#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8C078 uniprotkb:P49593 intact:EBI-937199|uniprotkb:Q80TS0|uniprotkb:Q8BXM8|uniprotkb:Q8C0G3|uniprotkb:Q8CH42|uniprotkb:Q8QZT7|ensembl:ENSMUSP00000107297 intact:EBI-719945|uniprotkb:Q96PM2|uniprotkb:A8K6G3|uniprotkb:B7Z2C3|ensembl:ENSP00000263212 psi-mi:kkcc2_mouse(display_long)|uniprotkb:Camkk2(gene name)|psi-mi:Camkk2(display_short)|uniprotkb:Kiaa0787(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase kinase beta(gene name synonym) psi-mi:ppm1f_human(display_long)|uniprotkb:"Ca(2+)/calmodulin-dependent protein kinase phosphatase"(gene name synonym)|uniprotkb:Partner of PIX 2(gene name synonym)|uniprotkb:PPM1F(gene name)|psi-mi:PPM1F(display_short)|uniprotkb:KIAA0015(gene name synonym)|uniprotkb:POPX2(gene name synonym)|uniprotkb:Protein fem-2 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Harvey et al. (2004) pubmed:15140879|mint:MINT-8215514|doi:10.1074/jbc.M400656200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7182724|mint:MINT-8215567 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186605.1|refseq:NP_663333.1|refseq:XP_006530293.1|refseq:XP_006530294.1|refseq:XP_017176252.1|ensembl:ENSMUSG00000029471(gene)|ensembl:ENSMUST00000111668(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q8C078|reactome:R-MMU-111932|reactome:R-MMU-442729|reactome:R-MMU-9619229|mint:MINT-8215570(identity) refseq:NP_055449.1|ensembl:ENSG00000100034(gene)|ensembl:ENST00000263212(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035690"|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903827"|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:P49593|reactome:R-HSA-9617324|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|mint:MINT-8215569(identity) - comment:- - comment:homomint|comment:mint|figure legend:t1 f5|partial coverage:partial coverage|curation depth:rapid curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/10/13 2014/10/16 rogid:sfp+8Ypk+JBYWVwzYsGqAXqZVTY10090 rogid:G2Zr0KQjJ8rebVMjL+Wf+OuY6rU9606 intact-crc:BCBFDDED84FE4069|rigid:qcAcRBZyUePoCTm9LEA0GIb2a4E false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8C078 uniprotkb:P49593 intact:EBI-937199|uniprotkb:Q80TS0|uniprotkb:Q8BXM8|uniprotkb:Q8C0G3|uniprotkb:Q8CH42|uniprotkb:Q8QZT7|ensembl:ENSMUSP00000107297 intact:EBI-719945|uniprotkb:Q96PM2|uniprotkb:A8K6G3|uniprotkb:B7Z2C3|ensembl:ENSP00000263212 psi-mi:kkcc2_mouse(display_long)|uniprotkb:Camkk2(gene name)|psi-mi:Camkk2(display_short)|uniprotkb:Kiaa0787(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase kinase beta(gene name synonym) psi-mi:ppm1f_human(display_long)|uniprotkb:"Ca(2+)/calmodulin-dependent protein kinase phosphatase"(gene name synonym)|uniprotkb:Partner of PIX 2(gene name synonym)|uniprotkb:PPM1F(gene name)|psi-mi:PPM1F(display_short)|uniprotkb:KIAA0015(gene name synonym)|uniprotkb:POPX2(gene name synonym)|uniprotkb:Protein fem-2 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Harvey et al. (2004) pubmed:15140879|mint:MINT-8215514|doi:10.1074/jbc.M400656200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7182749|mint:MINT-8215582 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186605.1|refseq:NP_663333.1|refseq:XP_006530293.1|refseq:XP_006530294.1|refseq:XP_017176252.1|ensembl:ENSMUSG00000029471(gene)|ensembl:ENSMUST00000111668(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q8C078|reactome:R-MMU-111932|reactome:R-MMU-442729|reactome:R-MMU-9619229|mint:MINT-8215585(identity) refseq:NP_055449.1|ensembl:ENSG00000100034(gene)|ensembl:ENST00000263212(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035690"|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903827"|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:P49593|reactome:R-HSA-9617324|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|mint:MINT-8215584(identity) - comment:- - comment:homomint|comment:mint|figure legend:t1 f5|partial coverage:partial coverage|curation depth:rapid curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/10/13 2014/10/16 rogid:sfp+8Ypk+JBYWVwzYsGqAXqZVTY10090 rogid:G2Zr0KQjJ8rebVMjL+Wf+OuY6rU9606 intact-crc:C714EA4FC95FCEA2|rigid:qcAcRBZyUePoCTm9LEA0GIb2a4E false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)