#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P34314	uniprotkb:O01427	intact:EBI-3890382|uniprotkb:P34323|uniprotkb:Q6SSJ1|uniprotkb:Q8I4N0|ensemblmetazoa:C07A9.3b.1	intact:EBI-312947|ensemblmetazoa:B0207.4.1	psi-mi:tlk1_caeel(display_long)|uniprotkb:tlk-1(gene name)|psi-mi:tlk-1(display_short)|uniprotkb:Tousled-like kinase 1(gene name synonym)|uniprotkb:C07A9.3(orf name)	psi-mi:air2_caeel(display_long)|uniprotkb:stu-7(gene name synonym)|uniprotkb:B0207.4(orf name)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)|uniprotkb:air-2(gene name)|psi-mi:air-2(display_short)	psi-mi:"MI:0018"(two hybrid)	Han et al. (2005)	pubmed:15916946|imex:IM-17180	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3890709|imex:IM-17180-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P34314|refseq:NP_499145.2|refseq:NP_871642.2|wormbase:C07A9.3a|wormbase:C07A9.3b|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensemblmetazoa:C07A9.3b.1(transcript)|ensemblmetazoa:WBGene00006579(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001672"(regulation of chromatin assembly or disassembly)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	refseq:NP_491714.1|wormbase:B0207.4|ensemblmetazoa:B0207.4.1(transcript)|ensemblmetazoa:WBGene00000099(gene)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031991"(regulation of actomyosin contractile ring contraction)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|dip:DIP-25477N|reactome:R-CEL-8854050	-	-	-	figure legend:See Supplement, paragraph 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/04/19	2014/10/16	rogid:sgyTsvp1Bpkku4LjjrDYEfurnHU6239	rogid:YZlndh7GD6pSNdkb4miBUf335Sc6239	intact-crc:745D777DBB20DBE9|rigid:ba2tHtx8Vw8ZJIikEcB9L7Mn/6k	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O01427	uniprotkb:P34314	intact:EBI-312947|ensemblmetazoa:B0207.4.1	intact:EBI-3890382|uniprotkb:P34323|uniprotkb:Q6SSJ1|uniprotkb:Q8I4N0|ensemblmetazoa:C07A9.3b.1	psi-mi:air2_caeel(display_long)|uniprotkb:stu-7(gene name synonym)|uniprotkb:B0207.4(orf name)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)|uniprotkb:air-2(gene name)|psi-mi:air-2(display_short)	psi-mi:tlk1_caeel(display_long)|uniprotkb:tlk-1(gene name)|psi-mi:tlk-1(display_short)|uniprotkb:Tousled-like kinase 1(gene name synonym)|uniprotkb:C07A9.3(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Han et al. (2005)	pubmed:15916946|imex:IM-17180	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3890381|imex:IM-17180-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_491714.1|wormbase:B0207.4|ensemblmetazoa:B0207.4.1(transcript)|ensemblmetazoa:WBGene00000099(gene)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031991"(regulation of actomyosin contractile ring contraction)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|dip:DIP-25477N|reactome:R-CEL-8854050	mint:P34314|refseq:NP_499145.2|refseq:NP_871642.2|wormbase:C07A9.3a|wormbase:C07A9.3b|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensemblmetazoa:C07A9.3b.1(transcript)|ensemblmetazoa:WBGene00006579(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001672"(regulation of chromatin assembly or disassembly)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	-	-	-	figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:6239(caeel-embryo)|taxid:6239(Caenorhabditis elegans embryo)	-	2011/04/19	2014/10/16	rogid:YZlndh7GD6pSNdkb4miBUf335Sc6239	rogid:sgyTsvp1Bpkku4LjjrDYEfurnHU6239	intact-crc:7BE83D209197D8FE|rigid:ba2tHtx8Vw8ZJIikEcB9L7Mn/6k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q19326	uniprotkb:P34314	intact:EBI-3890681|ensemblmetazoa:F10G7.3.1	intact:EBI-3890382|uniprotkb:P34323|uniprotkb:Q6SSJ1|uniprotkb:Q8I4N0|ensemblmetazoa:C07A9.3b.1	psi-mi:asf1_caeel(display_long)|uniprotkb:unc-85(gene name)|psi-mi:unc-85(display_short)|uniprotkb:Anti-silencing function protein 1(gene name synonym)|uniprotkb:asf-1(gene name synonym)|uniprotkb:F10G7.3(orf name)	psi-mi:tlk1_caeel(display_long)|uniprotkb:tlk-1(gene name)|psi-mi:tlk-1(display_short)|uniprotkb:Tousled-like kinase 1(gene name synonym)|uniprotkb:C07A9.3(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Han et al. (2005)	pubmed:15916946|imex:IM-17180	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3890651|imex:IM-17180-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR036747|refseq:NP_494837.2|wormbase:F10G7.3|interpro:IPR017282(Histone deposition protein Asf1)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|ensemblmetazoa:F10G7.3.1(transcript)|ensemblmetazoa:WBGene00006817(gene)|go:"GO:0005634"(nucleus)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016573"(histone acetylation)|go:"GO:0018991"(oviposition)|go:"GO:0042393"(histone binding)	mint:P34314|refseq:NP_499145.2|refseq:NP_871642.2|wormbase:C07A9.3a|wormbase:C07A9.3b|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensemblmetazoa:C07A9.3b.1(transcript)|ensemblmetazoa:WBGene00006579(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001672"(regulation of chromatin assembly or disassembly)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:Fig  4|resulting-ptm:Auto phosphorylation of TLK-1 and  phosphorylation of  ASF1 and MYBP.|comment:"TLK-1(S634E) protein showed consistently higher levels of kinase activity than TLK-1 or TLK-1(S634A). ASF-1 phosphorylation was increased when AIR-2/ICP-1 was added to TLK-1."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/04/19	2014/10/16	rogid:Niqref5aLt5WsSQSLUcRz5EVXTo6239	rogid:sgyTsvp1Bpkku4LjjrDYEfurnHU6239	intact-crc:E844E962882E0089|rigid:XfWJbUMdZkblD+BvlETKAXEQy8c	false	glutathione s tranferase tag:?-?	mutation increasing interaction:634-634|mutation increasing interaction:634-634|tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O01427	uniprotkb:G5EE37	intact:EBI-312947|ensemblmetazoa:B0207.4.1	intact:EBI-312981|ensemblmetazoa:Y39G10AR.13a.1|ensemblmetazoa:Y39G10AR.13a.2	psi-mi:air2_caeel(display_long)|uniprotkb:stu-7(gene name synonym)|uniprotkb:B0207.4(orf name)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)|uniprotkb:air-2(gene name)|psi-mi:air-2(display_short)	psi-mi:g5ee37_caeel(display_long)|uniprotkb:icp-1(gene name)|psi-mi:icp-1(display_short)|uniprotkb:Y39G10AR.13(orf name)|uniprotkb:CELE_Y39G10AR.13(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Han et al. (2005)	pubmed:15916946|imex:IM-17180	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3890410|imex:IM-17180-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_491714.1|wormbase:B0207.4|ensemblmetazoa:B0207.4.1(transcript)|ensemblmetazoa:WBGene00000099(gene)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031991"(regulation of actomyosin contractile ring contraction)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|dip:DIP-25477N|reactome:R-CEL-8854050	uniprotkb:Q9GSQ0(uniprot-removed-ac)|wormbase:Y39G10AR.13a|interpro:IPR039130|ensemblmetazoa:WBGene00002047(gene)|ensemblmetazoa:Y39G10AR.13a.1(transcript)|ensemblmetazoa:Y39G10AR.13a.2(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098813"(nuclear chromosome segregation)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|refseq:NP_490956.1	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:Fig  2A,  lane 2|resulting-ptm:autophosphorylation of AIR-2 and phosphorylation of ICP-1.|comment:"A marked increase in AIR-2 autophosphorylation and ICP-1 phosphorylation was seen in kinase reactions with all three fusion proteins (AIR-2, ICP-1, and TLK-1KD)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/04/19	2014/10/16	rogid:YZlndh7GD6pSNdkb4miBUf335Sc6239	rogid:wOoAvytoIzGSkKwLIoJM+rc5pa46239	intact-crc:A7B3280DD8DD774D|rigid:qX4VLERR0c2nNfCAldASS6sMyQs	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O01427	uniprotkb:G5EE37	intact:EBI-312947|ensemblmetazoa:B0207.4.1	intact:EBI-312981|ensemblmetazoa:Y39G10AR.13a.1|ensemblmetazoa:Y39G10AR.13a.2	psi-mi:air2_caeel(display_long)|uniprotkb:stu-7(gene name synonym)|uniprotkb:B0207.4(orf name)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)|uniprotkb:air-2(gene name)|psi-mi:air-2(display_short)	psi-mi:g5ee37_caeel(display_long)|uniprotkb:icp-1(gene name)|psi-mi:icp-1(display_short)|uniprotkb:Y39G10AR.13(orf name)|uniprotkb:CELE_Y39G10AR.13(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Han et al. (2005)	pubmed:15916946|imex:IM-17180	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3890486|imex:IM-17180-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_491714.1|wormbase:B0207.4|ensemblmetazoa:B0207.4.1(transcript)|ensemblmetazoa:WBGene00000099(gene)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031991"(regulation of actomyosin contractile ring contraction)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|dip:DIP-25477N|reactome:R-CEL-8854050	uniprotkb:Q9GSQ0(uniprot-removed-ac)|wormbase:Y39G10AR.13a|interpro:IPR039130|ensemblmetazoa:WBGene00002047(gene)|ensemblmetazoa:Y39G10AR.13a.1(transcript)|ensemblmetazoa:Y39G10AR.13a.2(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098813"(nuclear chromosome segregation)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|refseq:NP_490956.1	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:Fig  2A,  lane 4.  Fig 2D/E.|resulting-ptm:autophosphorylation of AIR-2 and phosphorylation of ICP-1 and TLK-1 KD.|caution:"\"TLK-1 KD\" has been entered as a D802A mutation, but this is not explicitly stated in the text."|comment:"A marked increase in AIR-2 autophosphorylation and ICP-1 phosphorylation was seen in kinase reactions with all three fusion proteins (AIR-2, ICP-1, and TLK-1KD)."|comment:"Mutation of TLK-1 Serine 634 to alanine (S634A) abolished AIR-2-mediated phosphorylation of TLK-1 fragment 454–650 (Figure 2E, lanes 2 and 3). However, the S634A mutation did not completely inhibit AIR-2 phosphorylation when incorporated into E. coli fusion proteins corresponding to full-length TLK-1."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/04/19	2014/10/16	rogid:YZlndh7GD6pSNdkb4miBUf335Sc6239	rogid:wOoAvytoIzGSkKwLIoJM+rc5pa46239	intact-crc:4304EA3538940DA5|rigid:znHoRkHJ234Ds9W7NuFcuyeeMAo	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O01427	uniprotkb:P34314	intact:EBI-312947|ensemblmetazoa:B0207.4.1	intact:EBI-3890382|uniprotkb:P34323|uniprotkb:Q6SSJ1|uniprotkb:Q8I4N0|ensemblmetazoa:C07A9.3b.1	psi-mi:air2_caeel(display_long)|uniprotkb:stu-7(gene name synonym)|uniprotkb:B0207.4(orf name)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)|uniprotkb:air-2(gene name)|psi-mi:air-2(display_short)	psi-mi:tlk1_caeel(display_long)|uniprotkb:tlk-1(gene name)|psi-mi:tlk-1(display_short)|uniprotkb:Tousled-like kinase 1(gene name synonym)|uniprotkb:C07A9.3(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Han et al. (2005)	pubmed:15916946|imex:IM-17180	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3890486|imex:IM-17180-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_491714.1|wormbase:B0207.4|ensemblmetazoa:B0207.4.1(transcript)|ensemblmetazoa:WBGene00000099(gene)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031991"(regulation of actomyosin contractile ring contraction)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|dip:DIP-25477N|reactome:R-CEL-8854050	mint:P34314|refseq:NP_499145.2|refseq:NP_871642.2|wormbase:C07A9.3a|wormbase:C07A9.3b|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensemblmetazoa:C07A9.3b.1(transcript)|ensemblmetazoa:WBGene00006579(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001672"(regulation of chromatin assembly or disassembly)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:Fig  2A,  lane 4.  Fig 2D/E.|resulting-ptm:autophosphorylation of AIR-2 and phosphorylation of ICP-1 and TLK-1 KD.|caution:"\"TLK-1 KD\" has been entered as a D802A mutation, but this is not explicitly stated in the text."|comment:"A marked increase in AIR-2 autophosphorylation and ICP-1 phosphorylation was seen in kinase reactions with all three fusion proteins (AIR-2, ICP-1, and TLK-1KD)."|comment:"Mutation of TLK-1 Serine 634 to alanine (S634A) abolished AIR-2-mediated phosphorylation of TLK-1 fragment 454–650 (Figure 2E, lanes 2 and 3). However, the S634A mutation did not completely inhibit AIR-2 phosphorylation when incorporated into E. coli fusion proteins corresponding to full-length TLK-1."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/04/19	2014/10/16	rogid:YZlndh7GD6pSNdkb4miBUf335Sc6239	rogid:sgyTsvp1Bpkku4LjjrDYEfurnHU6239	intact-crc:4304EA3538940DA5|rigid:znHoRkHJ234Ds9W7NuFcuyeeMAo	false	glutathione s tranferase tag:?-?	mutation decreasing interaction:634-634|maltose binding protein tag:?-?|mutation:802-802|sufficient binding region:454-650	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P34314	-	intact:EBI-3890382|uniprotkb:P34323|uniprotkb:Q6SSJ1|uniprotkb:Q8I4N0|ensemblmetazoa:C07A9.3b.1	-	psi-mi:tlk1_caeel(display_long)|uniprotkb:tlk-1(gene name)|psi-mi:tlk-1(display_short)|uniprotkb:Tousled-like kinase 1(gene name synonym)|uniprotkb:C07A9.3(orf name)	-	psi-mi:"MI:0424"(protein kinase assay)	Han et al. (2005)	pubmed:15916946|imex:IM-17180	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	-	psi-mi:"MI:0216"(palmitoylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3890720|imex:IM-17180-7	-	-	psi-mi:"MI:0503"(self)	-	psi-mi:"MI:0503"(self)	-	psi-mi:"MI:0326"(protein)	-	mint:P34314|refseq:NP_499145.2|refseq:NP_871642.2|wormbase:C07A9.3a|wormbase:C07A9.3b|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensemblmetazoa:C07A9.3b.1(transcript)|ensemblmetazoa:WBGene00006579(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001672"(regulation of chromatin assembly or disassembly)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	-	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:Fig  S1|resulting-ptm:Auto phosphorylation of TLK-1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/04/19	2014/10/16	rogid:sgyTsvp1Bpkku4LjjrDYEfurnHU6239	-	intact-crc:E5F3A33C3D476AF7	false	tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-
uniprotkb:O01427	uniprotkb:O01427	intact:EBI-312947|ensemblmetazoa:B0207.4.1	intact:EBI-312947|ensemblmetazoa:B0207.4.1	psi-mi:air2_caeel(display_long)|uniprotkb:stu-7(gene name synonym)|uniprotkb:B0207.4(orf name)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)|uniprotkb:air-2(gene name)|psi-mi:air-2(display_short)	psi-mi:air2_caeel(display_long)|uniprotkb:stu-7(gene name synonym)|uniprotkb:B0207.4(orf name)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)|uniprotkb:air-2(gene name)|psi-mi:air-2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Han et al. (2005)	pubmed:15916946|imex:IM-17180	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3890398|imex:IM-17180-2	-	-	psi-mi:"MI:0503"(self)	psi-mi:"MI:0503"(self)	psi-mi:"MI:0503"(self)	psi-mi:"MI:0503"(self)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_491714.1|wormbase:B0207.4|ensemblmetazoa:B0207.4.1(transcript)|ensemblmetazoa:WBGene00000099(gene)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031991"(regulation of actomyosin contractile ring contraction)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|dip:DIP-25477N|reactome:R-CEL-8854050	refseq:NP_491714.1|wormbase:B0207.4|ensemblmetazoa:B0207.4.1(transcript)|ensemblmetazoa:WBGene00000099(gene)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031991"(regulation of actomyosin contractile ring contraction)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|dip:DIP-25477N|reactome:R-CEL-8854050	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:Fig  2A|resulting-ptm:autophosphorylation|comment:"A marked increase in AIR-2 autophosphorylation and ICP-1 phosphorylation was seen in kinase reactions with all three fusion proteins (AIR-2, ICP-1, and TLK-1KD)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/04/19	2014/10/16	rogid:YZlndh7GD6pSNdkb4miBUf335Sc6239	rogid:YZlndh7GD6pSNdkb4miBUf335Sc6239	intact-crc:0E6D4009983240CF|rigid:vKsizfkHgmJMMcsKd3+LjM9yqUM	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)