#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35372	uniprotkb:P21333	intact:EBI-2624570|uniprotkb:B0FXJ1|uniprotkb:B8Q1L8|uniprotkb:B8Q1L9|uniprotkb:Q6UPP1|uniprotkb:Q86V80|uniprotkb:G8XRH8|uniprotkb:B2R9S7|uniprotkb:B8Q1L7|uniprotkb:Q12930|uniprotkb:Q4VWM1|uniprotkb:Q4VWM2|uniprotkb:Q4VWM3|uniprotkb:Q4VWM4|uniprotkb:Q4VWM6|uniprotkb:Q4VWX6|uniprotkb:Q5TDA1|uniprotkb:Q6UQ80|uniprotkb:Q7Z2D8|uniprotkb:Q8IWW3|uniprotkb:Q8IWW4|uniprotkb:Q9UCZ4|uniprotkb:Q9UN57|uniprotkb:G8XRH6|ensembl:ENSP00000328264|uniprotkb:E7EWZ3	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	psi-mi:oprm_human(display_long)|uniprotkb:OPRM1(gene name)|psi-mi:OPRM1(display_short)|uniprotkb:MOR1(gene name synonym)|uniprotkb:Mu opioid receptor(gene name synonym)|uniprotkb:Mu opiate receptor(gene name synonym)	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Onoprishvili et al. (2003)	pubmed:14573758	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-5321740	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272453.1|refseq:NP_001272455.1|refseq:NP_001272456.1|refseq:NP_001272457.1|refseq:NP_001138752.1|refseq:NP_001138753.1|refseq:NP_001272452.1|refseq:NP_000905.3|refseq:NP_001008503.2|refseq:NP_001008504.2|refseq:NP_001008505.2|refseq:NP_001138751.1|refseq:NP_001138754.1|refseq:NP_001138755.1|refseq:NP_001138756.1|refseq:NP_001138757.1|refseq:NP_001138758.1|refseq:NP_001138759.1|refseq:XP_016866395.1|ensembl:ENSG00000112038(gene)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|ensembl:ENST00000330432(transcript)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0042755"(eating behavior)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0005768"(endosome)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35372|reactome:R-HSA-111885|reactome:R-HSA-202040|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|reactome:R-HSA-418594|reactome:R-HSA-6785807|reactome:R-HSA-9022699|reactome:R-HSA-375276	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	-	-	-	figure legend:no figure|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|curation depth:mimix curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/12/19	2014/10/16	rogid:pfkhVhvpn9gSXiBRs1OBXJBCI3s9606	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	intact-crc:F49E643DEAD3E865|rigid:bsWRUPX95H/MccDRT7Cx2f5NLIA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35372	uniprotkb:P21333	intact:EBI-2624570|uniprotkb:B0FXJ1|uniprotkb:B8Q1L8|uniprotkb:B8Q1L9|uniprotkb:Q6UPP1|uniprotkb:Q86V80|uniprotkb:G8XRH8|uniprotkb:B2R9S7|uniprotkb:B8Q1L7|uniprotkb:Q12930|uniprotkb:Q4VWM1|uniprotkb:Q4VWM2|uniprotkb:Q4VWM3|uniprotkb:Q4VWM4|uniprotkb:Q4VWM6|uniprotkb:Q4VWX6|uniprotkb:Q5TDA1|uniprotkb:Q6UQ80|uniprotkb:Q7Z2D8|uniprotkb:Q8IWW3|uniprotkb:Q8IWW4|uniprotkb:Q9UCZ4|uniprotkb:Q9UN57|uniprotkb:G8XRH6|ensembl:ENSP00000328264|uniprotkb:E7EWZ3	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	psi-mi:oprm_human(display_long)|uniprotkb:OPRM1(gene name)|psi-mi:OPRM1(display_short)|uniprotkb:MOR1(gene name synonym)|uniprotkb:Mu opioid receptor(gene name synonym)|uniprotkb:Mu opiate receptor(gene name synonym)	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Onoprishvili et al. (2003)	pubmed:14573758	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-5328363	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272453.1|refseq:NP_001272455.1|refseq:NP_001272456.1|refseq:NP_001272457.1|refseq:NP_001138752.1|refseq:NP_001138753.1|refseq:NP_001272452.1|refseq:NP_000905.3|refseq:NP_001008503.2|refseq:NP_001008504.2|refseq:NP_001008505.2|refseq:NP_001138751.1|refseq:NP_001138754.1|refseq:NP_001138755.1|refseq:NP_001138756.1|refseq:NP_001138757.1|refseq:NP_001138758.1|refseq:NP_001138759.1|refseq:XP_016866395.1|ensembl:ENSG00000112038(gene)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|ensembl:ENST00000330432(transcript)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0042755"(eating behavior)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0005768"(endosome)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35372|reactome:R-HSA-111885|reactome:R-HSA-202040|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|reactome:R-HSA-418594|reactome:R-HSA-6785807|reactome:R-HSA-9022699|reactome:R-HSA-375276	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	-	-	-	figure legend:no figure|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|curation depth:mimix curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/12/19	2014/10/16	rogid:pfkhVhvpn9gSXiBRs1OBXJBCI3s9606	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	intact-crc:DB790C1A6AA74FF9|rigid:bsWRUPX95H/MccDRT7Cx2f5NLIA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21333	uniprotkb:P35372	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	intact:EBI-2624570|uniprotkb:B0FXJ1|uniprotkb:B8Q1L8|uniprotkb:B8Q1L9|uniprotkb:Q6UPP1|uniprotkb:Q86V80|uniprotkb:G8XRH8|uniprotkb:B2R9S7|uniprotkb:B8Q1L7|uniprotkb:Q12930|uniprotkb:Q4VWM1|uniprotkb:Q4VWM2|uniprotkb:Q4VWM3|uniprotkb:Q4VWM4|uniprotkb:Q4VWM6|uniprotkb:Q4VWX6|uniprotkb:Q5TDA1|uniprotkb:Q6UQ80|uniprotkb:Q7Z2D8|uniprotkb:Q8IWW3|uniprotkb:Q8IWW4|uniprotkb:Q9UCZ4|uniprotkb:Q9UN57|uniprotkb:G8XRH6|ensembl:ENSP00000328264|uniprotkb:E7EWZ3	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:oprm_human(display_long)|uniprotkb:OPRM1(gene name)|psi-mi:OPRM1(display_short)|uniprotkb:MOR1(gene name synonym)|uniprotkb:Mu opioid receptor(gene name synonym)|uniprotkb:Mu opiate receptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Onoprishvili et al. (2003)	pubmed:14573758	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-5321787	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	refseq:NP_001272453.1|refseq:NP_001272455.1|refseq:NP_001272456.1|refseq:NP_001272457.1|refseq:NP_001138752.1|refseq:NP_001138753.1|refseq:NP_001272452.1|refseq:NP_000905.3|refseq:NP_001008503.2|refseq:NP_001008504.2|refseq:NP_001008505.2|refseq:NP_001138751.1|refseq:NP_001138754.1|refseq:NP_001138755.1|refseq:NP_001138756.1|refseq:NP_001138757.1|refseq:NP_001138758.1|refseq:NP_001138759.1|refseq:XP_016866395.1|ensembl:ENSG00000112038(gene)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|ensembl:ENST00000330432(transcript)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0042755"(eating behavior)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0005768"(endosome)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35372|reactome:R-HSA-111885|reactome:R-HSA-202040|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|reactome:R-HSA-418594|reactome:R-HSA-6785807|reactome:R-HSA-9022699|reactome:R-HSA-375276	-	-	-	figure legend:2|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/12/19	2014/10/16	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	rogid:pfkhVhvpn9gSXiBRs1OBXJBCI3s9606	intact-crc:03867ED00AD6AA56|rigid:bsWRUPX95H/MccDRT7Cx2f5NLIA	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P21333	uniprotkb:P35372	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	intact:EBI-2624570|uniprotkb:B0FXJ1|uniprotkb:B8Q1L8|uniprotkb:B8Q1L9|uniprotkb:Q6UPP1|uniprotkb:Q86V80|uniprotkb:G8XRH8|uniprotkb:B2R9S7|uniprotkb:B8Q1L7|uniprotkb:Q12930|uniprotkb:Q4VWM1|uniprotkb:Q4VWM2|uniprotkb:Q4VWM3|uniprotkb:Q4VWM4|uniprotkb:Q4VWM6|uniprotkb:Q4VWX6|uniprotkb:Q5TDA1|uniprotkb:Q6UQ80|uniprotkb:Q7Z2D8|uniprotkb:Q8IWW3|uniprotkb:Q8IWW4|uniprotkb:Q9UCZ4|uniprotkb:Q9UN57|uniprotkb:G8XRH6|ensembl:ENSP00000328264|uniprotkb:E7EWZ3	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:oprm_human(display_long)|uniprotkb:OPRM1(gene name)|psi-mi:OPRM1(display_short)|uniprotkb:MOR1(gene name synonym)|uniprotkb:Mu opioid receptor(gene name synonym)|uniprotkb:Mu opiate receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Onoprishvili et al. (2003)	pubmed:14573758	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-5321816	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	refseq:NP_001272453.1|refseq:NP_001272455.1|refseq:NP_001272456.1|refseq:NP_001272457.1|refseq:NP_001138752.1|refseq:NP_001138753.1|refseq:NP_001272452.1|refseq:NP_000905.3|refseq:NP_001008503.2|refseq:NP_001008504.2|refseq:NP_001008505.2|refseq:NP_001138751.1|refseq:NP_001138754.1|refseq:NP_001138755.1|refseq:NP_001138756.1|refseq:NP_001138757.1|refseq:NP_001138758.1|refseq:NP_001138759.1|refseq:XP_016866395.1|ensembl:ENSG00000112038(gene)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|ensembl:ENST00000330432(transcript)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0042755"(eating behavior)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0005768"(endosome)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35372|reactome:R-HSA-111885|reactome:R-HSA-202040|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|reactome:R-HSA-418594|reactome:R-HSA-6785807|reactome:R-HSA-9022699|reactome:R-HSA-375276	-	-	-	figure legend:3|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/12/19	2014/10/16	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	rogid:pfkhVhvpn9gSXiBRs1OBXJBCI3s9606	intact-crc:585FF5D61F13ECA3|rigid:bsWRUPX95H/MccDRT7Cx2f5NLIA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35372	uniprotkb:P21333	intact:EBI-2624570|uniprotkb:B0FXJ1|uniprotkb:B8Q1L8|uniprotkb:B8Q1L9|uniprotkb:Q6UPP1|uniprotkb:Q86V80|uniprotkb:G8XRH8|uniprotkb:B2R9S7|uniprotkb:B8Q1L7|uniprotkb:Q12930|uniprotkb:Q4VWM1|uniprotkb:Q4VWM2|uniprotkb:Q4VWM3|uniprotkb:Q4VWM4|uniprotkb:Q4VWM6|uniprotkb:Q4VWX6|uniprotkb:Q5TDA1|uniprotkb:Q6UQ80|uniprotkb:Q7Z2D8|uniprotkb:Q8IWW3|uniprotkb:Q8IWW4|uniprotkb:Q9UCZ4|uniprotkb:Q9UN57|uniprotkb:G8XRH6|ensembl:ENSP00000328264|uniprotkb:E7EWZ3	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	psi-mi:oprm_human(display_long)|uniprotkb:OPRM1(gene name)|psi-mi:OPRM1(display_short)|uniprotkb:MOR1(gene name synonym)|uniprotkb:Mu opioid receptor(gene name synonym)|uniprotkb:Mu opiate receptor(gene name synonym)	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Onoprishvili et al. (2003)	pubmed:14573758	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-5328524	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272453.1|refseq:NP_001272455.1|refseq:NP_001272456.1|refseq:NP_001272457.1|refseq:NP_001138752.1|refseq:NP_001138753.1|refseq:NP_001272452.1|refseq:NP_000905.3|refseq:NP_001008503.2|refseq:NP_001008504.2|refseq:NP_001008505.2|refseq:NP_001138751.1|refseq:NP_001138754.1|refseq:NP_001138755.1|refseq:NP_001138756.1|refseq:NP_001138757.1|refseq:NP_001138758.1|refseq:NP_001138759.1|refseq:XP_016866395.1|ensembl:ENSG00000112038(gene)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|ensembl:ENST00000330432(transcript)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0042755"(eating behavior)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0005768"(endosome)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35372|reactome:R-HSA-111885|reactome:R-HSA-202040|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|reactome:R-HSA-418594|reactome:R-HSA-6785807|reactome:R-HSA-9022699|reactome:R-HSA-375276	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	-	-	-	figure legend:4|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|curation depth:mimix curation	taxid:9606(human-a7)|taxid:9606(Human A7 melanoma cell line)	-	2011/12/19	2014/10/16	rogid:pfkhVhvpn9gSXiBRs1OBXJBCI3s9606	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	intact-crc:3D34E1E8A54113CF|rigid:bsWRUPX95H/MccDRT7Cx2f5NLIA	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)