#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O43292 uniprotkb:P05187 intact:EBI-720225|uniprotkb:Q9NSS0|uniprotkb:Q9UQ31|ensembl:ENSP00000347206 intact:EBI-1211484|uniprotkb:P05188|uniprotkb:P06861|uniprotkb:Q53S78|uniprotkb:Q96DB7|ensembl:ENSP00000375881 psi-mi:gpaa1_human(display_long)|uniprotkb:GAA1 protein homolog(gene name synonym)|uniprotkb:GPAA1(gene name)|psi-mi:GPAA1(display_short)|uniprotkb:GAA1(gene name synonym) psi-mi:ppb1_human(display_long)|uniprotkb:ALPP(gene name)|psi-mi:ALPP(display_short)|uniprotkb:PLAP(gene name synonym)|uniprotkb:Placental alkaline phosphatase 1(gene name synonym)|uniprotkb:Alkaline phosphatase Regan isozyme(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chen et al. (2003) mint:MINT-8216706|pubmed:12616539|doi:10.1002/jcb.10439 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8617697|mint:MINT-8216714 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003792.1|ensembl:ENSG00000197858(gene)|ensembl:ENST00000355091(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006621"(protein retention in ER lumen)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016255"(attachment of GPI anchor to protein)|go:"GO:0042765"(GPI-anchor transamidase complex)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR007246(Gaa1-like, GPI transamidase component)|mint:O43292|reactome:R-HSA-162791|mint:MINT-8216717(identity) refseq:NP_001623.3|ensembl:ENSG00000163283(gene)|ensembl:ENST00000392027(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0031225"(anchored component of membrane)|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR018299|mint:P05187|rcsb pdb:1EW2|rcsb pdb:1ZEB|rcsb pdb:1ZED|rcsb pdb:1ZEF|rcsb pdb:2GLQ|rcsb pdb:3MK0|rcsb pdb:3MK1|rcsb pdb:3MK2|reactome:R-HSA-6811438|mint:MINT-8216716(identity) - - - comment:homomint|comment:mint|figure legend:f1 f2|partial coverage:partial coverage taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/10/17 2014/10/16 rogid:rAbNrvIdzfJFRNTZ5qxulRrc/KQ9606 rogid:JtfGSKMzJL3vP08X7lDS117PYbY9606 intact-crc:4980FED755080FE7|rigid:x5wl2LWuqOAvmBswCksvdVAgINk false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92643 uniprotkb:P05187 intact:EBI-8617711|ensembl:ENSP00000359848|intact:MINT-2813159|uniprotkb:O14822|uniprotkb:B2R7K3|uniprotkb:Q5TG77|uniprotkb:B4E2M3 intact:EBI-1211484|uniprotkb:P05188|uniprotkb:P06861|uniprotkb:Q53S78|uniprotkb:Q96DB7|ensembl:ENSP00000375881 psi-mi:gpi8_human(display_long)|uniprotkb:PIGK(gene name)|psi-mi:PIGK(display_short)|uniprotkb:GPI8(gene name synonym)|uniprotkb:Phosphatidylinositol-glycan biosynthesis class K protein(gene name synonym)|uniprotkb:GPI8 homolog(gene name synonym) psi-mi:ppb1_human(display_long)|uniprotkb:ALPP(gene name)|psi-mi:ALPP(display_short)|uniprotkb:PLAP(gene name synonym)|uniprotkb:Placental alkaline phosphatase 1(gene name synonym)|uniprotkb:Alkaline phosphatase Regan isozyme(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chen et al. (2003) mint:MINT-8216706|pubmed:12616539|doi:10.1002/jcb.10439 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8617706|mint:MINT-8216721 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000142892(gene)|ensembl:ENST00000370812(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003923"(GPI-anchor transamidase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0016255"(attachment of GPI anchor to protein)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042765"(GPI-anchor transamidase complex)|interpro:IPR001096(Peptidase C13, legumain)|interpro:IPR028361|mint:Q92643|reactome:R-HSA-162791|refseq:NP_005473.1|mint:MINT-8216724(identity) refseq:NP_001623.3|ensembl:ENSG00000163283(gene)|ensembl:ENST00000392027(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0031225"(anchored component of membrane)|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR018299|mint:P05187|rcsb pdb:1EW2|rcsb pdb:1ZEB|rcsb pdb:1ZED|rcsb pdb:1ZEF|rcsb pdb:2GLQ|rcsb pdb:3MK0|rcsb pdb:3MK1|rcsb pdb:3MK2|reactome:R-HSA-6811438|mint:MINT-8216723(identity) - function:Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein|comment:mint - comment:homomint|comment:mint|figure legend:f1 f2|partial coverage:partial coverage taxid:9606(human)|taxid:9606(Homo sapiens) - 2011/10/17 2014/10/16 rogid:FRRsPTVrMU/nfpydL7D59VLlXxY9606 rogid:JtfGSKMzJL3vP08X7lDS117PYbY9606 intact-crc:2DFA7AFF1FD8F534|rigid:bY5X9Dz6J7z/jMuGb1/G8HOi9QE false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)