#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62881	uniprotkb:Q9JHX4	intact:EBI-5234605	intact:EBI-4326675|ensembl:ENSRNOP00000016613|ensembl:ENSRNOP00000069982	psi-mi:nol3_rat(display_long)|uniprotkb:Nol3(gene name)|psi-mi:Nol3(display_short)|uniprotkb:Arc(gene name synonym)|uniprotkb:Apoptosis repressor with CARD(gene name synonym)	psi-mi:casp8_rat(display_long)|uniprotkb:Casp8(gene name)|psi-mi:Casp8(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tan et al. (2008)	pubmed:19001025|imex:IM-16834	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5234601|imex:IM-16834-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:708558|refseq:NP_445968.2|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014876"(response to injury involved in regulation of muscle adaptation)|go:"GO:0016020"(membrane)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019900"(kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0060547"(negative regulation of necrotic cell death)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903073"(negative regulation of death-inducing signaling complex assembly)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:0089720"(caspase binding)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)	rgd:620945|refseq:NP_071613.1|refseq:XP_006245077.1|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|reactome:R-RNO-111465|reactome:R-RNO-168638|reactome:R-RNO-264870|reactome:R-RNO-3371378|reactome:R-RNO-5218900|reactome:R-RNO-5357905|reactome:R-RNO-5660668|reactome:R-RNO-5675482|reactome:R-RNO-69416|reactome:R-RNO-75108|reactome:R-RNO-75153|reactome:R-RNO-75157|reactome:R-RNO-75158|ensembl:ENSRNOG00000012331(gene)|ensembl:ENSRNOT00000016613(transcript)|ensembl:ENSRNOT00000084498(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001841"(neural tube formation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009409"(response to cold)|go:"GO:0016485"(protein processing)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030690"(Noc1p-Noc2p complex)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070243"(regulation of thymocyte apoptotic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:0004197"(cysteine-type endopeptidase activity)	-	-	-	figure legend:6d|antagonist:"5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) inhibited the interaction."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2011/08/12	2014/10/16	rogid:QwB0Z0LGLx/LD8PZ621TJuuHn1010116	rogid:ctxelglBfzABJGefTMv+73JF+fM10116	intact-crc:95AF53C4EC43CA51|rigid:VLvBY9NT4RET2THLyQ2Pbak3T+0	false	mutation disrupting interaction:149-149	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8R2E7	uniprotkb:Q9JHX4	intact:EBI-4326723|ensembl:ENSRNOP00000066289	intact:EBI-4326675|ensembl:ENSRNOP00000016613|ensembl:ENSRNOP00000069982	psi-mi:q8r2e7_rat(display_long)|uniprotkb:rCG_48606(orf name)|uniprotkb:Fadd(gene name)|psi-mi:Fadd(display_short)|uniprotkb:fadd(gene name synonym)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)	psi-mi:casp8_rat(display_long)|uniprotkb:Casp8(gene name)|psi-mi:Casp8(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tan et al. (2008)	pubmed:19001025|imex:IM-16834	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4326719|imex:IM-16834-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628700|refseq:NP_690920.1|ensembl:ENSRNOG00000047035(gene)|ensembl:ENSRNOT00000075089(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002020"(protease binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0089720"(caspase binding)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097342"(ripoptosome)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2000454"(positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR016729(FADD)|reactome:R-RNO-3371378|reactome:R-RNO-5218900|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5675482|reactome:R-RNO-69416|reactome:R-RNO-75157|reactome:R-RNO-75158	rgd:620945|refseq:NP_071613.1|refseq:XP_006245077.1|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|reactome:R-RNO-111465|reactome:R-RNO-168638|reactome:R-RNO-264870|reactome:R-RNO-3371378|reactome:R-RNO-5218900|reactome:R-RNO-5357905|reactome:R-RNO-5660668|reactome:R-RNO-5675482|reactome:R-RNO-69416|reactome:R-RNO-75108|reactome:R-RNO-75153|reactome:R-RNO-75157|reactome:R-RNO-75158|ensembl:ENSRNOG00000012331(gene)|ensembl:ENSRNOT00000016613(transcript)|ensembl:ENSRNOT00000084498(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001841"(neural tube formation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009409"(response to cold)|go:"GO:0016485"(protein processing)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030690"(Noc1p-Noc2p complex)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070243"(regulation of thymocyte apoptotic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:0004197"(cysteine-type endopeptidase activity)	-	-	-	figure legend:6d|agonist:Isoprotenerol was required for this endogenous interaction to happen.|antagonist:nol3 over expression disrupted the interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2011/08/12	2014/10/16	rogid:h5Gl5L7YEMW71Kk+LQYTqjvu31Y10116	rogid:ctxelglBfzABJGefTMv+73JF+fM10116	intact-crc:4FA1138F91C590EB|rigid:Y01Po/Xn1iD+FvZtsbRoS5v7K8g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8R2E7	uniprotkb:Q9JHX4	intact:EBI-4326723|ensembl:ENSRNOP00000066289	intact:EBI-4326675|ensembl:ENSRNOP00000016613|ensembl:ENSRNOP00000069982	psi-mi:q8r2e7_rat(display_long)|uniprotkb:rCG_48606(orf name)|uniprotkb:Fadd(gene name)|psi-mi:Fadd(display_short)|uniprotkb:fadd(gene name synonym)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)	psi-mi:casp8_rat(display_long)|uniprotkb:Casp8(gene name)|psi-mi:Casp8(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tan et al. (2008)	pubmed:19001025|imex:IM-16834	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4326789|imex:IM-16834-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628700|refseq:NP_690920.1|ensembl:ENSRNOG00000047035(gene)|ensembl:ENSRNOT00000075089(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002020"(protease binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0089720"(caspase binding)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097342"(ripoptosome)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2000454"(positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR016729(FADD)|reactome:R-RNO-3371378|reactome:R-RNO-5218900|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5675482|reactome:R-RNO-69416|reactome:R-RNO-75157|reactome:R-RNO-75158	rgd:620945|refseq:NP_071613.1|refseq:XP_006245077.1|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|reactome:R-RNO-111465|reactome:R-RNO-168638|reactome:R-RNO-264870|reactome:R-RNO-3371378|reactome:R-RNO-5218900|reactome:R-RNO-5357905|reactome:R-RNO-5660668|reactome:R-RNO-5675482|reactome:R-RNO-69416|reactome:R-RNO-75108|reactome:R-RNO-75153|reactome:R-RNO-75157|reactome:R-RNO-75158|ensembl:ENSRNOG00000012331(gene)|ensembl:ENSRNOT00000016613(transcript)|ensembl:ENSRNOT00000084498(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001841"(neural tube formation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009409"(response to cold)|go:"GO:0016485"(protein processing)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030690"(Noc1p-Noc2p complex)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070243"(regulation of thymocyte apoptotic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:0004197"(cysteine-type endopeptidase activity)	-	-	-	figure legend:6d|agonist:Isoprotenerol was required for this endogenous interaction to happen.|antagonist:nol3 over expression decreased the interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2011/08/12	2014/10/16	rogid:h5Gl5L7YEMW71Kk+LQYTqjvu31Y10116	rogid:ctxelglBfzABJGefTMv+73JF+fM10116	intact-crc:3F0C59EE3D06A13A|rigid:acPSi0qCfoSw6g9biyxPDcBcFO8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8R2E7	uniprotkb:Q63199	intact:EBI-4326723|ensembl:ENSRNOP00000066289	intact:EBI-5234460	psi-mi:q8r2e7_rat(display_long)|uniprotkb:rCG_48606(orf name)|uniprotkb:Fadd(gene name)|psi-mi:Fadd(display_short)|uniprotkb:fadd(gene name synonym)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)	psi-mi:tnr6_rat(display_long)|uniprotkb:Fas(gene name)|psi-mi:Fas(display_short)|uniprotkb:Apt1(gene name synonym)|uniprotkb:Tnfrsf6(gene name synonym)|uniprotkb:Apo-1 antigen(gene name synonym)|uniprotkb:Apoptosis-mediating surface antigen FAS(gene name synonym)|uniprotkb:FASLG receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tan et al. (2008)	pubmed:19001025|imex:IM-16834	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4326789|imex:IM-16834-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628700|refseq:NP_690920.1|ensembl:ENSRNOG00000047035(gene)|ensembl:ENSRNOT00000075089(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002020"(protease binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0089720"(caspase binding)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097342"(ripoptosome)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2000454"(positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR016729(FADD)|reactome:R-RNO-3371378|reactome:R-RNO-5218900|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5675482|reactome:R-RNO-69416|reactome:R-RNO-75157|reactome:R-RNO-75158	rgd:619831|refseq:NP_631933.2|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR008063(Fas receptor)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR033998|interpro:IPR033999|reactome:R-RNO-3371378|reactome:R-RNO-5218900|reactome:R-RNO-69416|reactome:R-RNO-75157|go:"GO:0001552"(ovarian follicle atresia)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010626"(negative regulation of Schwann cell proliferation)|go:"GO:0010876"(lipid localization)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019900"(kinase binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0030141"(secretory granule)|go:"GO:0031104"(dendrite regeneration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0036337"(Fas signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042698"(ovulation cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0034097"(response to cytokine)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045619"(regulation of lymphocyte differentiation)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0046898"(response to cycloheximide)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070227"(lymphocyte apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070848"(response to growth factor)|go:"GO:0071234"(cellular response to phenylalanine)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097421"(liver regeneration)|go:"GO:0097440"(apical dendrite)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1900148"(negative regulation of Schwann cell migration)|go:"GO:1902617"(response to fluoride)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)	-	-	-	figure legend:6d|agonist:Isoprotenerol was required for this endogenous interaction to happen.|antagonist:nol3 over expression decreased the interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2011/08/12	2014/10/16	rogid:h5Gl5L7YEMW71Kk+LQYTqjvu31Y10116	rogid:mLpWGPLzEhmIIZrlx7rNn6oSuVs10116	intact-crc:3F0C59EE3D06A13A|rigid:acPSi0qCfoSw6g9biyxPDcBcFO8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)