#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q00944 uniprotkb:Q14451 intact:EBI-2896409|ensembl:ENSGALP00000044406 intact:EBI-970191|ensembl:ENSP00000310771|ensembl:ENSP00000377759|ensembl:ENSP00000377761|uniprotkb:B2RAV1|uniprotkb:B3KNL0|uniprotkb:B3KWP9|uniprotkb:B7WP75|uniprotkb:Q53YD3|uniprotkb:Q9Y220|uniprotkb:Q92568|uniprotkb:Q96DF9|intact:EBI-1257061|uniprotkb:J3KQM4 psi-mi:fak1_chick(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym) psi-mi:grb7_human(display_long)|uniprotkb:GRB7(gene name)|psi-mi:GRB7(display_short)|uniprotkb:GRB7 adapter protein(gene name synonym)|uniprotkb:Epidermal growth factor receptor GRB-7(gene name synonym)|uniprotkb:B47(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Shen et al. (2002) pubmed:12021278|imex:IM-17287 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-4288386|imex:IM-17287-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSGALG00000031741(gene)|ensembl:ENSGALT00000072414(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|rcsb pdb:2JKO|rcsb pdb:2JKQ|rcsb pdb:2L6F|rcsb pdb:2L6G|rcsb pdb:2L6H|go:"GO:0005524"(ATP binding)|rcsb pdb:3ZDT|rcsb pdb:4BRX|rcsb pdb:4C7T|rcsb pdb:4CYE|rcsb pdb:4D4R|rcsb pdb:4D4S|rcsb pdb:4D4V|rcsb pdb:4D4Y|rcsb pdb:4D55|rcsb pdb:4D58|rcsb pdb:4D5H|rcsb pdb:4D5K|rcsb pdb:6CB0|rcsb pdb:6GCR|rcsb pdb:6GCX|rcsb pdb:6TY3|rcsb pdb:6TY4|reactome:R-GGA-111465|reactome:R-GGA-2029482|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-3928662|reactome:R-GGA-418885|reactome:R-GGA-4420097|reactome:R-GGA-5663213|reactome:R-GGA-8874081|reactome:R-GGA-9009391|rcsb pdb:6GCW|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009268"(response to pH)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:1KTM|rcsb pdb:1PV3|rcsb pdb:1QVX|rcsb pdb:2AEH|rcsb pdb:2AL6|rcsb pdb:2J0J|rcsb pdb:2J0K|rcsb pdb:2J0L|rcsb pdb:2J0M|rcsb pdb:2JKK|rcsb pdb:2JKM|refseq:NP_990766.1 ensembl:ENSG00000141738(gene)|ensembl:ENST00000309156(transcript)|ensembl:ENST00000394209(transcript)|ensembl:ENST00000394211(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042995"(cell projection)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035032|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14451|rcsb pdb:1MW4|rcsb pdb:1WGR|rcsb pdb:2L4K|rcsb pdb:2QMS|rcsb pdb:3PQZ|rcsb pdb:4WWQ|rcsb pdb:4X6S|rcsb pdb:5D0J|rcsb pdb:5EEL|rcsb pdb:5EEQ|rcsb pdb:5TYI|rcsb pdb:5U06|rcsb pdb:5U1Q|go:"GO:0042802"(identical protein binding)|reactome:R-HSA-1306955|reactome:R-HSA-186763|reactome:R-HSA-210993|reactome:R-HSA-8853659|reactome:R-HSA-9696273|reactome:R-HSA-1433557|refseq:NP_001025173.1|refseq:NP_001229371.1|refseq:NP_001229372.1|refseq:NP_005301.2|refseq:NP_001317136.1|dip:DIP-502N - - - figure legend:fig 4|comment:"went back through a series of \"done as described previously\": human GRB7, chicken FAK1"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2011/06/20 2014/10/16 rogid:SNqKiUJ1MN55zVMmZ7LCQXCvVXs9031 rogid:XViWZjk5YwdZFTG3zs2aNdxeFVQ9606 intact-crc:4759C297A60A5F6B|rigid:4xZXO3m+daSIq8yrJUzz/B/RPSI false enhanced green fluorescent protein tag:?-? ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)