#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6R891	uniprotkb:O54828	intact:EBI-774681|uniprotkb:Q8K0X7|ensembl:ENSMUSP00000041732	intact:EBI-2657648|uniprotkb:A1L352|uniprotkb:Q9Z0S0|ensembl:ENSMUSP00000020920	psi-mi:neb2_mouse(display_long)|uniprotkb:Neurabin-II(gene name synonym)|uniprotkb:Spinophilin(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 9B(gene name synonym)|uniprotkb:Ppp1r9b(gene name)|psi-mi:Ppp1r9b(display_short)	psi-mi:rgs9_mouse(display_long)|uniprotkb:Rgs9(gene name)|psi-mi:Rgs9(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Charlton et al. (2008)	pubmed:18439408|imex:IM-17167	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-5282692|imex:IM-17167-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_758465.2|ensembl:ENSMUSG00000038976(gene)|ensembl:ENSMUST00000038696(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031175"(neuron projection development)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051015"(actin filament binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0061458"(reproductive system development)|go:"GO:0071315"(cellular response to morphine)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097338"(response to clozapine)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903119"(protein localization to actin cytoskeleton)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904372"(positive regulation of protein localization to actin cortical patch)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904386"(response to L-phenylalanine derivative)|go:"GO:1990778"(protein localization to cell periphery)|go:"GO:1990780"(cytoplasmic side of dendritic spine plasma membrane)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR029921|interpro:IPR036034|interpro:IPR040645|interpro:IPR043446|mint:Q6R891	refseq:NP_035398.2|ensembl:ENSMUSG00000020599(gene)|ensembl:ENSMUST00000020920(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0032355"(response to estradiol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905912"(regulation of calcium ion export across plasma membrane)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|rcsb pdb:2PBI|reactome:R-MMU-2514859|reactome:R-MMU-418594|reactome:R-MMU-6814122|interpro:IPR040759|interpro:IPR036390|dip:DIP-46389N	-	-	-	figure legend:3D|agonist:morphine and fentanyl treatment|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-striatum)|taxid:10090(Mouse striatum)	-	2011/12/13	2014/10/16	rogid:UKGG1FQWWvX56wsI2kQB1jU5uOc10090	rogid:kWw+4GrN+elOvNTChcpFpspSujw10090	intact-crc:1FF1626564E4B9B6|rigid:bmxEnWdwlP3lSXxyRrJ9nMjX87A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6R891	uniprotkb:P62881	intact:EBI-774681|uniprotkb:Q8K0X7|ensembl:ENSMUSP00000041732	intact:EBI-772008|uniprotkb:O35354|uniprotkb:P54314|uniprotkb:Q91WB3|ensembl:ENSMUSP00000076155|ensembl:ENSMUSP00000149938	psi-mi:neb2_mouse(display_long)|uniprotkb:Neurabin-II(gene name synonym)|uniprotkb:Spinophilin(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 9B(gene name synonym)|uniprotkb:Ppp1r9b(gene name)|psi-mi:Ppp1r9b(display_short)	psi-mi:gnb5_mouse(display_long)|uniprotkb:Transducin beta chain 5(gene name synonym)|uniprotkb:Gbeta5(gene name synonym)|uniprotkb:Gnb5(gene name)|psi-mi:Gnb5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Charlton et al. (2008)	pubmed:18439408|imex:IM-17167	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-5282687|imex:IM-17167-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_758465.2|ensembl:ENSMUSG00000038976(gene)|ensembl:ENSMUST00000038696(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031175"(neuron projection development)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051015"(actin filament binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0061458"(reproductive system development)|go:"GO:0071315"(cellular response to morphine)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097338"(response to clozapine)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903119"(protein localization to actin cytoskeleton)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904372"(positive regulation of protein localization to actin cortical patch)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904386"(response to L-phenylalanine derivative)|go:"GO:1990778"(protein localization to cell periphery)|go:"GO:1990780"(cytoplasmic side of dendritic spine plasma membrane)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR029921|interpro:IPR036034|interpro:IPR040645|interpro:IPR043446|mint:Q6R891	refseq:NP_034443.1|refseq:NP_619733.1|dip:DIP-264N|ensembl:ENSMUSG00000032192(gene)|ensembl:ENSMUST00000076889(transcript)|ensembl:ENSMUST00000213990(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043209"(myelin sheath)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0051087"(chaperone binding)|go:"GO:0098793"(presynapse)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62881|rcsb pdb:2PBI|rcsb pdb:6N9G|reactome:R-MMU-1296041|reactome:R-MMU-202040|reactome:R-MMU-2514859|reactome:R-MMU-392170|reactome:R-MMU-392451|reactome:R-MMU-392851|reactome:R-MMU-400042|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-418217|reactome:R-MMU-418555|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418597|reactome:R-MMU-420092|reactome:R-MMU-428930|reactome:R-MMU-432040|reactome:R-MMU-456926|reactome:R-MMU-500657|reactome:R-MMU-6814122|reactome:R-MMU-8964315|reactome:R-MMU-8964616|reactome:R-MMU-9009391|reactome:R-MMU-997272|reactome:R-MMU-381676	-	-	-	agonist:morphine and fentanyl treatment|figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-striatum)|taxid:10090(Mouse striatum)	-	2011/12/13	2014/10/16	rogid:UKGG1FQWWvX56wsI2kQB1jU5uOc10090	rogid:p3EXabWuKKcJpLU4ZCrN0jcEgjk10090	intact-crc:120DDCF52C921F44|rigid:Lmv7bQuVDkcrdTlk+uy6PEYDIw4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6R891	uniprotkb:P42866	intact:EBI-774681|uniprotkb:Q8K0X7|ensembl:ENSMUSP00000041732	intact:EBI-5282656|uniprotkb:Q60768|uniprotkb:A1XGX3|uniprotkb:A1XGX4|uniprotkb:A1YAC3|uniprotkb:A1YAC4|uniprotkb:A5H7G2|uniprotkb:Q4U2P4|uniprotkb:Q4U2Q6|uniprotkb:Q548C6|uniprotkb:Q6YC50|uniprotkb:Q8CAN5|uniprotkb:Q8CGW2|uniprotkb:Q8CH73|uniprotkb:Q8CH74|uniprotkb:Q8CH75|uniprotkb:Q8VBU3|uniprotkb:Q8VBU6|uniprotkb:Q8VBX8|uniprotkb:Q8VI69|uniprotkb:Q8VI70|uniprotkb:Q8VI71|uniprotkb:Q8VIN3|uniprotkb:Q8VIN4|uniprotkb:Q8VIN5|uniprotkb:Q8VIN6|uniprotkb:Q8VIP0|uniprotkb:Q8VIP1|uniprotkb:Q9JIY1|uniprotkb:Q9R0D1|uniprotkb:Q9R1L9|uniprotkb:Q9R1M0|ensembl:ENSMUSP00000060590|ensembl:ENSMUSP00000090410|ensembl:ENSMUSP00000101232	psi-mi:neb2_mouse(display_long)|uniprotkb:Neurabin-II(gene name synonym)|uniprotkb:Spinophilin(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 9B(gene name synonym)|uniprotkb:Ppp1r9b(gene name)|psi-mi:Ppp1r9b(display_short)	psi-mi:oprm_mouse(display_long)|uniprotkb:Oprm1(gene name)|psi-mi:Oprm1(display_short)|uniprotkb:Mor(gene name synonym)|uniprotkb:Oprm(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Charlton et al. (2008)	pubmed:18439408|imex:IM-17167	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-5282654|imex:IM-17167-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_758465.2|ensembl:ENSMUSG00000038976(gene)|ensembl:ENSMUST00000038696(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031175"(neuron projection development)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051015"(actin filament binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0061458"(reproductive system development)|go:"GO:0071315"(cellular response to morphine)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097338"(response to clozapine)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903119"(protein localization to actin cytoskeleton)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904372"(positive regulation of protein localization to actin cortical patch)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904386"(response to L-phenylalanine derivative)|go:"GO:1990778"(protein localization to cell periphery)|go:"GO:1990780"(cytoplasmic side of dendritic spine plasma membrane)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR029921|interpro:IPR036034|interpro:IPR040645|interpro:IPR043446|mint:Q6R891	refseq:NP_001291866.1|refseq:NP_001291867.1|refseq:NP_001291877.1|refseq:NP_001291879.1|refseq:NP_001291884.1|refseq:NP_001289722.1|refseq:NP_001289723.1|refseq:NP_001289724.1|refseq:NP_001289725.1|refseq:NP_001034741.1|refseq:XP_017169315.1|refseq:XP_017169316.1|dip:DIP-46148N|ensembl:ENSMUSG00000000766(gene)|ensembl:ENSMUST00000056385(transcript)|ensembl:ENSMUST00000092734(transcript)|ensembl:ENSMUST00000105607(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4DKL|rcsb pdb:5C1M|rcsb pdb:6DDE|rcsb pdb:6DDF|reactome:R-MMU-111885|reactome:R-MMU-202040|reactome:R-MMU-375276|reactome:R-MMU-418594	-	-	-	figure legend:3A|agonist:morphine and fentanyl treatment|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-striatum)|taxid:10090(Mouse striatum)	-	2011/12/13	2014/10/16	rogid:UKGG1FQWWvX56wsI2kQB1jU5uOc10090	rogid:mjWGRgi4S39QR2gNvSpOkMlt/1s10090	intact-crc:C45A10CF9074A360|rigid:q/r/ZmnmQAt5IV5ytLLShMZcAQI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99MK8	uniprotkb:Q6R891	intact:EBI-771762|uniprotkb:Q99LL8|ensembl:ENSMUSP00000086114	intact:EBI-774681|uniprotkb:Q8K0X7|ensembl:ENSMUSP00000041732	psi-mi:arbk1_mouse(display_long)|uniprotkb:Grk2(gene name)|psi-mi:Grk2(display_short)|uniprotkb:Adrbk1(gene name synonym)|uniprotkb:G-protein-coupled receptor kinase 2(gene name synonym)	psi-mi:neb2_mouse(display_long)|uniprotkb:Neurabin-II(gene name synonym)|uniprotkb:Spinophilin(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 9B(gene name synonym)|uniprotkb:Ppp1r9b(gene name)|psi-mi:Ppp1r9b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Charlton et al. (2008)	pubmed:18439408|imex:IM-17167	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-5282682|imex:IM-17167-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001277747.1|dip:DIP-32413N|ensembl:ENSMUSG00000024858(gene)|ensembl:ENSMUST00000088737(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0003108"(negative regulation of the force of heart contraction by chemical signal)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0010661"(positive regulation of muscle cell apoptotic process)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019079"(viral genome replication)|go:"GO:0030424"(axon)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0031850"(delta-type opioid receptor binding)|go:"GO:0031851"(kappa-type opioid receptor binding)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0042311"(vasodilation)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1901081"(negative regulation of relaxation of smooth muscle)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|mint:Q99MK8|reactome:R-MMU-111933|reactome:R-MMU-416476|reactome:R-MMU-418555|reactome:R-MMU-5635838|reactome:R-MMU-8856825	refseq:NP_758465.2|ensembl:ENSMUSG00000038976(gene)|ensembl:ENSMUST00000038696(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031175"(neuron projection development)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051015"(actin filament binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0061458"(reproductive system development)|go:"GO:0071315"(cellular response to morphine)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097338"(response to clozapine)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903119"(protein localization to actin cytoskeleton)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904372"(positive regulation of protein localization to actin cortical patch)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904386"(response to L-phenylalanine derivative)|go:"GO:1990778"(protein localization to cell periphery)|go:"GO:1990780"(cytoplasmic side of dendritic spine plasma membrane)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR029921|interpro:IPR036034|interpro:IPR040645|interpro:IPR043446|mint:Q6R891	-	-	-	figure legend:3B|agonist:morphine and fentanyl treatment|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-striatum)|taxid:10090(Mouse striatum)	-	2011/12/13	2014/10/16	rogid:boMMNI7l5ABURK9gD6uoeiJy7z810090	rogid:UKGG1FQWWvX56wsI2kQB1jU5uOc10090	intact-crc:59D3AC2BED5D662A|rigid:b1SE/CjpvpJsZ1XSiMGZbqm6sac	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)