#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P67775 uniprotkb:O75663 intact:EBI-712311|ensembl:ENSP00000418447|uniprotkb:P05323|uniprotkb:P13197 intact:EBI-1054735|uniprotkb:Q5HYB2|uniprotkb:Q8IZ86|uniprotkb:B2R8V3|ensembl:ENSP00000356807 psi-mi:pp2aa_human(display_long)|uniprotkb:PPP2CA(gene name)|psi-mi:PPP2CA(display_short)|uniprotkb:Replication protein C(gene name synonym) psi-mi:tiprl_human(display_long)|uniprotkb:Putative MAPK-activating protein PM10(gene name synonym)|uniprotkb:TIPRL(gene name)|psi-mi:TIPRL(display_short)|uniprotkb:Type 2A-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) McConnell et al. (2007) doi:10.1038/sj.onc.1210406|pubmed:17384681|mint:MINT-8204133 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7357489|mint:MINT-8204762 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113575(gene)|ensembl:ENST00000481195(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904526"(regulation of microtubule binding)|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P67775|rcsb pdb:2IAE|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3FGA|rcsb pdb:3K7W|rcsb pdb:3P71|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4IYP|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2995383|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|rcsb pdb:3K7V|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_002706.1|dip:DIP-29395N|mint:MINT-8204764(identity) refseq:NP_001026970.1|refseq:NP_690866.1|ensembl:ENSG00000143155(gene)|ensembl:ENST00000367833(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005829"(cytosol)|go:"GO:0031929"(TOR signaling)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR007303(TIP41-like protein)|mint:O75663|rcsb pdb:5D9G|mint:MINT-8204765(identity) - - - comment:mint|figure legend:f1b f3|partial coverage:partial coverage taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/09/13 2014/10/16 rogid:Zynydo3YUFioN2iUl6oR0nVJ4YY9606 rogid:Z+oUe9UFwPgBwdol1xGBq1k3b049606 intact-crc:94600D0840B17812|rigid:t4QCYvPsdEXTDWRZbBrSSD4xusk false - binding-associated region:173-272(MINT-8204773) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75663 uniprotkb:P60510 intact:EBI-1054735|uniprotkb:Q5HYB2|uniprotkb:Q8IZ86|uniprotkb:B2R8V3|ensembl:ENSP00000356807 intact:EBI-1046072|uniprotkb:P33172|ensembl:ENSP00000279387|ensembl:ENSP00000455995 psi-mi:tiprl_human(display_long)|uniprotkb:Putative MAPK-activating protein PM10(gene name synonym)|uniprotkb:TIPRL(gene name)|psi-mi:TIPRL(display_short)|uniprotkb:Type 2A-interacting protein(gene name synonym) psi-mi:pp4c_human(display_long)|uniprotkb:Protein phosphatase X(gene name synonym)|uniprotkb:PPP4C(gene name)|psi-mi:PPP4C(display_short)|uniprotkb:PPP4(gene name synonym)|uniprotkb:PPX(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) McConnell et al. (2007) doi:10.1038/sj.onc.1210406|pubmed:17384681|mint:MINT-8204133 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7357502|mint:MINT-8204776 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001026970.1|refseq:NP_690866.1|ensembl:ENSG00000143155(gene)|ensembl:ENST00000367833(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005829"(cytosol)|go:"GO:0031929"(TOR signaling)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR007303(TIP41-like protein)|mint:O75663|rcsb pdb:5D9G|mint:MINT-8204780(identity) refseq:NP_002711.1|refseq:NP_001290432.1|refseq:NP_001290433.1|refseq:NP_001290435.1|refseq:NP_001290436.1|ensembl:ENSG00000149923(gene)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P60510|reactome:R-HSA-5693607|ensembl:ENST00000279387(transcript)|ensembl:ENST00000561610(transcript)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0030289"(protein phosphatase 4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|mint:MINT-8204778(identity) - - - figure legend:f3|comment:mint|partial coverage:partial coverage taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/09/13 2014/10/16 rogid:Z+oUe9UFwPgBwdol1xGBq1k3b049606 rogid:1x3NwIpQ/T3bO/yHgAZUDqNV4989606 intact-crc:E9D83A26399994ED|rigid:Ie3FLHxbdjrbDPj2kyynZF32hqc false binding-associated region:173-272(MINT-8204781) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O00743 uniprotkb:O75663 intact:EBI-359751|uniprotkb:Q5U0A2|uniprotkb:Q9UIC9|uniprotkb:B2R5V6|uniprotkb:B7Z5K9|uniprotkb:B7Z2W9|ensembl:ENSP00000362648 intact:EBI-1054735|uniprotkb:Q5HYB2|uniprotkb:Q8IZ86|uniprotkb:B2R8V3|ensembl:ENSP00000356807 psi-mi:ppp6_human(display_long)|uniprotkb:PPP6C(gene name)|psi-mi:PPP6C(display_short)|uniprotkb:PPP6(gene name synonym) psi-mi:tiprl_human(display_long)|uniprotkb:Putative MAPK-activating protein PM10(gene name synonym)|uniprotkb:TIPRL(gene name)|psi-mi:TIPRL(display_short)|uniprotkb:Type 2A-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) McConnell et al. (2007) doi:10.1038/sj.onc.1210406|pubmed:17384681|mint:MINT-8204133 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7357530|mint:MINT-8204786 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001116827.1|refseq:NP_001116841.1|refseq:NP_002712.1|dip:DIP-27581N|ensembl:ENSG00000119414(gene)|ensembl:ENST00000373547(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:O00743|reactome:R-HSA-171319|reactome:R-HSA-204005|mint:MINT-8204792(identity) refseq:NP_001026970.1|refseq:NP_690866.1|ensembl:ENSG00000143155(gene)|ensembl:ENST00000367833(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005829"(cytosol)|go:"GO:0031929"(TOR signaling)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR007303(TIP41-like protein)|mint:O75663|rcsb pdb:5D9G|mint:MINT-8204788(identity) - - - figure legend:f3|comment:mint|partial coverage:partial coverage taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/09/13 2014/10/16 rogid:IdVJPgcG3d38BpLEPVGIaKqBRVI9606 rogid:Z+oUe9UFwPgBwdol1xGBq1k3b049606 intact-crc:60E12C6EBD32B0E9|rigid:R/27WRprtu/MuSfypNLi7YVSrwQ false - binding-associated region:173-272(MINT-8204789) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)