#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y239	uniprotkb:Q9Y239	intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823	intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823	psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym)	psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Srimathi et al. (2008)	pubmed:18186648|imex:IM-16899	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-3842992|pdbe:2nz7|imex:IM-16899-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N	refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N	-	-	-	3d-resolution:1.9 A 0.266|3d-r-factors:R-value 0.222  R-free|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/16	2014/10/16	rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606	rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606	intact-crc:9DD079A270CF290A|rigid:ZxPAxmBuE5F41jp4kdRg2Q2uFNI	false	sufficient binding region:1-106	sufficient binding region:1-106	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y239	uniprotkb:Q9Y239	intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823	intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823	psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym)	psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Srimathi et al. (2008)	pubmed:18186648|imex:IM-16899	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-3843023|imex:IM-16899-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N	refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N	-	-	-	figure legend:Fig 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/16	2014/10/16	rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606	rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606	intact-crc:01B4D3F84314C685|rigid:ZxPAxmBuE5F41jp4kdRg2Q2uFNI	false	sufficient binding region:1-106|necessary binding region:96-106	sufficient binding region:1-106|necessary binding region:96-106	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)