#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P34537	uniprotkb:P52478	intact:EBI-316712|uniprotkb:Q65ZS6|ensemblmetazoa:R05D3.4b.1	intact:EBI-316677|uniprotkb:O45062|ensemblmetazoa:C35B1.1.1	psi-mi:bre1_caeel(display_long)|uniprotkb:RING-type E3 ubiquitin transferase bre-1(gene name synonym)|uniprotkb:rfp-1(gene name)|psi-mi:rfp-1(display_short)|uniprotkb:RING finger protein rfp-1(gene name synonym)|uniprotkb:R05D3.4(orf name)|uniprotkb:bre-1(gene name synonym)	psi-mi:ubc1_caeel(display_long)|uniprotkb:E2 ubiquitin-conjugating enzyme 1(gene name synonym)|uniprotkb:ubc-1(gene name)|psi-mi:ubc-1(display_short)|uniprotkb:C35B1.1(orf name)|uniprotkb:Ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:Ubiquitin carrier protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Crowe et al. (2004)	pubmed:14732404|imex:IM-16838	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3891086|imex:IM-16838-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001022699.1|refseq:NP_001022700.1|wormbase:R05D3.4a|wormbase:R05D3.4b|ensemblmetazoa:R05D3.4b.1(transcript)|ensemblmetazoa:WBGene00007008(gene)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006664"(glycolipid metabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|dip:DIP-24823N	refseq:NP_500480.1|wormbase:C35B1.1|reactome:R-CEL-983168|ensemblmetazoa:C35B1.1.1(transcript)|ensemblmetazoa:WBGene00006701(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1Q34|rcsb pdb:1Z3D|reactome:R-CEL-8866652|dip:DIP-24573N	-	-	-	figure legend:Results Paragraph 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/04/20	2014/10/16	rogid:s/wdruXbSj8Ah8bVOiyXM+hDw/k6239	rogid:OTI0++csUG/MdPm/yWpcZjpg/UM6239	intact-crc:FEB390571AEA3780|rigid:b6kQZdAXUZivyTs9RyrZxlCFymE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P52478	uniprotkb:P91133	intact:EBI-316677|uniprotkb:O45062|ensemblmetazoa:C35B1.1.1	intact:EBI-3891064|ensemblmetazoa:C32E8.11.1	psi-mi:ubc1_caeel(display_long)|uniprotkb:E2 ubiquitin-conjugating enzyme 1(gene name synonym)|uniprotkb:ubc-1(gene name)|psi-mi:ubc-1(display_short)|uniprotkb:C35B1.1(orf name)|uniprotkb:Ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:Ubiquitin carrier protein 1(gene name synonym)	psi-mi:ubr1_caeel(display_long)|uniprotkb:ubr-1(gene name)|psi-mi:ubr-1(display_short)|uniprotkb:N-recognin-1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha(gene name synonym)|uniprotkb:C32E8.11(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ubr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Crowe et al. (2004)	pubmed:14732404|imex:IM-16838	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3891057|imex:IM-16838-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_500480.1|wormbase:C35B1.1|reactome:R-CEL-983168|ensemblmetazoa:C35B1.1.1(transcript)|ensemblmetazoa:WBGene00006701(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1Q34|rcsb pdb:1Z3D|reactome:R-CEL-8866652|dip:DIP-24573N	refseq:NP_491231.2|wormbase:C32E8.11|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR039164|reactome:R-CEL-983168|ensemblmetazoa:C32E8.11.1(transcript)|ensemblmetazoa:WBGene00016326(gene)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0043058"(regulation of backward locomotion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|go:"GO:2000212"(negative regulation of glutamate metabolic process)|interpro:IPR044046	-	-	-	figure legend:Results Paragraph 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/04/20	2014/10/16	rogid:OTI0++csUG/MdPm/yWpcZjpg/UM6239	rogid:riBxNfY2CdYFSijlYZDrJt1kJUQ6239	intact-crc:344D4647D932E60F|rigid:adMNhoU4T1zXmjrOlChnaVkFaEE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P34537	uniprotkb:P52478	intact:EBI-316712|uniprotkb:Q65ZS6|ensemblmetazoa:R05D3.4b.1	intact:EBI-316677|uniprotkb:O45062|ensemblmetazoa:C35B1.1.1	psi-mi:bre1_caeel(display_long)|uniprotkb:RING-type E3 ubiquitin transferase bre-1(gene name synonym)|uniprotkb:rfp-1(gene name)|psi-mi:rfp-1(display_short)|uniprotkb:RING finger protein rfp-1(gene name synonym)|uniprotkb:R05D3.4(orf name)|uniprotkb:bre-1(gene name synonym)	psi-mi:ubc1_caeel(display_long)|uniprotkb:E2 ubiquitin-conjugating enzyme 1(gene name synonym)|uniprotkb:ubc-1(gene name)|psi-mi:ubc-1(display_short)|uniprotkb:C35B1.1(orf name)|uniprotkb:Ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:Ubiquitin carrier protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Crowe et al. (2004)	pubmed:14732404|imex:IM-16838	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4303998|imex:IM-16838-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001022699.1|refseq:NP_001022700.1|wormbase:R05D3.4a|wormbase:R05D3.4b|ensemblmetazoa:R05D3.4b.1(transcript)|ensemblmetazoa:WBGene00007008(gene)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006664"(glycolipid metabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|dip:DIP-24823N	refseq:NP_500480.1|wormbase:C35B1.1|reactome:R-CEL-983168|ensemblmetazoa:C35B1.1.1(transcript)|ensemblmetazoa:WBGene00006701(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1Q34|rcsb pdb:1Z3D|reactome:R-CEL-8866652|dip:DIP-24573N	-	-	-	figure legend:Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/04/20	2014/10/16	rogid:s/wdruXbSj8Ah8bVOiyXM+hDw/k6239	rogid:OTI0++csUG/MdPm/yWpcZjpg/UM6239	intact-crc:726EA911BAD3D558|rigid:b6kQZdAXUZivyTs9RyrZxlCFymE	false	sufficient binding region:1-329	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P34537	uniprotkb:P52478	intact:EBI-316712|uniprotkb:Q65ZS6|ensemblmetazoa:R05D3.4b.1	intact:EBI-316677|uniprotkb:O45062|ensemblmetazoa:C35B1.1.1	psi-mi:bre1_caeel(display_long)|uniprotkb:RING-type E3 ubiquitin transferase bre-1(gene name synonym)|uniprotkb:rfp-1(gene name)|psi-mi:rfp-1(display_short)|uniprotkb:RING finger protein rfp-1(gene name synonym)|uniprotkb:R05D3.4(orf name)|uniprotkb:bre-1(gene name synonym)	psi-mi:ubc1_caeel(display_long)|uniprotkb:E2 ubiquitin-conjugating enzyme 1(gene name synonym)|uniprotkb:ubc-1(gene name)|psi-mi:ubc-1(display_short)|uniprotkb:C35B1.1(orf name)|uniprotkb:Ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:Ubiquitin carrier protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Crowe et al. (2004)	pubmed:14732404|imex:IM-16838	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4303990|imex:IM-16838-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001022699.1|refseq:NP_001022700.1|wormbase:R05D3.4a|wormbase:R05D3.4b|ensemblmetazoa:R05D3.4b.1(transcript)|ensemblmetazoa:WBGene00007008(gene)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006664"(glycolipid metabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|dip:DIP-24823N	refseq:NP_500480.1|wormbase:C35B1.1|reactome:R-CEL-983168|ensemblmetazoa:C35B1.1.1(transcript)|ensemblmetazoa:WBGene00006701(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1Q34|rcsb pdb:1Z3D|reactome:R-CEL-8866652|dip:DIP-24573N	-	-	-	figure legend:Fig 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:6239(caeel-non_gavid_adul)|taxid:6239(Caenorhabditis elegans non-gavid adult)	-	2011/04/20	2014/10/16	rogid:s/wdruXbSj8Ah8bVOiyXM+hDw/k6239	rogid:OTI0++csUG/MdPm/yWpcZjpg/UM6239	intact-crc:ED1F427D48EF271F|rigid:b6kQZdAXUZivyTs9RyrZxlCFymE	false	sufficient binding region:1-329|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)