#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32927	uniprotkb:P27986	intact:EBI-1809771|uniprotkb:Q5JZI1|uniprotkb:Q6ICE0|ensembl:ENSP00000384053	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:il3rb_human(display_long)|uniprotkb:CSF2RB(gene name)|psi-mi:CSF2RB(display_short)|uniprotkb:IL3RB(gene name synonym)|uniprotkb:IL5RB(gene name synonym)|uniprotkb:GM-CSF/IL-3/IL-5 receptor common beta subunit(gene name synonym)|uniprotkb:CDw131(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guthridge et al. (2006)	pubmed:16437163|imex:IM-16336|mint:MINT-8286692|doi:10.1038/sj.emboj.7600948	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8039505|mint:MINT-8286707|imex:IM-16336-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000386.1|refseq:XP_005261397.1|dip:DIP-127N|ensembl:ENSG00000100368(gene)|ensembl:ENST00000403662(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0030526"(granulocyte macrophage colony-stimulating factor receptor complex)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038043"(interleukin-5-mediated signaling pathway)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR011365(Cytokine IL-3/IL-5/GM-CSF receptor common beta chain)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:1C8P|rcsb pdb:1EGJ|rcsb pdb:1GH7|rcsb pdb:2GYS|rcsb pdb:2NA8|rcsb pdb:2NA9|rcsb pdb:4NKQ|rcsb pdb:5DWU|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-5683826|reactome:R-HSA-5688849|reactome:R-HSA-5688890|reactome:R-HSA-912526|mint:MINT-8286709(identity)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-8286710(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-tf1)|taxid:9606(Human erythroleukaemia TF1 cells)	-	2011/11/03	2014/10/16	rogid:NZgW441MxxYgvAaUOGnwbuyj6uw9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:E34A6B8B7BC90EB0|rigid:M2IzB1A2Q9aip/cmC/imfquPC7s	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32927	uniprotkb:P31749	intact:EBI-1809771|uniprotkb:Q5JZI1|uniprotkb:Q6ICE0|ensembl:ENSP00000384053	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	psi-mi:il3rb_human(display_long)|uniprotkb:CSF2RB(gene name)|psi-mi:CSF2RB(display_short)|uniprotkb:IL3RB(gene name synonym)|uniprotkb:IL5RB(gene name synonym)|uniprotkb:GM-CSF/IL-3/IL-5 receptor common beta subunit(gene name synonym)|uniprotkb:CDw131(gene name synonym)	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guthridge et al. (2006)	pubmed:16437163|imex:IM-16336|mint:MINT-8286692|doi:10.1038/sj.emboj.7600948	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8039505|mint:MINT-8286707|imex:IM-16336-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000386.1|refseq:XP_005261397.1|dip:DIP-127N|ensembl:ENSG00000100368(gene)|ensembl:ENST00000403662(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0030526"(granulocyte macrophage colony-stimulating factor receptor complex)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038043"(interleukin-5-mediated signaling pathway)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR011365(Cytokine IL-3/IL-5/GM-CSF receptor common beta chain)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:1C8P|rcsb pdb:1EGJ|rcsb pdb:1GH7|rcsb pdb:2GYS|rcsb pdb:2NA8|rcsb pdb:2NA9|rcsb pdb:4NKQ|rcsb pdb:5DWU|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-5683826|reactome:R-HSA-5688849|reactome:R-HSA-5688890|reactome:R-HSA-912526|mint:MINT-8286709(identity)	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N|mint:MINT-8286724(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-tf1)|taxid:9606(Human erythroleukaemia TF1 cells)	-	2011/11/03	2014/10/16	rogid:NZgW441MxxYgvAaUOGnwbuyj6uw9606	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	intact-crc:E34A6B8B7BC90EB0|rigid:M2IzB1A2Q9aip/cmC/imfquPC7s	false	-	phosphorylated residue:473-473(MINT-8286731)|phosphorylated residue:308-308(MINT-8286729)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32927	uniprotkb:O60674	intact:EBI-1809771|uniprotkb:Q5JZI1|uniprotkb:Q6ICE0|ensembl:ENSP00000384053	intact:EBI-518647|uniprotkb:O14636|uniprotkb:O75297|intact:EBI-28977715|ensembl:ENSP00000371067	psi-mi:il3rb_human(display_long)|uniprotkb:CSF2RB(gene name)|psi-mi:CSF2RB(display_short)|uniprotkb:IL3RB(gene name synonym)|uniprotkb:IL5RB(gene name synonym)|uniprotkb:GM-CSF/IL-3/IL-5 receptor common beta subunit(gene name synonym)|uniprotkb:CDw131(gene name synonym)	psi-mi:jak2_human(display_long)|uniprotkb:Janus kinase 2(gene name synonym)|uniprotkb:JAK2(gene name)|psi-mi:JAK2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guthridge et al. (2006)	pubmed:16437163|imex:IM-16336|mint:MINT-8286692|doi:10.1038/sj.emboj.7600948	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8039505|mint:MINT-8286707|imex:IM-16336-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000386.1|refseq:XP_005261397.1|dip:DIP-127N|ensembl:ENSG00000100368(gene)|ensembl:ENST00000403662(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0030526"(granulocyte macrophage colony-stimulating factor receptor complex)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038043"(interleukin-5-mediated signaling pathway)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR011365(Cytokine IL-3/IL-5/GM-CSF receptor common beta chain)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:1C8P|rcsb pdb:1EGJ|rcsb pdb:1GH7|rcsb pdb:2GYS|rcsb pdb:2NA8|rcsb pdb:2NA9|rcsb pdb:4NKQ|rcsb pdb:5DWU|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-5683826|reactome:R-HSA-5688849|reactome:R-HSA-5688890|reactome:R-HSA-912526|mint:MINT-8286709(identity)	refseq:NP_001309133.1|ensembl:ENSG00000096968(gene)|ensembl:ENST00000381652(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000791"(euchromatin)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|ensembl:ENSP00000371067|refseq:NP_004963.1|refseq:NP_001309123.1|refseq:NP_001309124.1|refseq:NP_001309125.1|dip:DIP-33880N|go:"GO:0005730"(nucleolus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031904"(endosome lumen)|go:"GO:0031959"(mineralocorticoid receptor signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035401"("histone kinase activity (H3-Y41 specific)")|go:"GO:0035409"(histone H3-Y41 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060399"(positive regulation of growth hormone receptor signaling pathway)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0070757"(interleukin-35-mediated signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019749|interpro:IPR020635|interpro:IPR020693|interpro:IPR035588|interpro:IPR035589|interpro:IPR035860|interpro:IPR035963|interpro:IPR036860|interpro:IPR037838|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:O60674|rcsb pdb:2B7A|rcsb pdb:2W1I|rcsb pdb:2XA4|rcsb pdb:3E62|rcsb pdb:3E63|rcsb pdb:3E64|rcsb pdb:3FUP|rcsb pdb:3IO7|rcsb pdb:3IOK|rcsb pdb:3JY9|rcsb pdb:3KCK|rcsb pdb:3KRR|rcsb pdb:3LPB|rcsb pdb:3Q32|rcsb pdb:3RVG|rcsb pdb:3TJC|rcsb pdb:3TJD|rcsb pdb:3UGC|rcsb pdb:3ZMM|rcsb pdb:4AQC|rcsb pdb:4BBE|rcsb pdb:4BBF|rcsb pdb:4C61|rcsb pdb:4C62|rcsb pdb:4D0W|rcsb pdb:4D0X|rcsb pdb:4D1S|rcsb pdb:4E4M|rcsb pdb:4E6D|rcsb pdb:4E6Q|rcsb pdb:4F08|rcsb pdb:4F09|rcsb pdb:4FVP|rcsb pdb:4FVQ|rcsb pdb:4FVR|rcsb pdb:4GFM|rcsb pdb:4GMY|rcsb pdb:4HGE|rcsb pdb:4IVA|rcsb pdb:4JI9|rcsb pdb:4JIA|rcsb pdb:4P7E|rcsb pdb:4YTC|rcsb pdb:4YTF|rcsb pdb:4YTH|rcsb pdb:4YTI|rcsb pdb:4Z32|rcsb pdb:4ZIM|rcsb pdb:5CF4|rcsb pdb:5CF5|rcsb pdb:5CF6|rcsb pdb:5CF8|rcsb pdb:5HEZ|rcsb pdb:5I4N|rcsb pdb:5L3A|rcsb pdb:5TQ3|rcsb pdb:5TQ4|rcsb pdb:5TQ5|rcsb pdb:5TQ6|rcsb pdb:5TQ7|rcsb pdb:5TQ8|rcsb pdb:5USY|rcsb pdb:5USZ|rcsb pdb:5UT0|rcsb pdb:5UT1|rcsb pdb:5UT2|rcsb pdb:5UT3|rcsb pdb:5UT4|rcsb pdb:5UT5|rcsb pdb:5UT6|rcsb pdb:5WEV|rcsb pdb:5WIJ|rcsb pdb:5WIK|rcsb pdb:5WIL|rcsb pdb:5WIM|rcsb pdb:5WIN|rcsb pdb:6AAJ|rcsb pdb:6BBV|rcsb pdb:6BRW|rcsb pdb:6BS0|rcsb pdb:6BSS|rcsb pdb:6D2I|rcsb pdb:6DRW|rcsb pdb:6E2P|rcsb pdb:6E2Q|rcsb pdb:6G3C|rcsb pdb:6M9H|rcsb pdb:6OAV|rcsb pdb:6OBB|rcsb pdb:6OBF|rcsb pdb:6OBL|rcsb pdb:6OCC|rcsb pdb:6TPD|rcsb pdb:6VGL|rcsb pdb:6VN8|rcsb pdb:6VNB|rcsb pdb:6VNC|rcsb pdb:6VNE|rcsb pdb:6VNF|rcsb pdb:6VNG|rcsb pdb:6VNH|rcsb pdb:6VNI|rcsb pdb:6VNJ|rcsb pdb:6VNK|rcsb pdb:6VNL|rcsb pdb:6VNM|rcsb pdb:6VS3|rcsb pdb:6VSN|rcsb pdb:6WTN|rcsb pdb:6WTO|rcsb pdb:6WTP|rcsb pdb:6WTQ|rcsb pdb:6X8E|rcsb pdb:6XJK|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-1170546|reactome:R-HSA-1433557|reactome:R-HSA-2586552|reactome:R-HSA-3214858|reactome:R-HSA-512988|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6788467|reactome:R-HSA-6802946|rcsb pdb:5AEP|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-69231|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8984722|reactome:R-HSA-9006335|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912526|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9679191|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983231|mint:MINT-8286711(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-tf1)|taxid:9606(Human erythroleukaemia TF1 cells)	-	2011/11/03	2014/10/16	rogid:NZgW441MxxYgvAaUOGnwbuyj6uw9606	rogid:s2LnvkFxriuFzkRSlP9PI0h/wYk9606	intact-crc:E34A6B8B7BC90EB0|rigid:M2IzB1A2Q9aip/cmC/imfquPC7s	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32927	uniprotkb:P42229	intact:EBI-1809771|uniprotkb:Q5JZI1|uniprotkb:Q6ICE0|ensembl:ENSP00000384053	intact:EBI-749537|uniprotkb:Q1KLZ6|ensembl:ENSP00000341208|ensembl:ENSP00000468749|ensembl:ENSP00000503262|ensembl:ENSP00000504449	psi-mi:il3rb_human(display_long)|uniprotkb:CSF2RB(gene name)|psi-mi:CSF2RB(display_short)|uniprotkb:IL3RB(gene name synonym)|uniprotkb:IL5RB(gene name synonym)|uniprotkb:GM-CSF/IL-3/IL-5 receptor common beta subunit(gene name synonym)|uniprotkb:CDw131(gene name synonym)	psi-mi:sta5a_human(display_long)|uniprotkb:STAT5A(gene name)|psi-mi:STAT5A(display_short)|uniprotkb:STAT5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guthridge et al. (2006)	pubmed:16437163|imex:IM-16336|mint:MINT-8286692|doi:10.1038/sj.emboj.7600948	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8039505|mint:MINT-8286707|imex:IM-16336-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000386.1|refseq:XP_005261397.1|dip:DIP-127N|ensembl:ENSG00000100368(gene)|ensembl:ENST00000403662(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0030526"(granulocyte macrophage colony-stimulating factor receptor complex)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038043"(interleukin-5-mediated signaling pathway)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR011365(Cytokine IL-3/IL-5/GM-CSF receptor common beta chain)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:1C8P|rcsb pdb:1EGJ|rcsb pdb:1GH7|rcsb pdb:2GYS|rcsb pdb:2NA8|rcsb pdb:2NA9|rcsb pdb:4NKQ|rcsb pdb:5DWU|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-5683826|reactome:R-HSA-5688849|reactome:R-HSA-5688890|reactome:R-HSA-912526|mint:MINT-8286709(identity)	refseq:NP_003143.2|refseq:NP_001275647.1|refseq:NP_001275648.1|refseq:NP_001275649.1|dip:DIP-396N|ensembl:ENSG00000126561(gene)|ensembl:ENST00000345506(transcript)|ensembl:ENST00000590949(transcript)|ensembl:ENST00000676585(transcript)|ensembl:ENST00000677301(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42229|reactome:R-HSA-1170546|reactome:R-HSA-1251985|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772|mint:MINT-8286712(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-tf1)|taxid:9606(Human erythroleukaemia TF1 cells)	-	2011/11/03	2014/10/16	rogid:NZgW441MxxYgvAaUOGnwbuyj6uw9606	rogid:KwM9uGM/He9Ome/Pzi6u/SgC6NY9606	intact-crc:E34A6B8B7BC90EB0|rigid:M2IzB1A2Q9aip/cmC/imfquPC7s	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32927	uniprotkb:P31749	intact:EBI-1809771|uniprotkb:Q5JZI1|uniprotkb:Q6ICE0|ensembl:ENSP00000384053	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	psi-mi:il3rb_human(display_long)|uniprotkb:CSF2RB(gene name)|psi-mi:CSF2RB(display_short)|uniprotkb:IL3RB(gene name synonym)|uniprotkb:IL5RB(gene name synonym)|uniprotkb:GM-CSF/IL-3/IL-5 receptor common beta subunit(gene name synonym)|uniprotkb:CDw131(gene name synonym)	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guthridge et al. (2006)	pubmed:16437163|imex:IM-16336|mint:MINT-8286692|doi:10.1038/sj.emboj.7600948	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8039617|mint:MINT-8286736|imex:IM-16336-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000386.1|refseq:XP_005261397.1|dip:DIP-127N|ensembl:ENSG00000100368(gene)|ensembl:ENST00000403662(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0030526"(granulocyte macrophage colony-stimulating factor receptor complex)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038043"(interleukin-5-mediated signaling pathway)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR011365(Cytokine IL-3/IL-5/GM-CSF receptor common beta chain)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:1C8P|rcsb pdb:1EGJ|rcsb pdb:1GH7|rcsb pdb:2GYS|rcsb pdb:2NA8|rcsb pdb:2NA9|rcsb pdb:4NKQ|rcsb pdb:5DWU|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-5683826|reactome:R-HSA-5688849|reactome:R-HSA-5688890|reactome:R-HSA-912526|mint:MINT-8286738(identity)	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N|mint:MINT-8286746(identity)	-	-	-	figure legend:f5a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-monocyte)|taxid:9606(Human mononuclear cells)	-	2011/11/03	2014/10/16	rogid:NZgW441MxxYgvAaUOGnwbuyj6uw9606	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	intact-crc:164D62D2A6D22C44|rigid:U4zd9qz4zE+GcZXRrG3m1RyeVD4	false	-	phosphorylated residue:308-308(MINT-8286749)|phosphorylated residue:473-473(MINT-8286747)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32927	uniprotkb:P42229	intact:EBI-1809771|uniprotkb:Q5JZI1|uniprotkb:Q6ICE0|ensembl:ENSP00000384053	intact:EBI-749537|uniprotkb:Q1KLZ6|ensembl:ENSP00000341208|ensembl:ENSP00000468749|ensembl:ENSP00000503262|ensembl:ENSP00000504449	psi-mi:il3rb_human(display_long)|uniprotkb:CSF2RB(gene name)|psi-mi:CSF2RB(display_short)|uniprotkb:IL3RB(gene name synonym)|uniprotkb:IL5RB(gene name synonym)|uniprotkb:GM-CSF/IL-3/IL-5 receptor common beta subunit(gene name synonym)|uniprotkb:CDw131(gene name synonym)	psi-mi:sta5a_human(display_long)|uniprotkb:STAT5A(gene name)|psi-mi:STAT5A(display_short)|uniprotkb:STAT5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guthridge et al. (2006)	pubmed:16437163|imex:IM-16336|mint:MINT-8286692|doi:10.1038/sj.emboj.7600948	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8039617|mint:MINT-8286736|imex:IM-16336-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000386.1|refseq:XP_005261397.1|dip:DIP-127N|ensembl:ENSG00000100368(gene)|ensembl:ENST00000403662(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0030526"(granulocyte macrophage colony-stimulating factor receptor complex)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038043"(interleukin-5-mediated signaling pathway)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR011365(Cytokine IL-3/IL-5/GM-CSF receptor common beta chain)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:1C8P|rcsb pdb:1EGJ|rcsb pdb:1GH7|rcsb pdb:2GYS|rcsb pdb:2NA8|rcsb pdb:2NA9|rcsb pdb:4NKQ|rcsb pdb:5DWU|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-5683826|reactome:R-HSA-5688849|reactome:R-HSA-5688890|reactome:R-HSA-912526|mint:MINT-8286738(identity)	refseq:NP_003143.2|refseq:NP_001275647.1|refseq:NP_001275648.1|refseq:NP_001275649.1|dip:DIP-396N|ensembl:ENSG00000126561(gene)|ensembl:ENST00000345506(transcript)|ensembl:ENST00000590949(transcript)|ensembl:ENST00000676585(transcript)|ensembl:ENST00000677301(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42229|reactome:R-HSA-1170546|reactome:R-HSA-1251985|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772|mint:MINT-8286744(identity)	-	-	-	figure legend:f5a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-monocyte)|taxid:9606(Human mononuclear cells)	-	2011/11/03	2014/10/16	rogid:NZgW441MxxYgvAaUOGnwbuyj6uw9606	rogid:KwM9uGM/He9Ome/Pzi6u/SgC6NY9606	intact-crc:164D62D2A6D22C44|rigid:U4zd9qz4zE+GcZXRrG3m1RyeVD4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32927	uniprotkb:P29353	intact:EBI-1809771|uniprotkb:Q5JZI1|uniprotkb:Q6ICE0|ensembl:ENSP00000384053	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:il3rb_human(display_long)|uniprotkb:CSF2RB(gene name)|psi-mi:CSF2RB(display_short)|uniprotkb:IL3RB(gene name synonym)|uniprotkb:IL5RB(gene name synonym)|uniprotkb:GM-CSF/IL-3/IL-5 receptor common beta subunit(gene name synonym)|uniprotkb:CDw131(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Guthridge et al. (2006)	pubmed:16437163|imex:IM-16336|mint:MINT-8286692|doi:10.1038/sj.emboj.7600948	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8039735|mint:MINT-8286769|imex:IM-16336-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000386.1|refseq:XP_005261397.1|dip:DIP-127N|ensembl:ENSG00000100368(gene)|ensembl:ENST00000403662(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0030526"(granulocyte macrophage colony-stimulating factor receptor complex)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038043"(interleukin-5-mediated signaling pathway)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR011365(Cytokine IL-3/IL-5/GM-CSF receptor common beta chain)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:1C8P|rcsb pdb:1EGJ|rcsb pdb:1GH7|rcsb pdb:2GYS|rcsb pdb:2NA8|rcsb pdb:2NA9|rcsb pdb:4NKQ|rcsb pdb:5DWU|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-5683826|reactome:R-HSA-5688849|reactome:R-HSA-5688890|reactome:R-HSA-912526|mint:MINT-8286808(identity)	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N|mint:MINT-8286777(identity)	-	-	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/03	2014/10/16	rogid:NZgW441MxxYgvAaUOGnwbuyj6uw9606	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	intact-crc:FE54B640B6C768D5|rigid:9wOU2M96ibeaVDUMOKf+bqcIVZ0	false	tag:?-?(MINT-8286821)|phosphorylated residue:591-591(MINT-8286824)|phosphorylated residue:601-601(MINT-8286826)	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32927	uniprotkb:P27986	intact:EBI-1809771|uniprotkb:Q5JZI1|uniprotkb:Q6ICE0|ensembl:ENSP00000384053	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:il3rb_human(display_long)|uniprotkb:CSF2RB(gene name)|psi-mi:CSF2RB(display_short)|uniprotkb:IL3RB(gene name synonym)|uniprotkb:IL5RB(gene name synonym)|uniprotkb:GM-CSF/IL-3/IL-5 receptor common beta subunit(gene name synonym)|uniprotkb:CDw131(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Guthridge et al. (2006)	pubmed:16437163|imex:IM-16336|mint:MINT-8286692|doi:10.1038/sj.emboj.7600948	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8039735|mint:MINT-8286769|imex:IM-16336-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000386.1|refseq:XP_005261397.1|dip:DIP-127N|ensembl:ENSG00000100368(gene)|ensembl:ENST00000403662(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0030526"(granulocyte macrophage colony-stimulating factor receptor complex)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038043"(interleukin-5-mediated signaling pathway)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR011365(Cytokine IL-3/IL-5/GM-CSF receptor common beta chain)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:1C8P|rcsb pdb:1EGJ|rcsb pdb:1GH7|rcsb pdb:2GYS|rcsb pdb:2NA8|rcsb pdb:2NA9|rcsb pdb:4NKQ|rcsb pdb:5DWU|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-5683826|reactome:R-HSA-5688849|reactome:R-HSA-5688890|reactome:R-HSA-912526|mint:MINT-8286808(identity)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-8286773(identity)	-	-	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/03	2014/10/16	rogid:NZgW441MxxYgvAaUOGnwbuyj6uw9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:FE54B640B6C768D5|rigid:9wOU2M96ibeaVDUMOKf+bqcIVZ0	false	tag:?-?(MINT-8286821)|phosphorylated residue:591-591(MINT-8286824)|phosphorylated residue:601-601(MINT-8286826)	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32927	uniprotkb:P29353	intact:EBI-1809771|uniprotkb:Q5JZI1|uniprotkb:Q6ICE0|ensembl:ENSP00000384053	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:il3rb_human(display_long)|uniprotkb:CSF2RB(gene name)|psi-mi:CSF2RB(display_short)|uniprotkb:IL3RB(gene name synonym)|uniprotkb:IL5RB(gene name synonym)|uniprotkb:GM-CSF/IL-3/IL-5 receptor common beta subunit(gene name synonym)|uniprotkb:CDw131(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Guthridge et al. (2006)	pubmed:16437163|imex:IM-16336|mint:MINT-8286692|doi:10.1038/sj.emboj.7600948	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8039816|mint:MINT-8286829|imex:IM-16336-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000386.1|refseq:XP_005261397.1|dip:DIP-127N|ensembl:ENSG00000100368(gene)|ensembl:ENST00000403662(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0030526"(granulocyte macrophage colony-stimulating factor receptor complex)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038043"(interleukin-5-mediated signaling pathway)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR011365(Cytokine IL-3/IL-5/GM-CSF receptor common beta chain)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:1C8P|rcsb pdb:1EGJ|rcsb pdb:1GH7|rcsb pdb:2GYS|rcsb pdb:2NA8|rcsb pdb:2NA9|rcsb pdb:4NKQ|rcsb pdb:5DWU|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-5683826|reactome:R-HSA-5688849|reactome:R-HSA-5688890|reactome:R-HSA-912526|mint:MINT-8286835(identity)	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N|mint:MINT-8286833(identity)	-	-	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/03	2014/10/16	rogid:NZgW441MxxYgvAaUOGnwbuyj6uw9606	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	intact-crc:005BDB90543E0285|rigid:9wOU2M96ibeaVDUMOKf+bqcIVZ0	false	phosphorylated residue:591-591(MINT-8286838)|tag:?-?(MINT-8286840)	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32927	uniprotkb:P27986	intact:EBI-1809771|uniprotkb:Q5JZI1|uniprotkb:Q6ICE0|ensembl:ENSP00000384053	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:il3rb_human(display_long)|uniprotkb:CSF2RB(gene name)|psi-mi:CSF2RB(display_short)|uniprotkb:IL3RB(gene name synonym)|uniprotkb:IL5RB(gene name synonym)|uniprotkb:GM-CSF/IL-3/IL-5 receptor common beta subunit(gene name synonym)|uniprotkb:CDw131(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Guthridge et al. (2006)	pubmed:16437163|imex:IM-16336|mint:MINT-8286692|doi:10.1038/sj.emboj.7600948	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8039816|mint:MINT-8286829|imex:IM-16336-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000386.1|refseq:XP_005261397.1|dip:DIP-127N|ensembl:ENSG00000100368(gene)|ensembl:ENST00000403662(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0030526"(granulocyte macrophage colony-stimulating factor receptor complex)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038043"(interleukin-5-mediated signaling pathway)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR011365(Cytokine IL-3/IL-5/GM-CSF receptor common beta chain)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:1C8P|rcsb pdb:1EGJ|rcsb pdb:1GH7|rcsb pdb:2GYS|rcsb pdb:2NA8|rcsb pdb:2NA9|rcsb pdb:4NKQ|rcsb pdb:5DWU|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-5683826|reactome:R-HSA-5688849|reactome:R-HSA-5688890|reactome:R-HSA-912526|mint:MINT-8286835(identity)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-8286831(identity)	-	-	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/03	2014/10/16	rogid:NZgW441MxxYgvAaUOGnwbuyj6uw9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:005BDB90543E0285|rigid:9wOU2M96ibeaVDUMOKf+bqcIVZ0	false	phosphorylated residue:591-591(MINT-8286838)|tag:?-?(MINT-8286840)	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32927	uniprotkb:P27986	intact:EBI-1809771|uniprotkb:Q5JZI1|uniprotkb:Q6ICE0|ensembl:ENSP00000384053	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:il3rb_human(display_long)|uniprotkb:CSF2RB(gene name)|psi-mi:CSF2RB(display_short)|uniprotkb:IL3RB(gene name synonym)|uniprotkb:IL5RB(gene name synonym)|uniprotkb:GM-CSF/IL-3/IL-5 receptor common beta subunit(gene name synonym)|uniprotkb:CDw131(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Guthridge et al. (2006)	pubmed:16437163|imex:IM-16336|mint:MINT-8286692|doi:10.1038/sj.emboj.7600948	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8039839|mint:MINT-8286845|imex:IM-16336-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000386.1|refseq:XP_005261397.1|dip:DIP-127N|ensembl:ENSG00000100368(gene)|ensembl:ENST00000403662(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0030526"(granulocyte macrophage colony-stimulating factor receptor complex)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038043"(interleukin-5-mediated signaling pathway)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR011365(Cytokine IL-3/IL-5/GM-CSF receptor common beta chain)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:1C8P|rcsb pdb:1EGJ|rcsb pdb:1GH7|rcsb pdb:2GYS|rcsb pdb:2NA8|rcsb pdb:2NA9|rcsb pdb:4NKQ|rcsb pdb:5DWU|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-5683826|reactome:R-HSA-5688849|reactome:R-HSA-5688890|reactome:R-HSA-912526|mint:MINT-8286851(identity)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-8286847(identity)	-	-	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/03	2014/10/16	rogid:NZgW441MxxYgvAaUOGnwbuyj6uw9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:E6F1B97477973079|rigid:9wOU2M96ibeaVDUMOKf+bqcIVZ0	false	tag:?-?(MINT-8286852)|phosphorylated residue:601-601(MINT-8286854)	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32927	uniprotkb:P29353	intact:EBI-1809771|uniprotkb:Q5JZI1|uniprotkb:Q6ICE0|ensembl:ENSP00000384053	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:il3rb_human(display_long)|uniprotkb:CSF2RB(gene name)|psi-mi:CSF2RB(display_short)|uniprotkb:IL3RB(gene name synonym)|uniprotkb:IL5RB(gene name synonym)|uniprotkb:GM-CSF/IL-3/IL-5 receptor common beta subunit(gene name synonym)|uniprotkb:CDw131(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Guthridge et al. (2006)	pubmed:16437163|imex:IM-16336|mint:MINT-8286692|doi:10.1038/sj.emboj.7600948	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8039839|mint:MINT-8286845|imex:IM-16336-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000386.1|refseq:XP_005261397.1|dip:DIP-127N|ensembl:ENSG00000100368(gene)|ensembl:ENST00000403662(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0030526"(granulocyte macrophage colony-stimulating factor receptor complex)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038043"(interleukin-5-mediated signaling pathway)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR011365(Cytokine IL-3/IL-5/GM-CSF receptor common beta chain)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:1C8P|rcsb pdb:1EGJ|rcsb pdb:1GH7|rcsb pdb:2GYS|rcsb pdb:2NA8|rcsb pdb:2NA9|rcsb pdb:4NKQ|rcsb pdb:5DWU|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-5683826|reactome:R-HSA-5688849|reactome:R-HSA-5688890|reactome:R-HSA-912526|mint:MINT-8286851(identity)	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N|mint:MINT-8286849(identity)	-	-	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/11/03	2014/10/16	rogid:NZgW441MxxYgvAaUOGnwbuyj6uw9606	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	intact-crc:E6F1B97477973079|rigid:9wOU2M96ibeaVDUMOKf+bqcIVZ0	false	tag:?-?(MINT-8286852)|phosphorylated residue:601-601(MINT-8286854)	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0113"(western blot)