#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05186	uniprotkb:Q13114	intact:EBI-1054354|uniprotkb:A1A4E7|uniprotkb:O75090|uniprotkb:Q2TAI7|uniprotkb:Q59EJ7|uniprotkb:Q5BKZ5|uniprotkb:Q5VTG5|uniprotkb:Q6NZI8|uniprotkb:Q8WU32|uniprotkb:Q9UBK0|uniprotkb:B7Z387|uniprotkb:B2RMP8|uniprotkb:B7Z4Y6|ensembl:ENSP00000363965|ensembl:ENSP00000363973	intact:EBI-357631|uniprotkb:Q12990|uniprotkb:Q13076|uniprotkb:Q13947|uniprotkb:Q6AZX1|uniprotkb:Q9UNL1|ensembl:ENSP00000376500|ensembl:ENSP00000454207|uniprotkb:B7Z8C4	psi-mi:ppbt_human(display_long)|uniprotkb:Alkaline phosphatase liver/bone/kidney isozyme(gene name synonym)|uniprotkb:ALPL(gene name)|psi-mi:ALPL(display_short)|uniprotkb:Phosphoamidase(gene name synonym)|uniprotkb:Phosphocreatine phosphatase(gene name synonym)	psi-mi:traf3_human(display_long)|uniprotkb:TRAF3(gene name)|psi-mi:TRAF3(display_short)|uniprotkb:CAP1(gene name synonym)|uniprotkb:CRAF1(gene name synonym)|uniprotkb:CD40 receptor-associated factor 1(gene name synonym)|uniprotkb:CD40-binding protein(gene name synonym)|uniprotkb:LMP1-associated protein 1(gene name synonym)|uniprotkb:CAP-1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2004)	pubmed:15208311|mint:MINT-8216271|doi:10.1074/jbc.M405699200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7206953|mint:MINT-8216310	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000469.3|refseq:NP_001120973.2|refseq:NP_001170991.1|refseq:XP_005245875.1|refseq:XP_006710609.1|ensembl:ENSG00000162551(gene)|ensembl:ENST00000374832(transcript)|ensembl:ENST00000374840(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016462"(pyrophosphatase activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033280"(response to vitamin D)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071529"(cementum mineralization)|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR018299|reactome:R-HSA-163125|mint:MINT-8216313(identity)	ensembl:ENSG00000131323(gene)|ensembl:ENST00000392745(transcript)|ensembl:ENST00000560371(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|refseq:NP_001186356.1|refseq:NP_003291.2|refseq:NP_663777.1|refseq:NP_663778.1|go:"GO:0007165"(signal transduction)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027128|interpro:IPR037304|interpro:IPR043211|mint:Q13114|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:1FLK|rcsb pdb:1FLL|rcsb pdb:1L0A|rcsb pdb:1RF3|rcsb pdb:1ZMS|rcsb pdb:2ECY|rcsb pdb:2GKW|rcsb pdb:1KZZ|refseq:XP_011535420.1|reactome:R-HSA-5668541|reactome:R-HSA-5676594|reactome:R-HSA-5689896|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-5602571|refseq:XP_016877106.1|refseq:XP_016877107.1|dip:DIP-6222N|mint:MINT-8216312(identity)	-	-	-	comment:homomint|comment:mint|figure legend:fig2|curation depth:rapid curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2011/10/13	2014/10/16	rogid:iO0/TZ5yjqLOEZWp673XGt02mnI9606	rogid:9Tjx/USypDBBrPVyFOsLzM/bwzA9606	intact-crc:00A31C0CE4CABE8F|rigid:6MVAY1BhSHqHrx6Y2O4huy7tWfs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12933	uniprotkb:P05186	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	intact:EBI-1054354|uniprotkb:A1A4E7|uniprotkb:O75090|uniprotkb:Q2TAI7|uniprotkb:Q59EJ7|uniprotkb:Q5BKZ5|uniprotkb:Q5VTG5|uniprotkb:Q6NZI8|uniprotkb:Q8WU32|uniprotkb:Q9UBK0|uniprotkb:B7Z387|uniprotkb:B2RMP8|uniprotkb:B7Z4Y6|ensembl:ENSP00000363965|ensembl:ENSP00000363973	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:ppbt_human(display_long)|uniprotkb:Alkaline phosphatase liver/bone/kidney isozyme(gene name synonym)|uniprotkb:ALPL(gene name)|psi-mi:ALPL(display_short)|uniprotkb:Phosphoamidase(gene name synonym)|uniprotkb:Phosphocreatine phosphatase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2004)	pubmed:15208311|mint:MINT-8216271|doi:10.1074/jbc.M405699200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7206962|mint:MINT-8216320	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N|mint:MINT-8216323(identity)	refseq:NP_000469.3|refseq:NP_001120973.2|refseq:NP_001170991.1|refseq:XP_005245875.1|refseq:XP_006710609.1|ensembl:ENSG00000162551(gene)|ensembl:ENST00000374832(transcript)|ensembl:ENST00000374840(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016462"(pyrophosphatase activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033280"(response to vitamin D)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071529"(cementum mineralization)|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR018299|reactome:R-HSA-163125|mint:MINT-8216322(identity)	-	-	-	comment:homomint|comment:mint|figure legend:fig2|curation depth:rapid curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2011/10/13	2014/10/16	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	rogid:iO0/TZ5yjqLOEZWp673XGt02mnI9606	intact-crc:5467C5B13CF8B70F|rigid:anmnCw9djrxuKadtJAx2TVvskk4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99558	uniprotkb:P05186	intact:EBI-358011|uniprotkb:Q8IYN1|uniprotkb:A8K2D8|uniprotkb:D3DX67|ensembl:ENSP00000478552|ensembl:ENSP00000480974|ensembl:ENSP00000482657	intact:EBI-1054354|uniprotkb:A1A4E7|uniprotkb:O75090|uniprotkb:Q2TAI7|uniprotkb:Q59EJ7|uniprotkb:Q5BKZ5|uniprotkb:Q5VTG5|uniprotkb:Q6NZI8|uniprotkb:Q8WU32|uniprotkb:Q9UBK0|uniprotkb:B7Z387|uniprotkb:B2RMP8|uniprotkb:B7Z4Y6|ensembl:ENSP00000363965|ensembl:ENSP00000363973	psi-mi:m3k14_human(display_long)|uniprotkb:MAP3K14(gene name)|psi-mi:MAP3K14(display_short)|uniprotkb:NIK(gene name synonym)|uniprotkb:Serine/threonine-protein kinase NIK(gene name synonym)|uniprotkb:NF-kappa-beta-inducing kinase(gene name synonym)	psi-mi:ppbt_human(display_long)|uniprotkb:Alkaline phosphatase liver/bone/kidney isozyme(gene name synonym)|uniprotkb:ALPL(gene name)|psi-mi:ALPL(display_short)|uniprotkb:Phosphoamidase(gene name synonym)|uniprotkb:Phosphocreatine phosphatase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2004)	pubmed:15208311|mint:MINT-8216271|doi:10.1074/jbc.M405699200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7207016|mint:MINT-8216341	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003945.2|refseq:XP_011523743.1|dip:DIP-27522N|ensembl:ENSG00000006062(gene)|ensembl:ENST00000344686(transcript)|ensembl:ENST00000376926(transcript)|ensembl:ENST00000617331(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017425(Mitogen-activated protein kinase kinase kinase 14)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042787|mint:Q99558|rcsb pdb:4DN5|rcsb pdb:4G3D|rcsb pdb:4IDT|rcsb pdb:4IDV|rcsb pdb:6WPP|rcsb pdb:6Z1Q|rcsb pdb:6Z1T|reactome:R-HSA-389357|reactome:R-HSA-5607761|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5676594|mint:MINT-8216344(identity)	refseq:NP_000469.3|refseq:NP_001120973.2|refseq:NP_001170991.1|refseq:XP_005245875.1|refseq:XP_006710609.1|ensembl:ENSG00000162551(gene)|ensembl:ENST00000374832(transcript)|ensembl:ENST00000374840(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016462"(pyrophosphatase activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033280"(response to vitamin D)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071529"(cementum mineralization)|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR018299|reactome:R-HSA-163125|mint:MINT-8216343(identity)	-	-	-	comment:homomint|comment:mint|figure legend:fig2C|curation depth:rapid curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2011/10/13	2014/10/16	rogid:GBmoUEm+pGubNnnauGgKgMyeiqA9606	rogid:iO0/TZ5yjqLOEZWp673XGt02mnI9606	intact-crc:B98193EE9602633F|rigid:cz4Y0L6Sv7gU3KlrpoNJQwIXRD0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99558	uniprotkb:P05186	intact:EBI-358011|uniprotkb:Q8IYN1|uniprotkb:A8K2D8|uniprotkb:D3DX67|ensembl:ENSP00000478552|ensembl:ENSP00000480974|ensembl:ENSP00000482657	intact:EBI-1054354|uniprotkb:A1A4E7|uniprotkb:O75090|uniprotkb:Q2TAI7|uniprotkb:Q59EJ7|uniprotkb:Q5BKZ5|uniprotkb:Q5VTG5|uniprotkb:Q6NZI8|uniprotkb:Q8WU32|uniprotkb:Q9UBK0|uniprotkb:B7Z387|uniprotkb:B2RMP8|uniprotkb:B7Z4Y6|ensembl:ENSP00000363965|ensembl:ENSP00000363973	psi-mi:m3k14_human(display_long)|uniprotkb:MAP3K14(gene name)|psi-mi:MAP3K14(display_short)|uniprotkb:NIK(gene name synonym)|uniprotkb:Serine/threonine-protein kinase NIK(gene name synonym)|uniprotkb:NF-kappa-beta-inducing kinase(gene name synonym)	psi-mi:ppbt_human(display_long)|uniprotkb:Alkaline phosphatase liver/bone/kidney isozyme(gene name synonym)|uniprotkb:ALPL(gene name)|psi-mi:ALPL(display_short)|uniprotkb:Phosphoamidase(gene name synonym)|uniprotkb:Phosphocreatine phosphatase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2004)	pubmed:15208311|mint:MINT-8216271|doi:10.1074/jbc.M405699200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7206971|mint:MINT-8216325	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003945.2|refseq:XP_011523743.1|dip:DIP-27522N|ensembl:ENSG00000006062(gene)|ensembl:ENST00000344686(transcript)|ensembl:ENST00000376926(transcript)|ensembl:ENST00000617331(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017425(Mitogen-activated protein kinase kinase kinase 14)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042787|mint:Q99558|rcsb pdb:4DN5|rcsb pdb:4G3D|rcsb pdb:4IDT|rcsb pdb:4IDV|rcsb pdb:6WPP|rcsb pdb:6Z1Q|rcsb pdb:6Z1T|reactome:R-HSA-389357|reactome:R-HSA-5607761|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5676594|mint:MINT-8216328(identity)	refseq:NP_000469.3|refseq:NP_001120973.2|refseq:NP_001170991.1|refseq:XP_005245875.1|refseq:XP_006710609.1|ensembl:ENSG00000162551(gene)|ensembl:ENST00000374832(transcript)|ensembl:ENST00000374840(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016462"(pyrophosphatase activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033280"(response to vitamin D)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071529"(cementum mineralization)|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR018299|reactome:R-HSA-163125|mint:MINT-8216327(identity)	-	-	-	comment:homomint|comment:mint|figure legend:fig2|curation depth:rapid curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2011/10/13	2014/10/16	rogid:GBmoUEm+pGubNnnauGgKgMyeiqA9606	rogid:iO0/TZ5yjqLOEZWp673XGt02mnI9606	intact-crc:5909176F602B9CAE|rigid:cz4Y0L6Sv7gU3KlrpoNJQwIXRD0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99558	uniprotkb:P05186	intact:EBI-358011|uniprotkb:Q8IYN1|uniprotkb:A8K2D8|uniprotkb:D3DX67|ensembl:ENSP00000478552|ensembl:ENSP00000480974|ensembl:ENSP00000482657	intact:EBI-1054354|uniprotkb:A1A4E7|uniprotkb:O75090|uniprotkb:Q2TAI7|uniprotkb:Q59EJ7|uniprotkb:Q5BKZ5|uniprotkb:Q5VTG5|uniprotkb:Q6NZI8|uniprotkb:Q8WU32|uniprotkb:Q9UBK0|uniprotkb:B7Z387|uniprotkb:B2RMP8|uniprotkb:B7Z4Y6|ensembl:ENSP00000363965|ensembl:ENSP00000363973	psi-mi:m3k14_human(display_long)|uniprotkb:MAP3K14(gene name)|psi-mi:MAP3K14(display_short)|uniprotkb:NIK(gene name synonym)|uniprotkb:Serine/threonine-protein kinase NIK(gene name synonym)|uniprotkb:NF-kappa-beta-inducing kinase(gene name synonym)	psi-mi:ppbt_human(display_long)|uniprotkb:Alkaline phosphatase liver/bone/kidney isozyme(gene name synonym)|uniprotkb:ALPL(gene name)|psi-mi:ALPL(display_short)|uniprotkb:Phosphoamidase(gene name synonym)|uniprotkb:Phosphocreatine phosphatase(gene name synonym)	psi-mi:"MI:0401"(biochemical)	Hu et al. (2004)	pubmed:15208311|mint:MINT-8216271|doi:10.1074/jbc.M405699200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7207033|mint:MINT-8216333	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003945.2|refseq:XP_011523743.1|dip:DIP-27522N|ensembl:ENSG00000006062(gene)|ensembl:ENST00000344686(transcript)|ensembl:ENST00000376926(transcript)|ensembl:ENST00000617331(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017425(Mitogen-activated protein kinase kinase kinase 14)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042787|mint:Q99558|rcsb pdb:4DN5|rcsb pdb:4G3D|rcsb pdb:4IDT|rcsb pdb:4IDV|rcsb pdb:6WPP|rcsb pdb:6Z1Q|rcsb pdb:6Z1T|reactome:R-HSA-389357|reactome:R-HSA-5607761|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5676594|mint:MINT-8216336(identity)	refseq:NP_000469.3|refseq:NP_001120973.2|refseq:NP_001170991.1|refseq:XP_005245875.1|refseq:XP_006710609.1|ensembl:ENSG00000162551(gene)|ensembl:ENST00000374832(transcript)|ensembl:ENST00000374840(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016462"(pyrophosphatase activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033280"(response to vitamin D)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071529"(cementum mineralization)|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR018299|reactome:R-HSA-163125|mint:MINT-8216335(identity)	-	-	-	comment:homomint|comment:mint|figure legend:fig.2|curation depth:rapid curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/13	2014/10/16	rogid:GBmoUEm+pGubNnnauGgKgMyeiqA9606	rogid:iO0/TZ5yjqLOEZWp673XGt02mnI9606	intact-crc:2E7232C22D50C92D|rigid:cz4Y0L6Sv7gU3KlrpoNJQwIXRD0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05186	uniprotkb:Q99558	intact:EBI-1054354|uniprotkb:A1A4E7|uniprotkb:O75090|uniprotkb:Q2TAI7|uniprotkb:Q59EJ7|uniprotkb:Q5BKZ5|uniprotkb:Q5VTG5|uniprotkb:Q6NZI8|uniprotkb:Q8WU32|uniprotkb:Q9UBK0|uniprotkb:B7Z387|uniprotkb:B2RMP8|uniprotkb:B7Z4Y6|ensembl:ENSP00000363965|ensembl:ENSP00000363973	intact:EBI-358011|uniprotkb:Q8IYN1|uniprotkb:A8K2D8|uniprotkb:D3DX67|ensembl:ENSP00000478552|ensembl:ENSP00000480974|ensembl:ENSP00000482657	psi-mi:ppbt_human(display_long)|uniprotkb:Alkaline phosphatase liver/bone/kidney isozyme(gene name synonym)|uniprotkb:ALPL(gene name)|psi-mi:ALPL(display_short)|uniprotkb:Phosphoamidase(gene name synonym)|uniprotkb:Phosphocreatine phosphatase(gene name synonym)	psi-mi:m3k14_human(display_long)|uniprotkb:MAP3K14(gene name)|psi-mi:MAP3K14(display_short)|uniprotkb:NIK(gene name synonym)|uniprotkb:Serine/threonine-protein kinase NIK(gene name synonym)|uniprotkb:NF-kappa-beta-inducing kinase(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Hu et al. (2004)	pubmed:15208311|mint:MINT-8216271|doi:10.1074/jbc.M405699200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7207050|mint:MINT-8216353	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000469.3|refseq:NP_001120973.2|refseq:NP_001170991.1|refseq:XP_005245875.1|refseq:XP_006710609.1|ensembl:ENSG00000162551(gene)|ensembl:ENST00000374832(transcript)|ensembl:ENST00000374840(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016462"(pyrophosphatase activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033280"(response to vitamin D)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071529"(cementum mineralization)|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR018299|reactome:R-HSA-163125|mint:MINT-8216355(identity)	refseq:NP_003945.2|refseq:XP_011523743.1|dip:DIP-27522N|ensembl:ENSG00000006062(gene)|ensembl:ENST00000344686(transcript)|ensembl:ENST00000376926(transcript)|ensembl:ENST00000617331(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017425(Mitogen-activated protein kinase kinase kinase 14)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042787|mint:Q99558|rcsb pdb:4DN5|rcsb pdb:4G3D|rcsb pdb:4IDT|rcsb pdb:4IDV|rcsb pdb:6WPP|rcsb pdb:6Z1Q|rcsb pdb:6Z1T|reactome:R-HSA-389357|reactome:R-HSA-5607761|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5676594|mint:MINT-8216356(identity)	-	-	-	comment:homomint|comment:mint|figure legend:fig.2D|curation depth:rapid curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2011/10/13	2014/10/16	rogid:iO0/TZ5yjqLOEZWp673XGt02mnI9606	rogid:GBmoUEm+pGubNnnauGgKgMyeiqA9606	intact-crc:76E78B653D9967DE|rigid:cz4Y0L6Sv7gU3KlrpoNJQwIXRD0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)