#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8CGU4	uniprotkb:P23385	intact:EBI-4409108|uniprotkb:Q9JHW8|ensembl:ENSRNOP00000029533	intact:EBI-4410410	psi-mi:agap2_rat(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:grm1_rat(display_long)|uniprotkb:Grm1(gene name)|psi-mi:Grm1(display_short)|uniprotkb:Gprc1a(gene name synonym)|uniprotkb:Mglur1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Rong et al. (2003)	pubmed:14528310|imex:IM-16888	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4410408|imex:IM-16888-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628844|refseq:NP_075415.2|ensembl:ENSRNOG00000025584(gene)|ensembl:ENSRNOT00000031230(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q8CGU4|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)	rgd:2742|refseq:NP_001107802.1|refseq:NP_058707.1|mint:P23385|dip:DIP-44897N|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001256(GPCR, family 3, metabotropic glutamate receptor 1)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1EWK|rcsb pdb:1EWT|rcsb pdb:1EWV|rcsb pdb:1ISR|rcsb pdb:1ISS|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038038"(G protein-coupled receptor homodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098872"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)	go:"GO:0045202"(synapse)	-	-	figure legend:2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-hippocampus)|taxid:10116(Hippocampus of rat brain)	-	2011/09/23	2014/10/16	rogid:ag94DMSnF60z/fvBWdT0sLtYZ8M10116	rogid:Cy8lKGGALjqGP/e25gw+KqejF5c10116	intact-crc:09B602D2A0CA8930|rigid:XAGjGwC/u04yJLkOOKLRg7L5h5o	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q8CGU4	uniprotkb:Q9Z214-1	intact:EBI-4409108|uniprotkb:Q9JHW8|ensembl:ENSRNOP00000029533	intact:EBI-4410552	psi-mi:agap2_rat(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:q9z214-1(display_long)|uniprotkb:1c(isoform synonym)|uniprotkb:Vesl-1L(isoform synonym)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Homer(gene name synonym)|uniprotkb:Vesl(gene name synonym)|uniprotkb:PSD-Zip45(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rong et al. (2003)	pubmed:14528310|imex:IM-16888	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4410550|imex:IM-16888-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628844|refseq:NP_075415.2|ensembl:ENSRNOG00000025584(gene)|ensembl:ENSRNOT00000031230(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q8CGU4|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)	intact:EBI-2338940(isoform-parent)	-	-	-	figure legend:3d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2011/09/23	2014/10/16	rogid:ag94DMSnF60z/fvBWdT0sLtYZ8M10116	rogid:7yzSvJnto6+5zXH000SPZOIYe3w10116	intact-crc:D0D2571B59BF451B|rigid:Bgal9cwYKgeL8G04eQG0QmuI0yQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CGU4	uniprotkb:O88801	intact:EBI-4409108|uniprotkb:Q9JHW8|ensembl:ENSRNOP00000029533	intact:EBI-1187324|uniprotkb:O88802|ensembl:ENSRNOP00000070858	psi-mi:agap2_rat(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:home2_rat(display_long)|uniprotkb:Cupidin(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 2(gene name synonym)|uniprotkb:Homer2(gene name)|psi-mi:Homer2(display_short)|uniprotkb:Vesl2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rong et al. (2003)	pubmed:14528310|imex:IM-16888	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4410614|imex:IM-16888-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628844|refseq:NP_075415.2|ensembl:ENSRNOG00000025584(gene)|ensembl:ENSRNOT00000031230(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q8CGU4|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)	rgd:620705|refseq:NP_445761.1|ensembl:ENSRNOG00000061450(gene)|ensembl:ENSRNOT00000087785(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|reactome:R-RNO-6794361|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)	-	-	-	figure legend:3d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2011/09/23	2014/10/16	rogid:ag94DMSnF60z/fvBWdT0sLtYZ8M10116	rogid:GlTv3f+uSOfvYEN9xnH1msfLG2o10116	intact-crc:E9C00E83F622AFE2|rigid:fIxjHmFiDFUKjBSbjyGZ4iSWv6w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z214-1	uniprotkb:Q8CGU4	intact:EBI-4410552	intact:EBI-4409108|uniprotkb:Q9JHW8|ensembl:ENSRNOP00000029533	psi-mi:q9z214-1(display_long)|uniprotkb:1c(isoform synonym)|uniprotkb:Vesl-1L(isoform synonym)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Homer(gene name synonym)|uniprotkb:Vesl(gene name synonym)|uniprotkb:PSD-Zip45(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:agap2_rat(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rong et al. (2003)	pubmed:14528310|imex:IM-16888	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4410645|imex:IM-16888-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2338940(isoform-parent)	rgd:628844|refseq:NP_075415.2|ensembl:ENSRNOG00000025584(gene)|ensembl:ENSRNOT00000031230(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q8CGU4|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)	-	-	-	figure legend:7d|agonist:"Quisqualate (grm1 agonist) increased the interaction."|antagonist:"mPEP (grm1 specific antagonist) disrupted the interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-hippocampus)|taxid:10116(Hippocampus of rat brain)	-	2011/09/23	2014/10/16	rogid:7yzSvJnto6+5zXH000SPZOIYe3w10116	rogid:ag94DMSnF60z/fvBWdT0sLtYZ8M10116	intact-crc:DD61DEC7782270C6|rigid:Bgal9cwYKgeL8G04eQG0QmuI0yQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z214-1	uniprotkb:Q8CGU4	intact:EBI-4410552	intact:EBI-4409108|uniprotkb:Q9JHW8|ensembl:ENSRNOP00000029533	psi-mi:q9z214-1(display_long)|uniprotkb:1c(isoform synonym)|uniprotkb:Vesl-1L(isoform synonym)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Homer(gene name synonym)|uniprotkb:Vesl(gene name synonym)|uniprotkb:PSD-Zip45(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:agap2_rat(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rong et al. (2003)	pubmed:14528310|imex:IM-16888	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4410645|imex:IM-16888-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2338940(isoform-parent)	rgd:628844|refseq:NP_075415.2|ensembl:ENSRNOG00000025584(gene)|ensembl:ENSRNOT00000031230(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q8CGU4|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)	-	-	-	figure legend:7d|agonist:"Quisqualate (grm1 agonist) increased the interaction."|antagonist:"mPEP (grm1 specific antagonist) disrupted the interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-hippocampus)|taxid:10116(Hippocampus of rat brain)	-	2011/09/23	2014/10/16	rogid:7yzSvJnto6+5zXH000SPZOIYe3w10116	rogid:ag94DMSnF60z/fvBWdT0sLtYZ8M10116	intact-crc:DD61DEC7782270C6|rigid:Bgal9cwYKgeL8G04eQG0QmuI0yQ	false	-	sufficient binding region:183-193	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CGU4	uniprotkb:Q9Z214-1	intact:EBI-4409108|uniprotkb:Q9JHW8|ensembl:ENSRNOP00000029533	intact:EBI-4410552	psi-mi:agap2_rat(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:q9z214-1(display_long)|uniprotkb:1c(isoform synonym)|uniprotkb:Vesl-1L(isoform synonym)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Homer(gene name synonym)|uniprotkb:Vesl(gene name synonym)|uniprotkb:PSD-Zip45(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rong et al. (2003)	pubmed:14528310|imex:IM-16888	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4410638|imex:IM-16888-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628844|refseq:NP_075415.2|ensembl:ENSRNOG00000025584(gene)|ensembl:ENSRNOT00000031230(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q8CGU4|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)	intact:EBI-2338940(isoform-parent)	-	-	-	figure legend:7c|caution:The antibody used to co-inmunoprecipitate Homer 1c and agap2 could not distingiush between Homer 1c and Homer 2a. The interaction is annotated to Homer 1c because its presence in the complex was confirmed by a specific antibody in western blot.|agonist:"Quisqualate (grm1 agonist) increased the interaction."|antagonist:"mPEP (grm1 specific antagonist) disrupted the interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-hippocampus)|taxid:10116(Hippocampus of rat brain)	-	2011/09/23	2014/10/16	rogid:ag94DMSnF60z/fvBWdT0sLtYZ8M10116	rogid:7yzSvJnto6+5zXH000SPZOIYe3w10116	intact-crc:E484FBB476720FD2|rigid:Bgal9cwYKgeL8G04eQG0QmuI0yQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P23385	uniprotkb:Q8CGU4	intact:EBI-4410410	intact:EBI-4409108|uniprotkb:Q9JHW8|ensembl:ENSRNOP00000029533	psi-mi:grm1_rat(display_long)|uniprotkb:Grm1(gene name)|psi-mi:Grm1(display_short)|uniprotkb:Gprc1a(gene name synonym)|uniprotkb:Mglur1(gene name synonym)	psi-mi:agap2_rat(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rong et al. (2003)	pubmed:14528310|imex:IM-16888	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4410632|imex:IM-16888-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2742|refseq:NP_001107802.1|refseq:NP_058707.1|mint:P23385|dip:DIP-44897N|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001256(GPCR, family 3, metabotropic glutamate receptor 1)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1EWK|rcsb pdb:1EWT|rcsb pdb:1EWV|rcsb pdb:1ISR|rcsb pdb:1ISS|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038038"(G protein-coupled receptor homodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098872"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)	rgd:628844|refseq:NP_075415.2|ensembl:ENSRNOG00000025584(gene)|ensembl:ENSRNOT00000031230(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q8CGU4|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)	-	-	-	figure legend:7b|agonist:"Quisqualate (grm1 agonist) increased the interaction."|antagonist:"mPEP (grm1 specific antagonist) disrupted the interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-hippocampus)|taxid:10116(Hippocampus of rat brain)	-	2011/09/23	2014/10/16	rogid:Cy8lKGGALjqGP/e25gw+KqejF5c10116	rogid:ag94DMSnF60z/fvBWdT0sLtYZ8M10116	intact-crc:E0874331E3455062|rigid:XAGjGwC/u04yJLkOOKLRg7L5h5o	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z214-1	uniprotkb:P23385	intact:EBI-4410552	intact:EBI-4410410	psi-mi:q9z214-1(display_long)|uniprotkb:1c(isoform synonym)|uniprotkb:Vesl-1L(isoform synonym)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Homer(gene name synonym)|uniprotkb:Vesl(gene name synonym)|uniprotkb:PSD-Zip45(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:grm1_rat(display_long)|uniprotkb:Grm1(gene name)|psi-mi:Grm1(display_short)|uniprotkb:Gprc1a(gene name synonym)|uniprotkb:Mglur1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rong et al. (2003)	pubmed:14528310|imex:IM-16888	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4410625|imex:IM-16888-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2338940(isoform-parent)	rgd:2742|refseq:NP_001107802.1|refseq:NP_058707.1|mint:P23385|dip:DIP-44897N|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001256(GPCR, family 3, metabotropic glutamate receptor 1)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1EWK|rcsb pdb:1EWT|rcsb pdb:1EWV|rcsb pdb:1ISR|rcsb pdb:1ISS|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038038"(G protein-coupled receptor homodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098872"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)	-	-	-	figure legend:7a, 7d|caution:The antibody used to co-inmunoprecipitate Homer 1c and grm1 could not distingiush between Homer 1c and Homer 2a. The interaction is annotated to Homer 1c because its presence in the complex was confirmed by a specific antibody in western blot.|agonist:"Quisqualate (grm1 agonist) increased the interaction."|antagonist:"mPEP (grm1 specific antagonist) disrupted the interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-hippocampus)|taxid:10116(Hippocampus of rat brain)	-	2011/09/23	2014/10/16	rogid:7yzSvJnto6+5zXH000SPZOIYe3w10116	rogid:Cy8lKGGALjqGP/e25gw+KqejF5c10116	intact-crc:310C03690B943081|rigid:Hoy0BlqobTm6RgyFzA+7FEMHfZ4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CGU4	uniprotkb:Q9Z214-1	intact:EBI-4409108|uniprotkb:Q9JHW8|ensembl:ENSRNOP00000029533	intact:EBI-4410552	psi-mi:agap2_rat(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:q9z214-1(display_long)|uniprotkb:1c(isoform synonym)|uniprotkb:Vesl-1L(isoform synonym)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Homer(gene name synonym)|uniprotkb:Vesl(gene name synonym)|uniprotkb:PSD-Zip45(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rong et al. (2003)	pubmed:14528310|imex:IM-16888	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4412047|imex:IM-16888-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628844|refseq:NP_075415.2|ensembl:ENSRNOG00000025584(gene)|ensembl:ENSRNOT00000031230(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q8CGU4|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)	intact:EBI-2338940(isoform-parent)	-	-	-	figure legend:3c, 4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/23	2014/10/16	rogid:ag94DMSnF60z/fvBWdT0sLtYZ8M10116	rogid:7yzSvJnto6+5zXH000SPZOIYe3w10116	intact-crc:FF33AFC76E76F6DC|rigid:Bgal9cwYKgeL8G04eQG0QmuI0yQ	false	myc tag:?-?|necessary binding region:1-268|mutation disrupting interaction:187-187	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z214	uniprotkb:Q8CGU4	intact:EBI-2338940|uniprotkb:O08567|uniprotkb:O88800|uniprotkb:Q9QUJ8|uniprotkb:Q9QWN5	intact:EBI-4409108|uniprotkb:Q9JHW8|ensembl:ENSRNOP00000029533	psi-mi:home1_rat(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Homer(gene name synonym)|uniprotkb:Vesl(gene name synonym)|uniprotkb:PSD-Zip45(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:agap2_rat(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rong et al. (2003)	pubmed:14528310|imex:IM-16888	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4412064|imex:IM-16888-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628725|refseq:NP_113895.1|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|refseq:XP_006231837.1|mint:Q9Z214|interpro:IPR044100|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007623"(circadian rhythm)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042220"(response to cocaine)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|rcsb pdb:1DDV|rcsb pdb:1DDW|rcsb pdb:1I2H|rcsb pdb:3CVE|reactome:R-RNO-6794361	rgd:628844|refseq:NP_075415.2|ensembl:ENSRNOG00000025584(gene)|ensembl:ENSRNOT00000031230(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q8CGU4|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)	-	-	-	figure legend:4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/23	2014/10/16	rogid:7yzSvJnto6+5zXH000SPZOIYe3w10116	rogid:ag94DMSnF60z/fvBWdT0sLtYZ8M10116	intact-crc:84869F1ADFF2CF5B|rigid:Bgal9cwYKgeL8G04eQG0QmuI0yQ	false	glutathione s tranferase tag:?-?|sufficient binding region:1..1-110..110(IPR000697)	necessary binding region:180-225|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)