#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P20650 uniprotkb:O00555 intact:EBI-7491743|intact:MINT-4588994 intact:EBI-766279|uniprotkb:P78510|uniprotkb:P78511|uniprotkb:Q16290|uniprotkb:Q92690|uniprotkb:Q99790|uniprotkb:Q99791|uniprotkb:Q99792|uniprotkb:Q99793|uniprotkb:Q9UDC4|uniprotkb:J3KP41|uniprotkb:Q9NS88|intact:EBI-28985658|ensembl:ENSP00000353362 psi-mi:ppm1a_rat(display_long)|uniprotkb:Ppm1a(gene name)|psi-mi:Ppm1a(display_short)|uniprotkb:Pp2c1(gene name synonym)|uniprotkb:Pppm1a(gene name synonym)|uniprotkb:Protein phosphatase 2C isoform alpha(gene name synonym)|uniprotkb:Protein phosphatase IA(gene name synonym) psi-mi:cac1a_human(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.1(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 4(gene name synonym)|uniprotkb:Brain calcium channel I(gene name synonym)|uniprotkb:CACNA1A(gene name)|psi-mi:CACNA1A(display_short)|uniprotkb:CACH4(gene name synonym)|uniprotkb:CACN3(gene name synonym)|uniprotkb:CACNL1A4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Li et al. (2005) pubmed:15728831|mint:MINT-8277087|doi:10.1523/JNEUROSCI.4790-04.2005 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7491738|mint:MINT-8277288 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P20650|interpro:IPR036457|interpro:IPR036580|refseq:NP_058734.1|rgd:3373|refseq:XP_017449523.1|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|reactome:R-RNO-2173795|reactome:R-RNO-380972|go:"GO:0030145"(manganese ion binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR012911(Protein serine/threonine phosphatase 2C, C-terminal)|mint:MINT-8277290(identity) refseq:NP_001120693.1|refseq:NP_001120694.1|refseq:NP_001167551.1|refseq:NP_000059.3|refseq:NP_075461.2|ensembl:ENSP00000353362|ensembl:ENST00000637276|ensembl:ENSP00000489777|ensembl:ENST00000637432|ensembl:ENSP00000490617|ensembl:ENST00000638009|ensembl:ENSP00000489913|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005448(Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|go:"GO:0008219"(cell death)|interpro:IPR031649|rcsb pdb:3BXK|reactome:R-HSA-422356|reactome:R-HSA-112308|ensembl:ENSG00000141837(gene)|ensembl:ENST00000360228(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|mint:MINT-8277298(identity) - comment:mint|comment:homomint|function:Enzyme with a broad specificity - figure legend:f1b|comment:homomint|comment:mint|partial coverage:partial coverage taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/10/24 2018/09/18 rogid:4JTebFCZCV40HIPCRf8kcA71JMk10116 rogid:0zgBInaSveIMJzCcuCc46+jv2QY9606 intact-crc:0F77D2462E522B95|rigid:vx3tJTkcA4B4iUHA3NXJcz/wUHU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P20650 uniprotkb:Q01815 intact:EBI-7491743|intact:MINT-4588994 intact:EBI-644904|uniprotkb:Q04476|uniprotkb:Q61242|uniprotkb:Q99242|ensembl:ENSMUSP00000075021|ensembl:ENSMUSP00000077433 psi-mi:ppm1a_rat(display_long)|uniprotkb:Ppm1a(gene name)|psi-mi:Ppm1a(display_short)|uniprotkb:Pp2c1(gene name synonym)|uniprotkb:Pppm1a(gene name synonym)|uniprotkb:Protein phosphatase 2C isoform alpha(gene name synonym)|uniprotkb:Protein phosphatase IA(gene name synonym) psi-mi:cac1c_mouse(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)|uniprotkb:Mouse brain class C(gene name synonym)|uniprotkb:MELC-CC(gene name synonym)|uniprotkb:Cacna1c(gene name)|psi-mi:Cacna1c(display_short)|uniprotkb:Cach2(gene name synonym)|uniprotkb:Cacn2(gene name synonym)|uniprotkb:Cacnl1a1(gene name synonym)|uniprotkb:Cchl1a1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Li et al. (2005) pubmed:15728831|mint:MINT-8277087|doi:10.1523/JNEUROSCI.4790-04.2005 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7491800|mint:MINT-8277391 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P20650|interpro:IPR036457|interpro:IPR036580|refseq:NP_058734.1|rgd:3373|refseq:XP_017449523.1|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|reactome:R-RNO-2173795|reactome:R-RNO-380972|go:"GO:0030145"(manganese ion binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR012911(Protein serine/threonine phosphatase 2C, C-terminal)|mint:MINT-8277393(identity) refseq:NP_001153005.1|ensembl:ENSMUSG00000051331(gene)|ensembl:ENSMUST00000075591(transcript)|ensembl:ENSMUST00000078320(transcript)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007507"(heart development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030073"(insulin secretion)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086065"(cell communication involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1905030"(voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|reactome:R-MMU-422356|reactome:R-MMU-5576892|reactome:R-MMU-5576893|dip:DIP-32232N|mint:MINT-8277395(identity) - comment:mint|comment:homomint|function:Enzyme with a broad specificity - figure legend:f1b|comment:homomint|comment:mint|partial coverage:partial coverage taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/10/24 2014/10/16 rogid:4JTebFCZCV40HIPCRf8kcA71JMk10116 rogid:fl3WWY9hkShz2t1DpMRNX0t2OgU10090 intact-crc:7C8FF196A31271A2|rigid:YCp/L2/iEQXr2P4SlE0qf3vrBWQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P20650 uniprotkb:Q00975 intact:EBI-7491743|intact:MINT-4588994 intact:EBI-1055161|uniprotkb:B1AQK5|ensembl:ENSP00000360423 psi-mi:ppm1a_rat(display_long)|uniprotkb:Ppm1a(gene name)|psi-mi:Ppm1a(display_short)|uniprotkb:Pp2c1(gene name synonym)|uniprotkb:Pppm1a(gene name synonym)|uniprotkb:Protein phosphatase 2C isoform alpha(gene name synonym)|uniprotkb:Protein phosphatase IA(gene name synonym) psi-mi:cac1b_human(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 5(gene name synonym)|uniprotkb:Brain calcium channel III(gene name synonym)|uniprotkb:CACNA1B(gene name)|psi-mi:CACNA1B(display_short)|uniprotkb:CACH5(gene name synonym)|uniprotkb:CACNL1A5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Li et al. (2005) pubmed:15728831|mint:MINT-8277087|doi:10.1523/JNEUROSCI.4790-04.2005 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7491789|mint:MINT-8277371 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P20650|interpro:IPR036457|interpro:IPR036580|refseq:NP_058734.1|rgd:3373|refseq:XP_017449523.1|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|reactome:R-RNO-2173795|reactome:R-RNO-380972|go:"GO:0030145"(manganese ion binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR012911(Protein serine/threonine phosphatase 2C, C-terminal)|mint:MINT-8277373(identity) refseq:NP_000709.1|refseq:NP_001230741.1|ensembl:ENSG00000148408(gene)|ensembl:ENST00000371372(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0045202"(synapse)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:1904645"(response to amyloid-beta)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005447(Voltage-dependent calcium channel, N-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR043203|rcsb pdb:2LCM|reactome:R-HSA-112308|mint:MINT-8277375(identity) - comment:mint|comment:homomint|function:Enzyme with a broad specificity - figure legend:f1b|comment:homomint|comment:mint|partial coverage:partial coverage taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/10/24 2014/10/16 rogid:4JTebFCZCV40HIPCRf8kcA71JMk10116 rogid:R7OVT/57HywIdiczIgCa+cjqifA9606 intact-crc:D24C3562DD9B4F9B|rigid:WEz5RG3H1+/LRbQDYHeFm5oRrgk false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P20650 uniprotkb:Q00975 intact:EBI-7491743|intact:MINT-4588994 intact:EBI-1055161|uniprotkb:B1AQK5|ensembl:ENSP00000360423 psi-mi:ppm1a_rat(display_long)|uniprotkb:Ppm1a(gene name)|psi-mi:Ppm1a(display_short)|uniprotkb:Pp2c1(gene name synonym)|uniprotkb:Pppm1a(gene name synonym)|uniprotkb:Protein phosphatase 2C isoform alpha(gene name synonym)|uniprotkb:Protein phosphatase IA(gene name synonym) psi-mi:cac1b_human(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 5(gene name synonym)|uniprotkb:Brain calcium channel III(gene name synonym)|uniprotkb:CACNA1B(gene name)|psi-mi:CACNA1B(display_short)|uniprotkb:CACH5(gene name synonym)|uniprotkb:CACNL1A5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Li et al. (2005) pubmed:15728831|mint:MINT-8277087|doi:10.1523/JNEUROSCI.4790-04.2005 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7491811|mint:MINT-8277559 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P20650|interpro:IPR036457|interpro:IPR036580|refseq:NP_058734.1|rgd:3373|refseq:XP_017449523.1|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|reactome:R-RNO-2173795|reactome:R-RNO-380972|go:"GO:0030145"(manganese ion binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR012911(Protein serine/threonine phosphatase 2C, C-terminal)|mint:MINT-8277561(identity) refseq:NP_000709.1|refseq:NP_001230741.1|ensembl:ENSG00000148408(gene)|ensembl:ENST00000371372(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0045202"(synapse)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:1904645"(response to amyloid-beta)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005447(Voltage-dependent calcium channel, N-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR043203|rcsb pdb:2LCM|reactome:R-HSA-112308|mint:MINT-8277563(identity) - comment:mint|comment:homomint|function:Enzyme with a broad specificity - figure legend:f6a|comment:homomint|comment:mint|partial coverage:partial coverage taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/10/24 2014/10/16 rogid:4JTebFCZCV40HIPCRf8kcA71JMk10116 rogid:R7OVT/57HywIdiczIgCa+cjqifA9606 intact-crc:BF7A3F3F645968D0|rigid:WEz5RG3H1+/LRbQDYHeFm5oRrgk false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P20650 uniprotkb:Q00975 intact:EBI-7491743|intact:MINT-4588994 intact:EBI-1055161|uniprotkb:B1AQK5|ensembl:ENSP00000360423 psi-mi:ppm1a_rat(display_long)|uniprotkb:Ppm1a(gene name)|psi-mi:Ppm1a(display_short)|uniprotkb:Pp2c1(gene name synonym)|uniprotkb:Pppm1a(gene name synonym)|uniprotkb:Protein phosphatase 2C isoform alpha(gene name synonym)|uniprotkb:Protein phosphatase IA(gene name synonym) psi-mi:cac1b_human(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 5(gene name synonym)|uniprotkb:Brain calcium channel III(gene name synonym)|uniprotkb:CACNA1B(gene name)|psi-mi:CACNA1B(display_short)|uniprotkb:CACH5(gene name synonym)|uniprotkb:CACNL1A5(gene name synonym) psi-mi:"MI:0434"(phosphatase assay) Li et al. (2005) pubmed:15728831|mint:MINT-8277087|doi:10.1523/JNEUROSCI.4790-04.2005 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0203"(dephosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7491831|mint:MINT-8277548 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P20650|interpro:IPR036457|interpro:IPR036580|refseq:NP_058734.1|rgd:3373|refseq:XP_017449523.1|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|reactome:R-RNO-2173795|reactome:R-RNO-380972|go:"GO:0030145"(manganese ion binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR012911(Protein serine/threonine phosphatase 2C, C-terminal)|mint:MINT-8277550(identity) refseq:NP_000709.1|refseq:NP_001230741.1|ensembl:ENSG00000148408(gene)|ensembl:ENST00000371372(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0045202"(synapse)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:1904645"(response to amyloid-beta)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005447(Voltage-dependent calcium channel, N-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR043203|rcsb pdb:2LCM|reactome:R-HSA-112308|mint:MINT-8277551(identity) - comment:mint|comment:homomint|function:Enzyme with a broad specificity comment:"Resulting Phenotypic qualities (properties)[PATO]: PATO:0002263 (dephosphorylated)" figure legend:f5|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/24 2014/10/16 rogid:4JTebFCZCV40HIPCRf8kcA71JMk10116 rogid:R7OVT/57HywIdiczIgCa+cjqifA9606 intact-crc:1C3B4596F11D5A3B|rigid:WEz5RG3H1+/LRbQDYHeFm5oRrgk false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)