#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9NZC7 uniprotkb:Q61527 intact:EBI-4320739|uniprotkb:A8K323|uniprotkb:Q5MYT5|uniprotkb:Q96KM3|uniprotkb:Q96RF2|uniprotkb:Q9BTT8|uniprotkb:Q9NPC9|uniprotkb:Q9NRF4|uniprotkb:Q9NRF5|uniprotkb:Q9NRF6|uniprotkb:Q9NRK1|uniprotkb:Q9NZC5|ensembl:ENSP00000457230 intact:EBI-4398741|uniprotkb:B2KGF6|uniprotkb:B2KGF5|uniprotkb:O88460|uniprotkb:Q3UNS6|ensembl:ENSMUSP00000112713 psi-mi:wwox_human(display_long)|uniprotkb:WWOX(gene name)|psi-mi:WWOX(display_short)|uniprotkb:FOR(gene name synonym)|uniprotkb:WOX1(gene name synonym)|uniprotkb:Fragile site FRA16D oxidoreductase(gene name synonym)|uniprotkb:SDR41C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 41C member 1(gene name synonym) psi-mi:erbb4_mouse(display_long)|uniprotkb:Erbb4(gene name)|psi-mi:Erbb4(display_short)|uniprotkb:Mer4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Aqeilan et al. (2005) pubmed:16061658|imex:IM-16922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4321096|imex:IM-16922-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057457.1|refseq:NP_570607.1|refseq:NP_001278926.1|ensembl:ENST00000566780(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036020|interpro:IPR036291|interpro:IPR042732|mint:Q9NZC7|rcsb pdb:1WMV|reactome:R-HSA-1251985|reactome:R-HSA-8866904|reactome:R-HSA-8866907|ensembl:ENSG00000186153(gene) refseq:NP_034284.1|dip:DIP-29887N|refseq:XP_006495755.1|refseq:XP_006495756.1|ensembl:ENSMUSG00000062209(gene)|ensembl:ENSMUST00000119142(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038132"(neuregulin binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060074"(synapse maturation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1227986|reactome:R-MMU-1236394|reactome:R-MMU-1250196|reactome:R-MMU-1250342|reactome:R-MMU-1250347|reactome:R-MMU-1251985|reactome:R-MMU-1253288|reactome:R-MMU-1257604|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8863795|reactome:R-MMU-9018519 - - - figure legend:Figure 1A, 2A and 2C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2011/08/03 2014/10/16 rogid:YMGESSlld4QIPoFrcPX3zhwIy2E9606 rogid:AnrG/UB5hOb42Yw4+XrnDsPOb/g10090 intact-crc:A2F5461D77036A87|rigid:tLWejKnFj4ifoJOxaFgrvdkQIbA false mutation disrupting interaction:33-33|myc tag:?-? ha tag:?-?|mutation disrupting interaction:1035-1035,1301-1301 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q61527 uniprotkb:P46937-2 intact:EBI-4398741|uniprotkb:B2KGF6|uniprotkb:B2KGF5|uniprotkb:O88460|uniprotkb:Q3UNS6|ensembl:ENSMUSP00000112713 intact:EBI-4325216|ensembl:ENSP00000431574 psi-mi:erbb4_mouse(display_long)|uniprotkb:Erbb4(gene name)|psi-mi:Erbb4(display_short)|uniprotkb:Mer4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym) psi-mi:p46937-2(display_long)|uniprotkb:YAP1(gene name)|psi-mi:YAP1(display_short)|uniprotkb:YAP65(gene name synonym)|uniprotkb:Protein yorkie homolog(gene name synonym)|uniprotkb:Yes-associated protein YAP65 homolog(gene name synonym)|uniprotkb:YAP1-2alpha(isoform synonym)|uniprotkb:YAP2(isoform synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Aqeilan et al. (2005) pubmed:16061658|imex:IM-16922 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4325224|imex:IM-16922-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034284.1|dip:DIP-29887N|refseq:XP_006495755.1|refseq:XP_006495756.1|ensembl:ENSMUSG00000062209(gene)|ensembl:ENSMUST00000119142(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038132"(neuregulin binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060074"(synapse maturation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1227986|reactome:R-MMU-1236394|reactome:R-MMU-1250196|reactome:R-MMU-1250342|reactome:R-MMU-1250347|reactome:R-MMU-1251985|reactome:R-MMU-1253288|reactome:R-MMU-1257604|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8863795|reactome:R-MMU-9018519 intact:EBI-1044059(isoform-parent)|ensembl:ENSG00000137693(gene)|ensembl:ENST00000531439(transcript)|uniprotkb:P46937-2(isoform-parent) - - - figure legend:Figure 5A and 5B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2011/08/03 2014/10/16 rogid:AnrG/UB5hOb42Yw4+XrnDsPOb/g10090 rogid:IrKuT/ok9QIqFfWc+XaO6nOV9wY9606 intact-crc:E88EAADF8D6CE524|rigid:znQEhZJ9jKGjrQDWg99jWPj95Q8 false ha tag:?-? tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q61527 uniprotkb:Q9NZC7 intact:EBI-4398741|uniprotkb:B2KGF6|uniprotkb:B2KGF5|uniprotkb:O88460|uniprotkb:Q3UNS6|ensembl:ENSMUSP00000112713 intact:EBI-4320739|uniprotkb:A8K323|uniprotkb:Q5MYT5|uniprotkb:Q96KM3|uniprotkb:Q96RF2|uniprotkb:Q9BTT8|uniprotkb:Q9NPC9|uniprotkb:Q9NRF4|uniprotkb:Q9NRF5|uniprotkb:Q9NRF6|uniprotkb:Q9NRK1|uniprotkb:Q9NZC5|ensembl:ENSP00000457230 psi-mi:erbb4_mouse(display_long)|uniprotkb:Erbb4(gene name)|psi-mi:Erbb4(display_short)|uniprotkb:Mer4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym) psi-mi:wwox_human(display_long)|uniprotkb:WWOX(gene name)|psi-mi:WWOX(display_short)|uniprotkb:FOR(gene name synonym)|uniprotkb:WOX1(gene name synonym)|uniprotkb:Fragile site FRA16D oxidoreductase(gene name synonym)|uniprotkb:SDR41C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 41C member 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Aqeilan et al. (2005) pubmed:16061658|imex:IM-16922 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4325224|imex:IM-16922-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034284.1|dip:DIP-29887N|refseq:XP_006495755.1|refseq:XP_006495756.1|ensembl:ENSMUSG00000062209(gene)|ensembl:ENSMUST00000119142(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038132"(neuregulin binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060074"(synapse maturation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1227986|reactome:R-MMU-1236394|reactome:R-MMU-1250196|reactome:R-MMU-1250342|reactome:R-MMU-1250347|reactome:R-MMU-1251985|reactome:R-MMU-1253288|reactome:R-MMU-1257604|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8863795|reactome:R-MMU-9018519 refseq:NP_057457.1|refseq:NP_570607.1|refseq:NP_001278926.1|ensembl:ENST00000566780(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036020|interpro:IPR036291|interpro:IPR042732|mint:Q9NZC7|rcsb pdb:1WMV|reactome:R-HSA-1251985|reactome:R-HSA-8866904|reactome:R-HSA-8866907|ensembl:ENSG00000186153(gene) - - - figure legend:Figure 5A and 5B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2011/08/03 2014/10/16 rogid:AnrG/UB5hOb42Yw4+XrnDsPOb/g10090 rogid:YMGESSlld4QIPoFrcPX3zhwIy2E9606 intact-crc:E88EAADF8D6CE524|rigid:znQEhZJ9jKGjrQDWg99jWPj95Q8 false ha tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NZC7 uniprotkb:Q61527 intact:EBI-4320739|uniprotkb:A8K323|uniprotkb:Q5MYT5|uniprotkb:Q96KM3|uniprotkb:Q96RF2|uniprotkb:Q9BTT8|uniprotkb:Q9NPC9|uniprotkb:Q9NRF4|uniprotkb:Q9NRF5|uniprotkb:Q9NRF6|uniprotkb:Q9NRK1|uniprotkb:Q9NZC5|ensembl:ENSP00000457230 intact:EBI-4398741|uniprotkb:B2KGF6|uniprotkb:B2KGF5|uniprotkb:O88460|uniprotkb:Q3UNS6|ensembl:ENSMUSP00000112713 psi-mi:wwox_human(display_long)|uniprotkb:WWOX(gene name)|psi-mi:WWOX(display_short)|uniprotkb:FOR(gene name synonym)|uniprotkb:WOX1(gene name synonym)|uniprotkb:Fragile site FRA16D oxidoreductase(gene name synonym)|uniprotkb:SDR41C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 41C member 1(gene name synonym) psi-mi:erbb4_mouse(display_long)|uniprotkb:Erbb4(gene name)|psi-mi:Erbb4(display_short)|uniprotkb:Mer4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Aqeilan et al. (2005) pubmed:16061658|imex:IM-16922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-4321137|imex:IM-16922-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057457.1|refseq:NP_570607.1|refseq:NP_001278926.1|ensembl:ENST00000566780(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036020|interpro:IPR036291|interpro:IPR042732|mint:Q9NZC7|rcsb pdb:1WMV|reactome:R-HSA-1251985|reactome:R-HSA-8866904|reactome:R-HSA-8866907|ensembl:ENSG00000186153(gene) refseq:NP_034284.1|dip:DIP-29887N|refseq:XP_006495755.1|refseq:XP_006495756.1|ensembl:ENSMUSG00000062209(gene)|ensembl:ENSMUST00000119142(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038132"(neuregulin binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060074"(synapse maturation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1227986|reactome:R-MMU-1236394|reactome:R-MMU-1250196|reactome:R-MMU-1250342|reactome:R-MMU-1250347|reactome:R-MMU-1251985|reactome:R-MMU-1253288|reactome:R-MMU-1257604|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8863795|reactome:R-MMU-9018519 go:"GO:0005737"(cytoplasm) - - figure legend:Figure 3A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/08/03 2014/10/16 rogid:YMGESSlld4QIPoFrcPX3zhwIy2E9606 rogid:AnrG/UB5hOb42Yw4+XrnDsPOb/g10090 intact-crc:106324669987CD2B|rigid:tLWejKnFj4ifoJOxaFgrvdkQIbA false green fluorescent protein tag:?-? ha tag:?-? - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:Q9NZC7 uniprotkb:Q15303 intact:EBI-4320739|uniprotkb:A8K323|uniprotkb:Q5MYT5|uniprotkb:Q96KM3|uniprotkb:Q96RF2|uniprotkb:Q9BTT8|uniprotkb:Q9NPC9|uniprotkb:Q9NRF4|uniprotkb:Q9NRF5|uniprotkb:Q9NRF6|uniprotkb:Q9NRK1|uniprotkb:Q9NZC5|ensembl:ENSP00000457230 intact:EBI-80371|ensembl:ENSP00000342235|uniprotkb:Q2M1W1|uniprotkb:Q59EW4|uniprotkb:B7ZLE3|uniprotkb:B7ZLD7|uniprotkb:B7ZLE2 psi-mi:wwox_human(display_long)|uniprotkb:WWOX(gene name)|psi-mi:WWOX(display_short)|uniprotkb:FOR(gene name synonym)|uniprotkb:WOX1(gene name synonym)|uniprotkb:Fragile site FRA16D oxidoreductase(gene name synonym)|uniprotkb:SDR41C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 41C member 1(gene name synonym) psi-mi:erbb4_human(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Aqeilan et al. (2005) pubmed:16061658|imex:IM-16922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-4398784|imex:IM-16922-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057457.1|refseq:NP_570607.1|refseq:NP_001278926.1|ensembl:ENST00000566780(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036020|interpro:IPR036291|interpro:IPR042732|mint:Q9NZC7|rcsb pdb:1WMV|reactome:R-HSA-1251985|reactome:R-HSA-8866904|reactome:R-HSA-8866907|ensembl:ENSG00000186153(gene) go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0007416"(synapse assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0007507"(heart development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0007595"(lactation)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR032778|interpro:IPR036941|mint:Q15303|rcsb pdb:2AHX|rcsb pdb:2L2T|rcsb pdb:2LCX|rcsb pdb:2R4B|rcsb pdb:3BBT|rcsb pdb:3BBW|rcsb pdb:3BCE|rcsb pdb:3U2P|rcsb pdb:3U7U|rcsb pdb:3U9U|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-1253288|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-9018519|reactome:R-HSA-9620244|reactome:R-HSA-9664565|reactome:R-HSA-9665686|ensembl:ENSG00000178568(gene)|ensembl:ENST00000342788(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|ensembl:ENSP00000342235|ensembl:ENST00000436443|ensembl:ENSP00000403204|refseq:NP_001036064.1|refseq:NP_005226.1|refseq:XP_005246433.1|refseq:XP_005246434.1|dip:DIP-29650N go:"GO:0005737"(cytoplasm) - - figure legend:Figure 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2011/08/03 2014/10/16 rogid:YMGESSlld4QIPoFrcPX3zhwIy2E9606 rogid:B6LYhMaoSj5IT6caAnj1n262+H49606 intact-crc:60C6783B21C3DF77|rigid:2+G72B5m1CnqK36vmcHLqCIXDTs false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)