#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51817	uniprotkb:Q92917	intact:EBI-4302903|ensembl:ENSP00000262848	intact:EBI-746309|uniprotkb:Q59EK5|uniprotkb:Q9BQA8|intact:EBI-2561229|ensembl:ENSP00000156109	psi-mi:prkx_human(display_long)|uniprotkb:PRKX(gene name)|psi-mi:PRKX(display_short)|uniprotkb:PKX1(gene name synonym)|uniprotkb:Protein kinase PKX1(gene name synonym)	psi-mi:gpkow_human(display_long)|uniprotkb:Protein MOS2 homolog(gene name synonym)|uniprotkb:Protein T54(gene name synonym)|uniprotkb:GPKOW(gene name)|psi-mi:GPKOW(display_short)|uniprotkb:GPATC5(gene name synonym)|uniprotkb:GPATCH5(gene name synonym)|uniprotkb:T54(gene name synonym)|uniprotkb:G-patch domain-containing protein 5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Glesne et al. (2006)	pubmed:16491121|imex:IM-15797	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4302930|imex:IM-15797-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005035.1|ensembl:ENSG00000183943(gene)|ensembl:ENST00000262848(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060562"(epithelial tube morphogenesis)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000696"(regulation of epithelial cell differentiation involved in kidney development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-111931|reactome:R-HSA-442720|reactome:R-HSA-9660821|reactome:R-HSA-9664323	refseq:NP_056513.2|ensembl:ENSG00000068394(gene)|ensembl:ENST00000156109(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR000467(D111/G-patch)|interpro:IPR005824(KOW)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR026822|interpro:IPR041993|interpro:IPR041994|rcsb pdb:7DVQ|reactome:R-HSA-72163	psi-mi:"MI:0469"(intact)	-	-	figure legend:1st paragraph|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/07/08	2014/10/16	rogid:Sqf2/0cIwxzcO8Ynd+QZO5U5c5c9606	rogid:On+kGkO3EMoQBPFKeobmjPtZBxQ9606	intact-crc:426B87D925D16231|rigid:lK95Xj2gHsLTZuFkt3l1s6TU1dg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43541	uniprotkb:P51817	intact:EBI-976374|uniprotkb:O43654|uniprotkb:Q15799|uniprotkb:Q96E31|ensembl:ENSP00000288840|uniprotkb:Q9UKZ3|uniprotkb:A9J6M5|uniprotkb:Q7Z7L4	intact:EBI-4302903|ensembl:ENSP00000262848	psi-mi:smad6_human(display_long)|uniprotkb:SMAD family member 6(gene name synonym)|uniprotkb:SMAD6(gene name)|psi-mi:SMAD6(display_short)|uniprotkb:MADH6(gene name synonym)	psi-mi:prkx_human(display_long)|uniprotkb:PRKX(gene name)|psi-mi:PRKX(display_short)|uniprotkb:PKX1(gene name synonym)|uniprotkb:Protein kinase PKX1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Glesne et al. (2006)	pubmed:16491121|imex:IM-15797	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4302922|imex:IM-15797-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137834(gene)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035904"(aorta development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|reactome:R-HSA-201451|reactome:R-HSA-8941326|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|ensembl:ENST00000288840(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001657"(ureteric bud development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|ensembl:ENSP00000288840|ensembl:ENST00000557916|ensembl:ENSP00000452955|refseq:NP_005576.3|refseq:XP_011519863.1|dip:DIP-36708N	refseq:NP_005035.1|ensembl:ENSG00000183943(gene)|ensembl:ENST00000262848(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060562"(epithelial tube morphogenesis)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000696"(regulation of epithelial cell differentiation involved in kidney development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-111931|reactome:R-HSA-442720|reactome:R-HSA-9660821|reactome:R-HSA-9664323	psi-mi:"MI:0469"(intact)	-	-	figure legend:1st paragraph|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/07/08	2014/10/16	rogid:WXg8q9L+37KmYFAmxkfxqqXmcHE9606	rogid:Sqf2/0cIwxzcO8Ynd+QZO5U5c5c9606	intact-crc:AF5F47F390594C80|rigid:2u3cStThqZ+qgP8mTKVmNsFdIIg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P10644	uniprotkb:P51817	intact:EBI-476431|uniprotkb:Q567S7|uniprotkb:K7ER48|ensembl:ENSP00000351410|ensembl:ENSP00000376475|ensembl:ENSP00000445625|ensembl:ENSP00000464977|ensembl:ENSP00000466459	intact:EBI-4302903|ensembl:ENSP00000262848	psi-mi:kap0_human(display_long)|uniprotkb:Tissue-specific extinguisher 1(gene name synonym)|uniprotkb:PRKAR1A(gene name)|psi-mi:PRKAR1A(display_short)|uniprotkb:PKR1(gene name synonym)|uniprotkb:PRKAR1(gene name synonym)|uniprotkb:TSE1(gene name synonym)	psi-mi:prkx_human(display_long)|uniprotkb:PRKX(gene name)|psi-mi:PRKX(display_short)|uniprotkb:PKX1(gene name synonym)|uniprotkb:Protein kinase PKX1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Glesne et al. (2006)	pubmed:16491121|imex:IM-15797	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4302926|imex:IM-15797-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002725.1|refseq:NP_997636.1|refseq:NP_997637.1|refseq:XP_011523285.1|refseq:XP_011523286.1|refseq:XP_011523287.1|refseq:NP_001263218.1|refseq:NP_001263219.1|refseq:NP_001265362.1|dip:DIP-34368N|ensembl:ENSG00000108946(gene)|ensembl:ENST00000358598(transcript)|ensembl:ENST00000392711(transcript)|ensembl:ENST00000536854(transcript)|ensembl:ENST00000586397(transcript)|ensembl:ENST00000589228(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0097546"(ciliary base)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|rcsb pdb:5KJZ|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|interpro:IPR018490|mint:P10644|rcsb pdb:5KJX|rcsb pdb:5KJY	refseq:NP_005035.1|ensembl:ENSG00000183943(gene)|ensembl:ENST00000262848(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060562"(epithelial tube morphogenesis)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000696"(regulation of epithelial cell differentiation involved in kidney development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-111931|reactome:R-HSA-442720|reactome:R-HSA-9660821|reactome:R-HSA-9664323	psi-mi:"MI:0469"(intact)	-	-	figure legend:1st paragraph|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/07/08	2014/10/16	rogid:dUZaCJQnC0KZEG4pccIqoT066VY9606	rogid:Sqf2/0cIwxzcO8Ynd+QZO5U5c5c9606	intact-crc:B31D403E8CC03F09|rigid:Gdd3j6jKNgW5vP84/cK5/87UKjw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51817	uniprotkb:Q92917	intact:EBI-4302903|ensembl:ENSP00000262848	intact:EBI-746309|uniprotkb:Q59EK5|uniprotkb:Q9BQA8|intact:EBI-2561229|ensembl:ENSP00000156109	psi-mi:prkx_human(display_long)|uniprotkb:PRKX(gene name)|psi-mi:PRKX(display_short)|uniprotkb:PKX1(gene name synonym)|uniprotkb:Protein kinase PKX1(gene name synonym)	psi-mi:gpkow_human(display_long)|uniprotkb:Protein MOS2 homolog(gene name synonym)|uniprotkb:Protein T54(gene name synonym)|uniprotkb:GPKOW(gene name)|psi-mi:GPKOW(display_short)|uniprotkb:GPATC5(gene name synonym)|uniprotkb:GPATCH5(gene name synonym)|uniprotkb:T54(gene name synonym)|uniprotkb:G-patch domain-containing protein 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Glesne et al. (2006)	pubmed:16491121|imex:IM-15797	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4302949|imex:IM-15797-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005035.1|ensembl:ENSG00000183943(gene)|ensembl:ENST00000262848(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060562"(epithelial tube morphogenesis)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000696"(regulation of epithelial cell differentiation involved in kidney development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-111931|reactome:R-HSA-442720|reactome:R-HSA-9660821|reactome:R-HSA-9664323	refseq:NP_056513.2|ensembl:ENSG00000068394(gene)|ensembl:ENST00000156109(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR000467(D111/G-patch)|interpro:IPR005824(KOW)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR026822|interpro:IPR041993|interpro:IPR041994|rcsb pdb:7DVQ|reactome:R-HSA-72163	psi-mi:"MI:0469"(intact)	-	-	figure legend:fig1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2011/07/08	2014/10/16	rogid:Sqf2/0cIwxzcO8Ynd+QZO5U5c5c9606	rogid:On+kGkO3EMoQBPFKeobmjPtZBxQ9606	intact-crc:C5F5002CE25C1265|rigid:lK95Xj2gHsLTZuFkt3l1s6TU1dg	false	flag tag:n-n	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P10644	uniprotkb:P51817	intact:EBI-476431|uniprotkb:Q567S7|uniprotkb:K7ER48|ensembl:ENSP00000351410|ensembl:ENSP00000376475|ensembl:ENSP00000445625|ensembl:ENSP00000464977|ensembl:ENSP00000466459	intact:EBI-4302903|ensembl:ENSP00000262848	psi-mi:kap0_human(display_long)|uniprotkb:Tissue-specific extinguisher 1(gene name synonym)|uniprotkb:PRKAR1A(gene name)|psi-mi:PRKAR1A(display_short)|uniprotkb:PKR1(gene name synonym)|uniprotkb:PRKAR1(gene name synonym)|uniprotkb:TSE1(gene name synonym)	psi-mi:prkx_human(display_long)|uniprotkb:PRKX(gene name)|psi-mi:PRKX(display_short)|uniprotkb:PKX1(gene name synonym)|uniprotkb:Protein kinase PKX1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Glesne et al. (2006)	pubmed:16491121|imex:IM-15797	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4302945|imex:IM-15797-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002725.1|refseq:NP_997636.1|refseq:NP_997637.1|refseq:XP_011523285.1|refseq:XP_011523286.1|refseq:XP_011523287.1|refseq:NP_001263218.1|refseq:NP_001263219.1|refseq:NP_001265362.1|dip:DIP-34368N|ensembl:ENSG00000108946(gene)|ensembl:ENST00000358598(transcript)|ensembl:ENST00000392711(transcript)|ensembl:ENST00000536854(transcript)|ensembl:ENST00000586397(transcript)|ensembl:ENST00000589228(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0097546"(ciliary base)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|rcsb pdb:5KJZ|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|interpro:IPR018490|mint:P10644|rcsb pdb:5KJX|rcsb pdb:5KJY	refseq:NP_005035.1|ensembl:ENSG00000183943(gene)|ensembl:ENST00000262848(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060562"(epithelial tube morphogenesis)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000696"(regulation of epithelial cell differentiation involved in kidney development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-111931|reactome:R-HSA-442720|reactome:R-HSA-9660821|reactome:R-HSA-9664323	psi-mi:"MI:0469"(intact)	-	-	figure legend:fig1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2011/07/08	2014/10/16	rogid:dUZaCJQnC0KZEG4pccIqoT066VY9606	rogid:Sqf2/0cIwxzcO8Ynd+QZO5U5c5c9606	intact-crc:925C1171DAEB5F44|rigid:Gdd3j6jKNgW5vP84/cK5/87UKjw	false	v5 tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51817	uniprotkb:O43541	intact:EBI-4302903|ensembl:ENSP00000262848	intact:EBI-976374|uniprotkb:O43654|uniprotkb:Q15799|uniprotkb:Q96E31|ensembl:ENSP00000288840|uniprotkb:Q9UKZ3|uniprotkb:A9J6M5|uniprotkb:Q7Z7L4	psi-mi:prkx_human(display_long)|uniprotkb:PRKX(gene name)|psi-mi:PRKX(display_short)|uniprotkb:PKX1(gene name synonym)|uniprotkb:Protein kinase PKX1(gene name synonym)	psi-mi:smad6_human(display_long)|uniprotkb:SMAD family member 6(gene name synonym)|uniprotkb:SMAD6(gene name)|psi-mi:SMAD6(display_short)|uniprotkb:MADH6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Glesne et al. (2006)	pubmed:16491121|imex:IM-15797	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4302941|imex:IM-15797-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005035.1|ensembl:ENSG00000183943(gene)|ensembl:ENST00000262848(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060562"(epithelial tube morphogenesis)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000696"(regulation of epithelial cell differentiation involved in kidney development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-111931|reactome:R-HSA-442720|reactome:R-HSA-9660821|reactome:R-HSA-9664323	ensembl:ENSG00000137834(gene)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035904"(aorta development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|reactome:R-HSA-201451|reactome:R-HSA-8941326|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|ensembl:ENST00000288840(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001657"(ureteric bud development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|ensembl:ENSP00000288840|ensembl:ENST00000557916|ensembl:ENSP00000452955|refseq:NP_005576.3|refseq:XP_011519863.1|dip:DIP-36708N	psi-mi:"MI:0469"(intact)	-	-	figure legend:fig1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2011/07/08	2014/10/16	rogid:Sqf2/0cIwxzcO8Ynd+QZO5U5c5c9606	rogid:WXg8q9L+37KmYFAmxkfxqqXmcHE9606	intact-crc:6F40880253FE785D|rigid:2u3cStThqZ+qgP8mTKVmNsFdIIg	false	flag tag:n-n	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43541	uniprotkb:P51817	intact:EBI-976374|uniprotkb:O43654|uniprotkb:Q15799|uniprotkb:Q96E31|ensembl:ENSP00000288840|uniprotkb:Q9UKZ3|uniprotkb:A9J6M5|uniprotkb:Q7Z7L4	intact:EBI-4302903|ensembl:ENSP00000262848	psi-mi:smad6_human(display_long)|uniprotkb:SMAD family member 6(gene name synonym)|uniprotkb:SMAD6(gene name)|psi-mi:SMAD6(display_short)|uniprotkb:MADH6(gene name synonym)	psi-mi:prkx_human(display_long)|uniprotkb:PRKX(gene name)|psi-mi:PRKX(display_short)|uniprotkb:PKX1(gene name synonym)|uniprotkb:Protein kinase PKX1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Glesne et al. (2006)	pubmed:16491121|imex:IM-15797	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4305135|imex:IM-15797-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137834(gene)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035904"(aorta development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|reactome:R-HSA-201451|reactome:R-HSA-8941326|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|ensembl:ENST00000288840(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001657"(ureteric bud development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|ensembl:ENSP00000288840|ensembl:ENST00000557916|ensembl:ENSP00000452955|refseq:NP_005576.3|refseq:XP_011519863.1|dip:DIP-36708N	refseq:NP_005035.1|ensembl:ENSG00000183943(gene)|ensembl:ENST00000262848(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060562"(epithelial tube morphogenesis)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000696"(regulation of epithelial cell differentiation involved in kidney development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-111931|reactome:R-HSA-442720|reactome:R-HSA-9660821|reactome:R-HSA-9664323	go:"GO:0004672"(protein kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)	-	-	figure legend:Fig 2B|resulting-ptm:Ser phosphorylation of SMAD6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/07/08	2014/10/16	rogid:WXg8q9L+37KmYFAmxkfxqqXmcHE9606	rogid:Sqf2/0cIwxzcO8Ynd+QZO5U5c5c9606	intact-crc:B8942F2B935D4A0D|rigid:2u3cStThqZ+qgP8mTKVmNsFdIIg	false	-	his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51817	-	intact:EBI-4302903|ensembl:ENSP00000262848	-	psi-mi:prkx_human(display_long)|uniprotkb:PRKX(gene name)|psi-mi:PRKX(display_short)|uniprotkb:PKX1(gene name synonym)|uniprotkb:Protein kinase PKX1(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Glesne et al. (2006)	pubmed:16491121|imex:IM-15797	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4305130|imex:IM-15797-3	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_005035.1|ensembl:ENSG00000183943(gene)|ensembl:ENST00000262848(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060562"(epithelial tube morphogenesis)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000696"(regulation of epithelial cell differentiation involved in kidney development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-111931|reactome:R-HSA-442720|reactome:R-HSA-9660821|reactome:R-HSA-9664323	-	go:"GO:0046777"(protein autophosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig 2B|resulting-ptm:Autophosphorylation of PRKX|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/07/08	2014/10/16	rogid:Sqf2/0cIwxzcO8Ynd+QZO5U5c5c9606	-	intact-crc:FA1C76189BA5C1B8	false	his tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	-
uniprotkb:O43541	uniprotkb:P51817	intact:EBI-976374|uniprotkb:O43654|uniprotkb:Q15799|uniprotkb:Q96E31|ensembl:ENSP00000288840|uniprotkb:Q9UKZ3|uniprotkb:A9J6M5|uniprotkb:Q7Z7L4	intact:EBI-4302903|ensembl:ENSP00000262848	psi-mi:smad6_human(display_long)|uniprotkb:SMAD family member 6(gene name synonym)|uniprotkb:SMAD6(gene name)|psi-mi:SMAD6(display_short)|uniprotkb:MADH6(gene name synonym)	psi-mi:prkx_human(display_long)|uniprotkb:PRKX(gene name)|psi-mi:PRKX(display_short)|uniprotkb:PKX1(gene name synonym)|uniprotkb:Protein kinase PKX1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Glesne et al. (2006)	pubmed:16491121|imex:IM-15797	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4302960|imex:IM-15797-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137834(gene)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035904"(aorta development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|reactome:R-HSA-201451|reactome:R-HSA-8941326|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|ensembl:ENST00000288840(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001657"(ureteric bud development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|ensembl:ENSP00000288840|ensembl:ENST00000557916|ensembl:ENSP00000452955|refseq:NP_005576.3|refseq:XP_011519863.1|dip:DIP-36708N	refseq:NP_005035.1|ensembl:ENSG00000183943(gene)|ensembl:ENST00000262848(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060562"(epithelial tube morphogenesis)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000696"(regulation of epithelial cell differentiation involved in kidney development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-111931|reactome:R-HSA-442720|reactome:R-HSA-9660821|reactome:R-HSA-9664323	psi-mi:"MI:0469"(intact)	-	-	figure legend:fig1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2011/07/08	2014/10/16	rogid:WXg8q9L+37KmYFAmxkfxqqXmcHE9606	rogid:Sqf2/0cIwxzcO8Ynd+QZO5U5c5c9606	intact-crc:8D56AB90C364912D|rigid:2u3cStThqZ+qgP8mTKVmNsFdIIg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43541	uniprotkb:P51817	intact:EBI-976374|uniprotkb:O43654|uniprotkb:Q15799|uniprotkb:Q96E31|ensembl:ENSP00000288840|uniprotkb:Q9UKZ3|uniprotkb:A9J6M5|uniprotkb:Q7Z7L4	intact:EBI-4302903|ensembl:ENSP00000262848	psi-mi:smad6_human(display_long)|uniprotkb:SMAD family member 6(gene name synonym)|uniprotkb:SMAD6(gene name)|psi-mi:SMAD6(display_short)|uniprotkb:MADH6(gene name synonym)	psi-mi:prkx_human(display_long)|uniprotkb:PRKX(gene name)|psi-mi:PRKX(display_short)|uniprotkb:PKX1(gene name synonym)|uniprotkb:Protein kinase PKX1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Glesne et al. (2006)	pubmed:16491121|imex:IM-15797	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4305105|imex:IM-15797-10	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137834(gene)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035904"(aorta development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|reactome:R-HSA-201451|reactome:R-HSA-8941326|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|ensembl:ENST00000288840(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001657"(ureteric bud development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|ensembl:ENSP00000288840|ensembl:ENST00000557916|ensembl:ENSP00000452955|refseq:NP_005576.3|refseq:XP_011519863.1|dip:DIP-36708N	refseq:NP_005035.1|ensembl:ENSG00000183943(gene)|ensembl:ENST00000262848(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060562"(epithelial tube morphogenesis)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000696"(regulation of epithelial cell differentiation involved in kidney development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-111931|reactome:R-HSA-442720|reactome:R-HSA-9660821|reactome:R-HSA-9664323	go:"GO:0004672"(protein kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)	-	-	figure legend:Fig 2A|resulting-ptm:Ser phosphorylation of SMAD6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/07/08	2014/10/16	rogid:WXg8q9L+37KmYFAmxkfxqqXmcHE9606	rogid:Sqf2/0cIwxzcO8Ynd+QZO5U5c5c9606	intact-crc:7DA9AFAAF35CA525|rigid:2u3cStThqZ+qgP8mTKVmNsFdIIg	false	-	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P51817	-	intact:EBI-4302903|ensembl:ENSP00000262848	-	psi-mi:prkx_human(display_long)|uniprotkb:PRKX(gene name)|psi-mi:PRKX(display_short)|uniprotkb:PKX1(gene name synonym)|uniprotkb:Protein kinase PKX1(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Glesne et al. (2006)	pubmed:16491121|imex:IM-15797	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4305113|imex:IM-15797-11	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_005035.1|ensembl:ENSG00000183943(gene)|ensembl:ENST00000262848(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060562"(epithelial tube morphogenesis)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000696"(regulation of epithelial cell differentiation involved in kidney development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-111931|reactome:R-HSA-442720|reactome:R-HSA-9660821|reactome:R-HSA-9664323	-	go:"GO:0046777"(protein autophosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig 2A|resulting-ptm:Autophosphorylation of PRKX|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/07/08	2014/10/16	rogid:Sqf2/0cIwxzcO8Ynd+QZO5U5c5c9606	-	intact-crc:079CF7789A4AE92C	false	his tag:n-n	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-