#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O60921 uniprotkb:O60671 intact:EBI-1056174|uniprotkb:B4DFI9|ensembl:ENSP00000258774 intact:EBI-721835|uniprotkb:O75572|uniprotkb:O95304|uniprotkb:Q5KSM0|uniprotkb:Q5KSM1|uniprotkb:Q9UEP1|uniprotkb:Q1W161|ensembl:ENSP00000340879|ensembl:ENSP00000371469 psi-mi:hus1_human(display_long)|uniprotkb:HUS1(gene name)|psi-mi:HUS1(display_short) psi-mi:rad1_human(display_long)|uniprotkb:DNA repair exonuclease rad1 homolog(gene name synonym)|uniprotkb:Rad1-like DNA damage checkpoint protein(gene name synonym)|uniprotkb:RAD1(gene name)|psi-mi:RAD1(display_short)|uniprotkb:REC1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Sohn et al. (2009) pubmed:19464297|imex:IM-16955 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-3647468|wwpdb:3a1j|imex:IM-16955-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004498.1|ensembl:ENSG00000136273(gene)|ensembl:ENST00000258774(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR007150(Hus1-like protein)|interpro:IPR016580(Cell cycle checkpoint, HUS1)|mint:O60921|rcsb pdb:3A1J|rcsb pdb:3G65|rcsb pdb:3GGR|rcsb pdb:6J8Y|reactome:R-HSA-176187|reactome:R-HSA-5685938|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|refseq:XP_016867604.1|dip:DIP-40929N refseq:NP_002844.1|dip:DIP-46061N|ensembl:ENSG00000113456(gene)|ensembl:ENST00000341754(transcript)|ensembl:ENST00000382038(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0008853"(exodeoxyribonuclease III activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051598"(meiotic recombination checkpoint signaling)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR003011(Repair protein Rad1)|interpro:IPR003021(Repair protein Rad1/Rec1)|mint:O60671|rcsb pdb:3A1J|rcsb pdb:3G65|rcsb pdb:3GGR|rcsb pdb:6J8Y|reactome:R-HSA-176187|reactome:R-HSA-5685938|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473 go:"GO:0003677"(DNA binding) - - 3d-resolution:2.5 A|3d-r-factors:R-value 0.209 R-free 0.282|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/03/01 2014/10/16 rogid:VcKRVh32bKsc9M0aeBYVWktGU589606 rogid:/qtRi6bRt9RpbMSegtH/Jbw83Pg9606 intact-crc:C4F419376B2DE8F4|rigid:iWfKgjhTfyImWXuIukf6qHfpsKE false - sufficient binding region:13-275 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O60921 uniprotkb:Q99638 intact:EBI-1056174|uniprotkb:B4DFI9|ensembl:ENSP00000258774 intact:EBI-2606224|uniprotkb:B2RCZ8|uniprotkb:Q6FI29|uniprotkb:Q96C41|ensembl:ENSP00000311360 psi-mi:hus1_human(display_long)|uniprotkb:HUS1(gene name)|psi-mi:HUS1(display_short) psi-mi:rad9a_human(display_long)|uniprotkb:DNA repair exonuclease rad9 homolog A(gene name synonym)|uniprotkb:RAD9A(gene name)|psi-mi:RAD9A(display_short) psi-mi:"MI:0114"(x-ray crystallography) Sohn et al. (2009) pubmed:19464297|imex:IM-16955 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-3647468|wwpdb:3a1j|imex:IM-16955-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004498.1|ensembl:ENSG00000136273(gene)|ensembl:ENST00000258774(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR007150(Hus1-like protein)|interpro:IPR016580(Cell cycle checkpoint, HUS1)|mint:O60921|rcsb pdb:3A1J|rcsb pdb:3G65|rcsb pdb:3GGR|rcsb pdb:6J8Y|reactome:R-HSA-176187|reactome:R-HSA-5685938|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|refseq:XP_016867604.1|dip:DIP-40929N refseq:NP_004575.1|ensembl:ENSG00000172613(gene)|ensembl:ENST00000307980(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0008853"(exodeoxyribonuclease III activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR007268(Rad9)|interpro:IPR026584|mint:Q99638|rcsb pdb:3A1J|rcsb pdb:3G65|rcsb pdb:3GGR|rcsb pdb:6HM5|rcsb pdb:6J8Y|reactome:R-HSA-176187|reactome:R-HSA-5685938|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|refseq:NP_001230153.1|dip:DIP-24255N|dip:DIP-40930N go:"GO:0003677"(DNA binding) - - 3d-resolution:2.5 A|3d-r-factors:R-value 0.209 R-free 0.282|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/03/01 2014/10/16 rogid:VcKRVh32bKsc9M0aeBYVWktGU589606 rogid:W32q7Paqhs+FCM3bCprDXrqlG449606 intact-crc:C4F419376B2DE8F4|rigid:iWfKgjhTfyImWXuIukf6qHfpsKE false - sufficient binding region:1-266 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)