#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q7Z434	uniprotkb:P27958	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-706378|uniprotkb:O36579|uniprotkb:O36608|uniprotkb:O36609|uniprotkb:O36610	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:polg_hcv77(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2005)	pubmed:16301520|imex:IM-17191|pubmed:16301520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-3648904|imex:IM-17191-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	rcsb pdb:6WO5|rcsb pdb:6WOQ|rcsb pdb:5FGB|rcsb pdb:5FGC|rcsb pdb:5EOC|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|rcsb pdb:4MWF|rcsb pdb:4Q0X|rcsb pdb:4XVJ|interpro:IPR042205|interpro:IPR042209|rcsb pdb:5YXN|rcsb pdb:5YXU|rcsb pdb:1A1R|rcsb pdb:1A1V|rcsb pdb:1CWX|rcsb pdb:1HEI|rcsb pdb:1JR6|rcsb pdb:1N1L|rcsb pdb:1ONB|rcsb pdb:1R7C|rcsb pdb:1R7D|rcsb pdb:1R7E|rcsb pdb:1R7F|rcsb pdb:1R7G|rcsb pdb:1RGQ|rcsb pdb:2F9V|rcsb pdb:2HD0|rcsb pdb:2JXF|rcsb pdb:2KDR|rcsb pdb:2O8M|rcsb pdb:2OBO|rcsb pdb:2OBQ|rcsb pdb:4JZN|rcsb pdb:4JZO|rcsb pdb:2OC0|rcsb pdb:2OC1|rcsb pdb:2OC7|rcsb pdb:2OC8|rcsb pdb:2OIN|rcsb pdb:2P59|rcsb pdb:2XI2|rcsb pdb:2XI3|rcsb pdb:4N0Y|rcsb pdb:2N1P|rcsb pdb:2A4R|rcsb pdb:2XNI|interpro:IPR043128|interpro:IPR027417|rcsb pdb:2QV1|rcsb pdb:4CL1|rcsb pdb:5ERW|rcsb pdb:4Z0X|reactome:R-HSA-8854214|interpro:IPR038170|interpro:IPR038568|rcsb pdb:5JZI|rcsb pdb:3RC4|rcsb pdb:3RC5|rcsb pdb:6UYD|rcsb pdb:6BQJ|rcsb pdb:6BQK|rcsb pdb:6BZU|rcsb pdb:6BZV|rcsb pdb:6BZW|rcsb pdb:6BZY|interpro:IPR043502|interpro:IPR043504|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002039"(p53 binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019054"(modulation by virus of host cellular process)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0019082"(viral protein processing)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0033647"(host intracellular organelle)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039560"(suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0044833"(modulation by virus of host protein transport)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046762"(viral budding from endoplasmic reticulum membrane)|go:"GO:0046774"(suppression by virus of host intracellular interferon activity)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0050689"(negative regulation of defense response to virus by host)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051047"(positive regulation of secretion)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0060702"(negative regulation of endoribonuclease activity)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098670"(entry receptor-mediated virion attachment to host cell)|go:"GO:0098671"(adhesion receptor-mediated virion attachment to host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1900369"(negative regulation of RNA interference)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903301"(positive regulation of hexokinase activity)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|go:"GO:1990254"(keratin filament binding)	-	-	-	figure legend:Fig. 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293e)|taxid:9606(Human HEK293E or 293 c18 cell line)	-	2011/03/02	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:JTO6thKKerqFLVzcNGjB9C/ZPcQ63746	intact-crc:189BB77531ABE4F1|rigid:Ej7tjJotQJs+EVBdYnhJzjUqJPs	false	mutation decreasing interaction:508-508|ha tag:n-n	mutation increasing interaction:1165-1165|flag tag:n-n|sufficient binding region:1027-1711	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z434	uniprotkb:P27958	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-706378|uniprotkb:O36579|uniprotkb:O36608|uniprotkb:O36609|uniprotkb:O36610	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:polg_hcv77(display_long)	psi-mi:"MI:0663"(confocal microscopy)	Li et al. (2005)	pubmed:16301520|imex:IM-17191|pubmed:16301520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-3649059|imex:IM-17191-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	rcsb pdb:6WO5|rcsb pdb:6WOQ|rcsb pdb:5FGB|rcsb pdb:5FGC|rcsb pdb:5EOC|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|rcsb pdb:4MWF|rcsb pdb:4Q0X|rcsb pdb:4XVJ|interpro:IPR042205|interpro:IPR042209|rcsb pdb:5YXN|rcsb pdb:5YXU|rcsb pdb:1A1R|rcsb pdb:1A1V|rcsb pdb:1CWX|rcsb pdb:1HEI|rcsb pdb:1JR6|rcsb pdb:1N1L|rcsb pdb:1ONB|rcsb pdb:1R7C|rcsb pdb:1R7D|rcsb pdb:1R7E|rcsb pdb:1R7F|rcsb pdb:1R7G|rcsb pdb:1RGQ|rcsb pdb:2F9V|rcsb pdb:2HD0|rcsb pdb:2JXF|rcsb pdb:2KDR|rcsb pdb:2O8M|rcsb pdb:2OBO|rcsb pdb:2OBQ|rcsb pdb:4JZN|rcsb pdb:4JZO|rcsb pdb:2OC0|rcsb pdb:2OC1|rcsb pdb:2OC7|rcsb pdb:2OC8|rcsb pdb:2OIN|rcsb pdb:2P59|rcsb pdb:2XI2|rcsb pdb:2XI3|rcsb pdb:4N0Y|rcsb pdb:2N1P|rcsb pdb:2A4R|rcsb pdb:2XNI|interpro:IPR043128|interpro:IPR027417|rcsb pdb:2QV1|rcsb pdb:4CL1|rcsb pdb:5ERW|rcsb pdb:4Z0X|reactome:R-HSA-8854214|interpro:IPR038170|interpro:IPR038568|rcsb pdb:5JZI|rcsb pdb:3RC4|rcsb pdb:3RC5|rcsb pdb:6UYD|rcsb pdb:6BQJ|rcsb pdb:6BQK|rcsb pdb:6BZU|rcsb pdb:6BZV|rcsb pdb:6BZW|rcsb pdb:6BZY|interpro:IPR043502|interpro:IPR043504|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002039"(p53 binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019054"(modulation by virus of host cellular process)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0019082"(viral protein processing)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0033647"(host intracellular organelle)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039560"(suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0044833"(modulation by virus of host protein transport)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046762"(viral budding from endoplasmic reticulum membrane)|go:"GO:0046774"(suppression by virus of host intracellular interferon activity)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0050689"(negative regulation of defense response to virus by host)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051047"(positive regulation of secretion)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0060702"(negative regulation of endoribonuclease activity)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098670"(entry receptor-mediated virion attachment to host cell)|go:"GO:0098671"(adhesion receptor-mediated virion attachment to host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1900369"(negative regulation of RNA interference)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903301"(positive regulation of hexokinase activity)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|go:"GO:1990254"(keratin filament binding)	-	-	-	figure legend:Fig. 3C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293e)|taxid:9606(Human HEK293E or 293 c18 cell line)	-	2011/03/02	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:JTO6thKKerqFLVzcNGjB9C/ZPcQ63746	intact-crc:DBCF5BBD67ECD126|rigid:Ej7tjJotQJs+EVBdYnhJzjUqJPs	false	ha tag:n-n|mutation:508-508	flag tag:n-n|sufficient binding region:1027-1711	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q14653	uniprotkb:Q14653	intact:EBI-2650369|uniprotkb:Q5FBY1|uniprotkb:Q5FBY2|uniprotkb:Q7Z5G6|uniprotkb:A8K7L2|uniprotkb:B2RAZ3|ensembl:ENSP00000310127|ensembl:ENSP00000366344|ensembl:ENSP00000469113|uniprotkb:Q5FBY4	intact:EBI-2650369|uniprotkb:Q5FBY1|uniprotkb:Q5FBY2|uniprotkb:Q7Z5G6|uniprotkb:A8K7L2|uniprotkb:B2RAZ3|ensembl:ENSP00000310127|ensembl:ENSP00000366344|ensembl:ENSP00000469113|uniprotkb:Q5FBY4	psi-mi:irf3_human(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short)	psi-mi:irf3_human(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short)	psi-mi:"MI:0276"(blue native page)	Li et al. (2005)	pubmed:16301520|imex:IM-17191|pubmed:16301520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-3649688|imex:IM-17191-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001562.1|refseq:NP_001184053.1|ensembl:ENSG00000126456(gene)|ensembl:ENST00000309877(transcript)|ensembl:ENST00000377139(transcript)|ensembl:ENST00000597198(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071888"(macrophage apoptotic process)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|mint:Q14653|rcsb pdb:1J2F|rcsb pdb:1QWT|rcsb pdb:1T2K|rcsb pdb:1ZOQ|rcsb pdb:2O61|rcsb pdb:2O6G|rcsb pdb:2PI0|rcsb pdb:3A77|rcsb pdb:3QU6|rcsb pdb:5JEJ|rcsb pdb:5JEK|rcsb pdb:5JEL|rcsb pdb:5JEM|rcsb pdb:5JEO|rcsb pdb:5JER|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:7JFL|reactome:R-HSA-1169408|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3270619|reactome:R-HSA-877300|reactome:R-HSA-3134973|reactome:R-HSA-9013973|reactome:R-HSA-909733|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:NP_001184051.1|refseq:NP_001184052.1|refseq:NP_001184054.1|refseq:NP_001184055.1|refseq:NP_001184056.1|refseq:NP_001184057.1|refseq:XP_006723260.1|refseq:XP_006723261.1|refseq:XP_016882255.1|refseq:XP_016882256.1|dip:DIP-41448N	refseq:NP_001562.1|refseq:NP_001184053.1|ensembl:ENSG00000126456(gene)|ensembl:ENST00000309877(transcript)|ensembl:ENST00000377139(transcript)|ensembl:ENST00000597198(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071888"(macrophage apoptotic process)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|mint:Q14653|rcsb pdb:1J2F|rcsb pdb:1QWT|rcsb pdb:1T2K|rcsb pdb:1ZOQ|rcsb pdb:2O61|rcsb pdb:2O6G|rcsb pdb:2PI0|rcsb pdb:3A77|rcsb pdb:3QU6|rcsb pdb:5JEJ|rcsb pdb:5JEK|rcsb pdb:5JEL|rcsb pdb:5JEM|rcsb pdb:5JEO|rcsb pdb:5JER|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:7JFL|reactome:R-HSA-1169408|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3270619|reactome:R-HSA-877300|reactome:R-HSA-3134973|reactome:R-HSA-9013973|reactome:R-HSA-909733|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:NP_001184051.1|refseq:NP_001184052.1|refseq:NP_001184054.1|refseq:NP_001184055.1|refseq:NP_001184056.1|refseq:NP_001184057.1|refseq:XP_006723260.1|refseq:XP_006723261.1|refseq:XP_016882255.1|refseq:XP_016882256.1|dip:DIP-41448N	-	-	-	figure legend:Fig. 1D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293e)|taxid:9606(Human HEK293E or 293 c18 cell line)	-	2011/03/02	2014/10/16	rogid:hQC59YXQ7BOkhZzKbxYHcu1YWFA9606	rogid:hQC59YXQ7BOkhZzKbxYHcu1YWFA9606	intact-crc:8CFB2F67D5A1A41A|rigid:y/wjSxLhOsf5dKzciLRCT0YH2Ho	false	-	-	2	0	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)