#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O62090	uniprotkb:Q3LRZ3	intact:EBI-2917690|ensemblmetazoa:C37A5.9.1	intact:EBI-327368|uniprotkb:Q14V27|ensemblmetazoa:K02B12.4b.1	psi-mi:pry1_caeel(display_long)|uniprotkb:pry-1(gene name)|psi-mi:pry-1(display_short)|uniprotkb:Protein polyray(gene name synonym)|uniprotkb:C37A5.9(orf name)	psi-mi:axlp1_caeel(display_long)|uniprotkb:K02B12.4(orf name)|uniprotkb:axl-1(gene name)|psi-mi:axl-1(display_short)	psi-mi:"MI:0018"(two hybrid)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651517|imex:IM-16932-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:C37A5.9.1(transcript)|ensemblmetazoa:WBGene00004202(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016020"(membrane)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0040027"(negative regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|refseq:NP_493474.2|wormbase:C37A5.9|interpro:IPR001158(DIX)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR029071|interpro:IPR038207|interpro:IPR036305|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-4641262|interpro:IPR043581	refseq:NP_001040671.1|refseq:NP_001040672.1|wormbase:K02B12.4a|wormbase:K02B12.4b|interpro:IPR001158(DIX)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR029071|ensemblmetazoa:K02B12.4b.1(transcript)|ensemblmetazoa:WBGene00010497(gene)|go:"GO:0007411"(axon guidance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR038207|interpro:IPR036305|interpro:IPR043581	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/03/09	2014/10/16	rogid:wP7agAsMufX8vM8YKMhlLznEqhs6239	rogid:x9cDaeXpEVlOKmaBrHm0Y5sf0vs6239	intact-crc:273775FB0FC8521D|rigid:1GpFPjkrpCGmsb+chf+PLE9Chw0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9U2Q9	uniprotkb:Q3LRZ3	intact:EBI-330089|uniprotkb:Q9Y0C2|ensemblmetazoa:Y18D10A.5.1	intact:EBI-327368|uniprotkb:Q14V27|ensemblmetazoa:K02B12.4b.1	psi-mi:gsk3_caeel(display_long)|uniprotkb:gsk-3(gene name)|psi-mi:gsk-3(display_short)|uniprotkb:sgg-1(gene name synonym)|uniprotkb:Y18D10A.5(orf name)	psi-mi:axlp1_caeel(display_long)|uniprotkb:K02B12.4(orf name)|uniprotkb:axl-1(gene name)|psi-mi:axl-1(display_short)	psi-mi:"MI:0018"(two hybrid)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651550|imex:IM-16932-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_493243.1|wormbase:Y18D10A.5|mint:Q9U2Q9|dip:DIP-25216N|ensemblmetazoa:WBGene00001746(gene)|ensemblmetazoa:Y18D10A.5.1(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060069"(Wnt signaling pathway, regulating spindle positioning)|go:"GO:0070986"(left/right axis specification)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1903356"(positive regulation of distal tip cell migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-3371453|reactome:R-CEL-399956|reactome:R-CEL-4641262	refseq:NP_001040671.1|refseq:NP_001040672.1|wormbase:K02B12.4a|wormbase:K02B12.4b|interpro:IPR001158(DIX)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR029071|ensemblmetazoa:K02B12.4b.1(transcript)|ensemblmetazoa:WBGene00010497(gene)|go:"GO:0007411"(axon guidance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR038207|interpro:IPR036305|interpro:IPR043581	-	-	-	figure legend:Fig 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/03/09	2014/10/16	rogid:nP6ix+jIij252trr3joE6r80xYo6239	rogid:x9cDaeXpEVlOKmaBrHm0Y5sf0vs6239	intact-crc:2EFD3FF112196C05|rigid:gor0JNrHL7W1IYlQjttrfwBdgYs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O62090	uniprotkb:Q22227	intact:EBI-2917690|ensemblmetazoa:C37A5.9.1	intact:EBI-316403|ensemblmetazoa:T05C12.6a.1|intact:EBI-2315994|intact:EBI-2924320|uniprotkb:G5EC49|uniprotkb:O76471|uniprotkb:Q95ZQ0	psi-mi:pry1_caeel(display_long)|uniprotkb:pry-1(gene name)|psi-mi:pry-1(display_short)|uniprotkb:Protein polyray(gene name synonym)|uniprotkb:C37A5.9(orf name)	psi-mi:mig5_caeel(display_long)|uniprotkb:Abnormal cell migration protein 5(gene name synonym)|uniprotkb:T05C12.6(orf name)|uniprotkb:mig-5(gene name)|psi-mi:mig-5(display_short)	psi-mi:"MI:0018"(two hybrid)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651554|imex:IM-16932-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:C37A5.9.1(transcript)|ensemblmetazoa:WBGene00004202(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016020"(membrane)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0040027"(negative regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|refseq:NP_493474.2|wormbase:C37A5.9|interpro:IPR001158(DIX)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR029071|interpro:IPR038207|interpro:IPR036305|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-4641262|interpro:IPR043581	reactome:R-CEL-5663220|refseq:NP_001022316.1|wormbase:T05C12.6a|ensemblmetazoa:T05C12.6a.1(transcript)|ensemblmetazoa:WBGene00003241(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001764"(neuron migration)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0016477"(cell migration)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030054"(cell junction)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040039"(inductive cell migration)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0060069"(Wnt signaling pathway, regulating spindle positioning)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060573"(cell fate specification involved in pattern specification)|go:"GO:0070986"(left/right axis specification)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|go:"GO:0048730"(epidermis morphogenesis)|refseq:NP_001022317.1|refseq:NP_001022318.1|wormbase:T05C12.6b|wormbase:T05C12.6c|dip:DIP-27038N|reactome:R-CEL-201688|reactome:R-CEL-4086400|reactome:R-CEL-4641258|reactome:R-CEL-5099900|reactome:R-CEL-2028269|reactome:R-CEL-4641262|reactome:R-CEL-8856825|reactome:R-CEL-8856828	-	-	-	figure legend:Fig 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/03/09	2014/10/16	rogid:wP7agAsMufX8vM8YKMhlLznEqhs6239	rogid:Pp8SAvLL8oifjCuQDA+XKc3EON86239	intact-crc:50604D41008AF4B1|rigid:0jk7JI7/nbROscftR5WGM+QaLQE	false	-	sufficient binding region:1-308	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q18825	uniprotkb:O62090	intact:EBI-2528850|ensemblmetazoa:C54D1.6.1	intact:EBI-2917690|ensemblmetazoa:C37A5.9.1	psi-mi:bar1_caeel(display_long)|uniprotkb:bar-1(gene name)|psi-mi:bar-1(display_short)|uniprotkb:pvl-1(gene name synonym)|uniprotkb:spy-1(gene name synonym)|uniprotkb:Protruding vulva protein 1(gene name synonym)|uniprotkb:Suppressor of polyray 1(gene name synonym)|uniprotkb:C54D1.6(orf name)	psi-mi:pry1_caeel(display_long)|uniprotkb:pry-1(gene name)|psi-mi:pry-1(display_short)|uniprotkb:Protein polyray(gene name synonym)|uniprotkb:C37A5.9(orf name)	psi-mi:"MI:0018"(two hybrid)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651533|imex:IM-16932-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_509206.1|wormbase:C54D1.6|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|interpro:IPR013284(Beta-catenin)|ensemblmetazoa:C54D1.6.1(transcript)|ensemblmetazoa:WBGene00000238(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001708"(cell fate specification)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007617"(mating behavior)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0016020"(membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018991"(oviposition)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0040024"(dauer larval development)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0043058"(regulation of backward locomotion)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070986"(left/right axis specification)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903356"(positive regulation of distal tip cell migration)|go:"GO:0040035"(hermaphrodite genitalia development)|reactome:R-CEL-6798695|reactome:R-CEL-5218920|reactome:R-CEL-6809371|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407	ensemblmetazoa:C37A5.9.1(transcript)|ensemblmetazoa:WBGene00004202(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016020"(membrane)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0040027"(negative regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|refseq:NP_493474.2|wormbase:C37A5.9|interpro:IPR001158(DIX)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR029071|interpro:IPR038207|interpro:IPR036305|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-4641262|interpro:IPR043581	-	-	-	figure legend:Fig 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/03/09	2014/10/16	rogid:2cYTDh2x+j/Ln7GTP5KQQ3eZO3A6239	rogid:wP7agAsMufX8vM8YKMhlLznEqhs6239	intact-crc:DBB537659B9ACFF0|rigid:4updoY9q4d++VKNb0ot4tg46AB8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q18825	uniprotkb:Q3LRZ3	intact:EBI-2528850|ensemblmetazoa:C54D1.6.1	intact:EBI-327368|uniprotkb:Q14V27|ensemblmetazoa:K02B12.4b.1	psi-mi:bar1_caeel(display_long)|uniprotkb:bar-1(gene name)|psi-mi:bar-1(display_short)|uniprotkb:pvl-1(gene name synonym)|uniprotkb:spy-1(gene name synonym)|uniprotkb:Protruding vulva protein 1(gene name synonym)|uniprotkb:Suppressor of polyray 1(gene name synonym)|uniprotkb:C54D1.6(orf name)	psi-mi:axlp1_caeel(display_long)|uniprotkb:K02B12.4(orf name)|uniprotkb:axl-1(gene name)|psi-mi:axl-1(display_short)	psi-mi:"MI:0018"(two hybrid)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651528|imex:IM-16932-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_509206.1|wormbase:C54D1.6|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|interpro:IPR013284(Beta-catenin)|ensemblmetazoa:C54D1.6.1(transcript)|ensemblmetazoa:WBGene00000238(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001708"(cell fate specification)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007617"(mating behavior)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0016020"(membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018991"(oviposition)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0040024"(dauer larval development)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0043058"(regulation of backward locomotion)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070986"(left/right axis specification)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903356"(positive regulation of distal tip cell migration)|go:"GO:0040035"(hermaphrodite genitalia development)|reactome:R-CEL-6798695|reactome:R-CEL-5218920|reactome:R-CEL-6809371|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407	refseq:NP_001040671.1|refseq:NP_001040672.1|wormbase:K02B12.4a|wormbase:K02B12.4b|interpro:IPR001158(DIX)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR029071|ensemblmetazoa:K02B12.4b.1(transcript)|ensemblmetazoa:WBGene00010497(gene)|go:"GO:0007411"(axon guidance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR038207|interpro:IPR036305|interpro:IPR043581	-	-	-	figure legend:Fig 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/03/09	2014/10/16	rogid:2cYTDh2x+j/Ln7GTP5KQQ3eZO3A6239	rogid:x9cDaeXpEVlOKmaBrHm0Y5sf0vs6239	intact-crc:D6E74523753B921F|rigid:pPBLHTi+g0y72yvbPpZEhgWXrRw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O62090	uniprotkb:Q9U2Q9	intact:EBI-2917690|ensemblmetazoa:C37A5.9.1	intact:EBI-330089|uniprotkb:Q9Y0C2|ensemblmetazoa:Y18D10A.5.1	psi-mi:pry1_caeel(display_long)|uniprotkb:pry-1(gene name)|psi-mi:pry-1(display_short)|uniprotkb:Protein polyray(gene name synonym)|uniprotkb:C37A5.9(orf name)	psi-mi:gsk3_caeel(display_long)|uniprotkb:gsk-3(gene name)|psi-mi:gsk-3(display_short)|uniprotkb:sgg-1(gene name synonym)|uniprotkb:Y18D10A.5(orf name)	psi-mi:"MI:0018"(two hybrid)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651545|imex:IM-16932-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:C37A5.9.1(transcript)|ensemblmetazoa:WBGene00004202(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016020"(membrane)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0040027"(negative regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|refseq:NP_493474.2|wormbase:C37A5.9|interpro:IPR001158(DIX)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR029071|interpro:IPR038207|interpro:IPR036305|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-4641262|interpro:IPR043581	refseq:NP_493243.1|wormbase:Y18D10A.5|mint:Q9U2Q9|dip:DIP-25216N|ensemblmetazoa:WBGene00001746(gene)|ensemblmetazoa:Y18D10A.5.1(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060069"(Wnt signaling pathway, regulating spindle positioning)|go:"GO:0070986"(left/right axis specification)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1903356"(positive regulation of distal tip cell migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-3371453|reactome:R-CEL-399956|reactome:R-CEL-4641262	-	-	-	figure legend:Fig 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/03/09	2014/10/16	rogid:wP7agAsMufX8vM8YKMhlLznEqhs6239	rogid:nP6ix+jIij252trr3joE6r80xYo6239	intact-crc:FB0D003F69A1BD02|rigid:xF4vg3AX9tFnxxBkcWZS7vW4/UI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3LRZ3	uniprotkb:Q22227	intact:EBI-327368|uniprotkb:Q14V27|ensemblmetazoa:K02B12.4b.1	intact:EBI-316403|ensemblmetazoa:T05C12.6a.1|intact:EBI-2315994|intact:EBI-2924320|uniprotkb:G5EC49|uniprotkb:O76471|uniprotkb:Q95ZQ0	psi-mi:axlp1_caeel(display_long)|uniprotkb:K02B12.4(orf name)|uniprotkb:axl-1(gene name)|psi-mi:axl-1(display_short)	psi-mi:mig5_caeel(display_long)|uniprotkb:Abnormal cell migration protein 5(gene name synonym)|uniprotkb:T05C12.6(orf name)|uniprotkb:mig-5(gene name)|psi-mi:mig-5(display_short)	psi-mi:"MI:0018"(two hybrid)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651561|imex:IM-16932-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001040671.1|refseq:NP_001040672.1|wormbase:K02B12.4a|wormbase:K02B12.4b|interpro:IPR001158(DIX)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR029071|ensemblmetazoa:K02B12.4b.1(transcript)|ensemblmetazoa:WBGene00010497(gene)|go:"GO:0007411"(axon guidance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR038207|interpro:IPR036305|interpro:IPR043581	reactome:R-CEL-5663220|refseq:NP_001022316.1|wormbase:T05C12.6a|ensemblmetazoa:T05C12.6a.1(transcript)|ensemblmetazoa:WBGene00003241(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001764"(neuron migration)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0016477"(cell migration)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030054"(cell junction)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040039"(inductive cell migration)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0060069"(Wnt signaling pathway, regulating spindle positioning)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060573"(cell fate specification involved in pattern specification)|go:"GO:0070986"(left/right axis specification)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|go:"GO:0048730"(epidermis morphogenesis)|refseq:NP_001022317.1|refseq:NP_001022318.1|wormbase:T05C12.6b|wormbase:T05C12.6c|dip:DIP-27038N|reactome:R-CEL-201688|reactome:R-CEL-4086400|reactome:R-CEL-4641258|reactome:R-CEL-5099900|reactome:R-CEL-2028269|reactome:R-CEL-4641262|reactome:R-CEL-8856825|reactome:R-CEL-8856828	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/03/09	2014/10/16	rogid:x9cDaeXpEVlOKmaBrHm0Y5sf0vs6239	rogid:Pp8SAvLL8oifjCuQDA+XKc3EON86239	intact-crc:2CF97DD94D395888|rigid:1kLuZKwvIANm6T8v+seJ7DoKNUo	false	-	sufficient binding region:1-308	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3LRZ3	uniprotkb:Q18239	intact:EBI-327368|uniprotkb:Q14V27|ensemblmetazoa:K02B12.4b.1	intact:EBI-314248|ensemblmetazoa:C27A2.6.1	psi-mi:axlp1_caeel(display_long)|uniprotkb:K02B12.4(orf name)|uniprotkb:axl-1(gene name)|psi-mi:axl-1(display_short)	psi-mi:q18239_caeel(display_long)|uniprotkb:dsh-2(gene name)|psi-mi:dsh-2(display_short)|uniprotkb:CELE_C27A2.6(orf name)|uniprotkb:C27A2.6(orf name)	psi-mi:"MI:0018"(two hybrid)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651564|imex:IM-16932-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001040671.1|refseq:NP_001040672.1|wormbase:K02B12.4a|wormbase:K02B12.4b|interpro:IPR001158(DIX)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR029071|ensemblmetazoa:K02B12.4b.1(transcript)|ensemblmetazoa:WBGene00010497(gene)|go:"GO:0007411"(axon guidance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR038207|interpro:IPR036305|interpro:IPR043581	wormbase:C27A2.6|reactome:R-CEL-201688|reactome:R-CEL-4086400|reactome:R-CEL-4641258|ensemblmetazoa:C27A2.6.1(transcript)|ensemblmetazoa:WBGene00001102(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0008104"(protein localization)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0060069"(Wnt signaling pathway, regulating spindle positioning)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070986"(left/right axis specification)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR026542|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|reactome:R-CEL-5663220|refseq:NP_494937.4|dip:DIP-24740N|reactome:R-CEL-5099900|reactome:R-CEL-2028269|reactome:R-CEL-4641262|reactome:R-CEL-8856825|reactome:R-CEL-8856828	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/03/09	2015/12/04	rogid:x9cDaeXpEVlOKmaBrHm0Y5sf0vs6239	rogid:yDb25aMPWu/bsUAWs6+ZIhpWpOU6239	intact-crc:7BF690F6C09195B7|rigid:kgT1uWUYoBEQXwi/iNtXf2YXQdc	false	-	sufficient binding region:1-451	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O62090	uniprotkb:Q21227	intact:EBI-2917690|ensemblmetazoa:C37A5.9.1	intact:EBI-2413521|uniprotkb:O62302|ensemblmetazoa:K04G2.8b.1	psi-mi:pry1_caeel(display_long)|uniprotkb:pry-1(gene name)|psi-mi:pry-1(display_short)|uniprotkb:Protein polyray(gene name synonym)|uniprotkb:C37A5.9(orf name)	psi-mi:apr1_caeel(display_long)|uniprotkb:apr-1(gene name)|psi-mi:apr-1(display_short)|uniprotkb:K04G2.8(orf name)	psi-mi:"MI:0018"(two hybrid)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651593|imex:IM-16932-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:C37A5.9.1(transcript)|ensemblmetazoa:WBGene00004202(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016020"(membrane)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0040027"(negative regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|refseq:NP_493474.2|wormbase:C37A5.9|interpro:IPR001158(DIX)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR029071|interpro:IPR038207|interpro:IPR036305|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-4641262|interpro:IPR043581	refseq:NP_001021547.1|refseq:NP_492217.2|wormbase:K04G2.8a|wormbase:K04G2.8b|reactome:R-CEL-195253|reactome:R-CEL-3769402|dip:DIP-41257N|reactome:R-CEL-196299|reactome:R-CEL-111465|ensemblmetazoa:K04G2.8b.1(transcript)|ensemblmetazoa:WBGene00000156(gene)|go:"GO:0000003"(reproduction)|go:"GO:0001708"(cell fate specification)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0002119"(nematode larval development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0015031"(protein transport)|go:"GO:0016342"(catenin complex)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0040025"(vulval development)|go:"GO:0040027"(negative regulation of vulval development)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/03/09	2014/10/16	rogid:wP7agAsMufX8vM8YKMhlLznEqhs6239	rogid:3MPRfH/P3BFnIp1q673XvP3KSM06239	intact-crc:3274E9285CC5BD4F|rigid:ZkNMFxXInIb4qu+riAsD/uWbUqE	false	-	sufficient binding region:598-1186	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O44326	uniprotkb:Q967F4	intact:EBI-317320|ensemblmetazoa:K05C4.6a.1|ensemblmetazoa:K05C4.6a.2	intact:EBI-2528888|uniprotkb:O44327|ensemblmetazoa:W02B9.1b.1|ensemblmetazoa:W02B9.1b.2|uniprotkb:B2MZC5|uniprotkb:H2FLJ9|uniprotkb:H2FLK0	psi-mi:hmp2_caeel(display_long)|uniprotkb:hmp-2(gene name)|psi-mi:hmp-2(display_short)|uniprotkb:Protein humpback-2(gene name synonym)|uniprotkb:K05C4.6(orf name)	psi-mi:hmr1_caeel(display_long)|uniprotkb:hmr-1(gene name)|psi-mi:hmr-1(display_short)|uniprotkb:Protein Hammerhead(gene name synonym)|uniprotkb:W02B9.1(orf name)	psi-mi:"MI:0018"(two hybrid)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651598|imex:IM-16932-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	wormbase:K05C4.6a|reactome:R-CEL-8853884|refseq:NP_001252426.1|rcsb pdb:4R0Z|rcsb pdb:4R10|rcsb pdb:4R11|rcsb pdb:5XA5|interpro:IPR016024(Armadillo-type fold)|ensemblmetazoa:K05C4.6a.1(transcript)|ensemblmetazoa:K05C4.6a.2(transcript)|ensemblmetazoa:WBGene00001979(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070986"(left/right axis specification)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|reactome:R-CEL-6798695|reactome:R-CEL-351906|reactome:R-CEL-525793|reactome:R-CEL-8980692|reactome:R-CEL-9013406|reactome:R-CEL-9013407|dip:DIP-27261N|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-201681|reactome:R-CEL-201722|reactome:R-CEL-3134973|reactome:R-CEL-3769402|reactome:R-CEL-4086398|reactome:R-CEL-5218920|reactome:R-CEL-6809371|reactome:R-CEL-8951430	ensemblmetazoa:W02B9.1b.1(transcript)|ensemblmetazoa:W02B9.1b.2(transcript)|ensemblmetazoa:WBGene00001980(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0003384"(apical constriction involved in gastrulation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007369"(gastrulation)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR001791(Laminin G)|interpro:IPR002126(Cadherin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015919(Cadherin-like)|interpro:IPR018247|interpro:IPR020894|rcsb pdb:4R10|rcsb pdb:4R11|interpro:IPR000742(EGF-like, type 3)|refseq:NP_001021650.1|wormbase:W02B9.1a|wormbase:W02B9.1b|wormbase:W02B9.1d|wormbase:W02B9.1c|wormbase:W02B9.1e|refseq:NP_001021649.2|refseq:NP_001129794.1|refseq:NP_001251561.1|refseq:NP_001251562.1|dip:DIP-56285N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/03/09	2014/10/16	rogid:8DLyhATsxCZq1Vthd5haUE54Kmw6239	rogid:ogbuiUw6rS5+SMw515Bday0fg246239	intact-crc:2B642406A39E6ABE|rigid:ev3Gecv0RWZ87bpfqg6J4pGOq6w	false	sufficient binding region:1-547	sufficient binding region:1124-1223	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49841	uniprotkb:O15169	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-710484|uniprotkb:Q4TT26|uniprotkb:Q4TT27|ensembl:ENSP00000262320|uniprotkb:Q86YA7|uniprotkb:Q8WVW6|uniprotkb:Q96S28	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:axin1_human(display_long)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:AXIN1(gene name)|psi-mi:AXIN1(display_short)|uniprotkb:AXIN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651836|imex:IM-16932-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	refseq:NP_003493.1|refseq:NP_851393.1|ensembl:ENSG00000103126(gene)|ensembl:ENST00000262320(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034622"|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:O15169|rcsb pdb:1DK8|rcsb pdb:1EMU|rcsb pdb:1O9U|rcsb pdb:3ZDI|rcsb pdb:4B7T|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4NU1|rcsb pdb:5WZZ|rcsb pdb:6JCK|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689880|reactome:R-HSA-8931987|reactome:R-HSA-8939256|reactome:R-HSA-9018519|dip:DIP-34630N	-	-	-	figure legend:Fig 3B|antagonist:"FRATtide:a peptide corresponding to residues 188 - 226 of human FRAT1."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/09	2014/10/16	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:uO+LxY/7ibIZqdd5onbfXqGAZeo9606	intact-crc:95D9F6CC2EFBD9E9|rigid:m32pJ7YUONUDrgnUZe2m7Lj8KJ4	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:501-560	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P49841	uniprotkb:O62090	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-2917690|ensemblmetazoa:C37A5.9.1	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:pry1_caeel(display_long)|uniprotkb:pry-1(gene name)|psi-mi:pry-1(display_short)|uniprotkb:Protein polyray(gene name synonym)|uniprotkb:C37A5.9(orf name)	psi-mi:"MI:0096"(pull down)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651820|imex:IM-16932-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	ensemblmetazoa:C37A5.9.1(transcript)|ensemblmetazoa:WBGene00004202(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016020"(membrane)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0040027"(negative regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|refseq:NP_493474.2|wormbase:C37A5.9|interpro:IPR001158(DIX)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR029071|interpro:IPR038207|interpro:IPR036305|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-4641262|interpro:IPR043581	-	-	-	figure legend:Fig 3B|antagonist:"FRATtide:a peptide corresponding to residues 188 - 226 of human FRAT1."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/09	2014/10/16	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:wP7agAsMufX8vM8YKMhlLznEqhs6239	intact-crc:1B570233F442EC32|rigid:pmydv9qvTN0F2GdLZCb7l8rrSaQ	false	35s radiolabel:?-?	sufficient binding region:200-399|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q3LRZ3	uniprotkb:Q9U2Q9	intact:EBI-327368|uniprotkb:Q14V27|ensemblmetazoa:K02B12.4b.1	intact:EBI-330089|uniprotkb:Q9Y0C2|ensemblmetazoa:Y18D10A.5.1	psi-mi:axlp1_caeel(display_long)|uniprotkb:K02B12.4(orf name)|uniprotkb:axl-1(gene name)|psi-mi:axl-1(display_short)	psi-mi:gsk3_caeel(display_long)|uniprotkb:gsk-3(gene name)|psi-mi:gsk-3(display_short)|uniprotkb:sgg-1(gene name synonym)|uniprotkb:Y18D10A.5(orf name)	psi-mi:"MI:0096"(pull down)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651648|imex:IM-16932-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001040671.1|refseq:NP_001040672.1|wormbase:K02B12.4a|wormbase:K02B12.4b|interpro:IPR001158(DIX)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR029071|ensemblmetazoa:K02B12.4b.1(transcript)|ensemblmetazoa:WBGene00010497(gene)|go:"GO:0007411"(axon guidance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR038207|interpro:IPR036305|interpro:IPR043581	refseq:NP_493243.1|wormbase:Y18D10A.5|mint:Q9U2Q9|dip:DIP-25216N|ensemblmetazoa:WBGene00001746(gene)|ensemblmetazoa:Y18D10A.5.1(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060069"(Wnt signaling pathway, regulating spindle positioning)|go:"GO:0070986"(left/right axis specification)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1903356"(positive regulation of distal tip cell migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-3371453|reactome:R-CEL-399956|reactome:R-CEL-4641262	-	-	-	figure legend:Fig 3A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/09	2014/10/16	rogid:x9cDaeXpEVlOKmaBrHm0Y5sf0vs6239	rogid:nP6ix+jIij252trr3joE6r80xYo6239	intact-crc:B5C5FEA3C951E465|rigid:gor0JNrHL7W1IYlQjttrfwBdgYs	false	sufficient binding region:104-259|glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O15169	uniprotkb:Q9U2Q9	intact:EBI-710484|uniprotkb:Q4TT26|uniprotkb:Q4TT27|ensembl:ENSP00000262320|uniprotkb:Q86YA7|uniprotkb:Q8WVW6|uniprotkb:Q96S28	intact:EBI-330089|uniprotkb:Q9Y0C2|ensemblmetazoa:Y18D10A.5.1	psi-mi:axin1_human(display_long)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:AXIN1(gene name)|psi-mi:AXIN1(display_short)|uniprotkb:AXIN(gene name synonym)	psi-mi:gsk3_caeel(display_long)|uniprotkb:gsk-3(gene name)|psi-mi:gsk-3(display_short)|uniprotkb:sgg-1(gene name synonym)|uniprotkb:Y18D10A.5(orf name)	psi-mi:"MI:0096"(pull down)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651644|imex:IM-16932-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003493.1|refseq:NP_851393.1|ensembl:ENSG00000103126(gene)|ensembl:ENST00000262320(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034622"|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:O15169|rcsb pdb:1DK8|rcsb pdb:1EMU|rcsb pdb:1O9U|rcsb pdb:3ZDI|rcsb pdb:4B7T|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4NU1|rcsb pdb:5WZZ|rcsb pdb:6JCK|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689880|reactome:R-HSA-8931987|reactome:R-HSA-8939256|reactome:R-HSA-9018519|dip:DIP-34630N	refseq:NP_493243.1|wormbase:Y18D10A.5|mint:Q9U2Q9|dip:DIP-25216N|ensemblmetazoa:WBGene00001746(gene)|ensemblmetazoa:Y18D10A.5.1(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060069"(Wnt signaling pathway, regulating spindle positioning)|go:"GO:0070986"(left/right axis specification)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1903356"(positive regulation of distal tip cell migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-3371453|reactome:R-CEL-399956|reactome:R-CEL-4641262	-	-	-	figure legend:Fig 3A|caution:"The mutation of human Axin   is stated to be L521P, but no leucine is currently  present at residue 521, nor  in the previous version of the sequence.  The mutation is most likely to be at L392P within the GSK3B binding region, as also  found in the mouse axin protein, O35625.     (Bax et al,.  Structure, Vol 9,  2001. p1143-1152 )"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/09	2014/10/16	rogid:uO+LxY/7ibIZqdd5onbfXqGAZeo9606	rogid:nP6ix+jIij252trr3joE6r80xYo6239	intact-crc:005F1B6FBC2371B7|rigid:D/IVhzpBBxP6uJ3XBhW9M6D1o4c	false	glutathione s tranferase tag:?-?|mutation decreasing interaction:521-521|sufficient binding region:501-560	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9U2Q9	uniprotkb:O62090	intact:EBI-330089|uniprotkb:Q9Y0C2|ensemblmetazoa:Y18D10A.5.1	intact:EBI-2917690|ensemblmetazoa:C37A5.9.1	psi-mi:gsk3_caeel(display_long)|uniprotkb:gsk-3(gene name)|psi-mi:gsk-3(display_short)|uniprotkb:sgg-1(gene name synonym)|uniprotkb:Y18D10A.5(orf name)	psi-mi:pry1_caeel(display_long)|uniprotkb:pry-1(gene name)|psi-mi:pry-1(display_short)|uniprotkb:Protein polyray(gene name synonym)|uniprotkb:C37A5.9(orf name)	psi-mi:"MI:0096"(pull down)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651652|imex:IM-16932-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_493243.1|wormbase:Y18D10A.5|mint:Q9U2Q9|dip:DIP-25216N|ensemblmetazoa:WBGene00001746(gene)|ensemblmetazoa:Y18D10A.5.1(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0060069"(Wnt signaling pathway, regulating spindle positioning)|go:"GO:0070986"(left/right axis specification)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1903356"(positive regulation of distal tip cell migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039192|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-3371453|reactome:R-CEL-399956|reactome:R-CEL-4641262	ensemblmetazoa:C37A5.9.1(transcript)|ensemblmetazoa:WBGene00004202(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016020"(membrane)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0040027"(negative regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|refseq:NP_493474.2|wormbase:C37A5.9|interpro:IPR001158(DIX)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR029071|interpro:IPR038207|interpro:IPR036305|reactome:R-CEL-195253|reactome:R-CEL-196299|reactome:R-CEL-4641262|interpro:IPR043581	-	-	-	figure legend:Fig 3A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/09	2014/10/16	rogid:nP6ix+jIij252trr3joE6r80xYo6239	rogid:wP7agAsMufX8vM8YKMhlLznEqhs6239	intact-crc:5BA044C9DC97FF1D|rigid:xF4vg3AX9tFnxxBkcWZS7vW4/UI	false	35s radiolabel:?-?	sufficient binding region:200-399|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q3LRZ3	uniprotkb:P49841	intact:EBI-327368|uniprotkb:Q14V27|ensemblmetazoa:K02B12.4b.1	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:axlp1_caeel(display_long)|uniprotkb:K02B12.4(orf name)|uniprotkb:axl-1(gene name)|psi-mi:axl-1(display_short)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Oosterveen et al. (2007)	pubmed:17601533|imex:IM-16932	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3651806|imex:IM-16932-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001040671.1|refseq:NP_001040672.1|wormbase:K02B12.4a|wormbase:K02B12.4b|interpro:IPR001158(DIX)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR029071|ensemblmetazoa:K02B12.4b.1(transcript)|ensemblmetazoa:WBGene00010497(gene)|go:"GO:0007411"(axon guidance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR038207|interpro:IPR036305|interpro:IPR043581	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	-	-	-	figure legend:Fig 3B|antagonist:"FRATtide:a peptide corresponding to residues 188 - 226 of human FRAT1."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/09	2014/10/16	rogid:x9cDaeXpEVlOKmaBrHm0Y5sf0vs6239	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	intact-crc:742AE6ED4446A826|rigid:NjEESkn4IvsirEpcJfNgcJVJVKQ	false	sufficient binding region:140-259|glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)