#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P34998	uniprotkb:P06850	intact:EBI-3870393|uniprotkb:Q13008|uniprotkb:Q4QRJ1|uniprotkb:Q9UK64|uniprotkb:B4DIE9|ensembl:ENSP00000381333|ensembl:ENSP00000480396	intact:EBI-3870390|uniprotkb:B3KQS4|ensembl:ENSP00000276571	psi-mi:crfr1_human(display_long)|uniprotkb:CRHR1(gene name)|psi-mi:CRHR1(display_short)|uniprotkb:CRFR(gene name synonym)|uniprotkb:CRFR1(gene name synonym)|uniprotkb:CRHR(gene name synonym)|uniprotkb:Corticotropin-releasing hormone receptor 1(gene name synonym)	psi-mi:crf_human(display_long)|uniprotkb:CRH(gene name)|psi-mi:CRH(display_short)|uniprotkb:Corticotropin-releasing factor(gene name synonym)|uniprotkb:Corticotropin-releasing hormone(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Pioszak et al. (2008)	pubmed:18801728|imex:IM-16901	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-3870396|pdbe:3EHU|imex:IM-16901-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138618.1|refseq:NP_001138619.1|refseq:NP_001138620.1|refseq:NP_004373.2|refseq:NP_001289945.1|refseq:NP_001289947.1|refseq:NP_001243228.1|ensembl:ENSG00000120088(gene)|ensembl:ENSG00000276191(gene)|ensembl:ENST00000398285(transcript)|ensembl:ENST00000616274(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007565"(female pregnancy)|go:"GO:0007567"(parturition)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0010578"(regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway)|go:"GO:0015056"(corticotrophin-releasing factor receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043404"(corticotropin-releasing hormone receptor activity)|go:"GO:0051424"(corticotropin-releasing hormone binding)|go:"GO:0051458"(corticotropin secretion)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:2000852"(regulation of corticosterone secretion)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003051(GPCR, family 2, corticotropin releasing factor receptor)|interpro:IPR003052(GPCR, family 2, corticotropin releasing factor receptor, type 1)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|mint:P34998|rcsb pdb:2L27|rcsb pdb:3EHS|rcsb pdb:3EHT|rcsb pdb:3EHU|rcsb pdb:4K5Y|rcsb pdb:4Z9G|rcsb pdb:6P9X|rcsb pdb:6PB0|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:XP_016868579.1|refseq:XP_016868580.1|refseq:XP_016868581.1|refseq:XP_016868582.1|refseq:NP_000747.1|ensembl:ENSG00000147571(gene)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007565"(female pregnancy)|go:"GO:0007567"(parturition)|go:"GO:0007611"(learning or memory)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008628"(hormone-mediated apoptotic signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0017045"(corticotropin-releasing hormone activity)|ensembl:ENST00000276571(transcript)|go:"GO:0021854"(hypothalamus development)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0033685"(negative regulation of luteinizing hormone secretion)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042322"(negative regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042493"|go:"GO:0043196"(varicosity)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0045472"(response to ether)|go:"GO:0048265"(response to pain)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051431"(corticotropin-releasing hormone receptor 2 binding)|go:"GO:0051461"(positive regulation of corticotropin secretion)|go:"GO:0051464"(positive regulation of cortisol secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060456"(positive regulation of digestive system process)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070093"(negative regulation of glucagon secretion)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000854"(positive regulation of corticosterone secretion)|go:"GO:2000987"(positive regulation of behavioral fear response)|interpro:IPR000187(Corticotropin-releasing factor, CRF)|interpro:IPR003620(Urocortin/corticotropin-releasing factor)|interpro:IPR018446|rcsb pdb:1GO9|rcsb pdb:1GOE|rcsb pdb:3EHT|rcsb pdb:3EHU|rcsb pdb:6P9X|reactome:R-HSA-373080|reactome:R-HSA-9022702|reactome:R-HSA-9660821|reactome:R-HSA-418555	pdbe:3EHT(see-also)	-	-	3d-resolution:1.96|3d-r-factors:R-value 0.212  R-free 0.256|comment:CRF is a synthetic peptide|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/04/12	2014/10/16	rogid:iJS6/XivyhoGCNtSxf6TXEqqNak9606	rogid:a+6FxPeYe5rypIWTmK6GHR17f9E9606	intact-crc:E50D5D83DC8E30FF|rigid:HFVBB/EHXCxt5mESVvKKCMJ10y4	false	sufficient binding region:24-119|maltose binding protein tag:n-n	sufficient binding region:22-41	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P34998	uniprotkb:P06850	intact:EBI-3870393|uniprotkb:Q13008|uniprotkb:Q4QRJ1|uniprotkb:Q9UK64|uniprotkb:B4DIE9|ensembl:ENSP00000381333|ensembl:ENSP00000480396	intact:EBI-3870390|uniprotkb:B3KQS4|ensembl:ENSP00000276571	psi-mi:crfr1_human(display_long)|uniprotkb:CRHR1(gene name)|psi-mi:CRHR1(display_short)|uniprotkb:CRFR(gene name synonym)|uniprotkb:CRFR1(gene name synonym)|uniprotkb:CRHR(gene name synonym)|uniprotkb:Corticotropin-releasing hormone receptor 1(gene name synonym)	psi-mi:crf_human(display_long)|uniprotkb:CRH(gene name)|psi-mi:CRH(display_short)|uniprotkb:Corticotropin-releasing factor(gene name synonym)|uniprotkb:Corticotropin-releasing hormone(gene name synonym)	psi-mi:"MI:0905"(amplified luminescent proximity homogeneous assay)	Pioszak et al. (2008)	pubmed:18801728|imex:IM-16901	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-3870856|imex:IM-16901-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138618.1|refseq:NP_001138619.1|refseq:NP_001138620.1|refseq:NP_004373.2|refseq:NP_001289945.1|refseq:NP_001289947.1|refseq:NP_001243228.1|ensembl:ENSG00000120088(gene)|ensembl:ENSG00000276191(gene)|ensembl:ENST00000398285(transcript)|ensembl:ENST00000616274(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007565"(female pregnancy)|go:"GO:0007567"(parturition)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0010578"(regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway)|go:"GO:0015056"(corticotrophin-releasing factor receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043404"(corticotropin-releasing hormone receptor activity)|go:"GO:0051424"(corticotropin-releasing hormone binding)|go:"GO:0051458"(corticotropin secretion)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:2000852"(regulation of corticosterone secretion)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003051(GPCR, family 2, corticotropin releasing factor receptor)|interpro:IPR003052(GPCR, family 2, corticotropin releasing factor receptor, type 1)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|mint:P34998|rcsb pdb:2L27|rcsb pdb:3EHS|rcsb pdb:3EHT|rcsb pdb:3EHU|rcsb pdb:4K5Y|rcsb pdb:4Z9G|rcsb pdb:6P9X|rcsb pdb:6PB0|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:XP_016868579.1|refseq:XP_016868580.1|refseq:XP_016868581.1|refseq:XP_016868582.1|refseq:NP_000747.1|ensembl:ENSG00000147571(gene)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007565"(female pregnancy)|go:"GO:0007567"(parturition)|go:"GO:0007611"(learning or memory)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008628"(hormone-mediated apoptotic signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0017045"(corticotropin-releasing hormone activity)|ensembl:ENST00000276571(transcript)|go:"GO:0021854"(hypothalamus development)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0033685"(negative regulation of luteinizing hormone secretion)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042322"(negative regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042493"|go:"GO:0043196"(varicosity)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0045472"(response to ether)|go:"GO:0048265"(response to pain)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051431"(corticotropin-releasing hormone receptor 2 binding)|go:"GO:0051461"(positive regulation of corticotropin secretion)|go:"GO:0051464"(positive regulation of cortisol secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060456"(positive regulation of digestive system process)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070093"(negative regulation of glucagon secretion)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000854"(positive regulation of corticosterone secretion)|go:"GO:2000987"(positive regulation of behavioral fear response)|interpro:IPR000187(Corticotropin-releasing factor, CRF)|interpro:IPR003620(Urocortin/corticotropin-releasing factor)|interpro:IPR018446|rcsb pdb:1GO9|rcsb pdb:1GOE|rcsb pdb:3EHT|rcsb pdb:3EHU|rcsb pdb:6P9X|reactome:R-HSA-373080|reactome:R-HSA-9022702|reactome:R-HSA-9660821|reactome:R-HSA-418555	-	-	-	figure legend:fig 1 and fig 3e|comment:CRF is a synthetic peptide|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/04/12	2014/10/16	rogid:iJS6/XivyhoGCNtSxf6TXEqqNak9606	rogid:a+6FxPeYe5rypIWTmK6GHR17f9E9606	intact-crc:315693D781E727AA|rigid:HFVBB/EHXCxt5mESVvKKCMJ10y4	false	maltose binding protein tag:n-n|sufficient binding region:24-119|his tag:c-c	sufficient binding region:12-41|biotin tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)