#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-3959072	uniprotkb:Q9N3T2	-	intact:EBI-318437|ensemblmetazoa:Y47G6A.8.1|ensemblmetazoa:Y47G6A.8.2	psi-mi:cttgaggcagagtcc(display_short)|psi-mi:EBI-3959072(display_long)	psi-mi:fen1_caeel(display_long)|uniprotkb:Y47G6A.8(orf name)|uniprotkb:crn-1(gene name)|psi-mi:crn-1(display_short)|uniprotkb:Cell death-related nuclease 1(gene name synonym)|uniprotkb:Flap structure-specific endonuclease 1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0844"(phosphotransfer reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3959151|imex:IM-16875-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_491168.1|wormbase:Y47G6A.8|reactome:R-CEL-69166|ensemblmetazoa:WBGene00000794(gene)|ensemblmetazoa:Y47G6A.8.1(transcript)|ensemblmetazoa:Y47G6A.8.2(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0048256"(flap endonuclease activity)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR023426|interpro:IPR029060|interpro:IPR036279|reactome:R-CEL-5651801|dip:DIP-26974N|reactome:R-CEL-5685939	-	-	-	figure legend:Fig 2D, 3D.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	-	rogid:T4RC9oK5ryCPQhp7SLqwnz+dQ/w6239	intact-crc:9124639BFACA1711	false	-	mutation disrupting interaction:233-234|mutation disrupting interaction:160-160	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-3959072	intact:EBI-3959069	-	-	psi-mi:cttgaggcagagtcc(display_short)|psi-mi:EBI-3959072(display_long)	psi-mi:ggactctgcctcaagacggtagtcaacgtggtgtg(display_short)|psi-mi:EBI-3959069(display_long)	psi-mi:"MI:0415"(enzymatic study)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0844"(phosphotransfer reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3959151|imex:IM-16875-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	figure legend:Fig 2D, 3D.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	-	-	intact-crc:9124639BFACA1711	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-3959072	uniprotkb:Q95NM6	-	intact:EBI-514727|ensemblmetazoa:C41D11.8.1	psi-mi:cttgaggcagagtcc(display_short)|psi-mi:EBI-3959072(display_long)	psi-mi:nucg_caeel(display_long)|uniprotkb:Ced-3 protease suppressor 6(gene name synonym)|uniprotkb:cps-6(gene name)|psi-mi:cps-6(display_short)|uniprotkb:C41D11.8(orf name)	psi-mi:"MI:0415"(enzymatic study)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0844"(phosphotransfer reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3959151|imex:IM-16875-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_491371.1|wormbase:C41D11.8|interpro:IPR018524|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR020821|ensemblmetazoa:C41D11.8.1(transcript)|ensemblmetazoa:WBGene00000787(gene)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046872"(metal ion binding)|rcsb pdb:5GKC|rcsb pdb:5GKP|rcsb pdb:3S5B|rcsb pdb:4QN0|interpro:IPR040255	-	-	-	figure legend:Fig 2D, 3D.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	-	rogid:/Uve+VvpV/bNMZedVIvfebHjvwA6239	intact-crc:9124639BFACA1711	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-3946149	intact:EBI-3959072	-	-	psi-mi:cacaccacgttgactaccgt_minus_1-4_nucleotides_at_3'_end(display_short)|psi-mi:EBI-3946149(display_long)	psi-mi:cttgaggcagagtcc(display_short)|psi-mi:EBI-3959072(display_long)	psi-mi:"MI:0415"(enzymatic study)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3959137|imex:IM-16875-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	figure legend:Fig 2C, 3D.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	-	-	intact-crc:F61276D8D82E5A0C	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-3946149	uniprotkb:Q9N3T2	-	intact:EBI-318437|ensemblmetazoa:Y47G6A.8.1|ensemblmetazoa:Y47G6A.8.2	psi-mi:cacaccacgttgactaccgt_minus_1-4_nucleotides_at_3'_end(display_short)|psi-mi:EBI-3946149(display_long)	psi-mi:fen1_caeel(display_long)|uniprotkb:Y47G6A.8(orf name)|uniprotkb:crn-1(gene name)|psi-mi:crn-1(display_short)|uniprotkb:Cell death-related nuclease 1(gene name synonym)|uniprotkb:Flap structure-specific endonuclease 1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3959137|imex:IM-16875-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_491168.1|wormbase:Y47G6A.8|reactome:R-CEL-69166|ensemblmetazoa:WBGene00000794(gene)|ensemblmetazoa:Y47G6A.8.1(transcript)|ensemblmetazoa:Y47G6A.8.2(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0048256"(flap endonuclease activity)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR023426|interpro:IPR029060|interpro:IPR036279|reactome:R-CEL-5651801|dip:DIP-26974N|reactome:R-CEL-5685939	-	-	-	figure legend:Fig 2C, 3D.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	-	rogid:T4RC9oK5ryCPQhp7SLqwnz+dQ/w6239	intact-crc:F61276D8D82E5A0C	false	-	mutation decreasing interaction:160-160|mutation disrupting interaction:233-234	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-3946149	intact:EBI-3959069	-	-	psi-mi:cacaccacgttgactaccgt_minus_1-4_nucleotides_at_3'_end(display_short)|psi-mi:EBI-3946149(display_long)	psi-mi:ggactctgcctcaagacggtagtcaacgtggtgtg(display_short)|psi-mi:EBI-3959069(display_long)	psi-mi:"MI:0415"(enzymatic study)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3959137|imex:IM-16875-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	figure legend:Fig 2C, 3D.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	-	-	intact-crc:F61276D8D82E5A0C	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-3946149	uniprotkb:Q95NM6	-	intact:EBI-514727|ensemblmetazoa:C41D11.8.1	psi-mi:cacaccacgttgactaccgt_minus_1-4_nucleotides_at_3'_end(display_short)|psi-mi:EBI-3946149(display_long)	psi-mi:nucg_caeel(display_long)|uniprotkb:Ced-3 protease suppressor 6(gene name synonym)|uniprotkb:cps-6(gene name)|psi-mi:cps-6(display_short)|uniprotkb:C41D11.8(orf name)	psi-mi:"MI:0415"(enzymatic study)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3959137|imex:IM-16875-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_491371.1|wormbase:C41D11.8|interpro:IPR018524|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR020821|ensemblmetazoa:C41D11.8.1(transcript)|ensemblmetazoa:WBGene00000787(gene)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046872"(metal ion binding)|rcsb pdb:5GKC|rcsb pdb:5GKP|rcsb pdb:3S5B|rcsb pdb:4QN0|interpro:IPR040255	-	-	-	figure legend:Fig 2C, 3D.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	-	rogid:/Uve+VvpV/bNMZedVIvfebHjvwA6239	intact-crc:F61276D8D82E5A0C	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-3946149	intact:EBI-3959072	-	-	psi-mi:cacaccacgttgactaccgt_minus_1-4_nucleotides_at_3'_end(display_short)|psi-mi:EBI-3946149(display_long)	psi-mi:cttgaggcagagtcc(display_short)|psi-mi:EBI-3959072(display_long)	psi-mi:"MI:0415"(enzymatic study)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3946053|imex:IM-16875-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	figure legend:Fig 2C, 3C.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	-	-	intact-crc:6E91F92C077F92D3	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-3946149	uniprotkb:Q9N3T2	-	intact:EBI-318437|ensemblmetazoa:Y47G6A.8.1|ensemblmetazoa:Y47G6A.8.2	psi-mi:cacaccacgttgactaccgt_minus_1-4_nucleotides_at_3'_end(display_short)|psi-mi:EBI-3946149(display_long)	psi-mi:fen1_caeel(display_long)|uniprotkb:Y47G6A.8(orf name)|uniprotkb:crn-1(gene name)|psi-mi:crn-1(display_short)|uniprotkb:Cell death-related nuclease 1(gene name synonym)|uniprotkb:Flap structure-specific endonuclease 1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3946053|imex:IM-16875-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_491168.1|wormbase:Y47G6A.8|reactome:R-CEL-69166|ensemblmetazoa:WBGene00000794(gene)|ensemblmetazoa:Y47G6A.8.1(transcript)|ensemblmetazoa:Y47G6A.8.2(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0048256"(flap endonuclease activity)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR023426|interpro:IPR029060|interpro:IPR036279|reactome:R-CEL-5651801|dip:DIP-26974N|reactome:R-CEL-5685939	-	-	-	figure legend:Fig 2C, 3C.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	-	rogid:T4RC9oK5ryCPQhp7SLqwnz+dQ/w6239	intact-crc:6E91F92C077F92D3	false	-	mutation decreasing interaction:160-160|mutation disrupting interaction:233-234	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-3946149	intact:EBI-3959069	-	-	psi-mi:cacaccacgttgactaccgt_minus_1-4_nucleotides_at_3'_end(display_short)|psi-mi:EBI-3946149(display_long)	psi-mi:ggactctgcctcaagacggtagtcaacgtggtgtg(display_short)|psi-mi:EBI-3959069(display_long)	psi-mi:"MI:0415"(enzymatic study)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3946053|imex:IM-16875-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	figure legend:Fig 2C, 3C.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	-	-	intact-crc:6E91F92C077F92D3	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-3946149	uniprotkb:Q95NM6	-	intact:EBI-514727|ensemblmetazoa:C41D11.8.1	psi-mi:cacaccacgttgactaccgt_minus_1-4_nucleotides_at_3'_end(display_short)|psi-mi:EBI-3946149(display_long)	psi-mi:nucg_caeel(display_long)|uniprotkb:Ced-3 protease suppressor 6(gene name synonym)|uniprotkb:cps-6(gene name)|psi-mi:cps-6(display_short)|uniprotkb:C41D11.8(orf name)	psi-mi:"MI:0415"(enzymatic study)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3946053|imex:IM-16875-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_491371.1|wormbase:C41D11.8|interpro:IPR018524|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR020821|ensemblmetazoa:C41D11.8.1(transcript)|ensemblmetazoa:WBGene00000787(gene)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046872"(metal ion binding)|rcsb pdb:5GKC|rcsb pdb:5GKP|rcsb pdb:3S5B|rcsb pdb:4QN0|interpro:IPR040255	-	-	-	figure legend:Fig 2C, 3C.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	-	rogid:/Uve+VvpV/bNMZedVIvfebHjvwA6239	intact-crc:6E91F92C077F92D3	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-3959168	uniprotkb:Q9N3T2	-	intact:EBI-318437|ensemblmetazoa:Y47G6A.8.1|ensemblmetazoa:Y47G6A.8.2	psi-mi:cacgttgactaccgtc(display_short)|psi-mi:EBI-3959168(display_long)	psi-mi:fen1_caeel(display_long)|uniprotkb:Y47G6A.8(orf name)|uniprotkb:crn-1(gene name)|psi-mi:crn-1(display_short)|uniprotkb:Cell death-related nuclease 1(gene name synonym)|uniprotkb:Flap structure-specific endonuclease 1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3946137|imex:IM-16875-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_491168.1|wormbase:Y47G6A.8|reactome:R-CEL-69166|ensemblmetazoa:WBGene00000794(gene)|ensemblmetazoa:Y47G6A.8.1(transcript)|ensemblmetazoa:Y47G6A.8.2(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0048256"(flap endonuclease activity)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR023426|interpro:IPR029060|interpro:IPR036279|reactome:R-CEL-5651801|dip:DIP-26974N|reactome:R-CEL-5685939	-	-	-	figure legend:Fig 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	-	rogid:T4RC9oK5ryCPQhp7SLqwnz+dQ/w6239	intact-crc:09EA253BC064B13F	false	-	mutation decreasing interaction:160-160|mutation disrupting interaction:233-234	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-3959168	intact:EBI-3946067	-	-	psi-mi:cacgttgactaccgtc(display_short)|psi-mi:EBI-3959168(display_long)	psi-mi:gatgtcaagcagtcctaactttgaggcagtcc(display_short)|psi-mi:EBI-3946067(display_long)	psi-mi:"MI:0415"(enzymatic study)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3946137|imex:IM-16875-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	figure legend:Fig 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	-	-	intact-crc:09EA253BC064B13F	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-3959168	intact:EBI-3959164	-	-	psi-mi:cacgttgactaccgtc(display_short)|psi-mi:EBI-3959168(display_long)	psi-mi:ggactctgcctcaagacggtagtcaacgtg(display_short)|psi-mi:EBI-3959164(display_long)	psi-mi:"MI:0415"(enzymatic study)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3946137|imex:IM-16875-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	figure legend:Fig 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	-	-	intact-crc:09EA253BC064B13F	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9N3T2	uniprotkb:Q95NM6	intact:EBI-318437|ensemblmetazoa:Y47G6A.8.1|ensemblmetazoa:Y47G6A.8.2	intact:EBI-514727|ensemblmetazoa:C41D11.8.1	psi-mi:fen1_caeel(display_long)|uniprotkb:Y47G6A.8(orf name)|uniprotkb:crn-1(gene name)|psi-mi:crn-1(display_short)|uniprotkb:Cell death-related nuclease 1(gene name synonym)|uniprotkb:Flap structure-specific endonuclease 1(gene name synonym)	psi-mi:nucg_caeel(display_long)|uniprotkb:Ced-3 protease suppressor 6(gene name synonym)|uniprotkb:cps-6(gene name)|psi-mi:cps-6(display_short)|uniprotkb:C41D11.8(orf name)	psi-mi:"MI:0096"(pull down)	Parrish et al. (2003)	pubmed:12840007|imex:IM-16875	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3946017|imex:IM-16875-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_491168.1|wormbase:Y47G6A.8|reactome:R-CEL-69166|ensemblmetazoa:WBGene00000794(gene)|ensemblmetazoa:Y47G6A.8.1(transcript)|ensemblmetazoa:Y47G6A.8.2(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0048256"(flap endonuclease activity)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR023426|interpro:IPR029060|interpro:IPR036279|reactome:R-CEL-5651801|dip:DIP-26974N|reactome:R-CEL-5685939	refseq:NP_491371.1|wormbase:C41D11.8|interpro:IPR018524|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR020821|ensemblmetazoa:C41D11.8.1(transcript)|ensemblmetazoa:WBGene00000787(gene)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046872"(metal ion binding)|rcsb pdb:5GKC|rcsb pdb:5GKP|rcsb pdb:3S5B|rcsb pdb:4QN0|interpro:IPR040255	-	-	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/20	2014/10/16	rogid:T4RC9oK5ryCPQhp7SLqwnz+dQ/w6239	rogid:/Uve+VvpV/bNMZedVIvfebHjvwA6239	intact-crc:BDB62549BA32A1F6|rigid:HG26W+FxlGbBs+g4bELUeolXdY4	false	glutathione s tranferase tag:?-?|sufficient binding region:21-382	35s radiolabel:?-?|sufficient binding region:21-308	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)