#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q10666 uniprotkb:O17695 intact:EBI-317870|uniprotkb:O45007|ensemblmetazoa:W10C8.2.1 intact:EBI-318045|ensemblmetazoa:C53A5.3.1 psi-mi:pop1_caeel(display_long)|uniprotkb:pop-1(gene name)|psi-mi:pop-1(display_short)|uniprotkb:W10C8.2(orf name)|uniprotkb:Posterior pharynx defect protein 1(gene name synonym) psi-mi:hda1_caeel(display_long)|uniprotkb:hda-1(gene name)|psi-mi:hda-1(display_short)|uniprotkb:C53A5.3(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Calvo et al. (2001) pubmed:11742996|imex:IM-17297 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3952117|imex:IM-17297-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-CEL-4641265|wormbase:W10C8.2|reactome:R-CEL-8853884|reactome:R-CEL-3769402|refseq:NP_491053.4|ensemblmetazoa:W10C8.2.1(transcript)|ensemblmetazoa:WBGene00004077(gene)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061853"(regulation of neuroblast migration)|go:"GO:2000746"(regulation of defecation rhythm)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR024940|interpro:IPR028782|interpro:IPR036910|rcsb pdb:3C2G|go:"GO:1990907"(beta-catenin-TCF complex)|dip:DIP-25683N|reactome:R-CEL-201722|reactome:R-CEL-4086398|reactome:R-CEL-8951430 refseq:NP_506599.1|wormbase:C53A5.3|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045138"(nematode male tail tip morphogenesis)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:1903854"(negative regulation of stress response to copper ion)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|ensemblmetazoa:C53A5.3.1(transcript)|ensemblmetazoa:WBGene00001834(gene)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0040027"(negative regulation of vulval development)|go:"GO:0042001"(hermaphrodite somatic sex determination)|go:"GO:0043073"(germ cell nucleus)|dip:DIP-26427N - - - figure legend:Fig 5D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel-embryo)|taxid:6239(Caenorhabditis elegans embryo) - 2011/05/24 2014/10/16 rogid:kzktFe2ZSDObXvcMQsdR9o90wGI6239 rogid:muul0dZ9oQUpxzy9aG7qV1lNlrI6239 intact-crc:857454AE7AE42E84|rigid:cdy+pzco3572YIOppAwknpAV70w false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O02482 uniprotkb:Q10666 intact:EBI-314716|uniprotkb:P91912|ensemblmetazoa:W02D3.9.1|ensemblmetazoa:W02D3.9.2 intact:EBI-317870|uniprotkb:O45007|ensemblmetazoa:W10C8.2.1 psi-mi:unc37_caeel(display_long)|uniprotkb:unc-37(gene name)|psi-mi:unc-37(display_short)|uniprotkb:esg(gene name synonym)|uniprotkb:W02D3.9(orf name)|uniprotkb:Uncoordinated protein 37(gene name synonym) psi-mi:pop1_caeel(display_long)|uniprotkb:pop-1(gene name)|psi-mi:pop-1(display_short)|uniprotkb:W10C8.2(orf name)|uniprotkb:Posterior pharynx defect protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Calvo et al. (2001) pubmed:11742996|imex:IM-17297 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3952119|imex:IM-17297-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-CEL-4641265|refseq:NP_491932.1|wormbase:W02D3.9|reactome:R-CEL-3769402|ensemblmetazoa:W02D3.9.1(transcript)|ensemblmetazoa:W02D3.9.2(transcript)|ensemblmetazoa:WBGene00006773(gene)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008134"(transcription factor binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|dip:DIP-27333N|reactome:R-CEL-201722 reactome:R-CEL-4641265|wormbase:W10C8.2|reactome:R-CEL-8853884|reactome:R-CEL-3769402|refseq:NP_491053.4|ensemblmetazoa:W10C8.2.1(transcript)|ensemblmetazoa:WBGene00004077(gene)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061853"(regulation of neuroblast migration)|go:"GO:2000746"(regulation of defecation rhythm)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR024940|interpro:IPR028782|interpro:IPR036910|rcsb pdb:3C2G|go:"GO:1990907"(beta-catenin-TCF complex)|dip:DIP-25683N|reactome:R-CEL-201722|reactome:R-CEL-4086398|reactome:R-CEL-8951430 - - - figure legend:Fig 5E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel-embryo)|taxid:6239(Caenorhabditis elegans embryo) - 2011/05/24 2014/10/16 rogid:+e4X3QH+GChhuO2oAhaNGVwnO/o6239 rogid:kzktFe2ZSDObXvcMQsdR9o90wGI6239 intact-crc:BE292173B15673A4|rigid:w13ef4byXhxHQpkInNtQn1mYCkk false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O02482 uniprotkb:Q10666 intact:EBI-314716|uniprotkb:P91912|ensemblmetazoa:W02D3.9.1|ensemblmetazoa:W02D3.9.2 intact:EBI-317870|uniprotkb:O45007|ensemblmetazoa:W10C8.2.1 psi-mi:unc37_caeel(display_long)|uniprotkb:unc-37(gene name)|psi-mi:unc-37(display_short)|uniprotkb:esg(gene name synonym)|uniprotkb:W02D3.9(orf name)|uniprotkb:Uncoordinated protein 37(gene name synonym) psi-mi:pop1_caeel(display_long)|uniprotkb:pop-1(gene name)|psi-mi:pop-1(display_short)|uniprotkb:W10C8.2(orf name)|uniprotkb:Posterior pharynx defect protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Calvo et al. (2001) pubmed:11742996|imex:IM-17297 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3956787|imex:IM-17297-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-CEL-4641265|refseq:NP_491932.1|wormbase:W02D3.9|reactome:R-CEL-3769402|ensemblmetazoa:W02D3.9.1(transcript)|ensemblmetazoa:W02D3.9.2(transcript)|ensemblmetazoa:WBGene00006773(gene)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008134"(transcription factor binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|dip:DIP-27333N|reactome:R-CEL-201722 reactome:R-CEL-4641265|wormbase:W10C8.2|reactome:R-CEL-8853884|reactome:R-CEL-3769402|refseq:NP_491053.4|ensemblmetazoa:W10C8.2.1(transcript)|ensemblmetazoa:WBGene00004077(gene)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061853"(regulation of neuroblast migration)|go:"GO:2000746"(regulation of defecation rhythm)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR024940|interpro:IPR028782|interpro:IPR036910|rcsb pdb:3C2G|go:"GO:1990907"(beta-catenin-TCF complex)|dip:DIP-25683N|reactome:R-CEL-201722|reactome:R-CEL-4086398|reactome:R-CEL-8951430 - - - figure legend:Fig 5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/05/24 2014/10/16 rogid:+e4X3QH+GChhuO2oAhaNGVwnO/o6239 rogid:kzktFe2ZSDObXvcMQsdR9o90wGI6239 intact-crc:B83A45992EED8CA8|rigid:w13ef4byXhxHQpkInNtQn1mYCkk false ha tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q10666 uniprotkb:O17695 intact:EBI-317870|uniprotkb:O45007|ensemblmetazoa:W10C8.2.1 intact:EBI-318045|ensemblmetazoa:C53A5.3.1 psi-mi:pop1_caeel(display_long)|uniprotkb:pop-1(gene name)|psi-mi:pop-1(display_short)|uniprotkb:W10C8.2(orf name)|uniprotkb:Posterior pharynx defect protein 1(gene name synonym) psi-mi:hda1_caeel(display_long)|uniprotkb:hda-1(gene name)|psi-mi:hda-1(display_short)|uniprotkb:C53A5.3(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Calvo et al. (2001) pubmed:11742996|imex:IM-17297 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-3952059|imex:IM-17297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-CEL-4641265|wormbase:W10C8.2|reactome:R-CEL-8853884|reactome:R-CEL-3769402|refseq:NP_491053.4|ensemblmetazoa:W10C8.2.1(transcript)|ensemblmetazoa:WBGene00004077(gene)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061853"(regulation of neuroblast migration)|go:"GO:2000746"(regulation of defecation rhythm)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR024940|interpro:IPR028782|interpro:IPR036910|rcsb pdb:3C2G|go:"GO:1990907"(beta-catenin-TCF complex)|dip:DIP-25683N|reactome:R-CEL-201722|reactome:R-CEL-4086398|reactome:R-CEL-8951430 refseq:NP_506599.1|wormbase:C53A5.3|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045138"(nematode male tail tip morphogenesis)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:1903854"(negative regulation of stress response to copper ion)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|ensemblmetazoa:C53A5.3.1(transcript)|ensemblmetazoa:WBGene00001834(gene)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0040027"(negative regulation of vulval development)|go:"GO:0042001"(hermaphrodite somatic sex determination)|go:"GO:0043073"(germ cell nucleus)|dip:DIP-26427N - - - figure legend:Fig 5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/05/24 2014/10/16 rogid:kzktFe2ZSDObXvcMQsdR9o90wGI6239 rogid:muul0dZ9oQUpxzy9aG7qV1lNlrI6239 intact-crc:B99B40EC50C087A3|rigid:d4UKU9CehBeahGXwd0vXhd0HkAw false - flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q10666 uniprotkb:O02482 intact:EBI-317870|uniprotkb:O45007|ensemblmetazoa:W10C8.2.1 intact:EBI-314716|uniprotkb:P91912|ensemblmetazoa:W02D3.9.1|ensemblmetazoa:W02D3.9.2 psi-mi:pop1_caeel(display_long)|uniprotkb:pop-1(gene name)|psi-mi:pop-1(display_short)|uniprotkb:W10C8.2(orf name)|uniprotkb:Posterior pharynx defect protein 1(gene name synonym) psi-mi:unc37_caeel(display_long)|uniprotkb:unc-37(gene name)|psi-mi:unc-37(display_short)|uniprotkb:esg(gene name synonym)|uniprotkb:W02D3.9(orf name)|uniprotkb:Uncoordinated protein 37(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Calvo et al. (2001) pubmed:11742996|imex:IM-17297 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-3952059|imex:IM-17297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-CEL-4641265|wormbase:W10C8.2|reactome:R-CEL-8853884|reactome:R-CEL-3769402|refseq:NP_491053.4|ensemblmetazoa:W10C8.2.1(transcript)|ensemblmetazoa:WBGene00004077(gene)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061853"(regulation of neuroblast migration)|go:"GO:2000746"(regulation of defecation rhythm)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR024940|interpro:IPR028782|interpro:IPR036910|rcsb pdb:3C2G|go:"GO:1990907"(beta-catenin-TCF complex)|dip:DIP-25683N|reactome:R-CEL-201722|reactome:R-CEL-4086398|reactome:R-CEL-8951430 reactome:R-CEL-4641265|refseq:NP_491932.1|wormbase:W02D3.9|reactome:R-CEL-3769402|ensemblmetazoa:W02D3.9.1(transcript)|ensemblmetazoa:W02D3.9.2(transcript)|ensemblmetazoa:WBGene00006773(gene)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008134"(transcription factor binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|dip:DIP-27333N|reactome:R-CEL-201722 - - - figure legend:Fig 5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/05/24 2014/10/16 rogid:kzktFe2ZSDObXvcMQsdR9o90wGI6239 rogid:+e4X3QH+GChhuO2oAhaNGVwnO/o6239 intact-crc:B99B40EC50C087A3|rigid:d4UKU9CehBeahGXwd0vXhd0HkAw false - ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O17695 uniprotkb:O02482 intact:EBI-318045|ensemblmetazoa:C53A5.3.1 intact:EBI-314716|uniprotkb:P91912|ensemblmetazoa:W02D3.9.1|ensemblmetazoa:W02D3.9.2 psi-mi:hda1_caeel(display_long)|uniprotkb:hda-1(gene name)|psi-mi:hda-1(display_short)|uniprotkb:C53A5.3(orf name) psi-mi:unc37_caeel(display_long)|uniprotkb:unc-37(gene name)|psi-mi:unc-37(display_short)|uniprotkb:esg(gene name synonym)|uniprotkb:W02D3.9(orf name)|uniprotkb:Uncoordinated protein 37(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Calvo et al. (2001) pubmed:11742996|imex:IM-17297 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3952079|imex:IM-17297-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_506599.1|wormbase:C53A5.3|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045138"(nematode male tail tip morphogenesis)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:1903854"(negative regulation of stress response to copper ion)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|ensemblmetazoa:C53A5.3.1(transcript)|ensemblmetazoa:WBGene00001834(gene)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0040027"(negative regulation of vulval development)|go:"GO:0042001"(hermaphrodite somatic sex determination)|go:"GO:0043073"(germ cell nucleus)|dip:DIP-26427N reactome:R-CEL-4641265|refseq:NP_491932.1|wormbase:W02D3.9|reactome:R-CEL-3769402|ensemblmetazoa:W02D3.9.1(transcript)|ensemblmetazoa:W02D3.9.2(transcript)|ensemblmetazoa:WBGene00006773(gene)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008134"(transcription factor binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|dip:DIP-27333N|reactome:R-CEL-201722 - - - figure legend:Fig 5C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/05/24 2014/10/16 rogid:muul0dZ9oQUpxzy9aG7qV1lNlrI6239 rogid:+e4X3QH+GChhuO2oAhaNGVwnO/o6239 intact-crc:331421034D6071ED|rigid:GnW3Ux6RvGmFIyRPGlyPdG207po false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O17695 uniprotkb:Q10666 intact:EBI-318045|ensemblmetazoa:C53A5.3.1 intact:EBI-317870|uniprotkb:O45007|ensemblmetazoa:W10C8.2.1 psi-mi:hda1_caeel(display_long)|uniprotkb:hda-1(gene name)|psi-mi:hda-1(display_short)|uniprotkb:C53A5.3(orf name) psi-mi:pop1_caeel(display_long)|uniprotkb:pop-1(gene name)|psi-mi:pop-1(display_short)|uniprotkb:W10C8.2(orf name)|uniprotkb:Posterior pharynx defect protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Calvo et al. (2001) pubmed:11742996|imex:IM-17297 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3956778|imex:IM-17297-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_506599.1|wormbase:C53A5.3|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045138"(nematode male tail tip morphogenesis)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:1903854"(negative regulation of stress response to copper ion)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|ensemblmetazoa:C53A5.3.1(transcript)|ensemblmetazoa:WBGene00001834(gene)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008406"(gonad development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0040027"(negative regulation of vulval development)|go:"GO:0042001"(hermaphrodite somatic sex determination)|go:"GO:0043073"(germ cell nucleus)|dip:DIP-26427N reactome:R-CEL-4641265|wormbase:W10C8.2|reactome:R-CEL-8853884|reactome:R-CEL-3769402|refseq:NP_491053.4|ensemblmetazoa:W10C8.2.1(transcript)|ensemblmetazoa:WBGene00004077(gene)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010085"(polarity specification of proximal/distal axis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0040026"(positive regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043282"(pharyngeal muscle development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061853"(regulation of neuroblast migration)|go:"GO:2000746"(regulation of defecation rhythm)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR024940|interpro:IPR028782|interpro:IPR036910|rcsb pdb:3C2G|go:"GO:1990907"(beta-catenin-TCF complex)|dip:DIP-25683N|reactome:R-CEL-201722|reactome:R-CEL-4086398|reactome:R-CEL-8951430 - - - figure legend:Fig 5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/05/24 2014/10/16 rogid:muul0dZ9oQUpxzy9aG7qV1lNlrI6239 rogid:kzktFe2ZSDObXvcMQsdR9o90wGI6239 intact-crc:099AC4D97C90BBAF|rigid:cdy+pzco3572YIOppAwknpAV70w false flag tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)