#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q15363 uniprotkb:P55085 intact:EBI-998485|ensembl:ENSP00000262225 intact:EBI-4303189|uniprotkb:Q13317|uniprotkb:Q13346|ensembl:ENSP00000296677|uniprotkb:Q53XJ8 psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym) psi-mi:par2_human(display_long)|uniprotkb:F2RL1(gene name)|psi-mi:F2RL1(display_short)|uniprotkb:GPR11(gene name synonym)|uniprotkb:PAR2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor 11(gene name synonym)|uniprotkb:Thrombin receptor-like 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Luo et al. (2007) pubmed:17693410 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-4303336 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1 refseq:NP_005233.3|ensembl:ENSG00000164251(gene)|ensembl:ENST00000296677(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042311"(vasodilation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070661"(leukocyte proliferation)|go:"GO:0070963"(positive regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002281(Protease-activated receptor 2)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P55085|rcsb pdb:5NDD|rcsb pdb:5NDZ|rcsb pdb:5NJ6|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|dip:DIP-42044N - - - figure legend:no figure|curation depth:mimix curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2011/07/11 2014/10/16 rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606 rogid:j9cMnyj9C74tReGYkQvGFy+cez49606 intact-crc:E29BA24EA9C78AD0|rigid:/aPmLNbHnQZdetE7giYdPhqnKDw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q15363 uniprotkb:P55085 intact:EBI-998485|ensembl:ENSP00000262225 intact:EBI-4303189|uniprotkb:Q13317|uniprotkb:Q13346|ensembl:ENSP00000296677|uniprotkb:Q53XJ8 psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym) psi-mi:par2_human(display_long)|uniprotkb:F2RL1(gene name)|psi-mi:F2RL1(display_short)|uniprotkb:GPR11(gene name synonym)|uniprotkb:PAR2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor 11(gene name synonym)|uniprotkb:Thrombin receptor-like 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Luo et al. (2007) pubmed:17693410 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-4303347 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1 refseq:NP_005233.3|ensembl:ENSG00000164251(gene)|ensembl:ENST00000296677(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042311"(vasodilation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070661"(leukocyte proliferation)|go:"GO:0070963"(positive regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002281(Protease-activated receptor 2)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P55085|rcsb pdb:5NDD|rcsb pdb:5NDZ|rcsb pdb:5NJ6|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|dip:DIP-42044N - - - figure legend:1A|curation depth:mimix curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2011/07/11 2014/10/16 rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606 rogid:j9cMnyj9C74tReGYkQvGFy+cez49606 intact-crc:3A14EEB9E23633A5|rigid:/aPmLNbHnQZdetE7giYdPhqnKDw false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q63645 uniprotkb:Q63524 intact:EBI-4303358|uniprotkb:Q499T9|ensembl:ENSRNOP00000058298 intact:EBI-918600|ensembl:ENSRNOP00000001397 psi-mi:par2_rat(display_long)|uniprotkb:F2rl1(gene name)|psi-mi:F2rl1(display_short)|uniprotkb:Par2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 1(gene name synonym)|uniprotkb:Thrombin receptor-like 1(gene name synonym) psi-mi:tmed2_rat(display_long)|uniprotkb:RNP21.4(gene name synonym)|uniprotkb:Tmed2(gene name)|psi-mi:Tmed2(display_short)|uniprotkb:Rnp24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:COPI-coated vesicle membrane protein p24(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Luo et al. (2007) pubmed:17693410 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-4303379 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:620866|refseq:NP_446349.1|ensembl:ENSRNOG00000018003(gene)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0009306"(protein secretion)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042311"(vasodilation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0043547"(positive regulation of GTPase activity)|ensembl:ENSRNOT00000061580(transcript)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070661"(leukocyte proliferation)|go:"GO:0070963"(positive regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002281(Protease-activated receptor 2)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-375276|reactome:R-RNO-416476 rgd:69243|refseq:NP_113910.1|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|reactome:R-RNO-1912420|reactome:R-RNO-204005|reactome:R-RNO-5694530|reactome:R-RNO-6807878|reactome:R-RNO-6811434|ensembl:ENSRNOG00000001053(gene)|ensembl:ENSRNOT00000001397(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006903"(vesicle targeting) - - - figure legend:1C|curation depth:mimix curation taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell) - 2011/07/11 2014/10/16 rogid:p5LtfOKXRWrwRkAi2MKwhKAE1CQ10116 rogid:AkWi3UzhfnHE9tYW4/BJzXratrk10116 intact-crc:3616C35D70CF00F8|rigid:dRDFUpZAnQsUvWB1da9bQX37LLs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q63645 uniprotkb:Q63524 intact:EBI-4303358|uniprotkb:Q499T9|ensembl:ENSRNOP00000058298 intact:EBI-918600|ensembl:ENSRNOP00000001397 psi-mi:par2_rat(display_long)|uniprotkb:F2rl1(gene name)|psi-mi:F2rl1(display_short)|uniprotkb:Par2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 1(gene name synonym)|uniprotkb:Thrombin receptor-like 1(gene name synonym) psi-mi:tmed2_rat(display_long)|uniprotkb:RNP21.4(gene name synonym)|uniprotkb:Tmed2(gene name)|psi-mi:Tmed2(display_short)|uniprotkb:Rnp24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:COPI-coated vesicle membrane protein p24(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Luo et al. (2007) pubmed:17693410 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-4303630 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:620866|refseq:NP_446349.1|ensembl:ENSRNOG00000018003(gene)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0009306"(protein secretion)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042311"(vasodilation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0043547"(positive regulation of GTPase activity)|ensembl:ENSRNOT00000061580(transcript)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070661"(leukocyte proliferation)|go:"GO:0070963"(positive regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002281(Protease-activated receptor 2)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-375276|reactome:R-RNO-416476 rgd:69243|refseq:NP_113910.1|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|reactome:R-RNO-1912420|reactome:R-RNO-204005|reactome:R-RNO-5694530|reactome:R-RNO-6807878|reactome:R-RNO-6811434|ensembl:ENSRNOG00000001053(gene)|ensembl:ENSRNOT00000001397(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006903"(vesicle targeting) - - - figure legend:1B|curation depth:mimix curation taxid:10116(rat-astrocyte)|taxid:10116(Rattus norvegicus astrocyte) - 2011/07/11 2014/10/16 rogid:p5LtfOKXRWrwRkAi2MKwhKAE1CQ10116 rogid:AkWi3UzhfnHE9tYW4/BJzXratrk10116 intact-crc:38DAC9F0686184CD|rigid:dRDFUpZAnQsUvWB1da9bQX37LLs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q15363 uniprotkb:P55085 intact:EBI-998485|ensembl:ENSP00000262225 intact:EBI-4303189|uniprotkb:Q13317|uniprotkb:Q13346|ensembl:ENSP00000296677|uniprotkb:Q53XJ8 psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym) psi-mi:par2_human(display_long)|uniprotkb:F2RL1(gene name)|psi-mi:F2RL1(display_short)|uniprotkb:GPR11(gene name synonym)|uniprotkb:PAR2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor 11(gene name synonym)|uniprotkb:Thrombin receptor-like 1(gene name synonym) psi-mi:"MI:0096"(pull down) Luo et al. (2007) pubmed:17693410 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-4303394 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1 refseq:NP_005233.3|ensembl:ENSG00000164251(gene)|ensembl:ENST00000296677(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042311"(vasodilation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070661"(leukocyte proliferation)|go:"GO:0070963"(positive regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002281(Protease-activated receptor 2)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P55085|rcsb pdb:5NDD|rcsb pdb:5NDZ|rcsb pdb:5NJ6|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|dip:DIP-42044N - - - figure legend:2E-G|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/11 2014/10/16 rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606 rogid:j9cMnyj9C74tReGYkQvGFy+cez49606 intact-crc:3E2FA4C1BEEB16DB|rigid:/aPmLNbHnQZdetE7giYdPhqnKDw false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q15363 uniprotkb:P55085 intact:EBI-998485|ensembl:ENSP00000262225 intact:EBI-4303189|uniprotkb:Q13317|uniprotkb:Q13346|ensembl:ENSP00000296677|uniprotkb:Q53XJ8 psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym) psi-mi:par2_human(display_long)|uniprotkb:F2RL1(gene name)|psi-mi:F2RL1(display_short)|uniprotkb:GPR11(gene name synonym)|uniprotkb:PAR2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor 11(gene name synonym)|uniprotkb:Thrombin receptor-like 1(gene name synonym) psi-mi:"MI:0096"(pull down) Luo et al. (2007) pubmed:17693410 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-4303390 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1 refseq:NP_005233.3|ensembl:ENSG00000164251(gene)|ensembl:ENST00000296677(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042311"(vasodilation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070661"(leukocyte proliferation)|go:"GO:0070963"(positive regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002281(Protease-activated receptor 2)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P55085|rcsb pdb:5NDD|rcsb pdb:5NDZ|rcsb pdb:5NJ6|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|dip:DIP-42044N - - - figure legend:2A-D|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/07/11 2014/10/16 rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606 rogid:j9cMnyj9C74tReGYkQvGFy+cez49606 intact-crc:21859E874016DCFD|rigid:/aPmLNbHnQZdetE7giYdPhqnKDw false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P55085 uniprotkb:Q15363 intact:EBI-4303189|uniprotkb:Q13317|uniprotkb:Q13346|ensembl:ENSP00000296677|uniprotkb:Q53XJ8 intact:EBI-998485|ensembl:ENSP00000262225 psi-mi:par2_human(display_long)|uniprotkb:F2RL1(gene name)|psi-mi:F2RL1(display_short)|uniprotkb:GPR11(gene name synonym)|uniprotkb:PAR2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor 11(gene name synonym)|uniprotkb:Thrombin receptor-like 1(gene name synonym) psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Luo et al. (2007) pubmed:17693410 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-4303405 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005233.3|ensembl:ENSG00000164251(gene)|ensembl:ENST00000296677(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0031143"(pseudopodium)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042311"(vasodilation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070661"(leukocyte proliferation)|go:"GO:0070963"(positive regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002281(Protease-activated receptor 2)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P55085|rcsb pdb:5NDD|rcsb pdb:5NDZ|rcsb pdb:5NJ6|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|dip:DIP-42044N ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1 go:"GO:0005794"(Golgi apparatus) - - figure legend:3|curation depth:mimix curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2011/07/11 2014/10/16 rogid:j9cMnyj9C74tReGYkQvGFy+cez49606 rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606 intact-crc:718271D93B3249C9|rigid:/aPmLNbHnQZdetE7giYdPhqnKDw false - - - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining)