4KXQ|rcsb pdb:4ZZH|rcsb pdb:4ZZI|rcsb pdb:4ZZJ|rcsb pdb:5BTR|reactome:R-HSA-3371453|reactome:R-HSA-400253|reactome:R-HSA-427359|reactome:R-HSA-9617629|reactome:R-HSA-9707616|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000096717(gene)|ensembl:ENST00000212015(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001650"(fibrillar center)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002039"(p53 binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031393"(negative regulation of prostaglandin biosynthetic process)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035358"(regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042393"(histone binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042595"(behavioral response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0044321"(response to leptin)|go:"GO:0071441"(negative regulation of histone H3-K14 acetylation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0106230"(protein depropionylation)|go:"GO:0106231"(protein-propionyllysine depropionylase activity)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2000655"(negative regulation of cellular response to testosterone stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor) ensembl:ENSG00000137504(gene)|ensembl:ENST00000490820(transcript)|ensembl:ENST00000527447(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|refseq:NP_001034707.1|refseq:XP_016873577.1|refseq:XP_016873578.1|refseq:XP_016873579.1|refseq:XP_016873580.1|refseq:XP_016873581.1|refseq:XP_011543497.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|mint:Q9NS37|dip:DIP-33934N - - - figure legend:5F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|curation depth:mimix curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2011/11/24 2014/10/16 rogid:h3zVepuhRhzlINCluVuAn71Btjc9606 rogid:f4aOJ/8bwzLv6oFRz6dERW2dUIA9606 intact-crc:B1A6FAF2DF2562B6|rigid:zrsZyAiVBgWKwp5/IlmuecfsFAw false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NS37 uniprotkb:Q9NS37 intact:EBI-632965|ensembl:ENSP00000433459|ensembl:ENSP00000434281|uniprotkb:Q52LT3|uniprotkb:B2R8Q9|uniprotkb:Q0P5U9 intact:EBI-632965|ensembl:ENSP00000433459|ensembl:ENSP00000434281|uniprotkb:Q52LT3|uniprotkb:B2R8Q9|uniprotkb:Q0P5U9 psi-mi:zhang_human(display_long)|uniprotkb:Host cell factor-binding transcription factor Zhangfei(gene name synonym)|uniprotkb:CREBZF(gene name)|psi-mi:CREBZF(display_short)|uniprotkb:ZF(gene name synonym) psi-mi:zhang_human(display_long)|uniprotkb:Host cell factor-binding transcription factor Zhangfei(gene name synonym)|uniprotkb:CREBZF(gene name)|psi-mi:CREBZF(display_short)|uniprotkb:ZF(gene name synonym) psi-mi:"MI:0096"(pull down) Xie et al. (2009) pubmed:19690166 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5274147 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000137504(gene)|ensembl:ENST00000490820(transcript)|ensembl:ENST00000527447(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|refseq:NP_001034707.1|refseq:XP_016873577.1|refseq:XP_016873578.1|refseq:XP_016873579.1|refseq:XP_016873580.1|refseq:XP_016873581.1|refseq:XP_011543497.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|mint:Q9NS37|dip:DIP-33934N ensembl:ENSG00000137504(gene)|ensembl:ENST00000490820(transcript)|ensembl:ENST00000527447(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|refseq:NP_001034707.1|refseq:XP_016873577.1|refseq:XP_016873578.1|refseq:XP_016873579.1|refseq:XP_016873580.1|refseq:XP_016873581.1|refseq:XP_011543497.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|mint:Q9NS37|dip:DIP-33934N - - - figure legend:S3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|curation depth:mimix curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2011/11/24 2014/10/16 rogid:f4aOJ/8bwzLv6oFRz6dERW2dUIA9606 rogid:f4aOJ/8bwzLv6oFRz6dERW2dUIA9606 intact-crc:5E2972FEB94D3171|rigid:NHHj98yXIvvcf2oB2wxiTvpvdIk false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P62509 uniprotkb:Q9NS37 intact:EBI-5274019|uniprotkb:O75454|uniprotkb:O96021|uniprotkb:Q8CHC9|uniprotkb:Q9R1F3|ensembl:ENSMUSP00000027906 intact:EBI-632965|ensembl:ENSP00000433459|ensembl:ENSP00000434281|uniprotkb:Q52LT3|uniprotkb:B2R8Q9|uniprotkb:Q0P5U9 psi-mi:err3_mouse(display_long)|uniprotkb:Esrrg(gene name)|psi-mi:Esrrg(display_short)|uniprotkb:Err3(gene name synonym)|uniprotkb:Kiaa0832(gene name synonym)|uniprotkb:Nr3b3(gene name synonym)|uniprotkb:Estrogen receptor-related protein 3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 3(gene name synonym) psi-mi:zhang_human(display_long)|uniprotkb:Host cell factor-binding transcription factor Zhangfei(gene name synonym)|uniprotkb:CREBZF(gene name)|psi-mi:CREBZF(display_short)|uniprotkb:ZF(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Xie et al. (2009) pubmed:19690166 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-5274126 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230721.1|refseq:NP_036065.1|refseq:XP_006497227.1|refseq:XP_006497228.1|refseq:XP_006497230.1|refseq:XP_006497233.1|ensembl:ENSMUSG00000026610(gene)|ensembl:ENSMUST00000027906(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1S9P|rcsb pdb:1S9Q|reactome:R-MMU-383280 ensembl:ENSG00000137504(gene)|ensembl:ENST00000490820(transcript)|ensembl:ENST00000527447(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|refseq:NP_001034707.1|refseq:XP_016873577.1|refseq:XP_016873578.1|refseq:XP_016873579.1|refseq:XP_016873580.1|refseq:XP_016873581.1|refseq:XP_011543497.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|mint:Q9NS37|dip:DIP-33934N go:"GO:0005634"(nucleus) - - figure legend:1D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|curation depth:mimix curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/11/24 2014/10/16 rogid:BMdGghKpGbkmaSL6DR6ApJU6Exk10090 rogid:f4aOJ/8bwzLv6oFRz6dERW2dUIA9606 intact-crc:5CC3ABC2790DA35E|rigid:kHUyrrjC+kR9EiJsP8NCIvhKr0Y false - - - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining)